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35 条记录 (耗时 0.026 秒)

    Optical indicator for detecting bacterial pathogens
    7.
    发明授权
    Optical indicator for detecting bacterial pathogens 有权
    用于检测细菌病原体的光学指示剂

    公开(公告)号：US08247220B2

    公开(公告)日：2012-08-21

    申请号：US12332843

    申请日：2008-12-11

    申请人： Stephanie M. Martin ,  John G. MacDonald ,  Erica M. Phillips

    发明人： Stephanie M. Martin ,  John G. MacDonald ,  Erica M. Phillips

    IPC分类号： C12M3/00

    CPC分类号： C12Q1/04 ,  B01L3/5023 ,  B01L3/5055 ,  B01L2300/069 ,  B01L2300/0809 ,  B01L2300/0825 ,  G01N21/78 ,  G01N33/52

    摘要： A clinical testing assay device that can differentiate bacterial from viral infections is described. The assay device has a sample contact zone with an absorbent pad on which a test sample is deposited and a detection zone with a colorant indicator that is sensitive to bacteria cells. The colorant indicator changes color when exposed to a bacteria sample. The color change signal can manifest relatively quickly, usually within a few minutes, and with an intensity correlative to the concentration of bacteria in a test sample. A method of use is also provided.

    摘要翻译： 描述了可以区分细菌与病毒感染的临床测试测定装置。 测定装置具有带有吸收垫的样品接触区，其上沉积测试样品和具有对细菌细胞敏感的着色剂指示剂的检测区。 着色剂指示剂在暴露于细菌样品时会改变颜色。 颜色变化信号通常可以在几分钟内相对快速地显现出来，其强度与测试样品中的细菌浓度相关。 还提供了一种使用方法。

    Vaginal treatment composition containing xylitol
    8.
    发明授权
    Vaginal treatment composition containing xylitol 有权
    含有木糖醇的阴道治疗组合物

    公开(公告)号：US07786176B2

    公开(公告)日：2010-08-31

    申请号：US11194064

    申请日：2005-07-29

    申请人： Stephanie M. Martin ,  Lei Huang ,  Shu-Ping Yang ,  Yanbin Huang ,  Julie Villanueva ,  Sharon Linda Greene ,  Kelly Arehart ,  Curtis Sayre ,  Robert B. Johnson

    发明人： Stephanie M. Martin ,  Lei Huang ,  Shu-Ping Yang ,  Yanbin Huang ,  Julie Villanueva ,  Sharon Linda Greene ,  Kelly Arehart ,  Curtis Sayre ,  Robert B. Johnson

    IPC分类号： A61K31/045

    CPC分类号： A61K9/0034 ,  A61K31/192 ,  A61K31/70 ,  A61K47/36

    摘要： A vaginal treatment composition that rapidly forms a gel when placed into contact with monovalent or polyvalent cations, such as sodium (Na+) and calcium (Ca2+) cations naturally found in vaginal mucosa, is provided. The gel may form in less than about 1 hour, in some embodiments less than about 1 minute, and in some embodiments, less than about 30 seconds. Among other things, such rapid gelation reduces the likelihood of leakage during use. In addition, because the gel may form intravaginally, it is more likely to retain its structure and shape over an extended period of time. In this manner, the gel may provide the prolonged release of a therapeutic agent that inhibits and/or treats vaginal infection. For instance, the gel may remain within the vagina for about 2 to about 48 hours to provide the desired effect.

    摘要翻译： 提供了一种当与阴离子粘膜天然存在的单价或多价阳离子（例如钠（Na +）和钙（Ca 2+））阳离子接触时，迅速形成凝胶的阴道治疗组合物。 凝胶可以在小于约1小时，在一些实施方案中小于约1分钟，并且在一些实施方案中小于约30秒形成。 除此之外，这种快速凝胶化可降低使用过程中泄漏的可能性。 另外，因为凝胶可以阴道内形成，所以更可能在延长的时间段内保持其结构和形状。 以这种方式，凝胶可提供抑制和/或治疗阴道感染的治疗剂的延长释放。 例如，凝胶可以保留在阴道内约2至约48小时以提供期望的效果。

    Array for Rapid Detection of a Microorganism
    9.
    发明申请
    Array for Rapid Detection of a Microorganism 有权
    用于快速检测微生物的阵列

