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17 条记录 (耗时 0.025 秒)

    PRODUCTION OF NON-YEAST STEROLS BY YEAST
    1.
    发明申请
    PRODUCTION OF NON-YEAST STEROLS BY YEAST 有权
    YEAST生产非YEAST STEROLS

    公开(公告)号：US20120231495A1

    公开(公告)日：2012-09-13

    申请号：US13510636

    申请日：2010-11-24

    申请人： Hans-Peter Hohmann ,  Martin Lehmann ,  Muriel Merkamm ,  Denis Pompon

    发明人： Hans-Peter Hohmann ,  Martin Lehmann ,  Muriel Merkamm ,  Denis Pompon

    IPC分类号： C12P33/06 ,  C12N15/53 ,  C12N15/81 ,  C12N1/19

    CPC分类号： C12P33/00 ,  C12N9/001 ,  C12N9/0067 ,  C12N9/0071 ,  C12N9/0083 ,  C12N9/1007 ,  C12P33/06

    摘要： This invention relates to the production of 7-dehydrocholesterol, 25-hydroxy-7-dehydrocholesterol, and 25-hydroxy ergosterol in yeast such as Saccharomyces cerevisiae. It also related to various enzymes catalyzing the reduction of the double bond at position 24 of lanosterol, dimethyl zymosterol, methyl zymosterol, zymosterol, cholesta-7, 24-dienol, or cholesta-5,7,24-trienol; or the hydroxylation at position 25 of ergosterol, 7-dehydrocholesterol, cholesta-8-enol, and cholesta-7-enol. It also relates to various nucleic acids encoding cholesterol C25-hydroxylases and sterol Δ24-reductases and their use to produce and hydroxylate 7-dehydrocholesterol or ergosterol. It also relates to the yeast strains so produced, and methods of making these sterols comprising the steps of cultivation a transformed yeast cell, and harvesting the resulting sterol(s).

    摘要翻译： 本发明涉及酵母如酿酒酵母中7-脱氢胆固醇，25-羟基-7-脱氢胆固醇和25-羟基麦角甾醇的生产。 它还涉及催化羊毛甾醇，二甲基十八烷醇，甲基十八醇，十八酮，胆甾烯-7,24-二烯醇或胆石酯-5,7,24-三烯酚在位置24处双键还原的各种酶。 或麦角甾醇，7-脱氢胆固醇，胆甾烯-8-烯醇和胆甾烯-7-烯醇在25位的羟基化。 它还涉及编码胆固醇C25-羟化酶和甾醇和Dgr; 24-还原酶的各种核酸，以及它们用于产生7-羟基胆固醇或麦角固醇羟基化的用途。 它还涉及如此制备的酵母菌株，以及制备这些甾醇的方法包括培养转化的酵母细胞的步骤，并收获所得的甾醇。

    DESMOSTEROL-PRODUCING YEAST STRAINS AND USES THEREOF
    2.
    发明申请
    DESMOSTEROL-PRODUCING YEAST STRAINS AND USES THEREOF 有权
    生产木霉素的YEAST菌株及其用途

    公开(公告)号：US20120276586A1

    公开(公告)日：2012-11-01

    申请号：US13479355

    申请日：2012-05-24

    申请人： Denis POMPON ,  Bruno DUMAS ,  Roberto SPAGNOLI

    发明人： Denis POMPON ,  Bruno DUMAS ,  Roberto SPAGNOLI

    IPC分类号： C12N1/19 ,  C12P33/00

    CPC分类号： A61K51/0493 ,  C07B2200/05 ,  C12P33/00

    摘要： The invention concerns the production of cholesterol of the Fungi kingdom. More particularly, the invention concerns genetically modified Fungus independently producing cholesterol from a simple carbon source. The invention also concerns the use of the inventive Fungus for producing non-marked and marked cholesterol.

    摘要翻译： 本发明涉及真菌王国的胆固醇生产。 更具体地说，本发明涉及从简单碳源独立生产胆固醇的转基因真菌。 本发明还涉及本发明的真菌用于产生未标记和显着的胆固醇的用途。