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1.发明申请Acyloxyalkyl carbamate prodrugs of alpha-amino acids, methods of synthesis and use 失效α-氨基酸的氨基甲酸氨基甲酸酯前体药物，合成和使用方法公开(公告)号：US20080051458A1
公开(公告)日：2008-02-28
申请号：US11878661
申请日：2007-07-26
申请人： Xuedong Dai , Archana Gangakhedkar , Jia-Ning Xiang , Mark Gallop
发明人： Xuedong Dai , Archana Gangakhedkar , Jia-Ning Xiang , Mark Gallop
IPC分类号： A61K31/195 , A61P25/18 , C07C61/04 , C07C61/08
CPC分类号： C07C271/16 , C07C271/24 , C07C271/34 , C07C271/36 , C07C2601/02 , C07C2601/14
摘要： Acyloxyalkyl carbamate prodrugs of α-amino acids, pharmaceutical compositions thereof, methods of making acyloxyalkyl carbamate prodrugs of α-amino acids and methods of using acyloxyalkyl carbamate prodrugs of α-amino acids, and pharmaceutical compositions thereof to treat a disease are disclosed. Acyloxyalkyl carbamate prodrugs of α-amino acids suitable for oral administration using sustained release dosage forms are also disclosed.
摘要翻译： 公开了α-氨基酸的氰氧基烷基氨基甲酸酯前药，其药物组合物，制备α-氨基酸的酰氨基烷基氨基甲酸酯前药的方法和使用α-氨基酸的氨基甲酸酰氨基甲酸酯前药的方法及其药物组合物来治疗疾病。 还公开了适用于使用持续释放剂型的口服给药的α-氨基酸的氨基氧基烷基氨基甲酸酯前药。
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公开(公告)号：US20050282891A1
公开(公告)日：2005-12-22
申请号：US11145159
申请日：2005-06-03
申请人： Jia-Ning Xiang , Mark Gallop , Cindy Zhou , Mark Nguyen , Xuedong Dai , Jianhua Li , Kenneth Cundy , Nelson Jumbe
发明人： Jia-Ning Xiang , Mark Gallop , Cindy Zhou , Mark Nguyen , Xuedong Dai , Jianhua Li , Kenneth Cundy , Nelson Jumbe
IPC分类号： A61K31/216 , A61K31/235 , A61K31/24 , A61K31/277 , A61K31/4409 , A61K31/455 , A61K31/609 , A61K31/618 , A61P25/16 , C07C229/34 , C07C229/36 , C07C235/48 , C07C235/60 , C07C255/59 , C07D213/79 , C07D213/80
CPC分类号： C07C235/60 , C07C229/34 , C07C229/36 , C07C235/48 , C07C2601/14 , C07D213/79 , C07D213/80 , C07D213/803
摘要： Prodrugs of levodopa, methods of making prodrugs of levodopa, methods of using prodrugs of levodopa, and compositions of prodrugs of levodopa are disclosed.
摘要翻译： 公开了左旋多巴的前药，制备左旋多巴的前药的方法，使用左旋多巴的前药的方法和左旋多巴的前药组合物。
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公开(公告)号：US20060020028A1
公开(公告)日：2006-01-26
申请号：US11145280
申请日：2005-06-03
申请人： Jia-Ning Xiang , Mark Gallop , Cindy Zhou , Mark Nguyen , Xuedong Dai , Jianhua Li , Kenneth Cundy
发明人： Jia-Ning Xiang , Mark Gallop , Cindy Zhou , Mark Nguyen , Xuedong Dai , Jianhua Li , Kenneth Cundy
IPC分类号： A61K31/215 , C07C229/34
CPC分类号： C07C229/36
摘要： Prodrugs of levodopa, methods of making prodrugs of levodopa, methods of using prodrugs of levodopa, and compositions of prodrugs of levodopa are disclosed.
