公开(公告)号：US06735458B2

公开(公告)日：2004-05-11

申请号：US10262523

申请日：2002-10-01

申请人： Xuefeng Cheng ,  Xiaorong Xu ,  Shuoming Zhou ,  Lai Wang ,  Ming Wang ,  Feng Li ,  Guobao Hu

发明人： Xuefeng Cheng ,  Xiaorong Xu ,  Shuoming Zhou ,  Lai Wang ,  Ming Wang ,  Feng Li ,  Guobao Hu

IPC分类号： A61B500

CPC分类号： A61B5/1495 ,  A61B5/14546 ,  A61B5/14551 ,  A61B5/14552 ,  A61B5/14553 ,  A61B2562/0233 ,  A61B2562/0242 ,  A61B2562/043 ,  A61B2562/046 ,  G01N21/359 ,  G01N21/49 ,  G01N2021/3144

摘要： The present invention generally relates to optical imaging systems and methods for providing images of two-dimensional and/or three-dimensional distribution of properties of chromophores in various physiological media. More particularly, the present invention relates to optical imaging systems, optical probes thereof, and methods therefor utilizing self-calibration of their output signals. A typical self-calibrating optical imaging system includes at least one wave source, at least one wave detector, a signal analyzer, a signal processor, and an image processor. The signal analyzer receives, from the wave detector, an output signal representative of the distribution of the chromophores or their properties in target areas of the medium. The signal analyzer analyzes amplitudes of the output signal and selects multiple points of the output signal having substantially similar amplitudes. The signal processor calculates a baseline corresponding to a representative amplitude of the similar amplitudes and provides a self-calibrated output signal. The image processor constructs the images of the distribution of the chromophores or their properties from the self-calibrated first output signals.

摘要翻译： 本发明一般涉及用于提供各种生理介质中发色团性质的二维和/或三维分布的图像的光学成像系统和方法。 更具体地说，本发明涉及光学成像系统及其光学探针，以及利用其输出信号的自校准的方法。 典型的自校准光学成像系统包括至少一个波源，至少一个波检测器，信号分析器，信号处理器和图像处理器。 信号分析仪从波检测器接收表示发色团分布的输出信号或其在介质的目标区域中的性质。 信号分析仪分析输出信号的幅度，并选择具有基本相似幅度的输出信号的多个点。 信号处理器计算对应于类似幅度的代表幅度的基线，并提供自校准输出信号。 图像处理器从自校准的第一输出信号构建发色团分布或其特性的图像。

公开(公告)号：US06516209B2

公开(公告)日：2003-02-04

申请号：US09778618

申请日：2001-02-06

申请人： Xuefeng Cheng ,  Xiaorong Xu ,  Shuoming Zhou ,  Lai Wang ,  Ming Wang ,  Feng Li ,  Guobao Hu

发明人： Xuefeng Cheng ,  Xiaorong Xu ,  Shuoming Zhou ,  Lai Wang ,  Ming Wang ,  Feng Li ,  Guobao Hu

IPC分类号： A61B500

CPC分类号： A61B5/1495 ,  A61B5/14546 ,  A61B5/14551 ,  A61B5/14552 ,  A61B5/14553 ,  A61B2562/0233 ,  A61B2562/0242 ,  A61B2562/043 ,  A61B2562/046 ,  G01N21/359 ,  G01N21/49 ,  G01N2021/3144

摘要： The present invention generally relates to optical imaging systems and methods for providing images of two-dimensional and/or three-dimensional distribution of properties of chromophores in various physiological media. More particularly, the present invention relates to optical imaging systems, optical probes thereof, and methods therefore utilizing self-calibration of their output signals. A typical self-calibrating optical imaging system includes at least one wave source, at least one wave detector, a signal analyzer, a signal processor, and an image processor. The signal analyzer receives, from the wave detector, an output signal representative of the distribution of the chromophores or their properties in target areas of the medium. The signal analyzer analyzes amplitudes of the output signal and selects multiple points of the output signal having substantially similar amplitudes. The signal processor calculates a baseline corresponding to a representative amplitude of the similar amplitudes and provides a self-calibrated output signal. The image processor constructs the images of the distribution of the chromophores or their properties from the self-calibrated first output signals.

