公开(公告)号：US07598792B2

公开(公告)日：2009-10-06

申请号：US11266486

申请日：2005-11-04

申请人： Yan-Fei Liu ,  Zhihua Yang ,  Wilson Eberle

发明人： Yan-Fei Liu ,  Zhihua Yang ,  Wilson Eberle

IPC分类号： H03K17/74

CPC分类号： H02M1/088 ,  H02M1/08 ,  H02M3/33592 ,  H02M3/3376 ,  Y02B70/1433 ,  Y02B70/1475

摘要： A resonate gate drive circuit for driving at least one power switching device recovers energy loss for charging and discharging the gate capacitance of the power switching devices. The gate drive circuit uses a current source to charge and discharge the gate capacitance with a high current, reducing the switching loss of the power switching device. The gate drive circuit comprises four semiconductor bidirectional conducting switching devices connected in a full-bridge configuration. An inductor connected across the bridge configuration provides the current source. The gate drive circuit may be used in single and dual high-side and low-side, symmetrical or complementary, power converter gate drive applications.

摘要翻译： 用于驱动至少一个功率开关装置的谐振栅极驱动电路恢复能量损耗，以便对功率开关器件的栅极电容进行充电和放电。 栅极驱动电路使用电流源以高电流对栅极电容进行充电和放电，从而降低功率开关器件的开关损耗。 栅极驱动电路包括以全桥配置连接的四个半导体双向导通开关器件。 通过桥接配置连接的电感器提供电流源。 栅极驱动电路可用于单和双高侧，低边，对称或互补的功率转换器栅极驱动应用。

公开(公告)号：US20060170043A1

公开(公告)日：2006-08-03

申请号：US11266486

申请日：2005-11-04

申请人： Yan-Fei Liu ,  Zhihua Yang ,  Wilson Eberle

发明人： Yan-Fei Liu ,  Zhihua Yang ,  Wilson Eberle

IPC分类号： H01L29/76 ,  H01L29/94

CPC分类号： H02M1/088 ,  H02M1/08 ,  H02M3/33592 ,  H02M3/3376 ,  Y02B70/1433 ,  Y02B70/1475

摘要： A resonate gate drive circuit for driving at least one power switching device recovers energy loss for charging and discharging the gate capacitance of the power switching devices. The gate drive circuit uses a current source to charge and discharge the gate capacitance with a high current, reducing the switching loss of the power switching device. The gate drive circuit comprises four semiconductor bidirectional conducting switching devices connected in a full-bridge configuration. An inductor connected across the bridge configuration provides the current source. The gate drive circuit may be used in single and dual high-side and low-side, symmetrical or complementary, power converter gate drive applications.

公开(公告)号：US20060170042A1

公开(公告)日：2006-08-03

申请号：US11045055

申请日：2005-01-31

申请人： Zhihua Yang ,  Yan-Fei Liu

发明人： Zhihua Yang ,  Yan-Fei Liu

IPC分类号： H01L29/76

CPC分类号： H03K17/04163 ,  H02M1/08 ,  H03K17/04123

摘要： A resonate gate drive circuit for driving at least one power switching devices recovers energy loss for charging and discharging the input capacitance of the power switching devices. The gate drive circuit charging and discharging the gate capacitor with a high level current, so the switching loss of the power switching devices can also be reduced. The gate drive circuit can clamp and keep the voltage across the gate capacitor to a certain level while the power switching devices turn on, and it can also clamp and keep the voltage across the gate capacitor to almost zero while the power switching devices turn off. The gate drive circuit comprises four small semiconductor bidirectional 10 conducting switching devices connected in full-bridge configuration. An inductor is connected to the two junctions of the full-bridge configuration to help switching the current direction. A capacitor in series with the inductor is necessary for some applications. A bootstrap circuit, which is widely used in conventional gate drive circuitry, is also necessary for this resonant gate drive circuit when it is adopted for high-side and low-side applications.

