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公开(公告)号：US20200239632A1
公开(公告)日：2020-07-30
申请号：US16583885
申请日：2019-09-26
申请人： X-Therma, Inc.
发明人： Xiaoxi Wei
摘要： The present invention provides peptoid polymers and salts thereof that comprise hydrophobic and polar peptoid monomers and are capable of reducing or inhibiting the formation of ice crystals at sub 0° C. temperatures. Also provided are peptoid-peptide hybrids and salts thereof comprising the peptoid polymers provided herein. The peptoid polymers, peptoid-peptide hybrids, and salts thereof provided herein are useful for making cryoprotectant solutions. The peptoid polymers, peptoid-peptide hybrids, salts thereof, and cryoprotectant solutions provided herein are useful for making antifreeze solutions, frozen food products, and cosmetic care products. Also provided herein are methods for preserving a tissue, an organ, a cell, or a biological macromolecule using the compositions described herein.
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公开(公告)号：US12048304B2
公开(公告)日：2024-07-30
申请号：US17219461
申请日：2021-03-31
申请人： X-Therma, Inc.
发明人： Xiaoxi Wei
IPC分类号： A01N1/02
CPC分类号： A01N1/0252 , A01N1/0221
摘要： The present technology relates to apparatuses and methods for preserving biological material, for example cryopreserved biological material, such as cells, tissues, and organs for storage and/or transport. Apparatuses and methods of the present technology preserve biological material at a target temperature within a range of 8° C. to −40° C. for extended periods of time, for example at least 4 hours. The target temperature and extended period of time may be achieved with the use of cold sources such as phase change materials (PCMs) in combination with insulation materials, such as vacuum insulation panels (VIPs) and/or aerogels.
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公开(公告)号：US20230276788A1
公开(公告)日：2023-09-07
申请号：US17974202
申请日：2022-10-26
申请人： X-THERMA, INC.
发明人： Xiaoxi Wei
IPC分类号： A01N1/02 , C08G69/10 , A23B4/20 , A61Q90/00 , C07K7/08 , A23L13/40 , A23L17/00 , A23L3/3526 , A23G9/38 , A61K8/88 , C07K14/00 , A23L3/37 , A23G9/32 , A61K8/64 , C07K7/06 , C09K3/18
CPC分类号： A01N1/0221 , C08G69/10 , A23B4/20 , A61Q90/00 , C07K7/08 , A23L13/42 , A23L17/00 , A23L3/3526 , A23G9/38 , A61K8/88 , C07K14/001 , A23L3/37 , A23G9/32 , A61K8/64 , C07K7/06 , C09K3/18 , A61K2800/54 , A23V2002/00
摘要： The present invention provides peptoid polymers capable of reducing or inhibiting the formation of ice crystals at sub 0° C. temperatures. Also provided are peptoid-peptide hybrids comprising the peptoid polymers provided herein. The peptoid polymers and peptoid-peptide hybrids provided herein are useful for making cryoprotectant solutions. The peptoid polymers, peptoid-peptide hybrids, and cryoprotectant solutions provided herein are useful for making antifreeze solutions, frozen food products, and cosmetic care products. Also provided herein are methods for preserving a tissue, an organ, a cell, or a biological macromolecule using the compositions described herein.
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公开(公告)号：US20190069537A1
公开(公告)日：2019-03-07
申请号：US15969256
申请日：2018-05-02
申请人： X-Therma, Inc.
发明人： Xiaoxi Wei
摘要： The present invention provides peptoid polymers capable of reducing or inhibiting the formation of ice crystals at sub 0° C. temperatures. Also provided are peptoid-peptide hybrids comprising the peptoid polymers provided herein. The peptoid polymers and peptoid-peptide hybrids provided herein are useful for making cryoprotectant solutions. The peptoid polymers, peptoid-peptide hybrids, and cryoprotectant solutions provided herein are useful for making antifreeze solutions, frozen food products, and cosmetic care products. Also provided herein are methods for preserving a tissue, an organ, a cell, or a biological macromolecule using the compositions described herein.
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公开(公告)号：US20210100238A1
公开(公告)日：2021-04-08
申请号：US16881794
申请日：2020-05-22
申请人： X-THERMA, INC.
发明人： Xiaoxi Wei
IPC分类号： A01N1/02 , C08G69/10 , A23B4/20 , A61Q90/00 , C07K7/08 , A23L13/40 , A23L17/00 , A23L3/3526 , A23G9/38 , A61K8/88 , C07K14/00 , A23L3/37 , A23G9/32 , A61K8/64 , C07K7/06 , C09K3/18
摘要： The present invention provides peptoid polymers capable of reducing or inhibiting the formation of ice crystals at sub 0° C. temperatures. Also provided are peptoid-peptide hybrids comprising the peptoid polymers provided herein. The peptoid polymers and peptoid-peptide hybrids provided herein are useful for making cryoprotectant solutions. The peptoid polymers, peptoid-peptide hybrids, and cryoprotectant solutions provided herein are useful for making antifreeze solutions, frozen food products, and cosmetic care products. Also provided herein are methods for preserving a tissue, an organ, a cell, or a biological macromolecule using the compositions described herein.