摘要翻译： 本发明一般涉及用于提供各种生理介质中发色团性质的二维和/或三维分布的图像的光学成像系统和方法。 更具体地，本发明涉及光学成像系统，其光学探针，以及因此利用其输出信号的自校准的方法。 典型的自校准光学成像系统包括至少一个波源，至少一个波检测器，信号分析器，信号处理器和图像处理器。 信号分析仪从波检测器接收表示发色团分布的输出信号或其在介质的目标区域中的性质。 信号分析仪分析输出信号的幅度，并选择具有基本相似幅度的输出信号的多个点。 信号处理器计算对应于类似幅度的代表幅度的基线，并提供自校准输出信号。 图像处理器从自校准的第一输出信号构建发色团分布或其特性的图像。

公开(公告)号：US06597931B1

公开(公告)日：2003-07-22

申请号：US09664972

申请日：2000-09-18

申请人： Xuefeng Cheng ,  Xiaorong Xu ,  Shuoming Zhou ,  Lai Wang

发明人： Xuefeng Cheng ,  Xiaorong Xu ,  Shuoming Zhou ,  Lai Wang

IPC分类号： A61B500

CPC分类号： A61B5/14546 ,  A61B5/14551 ,  A61B5/14552 ,  A61B5/14553 ,  A61B5/413 ,  A61B2562/0233 ,  A61B2562/0242 ,  A61B2562/043 ,  G01N21/359 ,  G01N21/49 ,  G01N2021/3144

摘要： The present invention generally relates to an apparatus and method for obtaining absolute values of concentrations of chromophores of a medium and/or absolute values of their ratios. More particularly, the present invention relates to non-invasive optical systems and methods for determining absolute values of oxygenated and/or deoxygenated hemoglobins and their ratios in a physiological medium. The optical system typically includes (1) a body, (2) a source module supported by the body, optically coupling with the medium, and irradiating into the medium multiple sets of electromagnetic waves with different wave characteristics, (3) a detector module supported by the body, optically coupling with the medium, and detecting such electromagnetic waves, and (4) a processing module operatively coupling with the detector module, and determining the absolute values of the concentrations and the ratios thereof from multiple wave equations applied to the source and detector modules. The processing module is designed to obtain such absolute values by a method typically including the steps of (1) obtaining multiple sets of wave equations, (2) eliminating source-dependent and detector-dependent parameters therefrom to obtain a set of intermediate equations, (3) providing a correlation of medium-dependent and geometry-dependent parameters with the chromophore concentrations or ratios thereof, (4) incorporating the correlation into the set of intermediate equations, and (5) obtaining the absolute values of the chromophore concentrations and ratios thereof.

摘要翻译： 本发明一般涉及一种用于获得介质的发色团的浓度的绝对值和/或其比率的绝对值的装置和方法。 更具体地，本发明涉及用于确定氧合和/或脱氧血红蛋白的绝对值及其在生理介质中的比例的非侵入性光学系统和方法。 光学系统通常包括（1）主体，（2）由主体支撑的源模块，与介质光学耦合，并向介质照射具有不同波特性的多组电磁波，（3）支撑的检测器模块 通过身体与介质光学耦合并检测这样的电磁波，以及（4）与检测器模块可操作地耦合的处理模块，以及从应用于源的多个波动方程确定浓度的绝对值和比率的绝对值 和检测器模块。 处理模块被设计成通过通常包括以下步骤的方法来获得这样的绝对值：（1）获得多组波动方程，（2）消除与源相关的参数和检测器相关的参数，以获得一组中间方程式（ 3）提供中等依赖性和几何依赖性参数与发色团浓度或其比例的相关性，（4）将相关性并入中间方程组中，以及（5）获得发色团浓度及其比例的绝对值 。

