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    Nucleotide sequence encoding human cyclin A
    4.
    发明授权
    Nucleotide sequence encoding human cyclin A 失效
    编码人细胞周期蛋白A的核苷酸序列

    公开(公告)号：US6103887A

    公开(公告)日：2000-08-15

    申请号：US210889

    申请日：1998-12-15

    申请人： Christian Brechot ,  Jian Wang ,  Xavier Chenivesse ,  Berthold Henglein ,  Frederique Zindy

    发明人： Christian Brechot ,  Jian Wang ,  Xavier Chenivesse ,  Berthold Henglein ,  Frederique Zindy

    IPC分类号： A61K38/00 ,  C07K14/47 ,  C07K16/18 ,  C12N15/113 ,  C12N15/12 ,  C07H21/04 ,  C12N15/11 ,  C12N15/63

    CPC分类号： C12N15/113 ,  C07K14/4738 ,  C07K16/18 ,  A61K38/00 ,  C12N2310/3513

    摘要： The invention is directed generally to a DNA sequence coding for human cyclin A and in particular to antibodies, or antisera including such antibodies, which bind to human cyclin A as encoded by the sequence of SEQ ID NO: 1 and which are useful in detecting cellular proliferation. The antibodies of the invention can be polyclonal or monoclonal, and are preferably generated by injection of purified human cyclin A into an animal host. The invention is particularly advantageous because it has been discovered that the gene encoding for human cyclin A is a site for integration of the hepatitis B virus associated with hepatocellular carcinoma, and by detecting human cyclin A through the use of the antibodies of the invention, one can detect and diagnose cell proliferation. Through the use of the present invention, cell proliferation and tumorigenesis can thus be detected at early stages, and such conditions can then be treated or inhibited by the use of anti-sense human cyclin A DNA.

    摘要翻译： 本发明一般涉及编码人类细胞周期蛋白A的DNA序列，特别是编码抗体或包含此类抗体的抗血清，其结合如SEQ ID NO：1的序列编码的人细胞周期蛋白A并且可用于检测细胞 增殖。 本发明的抗体可以是多克隆的或单克隆的，并且优选通过将纯化的人细胞周期蛋白A注射到动物宿主中来产生。 本发明是特别有利的，因为已经发现编码人细胞周期蛋白A的基因是与肝细胞癌相关的乙型肝炎病毒整合的位点，并且通过使用本发明的抗体检测人细胞周期蛋白A 可以检测和诊断细胞增殖。 通过使用本发明，因此可以在早期阶段检测细胞增殖和肿瘤发生，然后可以通过使用反义人细胞周期蛋白A DNA来治疗或抑制这些病症。

    Process for the detection of cell proliferation by detecting human cyclin A
    5.
    发明授权
    Process for the detection of cell proliferation by detecting human cyclin A 失效
    通过检测人细胞周期蛋白A检测细胞增殖的过程

    公开(公告)号：US5849508A

    公开(公告)日：1998-12-15

    申请号：US460895

    申请日：1995-06-05

    申请人： Christian Brechot ,  Jian Wang ,  Xavier Chenivesse ,  Berthold Henglein ,  Frederique Zindy

    发明人： Christian Brechot ,  Jian Wang ,  Xavier Chenivesse ,  Berthold Henglein ,  Frederique Zindy

    IPC分类号： A61K38/00 ,  C07K14/47 ,  C07K16/18 ,  C12N15/113 ,  C12N15/12 ,  G01N33/574 ,  G01N33/53 ,  G01N33/567

    CPC分类号： C12N15/113 ,  C07K14/4738 ,  C07K16/18 ,  A61K38/00 ,  C12N2310/3513

    摘要： The invention is directed generally to a DNA sequence coding for human cyclin A and in particular to antibodies, or antisera including such antibodies, which bind to human cyclin A as encoded by the sequence of SEQ ID NO: 1 and which are useful in detecting cellular proliferation. The antibodies of the invention can be polyclonal or monoclonal, and are preferably generated by injection of purified human cyclin A into an animal host. The invention is particularly advantageous because it has been discovered that the gene encoding for human cyclin A is a site for integration of the hepatitis B virus associated with hepatocellular carcinoma, and by detecting human cyclin A through the use of the antibodies of the invention, one can detect and diagnose cell proliferation. Through the use of the present invention, cell proliferation and tumorigenesis can thus be detected at early stages, and such conditions can then be treated or inhibited by the use of anti-sense human cyclin A DNA.

    摘要翻译： 本发明一般涉及编码人类细胞周期蛋白A的DNA序列，特别是编码抗体或包含此类抗体的抗血清，其结合如SEQ ID NO：1的序列编码的人细胞周期蛋白A，并且其可用于检测细胞 增殖。 本发明的抗体可以是多克隆的或单克隆的，并且优选通过将纯化的人细胞周期蛋白A注射到动物宿主中来产生。 本发明是特别有利的，因为已经发现编码人细胞周期蛋白A的基因是与肝细胞癌相关的乙型肝炎病毒整合的位点，并且通过使用本发明的抗体检测人细胞周期蛋白A 可以检测和诊断细胞增殖。 通过使用本发明，因此可以在早期阶段检测细胞增殖和肿瘤发生，然后可以通过使用反义人细胞周期蛋白A DNA来治疗或抑制这些病症。