摘要翻译： 用于驱动至少一个电力开关装置的谐振栅极驱动电路恢复用于对功率开关装置的输入电容进行充电和放电的能量损失。 栅极驱动电路以高电平电流对栅极电容器进行充电和放电，因此也可以降低功率开关器件的开关损耗。 栅极驱动电路可以在功率开关器件导通的同时将栅极电容器两端的电压钳位并保持一定水平，并且在电源开关器件关闭时，它也可以钳位并保持栅极电容器两端的电压几乎为零。 栅极驱动电路包括以全桥配置连接的四个小型半导体双向10导通开关装置。 电感器连接到全桥配置的两个连接点，以帮助切换电流方向。 与电感器串联的电容器对于某些应用是必需的。 当用于高边和低边应用时，该谐振栅极驱动电路也需要用于常规栅极驱动电路的自举电路。

公开(公告)号：US07612602B2

公开(公告)日：2009-11-03

申请号：US11045055

申请日：2005-01-31

申请人： Zhihua Yang ,  Yan-Fei Liu

发明人： Zhihua Yang ,  Yan-Fei Liu

IPC分类号： H03K17/74

CPC分类号： H03K17/04163 ,  H02M1/08 ,  H03K17/04123

摘要： A resonate gate drive circuit for driving at least one power switching devices recovers energy loss for charging and discharging the input capacitance of the power switching devices. The gate drive circuit charging and discharging the gate capacitor with a high level current, so the switching loss of the power switching devices can also be reduced. The gate drive circuit can clamp and keep the voltage across the gate capacitor to a certain level while the power switching devices turn on, and it can also clamp and keep the voltage across the gate capacitor to almost zero while the power switching devices turn off. The gate drive circuit comprises four small semiconductor bidirectional conducting switching devices connected in full-bridge configuration. An inductor is connected to the two junctions of the full-bridge configuration to help switching the current direction. A capacitor in series with the inductor is necessary for some applications. A bootstrap circuit, which is widely used in conventional gate drive circuitry, is also necessary for this resonant gate drive circuit when it is adopted for high-side and low-side applications.

摘要翻译： 用于驱动至少一个电力开关装置的谐振栅极驱动电路恢复用于对功率开关装置的输入电容进行充电和放电的能量损失。 栅极驱动电路以高电平电流对栅极电容器进行充电和放电，因此也可以降低功率开关器件的开关损耗。 栅极驱动电路可以在功率开关器件导通的同时将栅极电容器两端的电压钳位并保持一定水平，并且在电源开关器件关闭时，它也可以钳位并保持栅极电容器两端的电压几乎为零。 栅极驱动电路包括以全桥配置连接的四个小型半导体双向导通开关装置。 电感器连接到全桥配置的两个连接点，以帮助切换电流方向。 与电感器串联的电容器对于某些应用是必需的。 当用于高边和低边应用时，该谐振栅极驱动电路也需要用于常规栅极驱动电路的自举电路。

公开(公告)号：US20130040402A1

公开(公告)日：2013-02-14

申请号：US13599785

申请日：2012-08-30

申请人： Zhihua Yang ,  Athula Buddhagosha Attygalle

发明人： Zhihua Yang ,  Athula Buddhagosha Attygalle

IPC分类号： G01N1/28

CPC分类号： H01J49/142 ,  H01J49/167

摘要： Electrospray ionization techniques are used to generate reagents that ionize analytes for mass spectrometric analysis by charge transfer. Such techniques may be performed under ambient conditions. Suitable precursors for such reagents include ionizable nonpolar solvents, such as toluene or xylenes, polar solvents, such as water or alchohols, inert gases, such as helium or nitrogen, or combinations thereof. Environmental conditions in the ionization chamber of the mass spectrograph can be manipulated to generate a selected ion of an analyte in preference to other ions.

摘要翻译： 电喷雾离子化技术用于产生电离电离试剂，用于通过电荷转移进行质谱分析。 这样的技术可以在环境条件下进行。 用于这种试剂的合适的前体包括可电离的非极性溶剂，例如甲苯或二甲苯，极性溶剂如水或醇，惰性气体如氦或氮，或其组合。 可以操纵质谱仪的电离室中的环境条件以优先于其它离子产生分析物的选定离子。

公开(公告)号：US20130123471A1

公开(公告)日：2013-05-16

申请号：US13696251

申请日：2011-03-16

申请人： Zhihua Yang ,  Yuliang Ran

发明人： Zhihua Yang ,  Yuliang Ran

IPC分类号： C07K16/30 ,  A61K51/10

CPC分类号： C07K16/3007 ,  A61K51/1093 ,  A61K2039/505 ,  C07K2317/14 ,  C07K2317/24 ,  C07K2317/73

摘要： The invention discloses a humanized chimeric monoclonal antibody against carcinoembryonic antigen (CEA), polynucleotides encoding the antibody, expression vectors comprising the polynucleotides, and host cells containing the expression vectors. The invention also discloses uses of the antibody, polynucleotides, vectors and host cells for manufacturing medicaments for diagnosis and/or treatment of tumors.