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公开(公告)号：US20080103200A1
公开(公告)日：2008-05-01
申请号：US12001618
申请日：2007-12-11
申请人： Jia-Ning Xiang , Mark Gallop , Cindy Zhou , Mark Nguyen , Xuedong Dai , Jianhua Li , Kenneth Cundy
发明人： Jia-Ning Xiang , Mark Gallop , Cindy Zhou , Mark Nguyen , Xuedong Dai , Jianhua Li , Kenneth Cundy
IPC分类号： A61K31/215 , A61P25/14 , A61P9/12
CPC分类号： C07C229/36
摘要： Prodrugs of levodopa, methods of making prodrugs of levodopa, methods of using prodrugs of levodopa, and compositions of prodrugs of levodopa are disclosed.
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公开(公告)号：US20070010453A1
公开(公告)日：2007-01-11
申请号：US11440734
申请日：2006-05-22
申请人： Mark Gallop , Kenneth Cundy , Cindy Zhou , Fayang Qiu , Fenmei Yao , Jia-Ning Xiang , Ian Ollmann
发明人： Mark Gallop , Kenneth Cundy , Cindy Zhou , Fayang Qiu , Fenmei Yao , Jia-Ning Xiang , Ian Ollmann
IPC分类号： A61K38/05 , A61K38/04 , A61K31/553 , C07K5/06 , C07F5/04
CPC分类号： C07C205/43 , A61K38/00 , C07C45/567 , C07C209/48 , C07C229/28 , C07C271/22 , C07C2601/10 , C07C2601/14 , C07D213/80 , C07D267/04 , C07D307/58 , C07D317/32 , C07D317/40 , C07K5/0205 , C07C49/83 , C07C49/17
摘要： The present invention provides prodrugs of GABA analogs, pharmaceutical compositions of prodrugs of GABA analogs and methods for making prodrugs of GABA analogs. The present invention also provides methods for using prodrugs of GABA analogs and methods for using pharmaceutical compositions of prodrugs of GABA analogs for treating or preventing common diseases and/or disorders.
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公开(公告)号：US20060229361A1
公开(公告)日：2006-10-12
申请号：US11110909
申请日：2005-04-06
申请人： Mark Gallop , Kenneth Cundy , Cindy Zhou , Fenmei Yao , Jia-Ning Xiang , Ian Ollman , Fayang Qiu
发明人： Mark Gallop , Kenneth Cundy , Cindy Zhou , Fenmei Yao , Jia-Ning Xiang , Ian Ollman , Fayang Qiu
IPC分类号： A61K31/325 , C07C271/22
CPC分类号： C07C229/28 , A61K31/22 , A61K31/24 , C07C271/22 , C07C309/29 , C07C2601/04 , C07C2601/14 , C07C2601/18
摘要： The present invention provides prodrugs of GABA analogs, pharmaceutical compositions of prodrugs of GABA analogs and methods for making prodrugs of GABA analogs. The present invention also provides methods for using prodrugs of GABA analogs and methods for using pharmaceutical compositions of prodrugs of GABA analogs for treating or preventing common diseases and/or disorders.
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7.发明申请Methods for synthesis of prodrugs from 1-acyl-alkyl derivatives and compositions thereof 有权从1-酰基 - 烷基衍生物合成前药的方法及其组合物公开(公告)号：US20050239725A1
公开(公告)日：2005-10-27
申请号：US11158405
申请日：2005-06-21
申请人： Mark Gallop , Jia-Ning Xiang , Fenmei Yao , Laxminarayan Bhat , Cindy Zhou
发明人： Mark Gallop , Jia-Ning Xiang , Fenmei Yao , Laxminarayan Bhat , Cindy Zhou
IPC分类号： C07C271/12 , C07C271/22 , C07F9/40 , A61K31/704 , A61K31/325 , A61K31/445 , A61K31/496
CPC分类号： C07C269/06 , C07C271/12 , C07C271/22 , C07C2601/14 , C07F9/4087
摘要： The present invention provides a method for synthesizing 1-(acyloxy)-alkyl derivatives from 1-acyl-alkyl derivatives, which typically proceeds stereospecifically, in high yield, does not require the use of activated intermediates and/or toxic compounds and is readily amendable to scale-up. The current invention also provides 1-acyl-alkyl derivatives of known drug components and methods for synthesizing these 1-acyl-alkyl derivatives.
