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公开(公告)号：US20220112307A1
公开(公告)日：2022-04-14
申请号：US17549706
申请日：2021-12-13
Applicant: Xencor, Inc.
Inventor： Aaron Keith Chamberlain , John R. Desjarlais , Sher Bahadur Karki , Gregory Alan Lazar , Jost Vielmetter , Sean C. Yoder
Abstract: The present application relates to optimized IgG immunoglobulin variants, engineering methods for their generation, and their application, particularly for therapeutic purposes.
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公开(公告)号：US20210277095A1
公开(公告)日：2021-09-09
申请号：US17079299
申请日：2020-10-23
Applicant: Xencor, Inc.
Inventor： Aaron Keith Chamberlain , Bassil Dahiyat , John R. Desjarlais , Sher Bahadur Karki , Gregory Alan Lazar
Abstract: The present application relates to a variant Fc region comprising at least one modification relative to a wild-type human Fc region, where the modification selected from the group consisting of 434S, 252Y/428L, 252Y/434S, and 428L/434S, and the numbering is according to the EU index.
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公开(公告)号：US20240327508A1
公开(公告)日：2024-10-03
申请号：US18744537
申请日：2024-06-14
Applicant: Xencor, Inc.
Inventor： Aaron Keith Chamberlain , Bassil Dahiyat , John R. Desjarlais , Sher Bahadur Karki , Gregory Alan Lazar
IPC: C07K16/18 , A61K39/00 , C07K14/715 , C07K16/08 , C07K16/22 , C07K16/24 , C07K16/28 , C07K16/32 , C07K16/42
CPC classification number: C07K16/18 , C07K14/7151 , C07K16/082 , C07K16/22 , C07K16/241 , C07K16/2863 , C07K16/2866 , C07K16/2893 , C07K16/2896 , C07K16/32 , C07K16/4291 , A61K2039/505 , C07K2317/24 , C07K2317/52 , C07K2317/524 , C07K2317/526 , C07K2317/90 , C07K2319/30 , Y02A50/30
Abstract: The present application relates to a variant Fc region comprising at least one modification relative to a wild-type human Fc region, where the modification selected from the group consisting of 434S, 252Y/428L, 252Y/434S, and 428L/434S, and the numbering is according to the EU index.
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公开(公告)号：US20220281964A1
公开(公告)日：2022-09-08
申请号：US17746226
申请日：2022-05-17
Applicant: Xencor, Inc.
Inventor： Aaron Keith Chamberlain , Bassil Dahiyat , John R. Desjarlais , Sher Bahadur Karki , Gregory Alan Lazar
Abstract: The present application relates to a variant Fc region comprising at least one modification relative to a wild-type human Fc region, where the modification selected from the group consisting of 434S, 252Y/428L, 252Y/434S, and 428L/434S, and the numbering is according to the EU index.
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公开(公告)号：US11198739B2
公开(公告)日：2021-12-14
申请号：US15710322
申请日：2017-09-20
Applicant: Xencor, Inc.
Inventor： Aaron Keith Chamberlain , John R. Desjarlais , Sher Bahadur Karki , Gregory Alan Lazar , Jost Vielmetter , Sean C. Yoder
IPC: C07H21/02 , C07H21/04 , C12N5/02 , C12N5/16 , C12P21/06 , C12P21/04 , C07K16/32 , C07K16/28 , C07K16/00
Abstract: The present application relates to optimized IgG immunoglobulin variants, engineering methods for their generation, and their application, particularly for therapeutic purposes.
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Patent Agency Ranking
公开(公告)号：US20210115147A1
公开(公告)日：2021-04-22
申请号：US16985119
申请日：2020-08-04
Applicant: Xencor, Inc.
Inventor： Aaron Keith Chamberlain , Bassil Dahiyat , John Desjarlais , Sher Bahadur Karki , Gregory Lazar
Abstract: The present application relates to optimized IgG immunoglobulin variants, engineering methods for their generation, and their application, particularly for therapeutic purposes.
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公开(公告)号：US10336818B2
公开(公告)日：2019-07-02
申请号：US14459160
申请日：2014-08-13
Applicant: Xencor, Inc.
Inventor： Aaron Keith Chamberlain , Bassil Dahiyat , John R. Desjarlais , Sher Bahadur Karki , Gregory Alan Lazar
IPC: C07H21/04 , C12N5/00 , C12N1/20 , C12P21/06 , C12P21/04 , C07K16/18 , C07K16/08 , C07K16/22 , C07K16/24 , C07K16/28 , C07K16/32 , C07K16/42 , C07K14/715 , C07K16/00 , A61K39/00
Abstract: The present application relates to a variant Fc region comprising at least one modification relative to a wild-type human Fc region, where the modification selected from the group consisting of 434S, 252Y/428L, 252Y/434S, and 428L/434S, and the numbering is according to the EU index.
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公开(公告)号：US20180162950A1
公开(公告)日：2018-06-14
申请号：US15710322
申请日：2017-09-20
Applicant: Xencor, Inc.
Inventor： Aaron Keith Chamberlain , John R. Desjarlais , Sher Bahadur Karki , Gregory Alan Lazar , Jost Vielmetter , Sean C. Yoder
CPC classification number: C07K16/32 , C07K16/2878 , C07K16/2893 , C07K2317/24 , C07K2317/52 , C07K2317/526 , C07K2317/71 , C07K2317/72 , C07K2317/92 , C07K2317/94
Abstract: The present application relates to optimized IgG immunoglobulin variants, engineering methods for their generation, and their application, particularly for therapeutic purposes.
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公开(公告)号：US20250011440A1
公开(公告)日：2025-01-09
申请号：US18885442
申请日：2024-09-13
Applicant: Xencor, Inc.
Inventor： Aaron Keith Chamberlain , Bassil Dahiyat , John Desjarlais , Sher Bahadur Karki , Gregory Lazar
Abstract: The present application relates to optimized IgG immunoglobulin variants, engineering methods for their generation, and their application, particularly for therapeutic purposes.
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公开(公告)号：US20240239879A1
公开(公告)日：2024-07-18
申请号：US18440895
申请日：2024-02-13
Applicant: Xencor, Inc.
Inventor： Aaron Keith Chamberlain , Bassil Dahiyat , John R. Desjarlais , Sher Bahadur Karki , Gregory Alan Lazar
IPC: C07K16/18 , A61K39/00 , C07K14/715 , C07K16/08 , C07K16/22 , C07K16/24 , C07K16/28 , C07K16/32 , C07K16/42
CPC classification number: C07K16/18 , C07K14/7151 , C07K16/082 , C07K16/22 , C07K16/241 , C07K16/2863 , C07K16/2866 , C07K16/2893 , C07K16/2896 , C07K16/32 , C07K16/4291 , A61K2039/505 , C07K2317/24 , C07K2317/52 , C07K2317/524 , C07K2317/526 , C07K2317/90 , C07K2319/30 , Y02A50/30
Abstract: The present application relates to a variant Fc region comprising at least one modification relative to a wild-type human Fc region, where the modification selected from the group consisting of 434S, 252Y/428L, 252Y/434S, and 428L/434S, and the numbering is according to the EU index.
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