摘要翻译： 本发明公开了一种针对癌胚抗原（CEA）的人源化嵌合单克隆抗体，编码抗体的多核苷酸，包含多核苷酸的表达载体和含有表达载体的宿主细胞。 本发明还公开了用于制造用于诊断和/或治疗肿瘤的药物的抗体，多核苷酸，载体和宿主细胞的用途。

公开(公告)号：US09056911B2

公开(公告)日：2015-06-16

申请号：US13696251

申请日：2011-03-16

申请人： Zhihua Yang ,  Yuliang Ran

发明人： Zhihua Yang ,  Yuliang Ran

IPC分类号： C07K16/30 ,  C12N15/00 ,  A61K51/10 ,  A61K39/00

CPC分类号： C07K16/3007 ,  A61K51/1093 ,  A61K2039/505 ,  C07K2317/14 ,  C07K2317/24 ,  C07K2317/73

摘要： The invention discloses a humanized chimeric monoclonal antibody against carcinoembryonic antigen (CEA), polynucleotides encoding the antibody, expression vectors comprising the polynucleotides, and host cells containing the expression vectors. The invention also discloses uses of the antibody, polynucleotides, vectors and host cells for manufacturing medicaments for diagnosis and/or treatment of tumors.

摘要翻译： 本发明公开了一种针对癌胚抗原（CEA）的人源化嵌合单克隆抗体，编码抗体的多核苷酸，包含多核苷酸的表达载体和含有表达载体的宿主细胞。 本发明还公开了用于制造用于诊断和/或治疗肿瘤的药物的抗体，多核苷酸，载体和宿主细胞的用途。

公开(公告)号：US08664000B2

公开(公告)日：2014-03-04

申请号：US13599785

申请日：2012-08-30

申请人： Zhihua Yang ,  Athula Buddhagosha Attygalle

发明人： Zhihua Yang ,  Athula Buddhagosha Attygalle

IPC分类号： H01J49/14

CPC分类号： H01J49/142 ,  H01J49/167

摘要： Electrospray ionization techniques are used to generate reagents that ionize analytes for mass spectrometric analysis by charge transfer. Such techniques may be performed under ambient conditions. Suitable precursors for such reagents include ionizable nonpolar solvents, such as toluene or xylenes, polar solvents, such as water or alchohols, inert gases, such as helium or nitrogen, or combinations thereof. Environmental conditions in the ionization chamber of the mass spectrograph can be manipulated to generate a selected ion of an analyte in preference to other ions.

摘要翻译： 电喷雾离子化技术用于产生电离电离试剂，用于通过电荷转移进行质谱分析。 这样的技术可以在环境条件下进行。 用于这种试剂的合适的前体包括可电离的非极性溶剂，例如甲苯或二甲苯，极性溶剂如水或醇，惰性气体如氦或氮，或其组合。 可以操纵质谱仪的电离室中的环境条件以优先于其它离子产生分析物的选定离子。

公开(公告)号：US20110165695A1

公开(公告)日：2011-07-07

申请号：US12893597

申请日：2010-09-29

申请人： Chang-Ching Chan ,  Mark S. Bolgar ,  Scott A. Miller ,  Zhihua Yang ,  Athula Buddhagosha Attygalle

发明人： Chang-Ching Chan ,  Mark S. Bolgar ,  Scott A. Miller ,  Zhihua Yang ,  Athula Buddhagosha Attygalle

IPC分类号： G01N1/28

CPC分类号： H01J49/142 ,  H01J49/167

摘要： Electrospray ionization techniques are used to generate reagents that ionize analytes for mass spectrometric analysis by charge transfer. Such techniques may be performed under ambient conditions. Suitable precursors for such reagents include ionizable nonpolar solvents, such as toluene or xylenes, polar solvents, such as water or alcohols, inert gases, such as helium or nitrogen, or combinations thereof. Environmental conditions in the ionization chamber of the mass spectrograph can be manipulated to generate a selected ion of an analyte in preference to other ions.

摘要翻译： 电喷雾离子化技术用于产生电离电离试剂，用于通过电荷转移进行质谱分析。 这样的技术可以在环境条件下进行。 用于这种试剂的合适的前体包括可离子化的非极性溶剂如甲苯或二甲苯，极性溶剂如水或醇，惰性气体如氦或氮，或其组合。 可以操纵质谱仪的电离室中的环境条件以优先于其它离子产生分析物的选定离子。