公开(公告)号：US11219652B2

公开(公告)日：2022-01-11

申请号：US16993599

申请日：2020-08-14

申请人： Xiaolin Xie ,  Dezhu Zhang ,  Jianguo Meng ,  Yu Wang ,  Xuhua Zhou ,  Zhong Meng ,  Nan Hui ,  Juan Li

发明人： Xiaolin Xie ,  Dezhu Zhang ,  Jianguo Meng ,  Yu Wang ,  Xuhua Zhou ,  Zhong Meng ,  Nan Hui ,  Juan Li

IPC分类号： A61K36/16 ,  B01D11/02 ,  B01D37/00 ,  B01D21/26

摘要： A method for extracting herbal medicine includes: step one, spray extraction; step two, pressure filtration and concentration; step three, spray and countercurrent precipitation; and step four, concentrating reduced pressure and drying.

公开(公告)号：US10858312B1

公开(公告)日：2020-12-08

申请号：US16939766

申请日：2020-07-27

申请人： Xiaolin Xie ,  Dezhu Zhang ,  Zhong Meng ,  Jianguo Meng ,  Yu Wang ,  Shunjun Ding ,  Chengyuan Liang ,  Liang Xin ,  Jingyi Li ,  Jiayun Zhang ,  Kangxiong Wu ,  Juan Xia ,  Han Li

发明人： Xiaolin Xie ,  Dezhu Zhang ,  Zhong Meng ,  Jianguo Meng ,  Yu Wang ,  Shunjun Ding ,  Chengyuan Liang ,  Liang Xin ,  Jingyi Li ,  Jiayun Zhang ,  Kangxiong Wu ,  Juan Xia ,  Han Li

IPC分类号： C07C271/02 ,  C07C269/06

摘要： A compound of Formula I: is disclosed. A method of preparing the compound of Formula I is also disclosed. R is alkyl, haloalkyl, aryl, or substituted aryl. Preferably, R is —CH3, —CH2CH3, —CH2CH2CH3, —CH(CH3)2, —CH2CH2CH2CH3, —CF3, —CHF2, —CH2CF3,

公开(公告)号：US10336689B1

公开(公告)日：2019-07-02

申请号：US16359963

申请日：2019-03-20

申请人： Chengyuan Liang ,  Shunjun Ding ,  Nan Hui ,  Juan Li ,  Dezhu Zhang ,  Xiaolin Xie

发明人： Chengyuan Liang ,  Shunjun Ding ,  Nan Hui ,  Juan Li ,  Dezhu Zhang ,  Xiaolin Xie

IPC分类号： C07C251/24 ,  A61P35/00 ,  C07C249/02

摘要： A gossypol eflornithine Schiff base compound having the following Formula I: is disclosed. A method of preparing the compound of Formula I is also disclosed.

公开(公告)号：US10722500B2

公开(公告)日：2020-07-28

申请号：US16270563

申请日：2019-02-07

申请人： Xiaolin Xie ,  Dezhu Zhang ,  Shunjun Ding ,  Chengyuan Liang

发明人： Xiaolin Xie ,  Dezhu Zhang ,  Shunjun Ding ,  Chengyuan Liang

IPC分类号： A61K31/437 ,  A61P35/00 ,  G01N33/50

摘要： A gossypol 7-N-isatin Schiff base compounds compound with antitumor activities represented by formula I: is disclosed. In formula I, R is hydrogen, alkyl, cycloalkyl, alkoxy, unsubstituted or substituted phenyl, or substituted or substituted benzyl. A method of preparing the compound of formula I is also disclosed.

公开(公告)号：US09975849B1

公开(公告)日：2018-05-22

申请号：US15798877

申请日：2017-10-31

申请人： Xiaolin Xie ,  Dezhu Zhang ,  Chengyuan Liang ,  Lei Tian ,  Shunjun Ding ,  Xingke Ju

发明人： Xiaolin Xie ,  Dezhu Zhang ,  Chengyuan Liang ,  Lei Tian ,  Shunjun Ding ,  Xingke Ju

IPC分类号： C07C279/14 ,  C07C277/08

CPC分类号： C07C279/14 ,  C07B2200/07 ,  C07B2200/13 ,  C07C277/08

摘要： A compound with antitumor activities is represented by formula I: A method of preparing the compound of formula I is also disclosed.

