公开(公告)号：US20140219979A1

公开(公告)日：2014-08-07

申请号：US14221887

申请日：2014-03-21

Applicant: Yeda Research and Development Co. Ltd. ,  Yeda Research and Development Co. Ltd.

Inventor： Irun R. Cohen ,  Alexandra Zanin-Zhorov ,  Guy Tal ,  Francisco Quintana ,  Meirav Pisner ,  Ofer Lider

IPC: A61K38/17 ,  A61K35/14

CPC classification number: A61K38/1709 ,  A61K35/17 ,  A61K39/0008 ,  A61K2035/124 ,  A61K2039/5158 ,  A61K2039/53 ,  C12N5/0636 ,  C12N2501/07

Abstract: The present invention provides novel uses for peptide p277—positions 437-460 of human heat shock protein 60 (HSP60)—in modulation of immune responses and inflammatory diseases. The invention further provides novel uses for HSP60 and p277 in the treatment or prevention of hepatic disorders. The invention discloses methods for treating, preventing or ameliorating the symptoms of T cell mediated inflammatory and autoimmune disorders, including hepatic disorders, which comprise administering to a subject in need thereof a composition comprising as an active ingredient an effective quantity of a molecule selected from: HSP60, p277, fragments, analogs, homologs and derivatives thereof, and nucleic acids encoding same. Also disclosed are T cell vaccination methods for treating or preventing T cell mediated disorders.

Abstract translation: 本发明提供了人类热休克蛋白60（HSP60）的肽p277-位置437-460在调节免疫应答和炎性疾病方面的新用途。 本发明进一步提供HSP60和p277在治疗或预防肝病中的新用途。 本发明公开了治疗，预防或改善T细胞介导的炎症和自身免疫性疾病（包括肝脏疾病）的症状的方法，其包括向有需要的受试者施用包含有效量的选自以下的分子的组合物： HSP60，p277，其片段，类似物，同源物及其衍生物，以及编码其的核酸。 还公开了用于治疗或预防T细胞介导的病症的T细胞疫苗接种方法。

公开(公告)号：US10082503B2

公开(公告)日：2018-09-25

申请号：US14210409

申请日：2014-03-13

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.

Inventor： Irun R. Cohen ,  Eytan Domany ,  Francisco Javier Quintana ,  Guy Hed ,  Gad Getz

IPC: G06F19/24 ,  G01N33/564 ,  G01N33/68 ,  G06F19/18

CPC classification number: G01N33/564 ,  G01N33/6803 ,  G16B20/00 ,  G16B40/00

Abstract: Method, system and an article of manufacture for clustering and thereby identifying predefined antigens reactive with undetermined immunoglobulins of sera derived from patient subjects in need of diagnosis of disease or monitoring of treatment.

公开(公告)号：US20150018271A1

公开(公告)日：2015-01-15

申请号：US14379758

申请日：2013-02-28

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Irun R. Cohen ,  Raanan Margalit

IPC: A61K38/17 ,  A61K45/06

CPC classification number: A61K38/17 ,  A61K38/1709 ,  A61K45/06 ,  C07K14/47 ,  A61K2300/00

Abstract: The present invention provides methods of prevention and treatment of Type 2 diabetes (T2D) using peptides and analogs of heat shock protein 60 (hsp60), and for suppression, prevention and treatment of complications associated with T2D. The invention is exemplified using DiaPep277™, a peptide analog of human hsp60. The invention further relates treatment regimens useful for suppression, prevention or treatment of T2D.

Abstract translation: 本发明提供使用热休克蛋白60（hsp60）的肽和类似物预防和治疗2型糖尿病（T2D）的方法，以及用于抑制，预防和治疗与T2D相关并发症的方法。 使用人hsp60的肽类似物DiaPep277 TM来举例说明本发明。 本发明还涉及可用于抑制，预防或治疗T2D的治疗方案。

公开(公告)号：US20150011471A1

公开(公告)日：2015-01-08

申请号：US14379772

申请日：2013-02-28

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Irun R. Cohen ,  Raanan Margalit

IPC: A61K38/17

CPC classification number: A61K38/1709 ,  A61K9/0019 ,  A61K9/0024 ,  A61K38/164 ,  A61K47/44

Abstract: The present invention provides compositions for use in the treatment of long-established type 1 diabetes (T1D) using peptides and analogs of heat shock protein 60 (Hsp60). The invention is exemplified using DiaPep277, a peptide analog of human Hsp60, which is shown to induce increase in plasma C-peptide and regeneration of islet beta cells. The invention further relates to regimens useful for treatment of long established T1D in patients having no demonstrable islet beta cell-function.

Abstract translation: 本发明提供了使用热休克蛋白60（Hsp60）的肽和类似物治疗长期存在的1型糖尿病（T1D）的组合物。 使用DiaPep277（人Hsp60的肽类似物）来证明本发明，其显示诱导血浆C肽增加和胰岛β细胞的再生。 本发明还涉及可用于在没有可证实的胰岛β细胞功能的患者中治疗长期建立的T1D的方案。

公开(公告)号：US10545144B2

公开(公告)日：2020-01-28

申请号：US15108889

申请日：2014-12-31

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.

Inventor： Irun R. Cohen ,  Eytan Domany ,  Noam Shental ,  Ittai Fattal

IPC: G01N33/564 ,  C12Q1/6883

Abstract: Methods and kits for diagnosing systemic lupus erythematosus (SLE) in a subject are provided. Particularly, the present invention relates to specific oligonucleotide antibody reactivities useful in diagnosing SLE in a subject.

公开(公告)号：US20160320384A1

公开(公告)日：2016-11-03

申请号：US15107483

申请日：2014-12-31

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.