公开(公告)号：US06587703B2

公开(公告)日：2003-07-01

申请号：US09877515

申请日：2001-06-07

申请人： Xuefeng Cheng ,  Xiaorong Xu ,  Shuoming Zhou ,  Lai Wang

发明人： Xuefeng Cheng ,  Xiaorong Xu ,  Shuoming Zhou ,  Lai Wang

IPC分类号： A61B550

CPC分类号： A61B5/14546 ,  A61B5/14551 ,  A61B5/14552 ,  A61B5/14553 ,  A61B5/413 ,  A61B2562/0233 ,  A61B2562/0242 ,  A61B2562/043 ,  G01N21/359 ,  G01N21/49 ,  G01N2021/3144

摘要： The present invention generally relates to apparatus and methods for obtaining absolute values of concentrations of chromophores of a medium and/or absolute values of their ratios. In particular, the present invention relates to continuous wave spectroscopic optical systems and methods for determining the absolute values of deoxygenated and/or oxygenated hemoglobins and their ratios in a physiological medium. The optical system typically includes (1) a source module optically coupling with the medium and irradiating into the medium multiple sets of electromagnetic waves with different wave characteristics, (2) a detector module optically coupling with the medium and detecting electromagnetic waves, and (3) a processing module operatively coupling with the detector module, and determining the absolute values of the concentrations and the ratios thereof from multiple wave equations applied to the source and detector modules. The processing module is designed to obtain such absolute values by a method typically including the steps of (1) obtaining multiple sets of wave equations, (2) eliminating source-dependent and detector-dependent parameters therefrom to obtain a set of intermediate equations, (3) providing a correlation between medium-dependent and geometry-dependent parameters and the chromophore concentrations or ratios thereof, (4) incorporating the correlation into the set of intermediate equations, and (5) obtaining the absolute values of the chromophore concentrations and ratios thereof.

公开(公告)号：US20090326352A1

公开(公告)日：2009-12-31

申请号：US12449146

申请日：2008-02-13

申请人： Xuefeng Cheng

发明人： Xuefeng Cheng

IPC分类号： A61B5/1459

CPC分类号： A61B5/021 ,  A61B5/0205 ,  A61B5/02116 ,  A61B5/029 ,  A61B5/1455 ,  A61B5/14552 ,  A61B5/4884 ,  A61B5/6833 ,  A61B2562/0233 ,  A61B2562/043 ,  A61B2562/046

摘要： A device for non-invasively measuring at least one parameter of a cardiac blood vessel in a patient is provided. The device comprises at least one light source that emits light in the 400 nm to 1000 nm wavelength range; at least one photodetector adapted to receive light emitted by the light source and generate an output based on the received light, wherein said light is reflected from or transmitted through tissue of the patient, the output of said photodetector being correlated with a parameter of the blood vessel; and at least one probe for facilitating delivery of light from the light source to an external tissue site on the patient in the proximity of the cardiac blood vessel and receipt of light by the photodetector. A system and methods of monitoring/measuring cardiac parameters utilizing the device and/or system are also provided.

摘要翻译： 提供了用于非侵入性地测量患者心脏血管的至少一个参数的装置。 该装置包括发射400nm至1000nm波长范围内的光的至少一个光源; 至少一个光电检测器适于接收由光源发射的光并基于所接收的光产生输出，其中所述光从患者的组织反射或透过，所述光电检测器的输出与血液的参数相关 船只; 以及至少一个探针，用于促进光从光源传递到心脏血管附近的患者的外部组织部位，并且由光电检测器接收光。 还提供了利用设备和/或系统监测/测量心脏参数的系统和方法。

公开(公告)号：US20080177163A1

公开(公告)日：2008-07-24

申请号：US12017969

申请日：2008-01-22

申请人： Shih-Ping Wang ,  Xuefeng Cheng ,  Zengpin Yu

发明人： Shih-Ping Wang ,  Xuefeng Cheng ,  Zengpin Yu

IPC分类号： A61B5/1455

CPC分类号： A61B5/0073 ,  A61B5/14553 ,  A61B5/4064 ,  A61B5/6814 ,  A61B2562/0233 ,  A61B2562/046

摘要： Methods, systems, and related computer program products for non-invasive monitoring of a biological volume, such as a human brain, are described. In one preferred embodiment, each of a plurality of optical sources emits optical radiation into the biological volume each of a plurality of optical detectors detects optical radiation impinging thereupon from the biological volume. The optical measurements are processed to compute a requisite property value associated with each source-detector pair. For each source-detector pair, a volumetric basis region corresponding thereto is weighted by the requisite property value, the volumetric basis region being predetermined and representative of an estimated subvolume of the biological volume encountered by optical radiation emitted from that source and propagating to that detector. The weighted volumetric basis regions are accumulated into a volumetric cumulative array, and a display output is generated based at least in part on the volumetric cumulative array.