摘要翻译： 本发明提供了从1-酰基 - 烷基衍生物合成1-（酰氧基） - 烷基衍生物的方法，其通常以高产率立体选择性地进行，不需要使用活化的中间体和/或有毒化合物，并且易于修饰 放大。 本发明还提供已知药物成分的1-酰基 - 烷基衍生物和合成这些1-酰基 - 烷基衍生物的方法。
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公开(公告)号：US20060122125A1
公开(公告)日：2006-06-08
申请号：US11332607
申请日：2006-01-12
申请人： Mark Gallop , Jia-Ning Xiang , Fenmei Yao , Laxminarayan Bhat
发明人： Mark Gallop , Jia-Ning Xiang , Fenmei Yao , Laxminarayan Bhat
IPC分类号： A61K38/05 , A61K38/04 , A61K31/366 , A61K31/365 , C07K5/04 , C07K5/06
CPC分类号： C07D307/89 , C07D309/30 , C07D313/04
摘要： The present invention provides cyclic 1-(acyloxy)-alkyl prodrugs of GABA analogs, methods of making cyclic 1-(acyloxy)-alkyl prodrugs of GABA analogs and compositions of cyclic 1-(acyloxy)-alkyl prodrugs of GABA analogs. The present invention also provides methods of using cyclic 1-(acyloxy)-alkyl prodrugs of GABA analogs and compositions of cyclic 1-(acyloxy)-alkyl prodrugs of GABA analogs.
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9.发明申请公开(公告)号：US20080058546A1
公开(公告)日：2008-03-06
申请号：US11934035
申请日：2007-11-01
申请人： Stephen Raillard , Cindy Zhou , Fenmei Yao , Suresh Manthati , Jia-Ning Xiang , Mark Gallop
发明人： Stephen Raillard , Cindy Zhou , Fenmei Yao , Suresh Manthati , Jia-Ning Xiang , Mark Gallop
IPC分类号： C07C271/06
CPC分类号： C07C271/22 , A61K38/00 , C07C2601/14 , C07D309/06 , C07D335/02
摘要： The synthesis of 1-(acyloxy)-alkyl carbamates of GABA analogs from 1-haloalkyl carbamates of GABA analogs are described. Also described are new 1-haloalkyl carbamates of GABA analogs.
摘要翻译： 描述了GABA类似物的1-卤代烷基氨基甲酸酯的GABA类似物的1-（酰氧基） - 烷基氨基甲酸酯的合成。 还描述了GABA类似物的新的1-卤代烷基氨基甲酸酯。
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公开(公告)号：US20060287250A1
公开(公告)日：2006-12-21
申请号：US11511901
申请日：2006-08-21
申请人： Stephen Raillard , Cindy Zhou , Fenmei Yao , Suresh Manthati , Jia-Ning Xiang , Mark Gallop
发明人： Stephen Raillard , Cindy Zhou , Fenmei Yao , Suresh Manthati , Jia-Ning Xiang , Mark Gallop
CPC分类号： C07C271/22 , A61K38/00 , C07C2601/14 , C07D309/06 , C07D335/02
摘要： The synthesis of 1-(acyloxy)-alkyl carbamates of GABA analogs from 1-haloalkyl carbamates of GABA analogs are described. Also described are new 1-haloalkyl carbamates of GABA analogs.
摘要翻译： 描述了GABA类似物的1-卤代烷基氨基甲酸酯的GABA类似物的1-（酰氧基） - 烷基氨基甲酸酯的合成。 还描述了GABA类似物的新的1-卤代烷基氨基甲酸酯。
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