Inventor： Irun R. Cohen ,  Eytan Domany ,  Noam Shental ,  Ittai Fattal

IPC: G01N33/564 ,  C07K14/705 ,  A61K38/13 ,  C12Q1/68 ,  G01N33/68

CPC classification number: G01N33/564 ,  A61K38/00 ,  A61K38/13 ,  C07K14/70521 ,  C07K2319/30 ,  C12N2310/17 ,  C12Q1/6804 ,  G01N33/6854 ,  G01N2800/245 ,  G01N2800/52

Abstract: A method of assaying or monitoring the determining immunological competence of a subject, particularly for determining immunological competence in a subject, including but not limited to a transplant recipient, is provided. The method comprises measuring the levels of antibodies in a sample obtained from a subject to poly-guanine oligonucleotides.

Abstract translation: 提供了测定或监测受试者的测定免疫学能力的方法，特别是用于确定受试者的免疫学能力，包括但不限于移植受体。 该方法包括测量从受试者获得的样品中的聚鸟嘌呤寡核苷酸的抗体水平。

公开(公告)号：US20140088017A1

公开(公告)日：2014-03-27

申请号：US14119891

申请日：2012-05-23

Applicant: Universitätsklinikum Hamburg-Eppendorf ,  Yeda Research and Development Co. Ltd.

Inventor： Eran Ovadia ,  Irun R. Cohen ,  Johannes Herkel ,  Raanan Margalit ,  Melray Pevsner-Fishcher

IPC: C07K7/06 ,  G01N33/543

CPC classification number: G01N33/6854 ,  A61K31/343 ,  A61K38/08 ,  A61K38/1808 ,  A61K38/1825 ,  A61K38/1833 ,  A61K38/1841 ,  A61K38/185 ,  A61K38/1866 ,  A61K38/1891 ,  A61K38/30 ,  A61K45/06 ,  C07K7/06 ,  G01N33/54306 ,  G01N33/6896 ,  G01N2800/28 ,  G01N2800/52 ,  A61K2300/00

Abstract: The present invention relates to uses of a peptide comprising an amino acid sequence selected from the group consisting of SEQ ID NO: 1, SEQ ID NO: 2, analogues and derivatives thereof, for the treatment of neurodegenerative diseases, such as amyotrophic lateral sclerosis (ALS). The present invention further provides a method for assessing responsiveness to treatment with the peptide of the invention. In addition, the present invention relates to prognosis of ALS progression, using Akt and phosphorylated Akt as biomarkers.

Abstract translation: 本发明涉及包含选自SEQ ID NO：1，SEQ ID NO：2，其类似物和衍生物的氨基酸序列的肽用于治疗神经变性疾病如肌萎缩性侧索硬化（ ALS）。 本发明还提供了评估对本发明的肽的治疗反应性的方法。 此外，本发明涉及使用Akt和磷酸化Akt作为生物标志物的ALS进展的预后。

公开(公告)号：US11852634B2

公开(公告)日：2023-12-26

申请号：US17081013

申请日：2020-10-27

Applicant: Yeda Research and Development Co. Ltd. ,  Universitätsklinikum Hamburg-Eppendorf

Inventor： Eran Ovadia ,  Irun R. Cohen ,  Johannes Herkel ,  Raanan Margalit ,  Meirav Pevsner-Fischer

IPC: G01N33/68 ,  A61K38/08 ,  A61K38/18 ,  A61K31/343 ,  A61K38/30 ,  A61K45/06 ,  C07K7/06 ,  G01N33/543

CPC classification number: G01N33/6854 ,  A61K31/343 ,  A61K38/08 ,  A61K38/185 ,  A61K38/1808 ,  A61K38/1825 ,  A61K38/1833 ,  A61K38/1841 ,  A61K38/1866 ,  A61K38/1891 ,  A61K38/30 ,  A61K45/06 ,  C07K7/06 ,  G01N33/54306 ,  G01N33/6896 ,  G01N2800/28 ,  G01N2800/52

Abstract: The present invention relates to uses of a peptide comprising an amino acid sequence selected from the group consisting of SEQ ID NO: 1, SEQ ID NO: 2, analogues and derivatives thereof, for the treatment of neurodegenerative diseases, such as amyotrophic lateral sclerosis (ALS). The present invention further provides a method for assessing responsiveness to treatment with the peptide of the invention. In addition, the present invention relates to prognosis of ALS progression, using Akt and phosphorylated Akt as biomarkers.

公开(公告)号：US11002735B2

公开(公告)日：2021-05-11

申请号：US16748001

申请日：2020-01-21

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.

Inventor： Irun R. Cohen ,  Eytan Domany ,  Francisco Javier Quintana ,  Guy Hed ,  Gad Getz

IPC: G16B40/00 ,  G01N33/564 ,  G16B20/00 ,  G01N33/68

Abstract: Method, system and an article of manufacture for clustering and thereby identifying predefined antigens reactive with undetermined immunoglobulins of sera derived from patient subjects in need of diagnosis of disease or monitoring of treatment.

公开(公告)号：US20170016895A1

公开(公告)日：2017-01-19

申请号：US15108889

申请日：2014-12-31

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.

Inventor： Irun R. Cohen ,  Eytan Domany ,  Noam Shental ,  Ittai Fattal

IPC: G01N33/564 ,  C12Q1/68

Abstract: Methods and kits for diagnosing systemic lupus erythematosus (SLE) in a subject are provided. Particularly, the present invention relates to specific oligonucleotide antibody reactivities useful in diagnosing SLE in a subject.

Abstract translation: 提供用于诊断受试者系统性红斑狼疮（SLE）的方法和试剂盒。 特别地，本发明涉及可用于诊断受试者中SLE的特异性寡核苷酸抗体反应性。