摘要翻译： 描述了用于非侵入性监测生物体积的方法，系统和相关的计算机程序产品，例如人类大脑。 在一个优选实施例中，多个光源中的每一个将光辐射发射到生物体积中，多个光学检测器中的每一个检测器从生物体积检测入射的光辐射。 处理光学测量以计算与每个源 - 检测器对相关联的必要属性值。 对于每个源 - 检测器对，与其对应的体积基础区域由所需的属性值加权，体积基础区域是预定的，并且代表从该源发射并传播到该检测器的光辐射遇到的生物体积的估计子体积 。 加权体积基础区域被累积到体积累积阵列中，并且至少部分地基于体积累积阵列生成显示输出。

公开(公告)号：US20060015021A1

公开(公告)日：2006-01-19

申请号：US10877977

申请日：2004-06-29

申请人： Xuefeng Cheng

发明人： Xuefeng Cheng

IPC分类号： A61B5/00

CPC分类号： A61B5/0073 ,  A61B5/14552

摘要： The present invention relates to a non-invasive optical system equipped with optical tomographic scanning method and algorithm for quantifying scattering and absorption properties and chromophore concentrations of highly scattering medium such as biological tissues, for 3D mapping and imaging reconstruction of the spatial and temporal variations in such properties. The invention further relates to a method and an apparatus for simultaneous measurement of concentrations of biochemical substances and blood oxygen saturation inside a biological tissue and arterial blood.

公开(公告)号：US20100222658A1

公开(公告)日：2010-09-02

申请号：US12713368

申请日：2010-02-26

申请人： Xuefeng Cheng

发明人： Xuefeng Cheng

IPC分类号： A61B5/1455

CPC分类号： A61B5/6833 ,  A61B5/14553 ,  A61B5/4064

摘要： A method and system are provided which are useful for the non-invasive determination and monitoring of cerebral tissue oxygenation. The method comprises the steps of generating at least first and second jugular venous output signals against time based on the reflection of at least first and second wavelengths of light, respectively, from an external tissue site on the patient in the proximity of the internal jugular vein; obtaining corresponding first and second cardiac arterial output signals for the first and second wavelengths of light, respectively, from the patient, and separating the first and second cardiac arterial output signals from the first and second jugular venous output signals, respectively, to generate first and second cerebral venous output signals; and determining cerebral tissue oxygenation based on the first and second cerebral venous output signals. A system useful to monitor cerebral tissue oxygenation may comprise a first module for optically generating at least first and second jugular venous output signals against time at at least first and second wavelengths of light, respectively, from the patient; a second module for generating first and second cardiac arterial output signals at the first and second wavelengths of light, respectively, from the patient; and a signal processing means adapted to separate the first and second cardiac arterial output signals from the first and second jugular venous output signals, respectively, to yield first and second cerebral venous output signals, for the determination of cerebral tissue oxygenation.

摘要翻译： 提供了一种可用于非侵入性测定和监测脑组织氧合的方法和系统。 该方法包括以下步骤：基于至少第一和第二波长的光从内部颈静脉附近的患者的外部组织部位反射来产生针对时间的至少第一和第二颈静脉输出信号 ; 分别从患者获得用于第一和第二波长的光的相应的第一和第二心脏动脉输出信号，以及分别从第一和第二颈静脉输出信号分离第一和第二心脏动脉输出信号以产生第一和第二 第二大脑静脉输出信号; 以及基于第一和第二脑静脉输出信号确定脑组织氧合。 用于监测脑组织氧合的系统可以包括第一模块，其用于在来自患者的光的至少第一和第二波长的光下相对于时间光学地产生至少第一和第二颈静脉输出信号; 第二模块，用于分别在患者的第一和第二波长的光下产生第一和第二心脏动脉输出信号; 以及适于分别从第一和第二颈静脉输出信号分离第一和第二心脏动脉输出信号以产生第一和第二脑静脉输出信号以用于确定脑组织氧合的信号处理装置。