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公开(公告)号：US09986733B2
公开(公告)日：2018-06-05
申请号：US15486522
申请日：2017-04-13
申请人： X-Therma, Inc.
发明人： Xiaoxi Wei
CPC分类号： A01N1/0221 , A23G9/32 , A23V2002/00 , A61K8/64 , C07K7/06 , C08G69/10 , C09K3/18
摘要： The present invention provides peptoid polymers capable of reducing or inhibiting the formation of ice crystals at sub 0° C. temperatures. Also provided are peptoid-peptide hybrids comprising the peptoid polymers provided herein. The peptoid polymers and peptoid-peptide hybrids provided herein are useful for making cryoprotectant solutions. The peptoid polymers, peptoid-peptide hybrids, and cryoprotectant solutions provided herein are useful for making antifreeze solutions, frozen food products, and cosmetic care products. Also provided herein are methods for preserving a tissue, an organ, a cell, or a biological macromolecule using the compositions described herein.
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公开(公告)号：US20240084074A1
公开(公告)日：2024-03-14
申请号：US18161773
申请日：2023-01-30
申请人： X-Therma, Inc.
发明人： Xiaoxi Wei
CPC分类号： C08G69/10 , A23L3/3526 , A23L3/37 , A23L13/422 , A61K8/64 , A61K8/88 , C07K7/08 , C09K3/18 , A61K2800/54
摘要： The present invention provides peptoid polymers and salts thereof that comprise hydrophobic and polar peptoid monomers and are capable of reducing or inhibiting the formation of ice crystals at sub 0° C. temperatures. Also provided are peptoid-peptide hybrids and salts thereof comprising the peptoid polymers provided herein. The peptoid polymers, peptoid-peptide hybrids, and salts thereof provided herein are useful for making cryoprotectant solutions. The peptoid polymers, peptoid-peptide hybrids, salts thereof, and cryoprotectant solutions provided herein are useful for making antifreeze solutions, frozen food products, and cosmetic care products. Also provided herein are methods for preserving a tissue, an organ, a cell, or a biological macromolecule using the compositions described herein.
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公开(公告)号：US11608414B2
公开(公告)日：2023-03-21
申请号：US16583885
申请日：2019-09-26
申请人： X-Therma, Inc.
发明人： Xiaoxi Wei
摘要： The present invention provides peptoid polymers and salts thereof that comprise hydrophobic and polar peptoid monomers and are capable of reducing or inhibiting the formation of ice crystals at sub 0° C. temperatures. Also provided are peptoid-peptide hybrids and salts thereof comprising the peptoid polymers provided herein. The peptoid polymers, peptoid-peptide hybrids, and salts thereof provided herein are useful for making cryoprotectant solutions. The peptoid polymers, peptoid-peptide hybrids, salts thereof, and cryoprotectant solutions provided herein are useful for making antifreeze solutions, frozen food products, and cosmetic care products. Also provided herein are methods for preserving a tissue, an organ, a cell, or a biological macromolecule using the compositions described herein.
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公开(公告)号：US11564388B2
公开(公告)日：2023-01-31
申请号：US16583895
申请日：2019-09-26
申请人： X-Therma, Inc.
发明人： Xiaoxi Wei
IPC分类号： A01N1/02
摘要： The present invention provides methods for cryopreserving a population of cells with improved cell viability. In some aspects, the method comprises contacting a population of cells with a peptoid polymer comprising one or more polar peptoid monomers, e.g., formulated in a cryoprotectant solution, and cooling the population of cells at a temperature of from 0° C. to about −20° C. for a time period of at least about 3 hours to produce a population of supercooled cells. The supercooling methods of the present invention provide excellent post-thaw cell survival and recovery. In certain embodiments, the population of cells is present in a tissue or an organ that is cryopreserved by performing the supercooling methods of the present invention.
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公开(公告)号：US20200170241A1
公开(公告)日：2020-06-04
申请号：US16583895
申请日：2019-09-26
申请人： X-Therma, Inc.
发明人： Xiaoxi Wei
IPC分类号： A01N1/02
摘要： The present invention provides methods for cryopreserving a population of cells with improved cell viability. In some aspects, the method comprises contacting a population of cells with a peptoid polymer comprising one or more polar peptoid monomers, e.g., formulated in a cryoprotectant solution, and cooling the population of cells at a temperature of from 0° C. to about −20° C. for a time period of at least about 3 hours to produce a population of supercooled cells. The supercooling methods of the present invention provide excellent post-thaw cell survival and recovery. In certain embodiments, the population of cells is present in a tissue or an organ that is cryopreserved by performing the supercooling methods of the present invention.
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