    公开(公告)号：US20090221061A1

    公开(公告)日：2009-09-03

    申请号：US12464149

    申请日：2009-05-12

    申请人： Stephanie M. Martin ,  J. Gavin MacDonald ,  Jason Lye ,  Curtis Sayre ,  Kimberlee Thompson

    发明人： Stephanie M. Martin ,  J. Gavin MacDonald ,  Jason Lye ,  Curtis Sayre ,  Kimberlee Thompson

    IPC分类号： C12M1/34

    CPC分类号： C12Q1/04

    摘要： A method for detecting a microorganism or class of microorganisms is provided. More specifically, the method employs an array that contains a plurality of discrete regions (referred to as “addresses”) spaced apart on a solid support in a predetermined pattern. The addresses are selected so that the array provides a distinct spectral response (e.g., pattern of colors) or “fingerprint” for a particular microorganism or class of microorganisms. For example, the array may provide a certain spectral response in the presence of one microorganism or class of microoryanisms (e.g., gram-negative bacteria), but provide a completely different spectral response in the presence of another microorganism or class of microorganisms (e.g., gram-positive bacteria). Detection of the spectral response provided by the array may thus allow for differentiation between microorganisms.

    摘要翻译： 提供了一种用于检测微生物或微生物类别的方法。 更具体地，该方法采用包含在固体支持体上以预定图案间隔开的多个离散区域（称为“地址”）的阵列。 选择地址使得阵列为特定微生物或微生物类提供不同的光谱响应（例如，颜色图案）或“指纹”。 例如，阵列可以在一种微生物或类微生物（例如，革兰氏阴性细菌）的存在下提供特定的光谱响应，但是在另一种微生物或一类微生物的存在下提供完全不同的光谱响应（例如， 革兰氏阳性细菌）。 由阵列提供的光谱响应的检测因此可以允许微生物之间的分化。

    Thermochromic responsive elastic polymer substrate
    10.
    发明申请
    Thermochromic responsive elastic polymer substrate 审中-公开
    热变色响应弹性聚合物基材

    公开(公告)号：US20090143516A1

    公开(公告)日：2009-06-04

    申请号：US11998685

    申请日：2007-11-30

    申请人： John Gavin MacDonald ,  Stephanie M. Martin

    发明人： John Gavin MacDonald ,  Stephanie M. Martin

    IPC分类号： C08K5/17

    CPC分类号： A61M25/1027 ,  A41D13/11 ,  A41D19/0027 ,  A41D19/0055 ,  A61B5/015 ,  A61F6/04 ,  C08K5/0041 ,  G01K11/12 ,  G01K2207/00 ,  C08L21/00 ,  C08L13/02

    摘要： A material composition including a flexible, polymeric matrix and a reverse-thermochromic colorant is described. When subjected to a heat source, the polymeric material can change color from a pale or neutral color to a darker or more vibrant color of a Delta E (ΔE) change of >3. The reverse-thermochromic colorant exhibits a color change when exposed to a heat source within a period of about 30 seconds, and is observable by an unaided human eye under either natural daylight or ambient artificial normal lighting conditions. One or more different reverse-thermochromic colorants in combination may be incorporated. The polymeric matrix surrounds or encapsulates a solvatochromic dye molecule with a phenolate betaine structure. The polymeric matrix includes a dipole orientating agent that induces said solvatochromic dye to express locally when subjected to a temperature change. Various uses for the composition and articles that incorporate the composition are also described, in addition to a method of indicating the temperature of an object or environmental condition.

    摘要翻译： 描述了包括柔性聚合物基质和反向热变色着色剂的材料组合物。 当经受热源时，聚合物材料可以将颜色从浅色或中性色变为Delta E（DeltaE）变化> 3的较暗或更鲜艳的颜色。 反向热变色着色剂在约30秒的时间内暴露于热源时显示颜色变化，并且在自然日光或环境人造正常照明条件下由肉眼观察到。 可并入一种或多种不同的反相热色素着色剂。 聚合物基质围绕或封装具有酚盐甜菜碱结构的溶剂化色素染料分子。 聚合物基质包括偶极取向剂，其在经受温度变化时诱导所述溶剂化色素染料局部表达。 除了指示物体的温度或环境条件的方法之外，还描述了包含组合物的组合物和制品的各种用途。