公开(公告)号：US09758503B1

公开(公告)日：2017-09-12

申请号：US15489711

申请日：2017-04-17

申请人： Chengyuan Liang ,  Danni Tian ,  Minyi Jia ,  Xuechuan Wang ,  Xiaolin Xie ,  Dezhu Zhang

发明人： Chengyuan Liang ,  Danni Tian ,  Minyi Jia ,  Xuechuan Wang ,  Xiaolin Xie ,  Dezhu Zhang

IPC分类号： C07D311/56

CPC分类号： C07D311/56

摘要： A compound with antitumor activities is represented by formula A or formula B R1, R2, R3, and R4 are independently hydrogen, hydroxyl, alkoxy, halogen, formyl, unsubstituted or substituted alkyl, or unsubstituted or substituted cycloalkyl.

公开(公告)号：US11712457B2

公开(公告)日：2023-08-01

申请号：US17173622

申请日：2021-02-11

申请人： Qianqian Zhao ,  Jialin Li ,  Dan Yang ,  Jingyi Li ,  Liang Xin ,  Chunyang Shi ,  Xiaolin Xie ,  Dezhu Zhang ,  Ruina Bian ,  Xingke Ju ,  Chengyuan Liang ,  Yanjun Li ,  Qiao Zeng

发明人： Qianqian Zhao ,  Jialin Li ,  Dan Yang ,  Jingyi Li ,  Liang Xin ,  Chunyang Shi ,  Xiaolin Xie ,  Dezhu Zhang ,  Ruina Bian ,  Xingke Ju ,  Chengyuan Liang ,  Yanjun Li ,  Qiao Zeng

IPC分类号： A61K36/63 ,  A61P31/04 ,  A61K47/44 ,  A61K31/7034 ,  A61K31/7048

CPC分类号： A61K36/63 ,  A61K31/7034 ,  A61K31/7048 ,  A61K47/44 ,  A61P31/04 ,  A61K2236/15 ,  A61K2236/333 ,  A61K2236/35 ,  A61K2236/37 ,  A61K2236/51 ,  A61K2236/53

摘要： A Syringa microphylla seed extract includes the following components by weight based on a total weight of the Syringa microphylla seed extract: 0.4944-0.7142 mg/g of echinacoside, 6.624-7.617 mg/g of oleuropein, 0.4276-0.6309 mg/g of verbascoside, 3.927-4.684 mg/g of syringin, and 4.505-5.250 mg/g of forsythiaside B. A method of preparing the Syringa microphylla seed extract is disclosed. A composition for treating antibiotic-resistant infections that includes the Syringa microphylla seed extract is also disclosed.

公开(公告)号：US10729675B2

公开(公告)日：2020-08-04

申请号：US16270567

申请日：2019-02-07

申请人： Chengyuan Liang ,  Xingke Ju ,  Shunjun Ding ,  Lei Tian ,  Yuzhi Liu ,  Xiaolin Xie ,  Dezhu Zhang ,  Wenbo Yao ,  Dan Yang

发明人： Chengyuan Liang ,  Xingke Ju ,  Shunjun Ding ,  Lei Tian ,  Yuzhi Liu ,  Xiaolin Xie ,  Dezhu Zhang ,  Wenbo Yao ,  Dan Yang

IPC分类号： A61K31/404 ,  A61P35/00 ,  G01N33/50

摘要： A gossypol isatin Schiff base compound with antitumor activities represented by formula I: R1 and R2 are independently hydrogen, alkyl, cycloalkyl, alkoxy, nitro, halogen, unsubstituted or substituted phenyl, or unsubstituted or substituted benzyl. A method of preparing the compound of formula I is also disclosed.

公开(公告)号：US09758486B1

公开(公告)日：2017-09-12

申请号：US15489713

申请日：2017-04-17

申请人： Chengyuan Liang ,  Danni Tian ,  Minyi Jia ,  Xiaolin Xie ,  Dezhu Zhang ,  Weihui Ju ,  Shunjun Ding ,  Xuechuan Wang

发明人： Chengyuan Liang ,  Danni Tian ,  Minyi Jia ,  Xiaolin Xie ,  Dezhu Zhang ,  Weihui Ju ,  Shunjun Ding ,  Xuechuan Wang

IPC分类号： C07D231/36 ,  C07D231/22 ,  C07D231/26

CPC分类号： C07D231/36 ,  C07D231/22 ,  C07D231/26

摘要： A compound with antitumor activities represented by formula I: In formula I, R1 is alkyl, alkoxy, or ethenyl; and R2 is alkyl, alkoxy, or halogen.