公开(公告)号：US07747301B2

公开(公告)日：2010-06-29

申请号：US11233308

申请日：2005-09-22

申请人： Xuefeng Cheng ,  Daniel Hwan Kim ,  Butrus T. Khuri-Yakub

发明人： Xuefeng Cheng ,  Daniel Hwan Kim ,  Butrus T. Khuri-Yakub

IPC分类号： A61B5/145

CPC分类号： A61B5/0059 ,  A61B5/0048 ,  A61B5/0261 ,  A61B5/029 ,  A61B5/14539 ,  A61B5/14542 ,  A61B5/14551 ,  A61B5/1464 ,  A61B5/413 ,  A61B5/489 ,  A61B8/065 ,  A61B8/08 ,  A61B8/488 ,  G01S15/8968

摘要： Medical diagnostic system, apparatus and methods are disclosed. Optical transmitters generate radiation-containing photons having a specific interaction with at least one target chromophore in a target structure, preferably a blood vessel such as the interior jugular vein. The optical transmitters transmit the radiation into at least a first area including a substantial portion of the target structure and into a second area not including a substantial portion of the target structure. Optical receivers detect a portion radiation scattered from at least the first area and the second area. A processor estimates oxygenation, pH or cardiac output based on the scattered radiation detected from the first area, and the scattered radiation from the second area.

摘要翻译： 公开了医疗诊断系统，装置和方法。 光学发射器产生具有与目标结构中的至少一个目标发色团特别相互作用的辐射含有光子，优选为诸如颈内静脉的血管。 光发射机将辐射发射到包括目标结构的大部分的至少第一区域中，并进入不包括目标结构的大部分的第二区域。 光接收器检测从至少第一区域和第二区域散射的部分辐射。 处理器基于从第一区域检测到的散射辐射和来自第二区域的散射辐射来估计氧合，pH或心输出量。

公开(公告)号：US20100152559A1

公开(公告)日：2010-06-17

申请号：US12563887

申请日：2009-09-21

申请人： Xuefeng Cheng ,  Daniel Hwan Kim ,  Butrus T. Khuri-Yakub

发明人： Xuefeng Cheng ,  Daniel Hwan Kim ,  Butrus T. Khuri-Yakub

IPC分类号： A61B5/1455

CPC分类号： A61B5/0059 ,  A61B5/0048 ,  A61B5/0261 ,  A61B5/029 ,  A61B5/14539 ,  A61B5/14542 ,  A61B5/14551 ,  A61B5/1464 ,  A61B5/413 ,  A61B5/489 ,  A61B8/065 ,  A61B8/08 ,  A61B8/488 ,  G01S15/8968

摘要： Medical diagnostic system, apparatus and methods are disclosed. Optical transmitters generate radiation-containing photons having a specific interaction with at least one target chromophore in a target structure, preferably a blood vessel such as the interior jugular vein. The optical transmitters transmit the radiation into at least a first area including a substantial portion of the target structure and into a second area not including a substantial portion of the target structure. Optical receivers detect a portion radiation scattered from at least the first area and the second area. A processor estimates oxygenation, pH or cardiac output based on the scattered radiation detected from the first area, and the scattered radiation from the second area.

摘要翻译： 公开了医疗诊断系统，装置和方法。 光学发射器产生具有与目标结构中的至少一个目标发色团特别相互作用的辐射含有光子，优选为诸如颈内静脉的血管。 光发射机将辐射发射到包括目标结构的大部分的至少第一区域中，并进入不包括目标结构的大部分的第二区域。 光接收器检测从至少第一区域和第二区域散射的部分辐射。 处理器基于从第一区域检测到的散射辐射和来自第二区域的散射辐射来估计氧合，pH或心输出量。