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    Delta3, FTHMA-070, Tango85, Tango77, SPOIL,NEOKINE, Tango129 and integrin alpha subunit protein and nucleic acid molecules and uses thereof
    1.
    发明申请
    Delta3, FTHMA-070, Tango85, Tango77, SPOIL,NEOKINE, Tango129 and integrin alpha subunit protein and nucleic acid molecules and uses thereof 审中-公开
    Delta3，FTHMA-070，Tango85，Tango77，SPOIL，NEOKINE，Tango129和整合素α亚基蛋白和核酸分子及其用途

    公开(公告)号：US20060122373A1

    公开(公告)日：2006-06-08

    申请号：US11175714

    申请日：2005-07-05

    申请人： Sean McCarthy ,  David Gearing ,  Douglas Holtzman ,  Yang Pan ,  Samantha Busfield ,  Thomas Barnes ,  Charles Mackay ,  Jose Lora

    发明人： Sean McCarthy ,  David Gearing ,  Douglas Holtzman ,  Yang Pan ,  Samantha Busfield ,  Thomas Barnes ,  Charles Mackay ,  Jose Lora

    IPC分类号： C07K14/705 ,  C07K14/715 ,  C07H21/04 ,  C12P21/06

    CPC分类号： C12Q1/48 ,  A61K38/00 ,  C07K14/47 ,  C07K2319/00 ,  C12Q1/6876

    摘要： The invention provides novel Delta3, FTHMA-070, Tango85, Tango77, SPOIL, NEOKINE, Tango129 and A259 polypeptides, proteins, and nucleic acid molecules. In addition to isolated, full-length Delta3, FTHMA-070, Tango85, Tango77, SPOIL, NEOKINE, Tango129 and A259 proteins, the invention further provides isolated Delta3, FTHMA-070, Tango85, Tango77, SPOIL, NEOKINE, Tango129 and A259 fusion proteins, antigenic peptides and anti-Delta3, FTHMA-070, Tango85, Tango77, SPOIL, NEOKINE, Tango129 and A259 antibodies. The invention also provides Delta3, FTHMA-070, Tango85, Tango77, SPOIL, NEOKINE, Tango129 and A259 nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which the expression vectors have been introduced and non-human transgenic animals in which a Delta3, FTHMA-070, Tango85, Tango77, SPOIL, NEOKINE, Tango129 or A259 gene has been introduced or disrupted. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided.

    摘要翻译： 本发明提供新颖的Delta3，FTHMA-070，Tango85，Tango77，SPOIL，NEOKINE，Tango129和A259多肽，蛋白质和核酸分子。 除了分离的全长Delta3，FTHMA-070，Tango85，Tango77，SPOIL，NEOKINE，Tango129和A259蛋白外，本发明还提供了分离的Delta3，FTHMA-070，Tango85，Tango77，SPOIL，NEOKINE，Tango129和A259融合 蛋白质，抗原肽和抗Delta3，FTHMA-070，Tango85，Tango77，SPOIL，NEOKINE，Tango129和A259抗体。 本发明还提供了Delta3，FTHMA-070，Tango85，Tango77，SPOIL，NEOKINE，Tango129和A259核酸分子，含有本发明的核酸分子的重组表达载体，已经引入了表达载体的宿主细胞， 已经引入或破坏了Delta3，FTHMA-070，Tango85，Tango77，SPOIL，NEOKINE，Tango129或A259基因的人类转基因动物。 还提供利用本发明组合物的诊断，筛选和治疗方法。

    Novel integrin alpha subunit and uses thereof
    2.
    发明申请
    Novel integrin alpha subunit and uses thereof 审中-公开
    新型整合素α亚基及其用途

    公开(公告)号：US20050260702A1

    公开(公告)日：2005-11-24

    申请号：US10601368

    申请日：2003-06-23

    申请人： Yang Pan ,  Jose Lora

    发明人： Yang Pan ,  Jose Lora

    IPC分类号： A61K38/00 ,  C07K14/705 ,  C07K16/28 ,  C12N15/12 ,  C12P21/02 ,  C07H21/04 ,  C12N5/06

    CPC分类号： C07K16/2839 ,  A61K38/00 ,  A61K2039/505 ,  C07K14/70546

    摘要： The invention provides human and murine isolated nucleic acid molecules, designated A259 nucleic acid molecules, which encode secreted proteins with homology to integrin α subunits, specifically to integrin α10. The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a nucleic acid molecule of the invention has been introduced or disrupted. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic peptides and antibodies. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided.

    摘要翻译： 本发明提供人和鼠分离的核酸分子，命名为A259核酸分子，其编码与整联蛋白α亚基具有同源性的分泌蛋白，特别是整合素α10。 本发明还提供反义核酸分子，含有本发明的核酸分子的表达载体，已经引入了表达载体的宿主细胞和其中引入了本发明的核酸分子的非人转基因动物，或 中断了 本发明还进一步提供分离的多肽，融合多肽，抗原肽和抗体。 还提供利用本发明组合物的诊断，筛选和治疗方法。

    2150, human protein kinase family member and uses therefor
    3.
    发明申请
    2150, human protein kinase family member and uses therefor 有权

    公开(公告)号：US20050282189A1

    公开(公告)日：2005-12-22

    申请号：US11103065

    申请日：2005-04-11

    申请人： Rachel Meyers ,  Jose Lora

    发明人： Rachel Meyers ,  Jose Lora

    IPC分类号： C12N9/12 ,  C12Q1/68 ,  C07H21/04

    CPC分类号： C12N9/12 ,  C07K2319/00 ,  C12N9/1205

    摘要： The invention provides isolated nucleic acids molecules, designated 2150 nucleic acid molecules, which encode novel protein kinase family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 2150 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 2150 gene has been introduced or disrupted. The invention still further provides isolated 2150 proteins, fusion proteins, antigenic peptides and anti-2150 antibodies. Diagnostic and therapeutic methods utilizing compositions of the invention are also provided.

    2150, human protein kinase family member and uses therefor
    5.
    发明申请
    2150, human protein kinase family member and uses therefor 失效

    公开(公告)号：US20070190565A1

    公开(公告)日：2007-08-16

    申请号：US11713844

    申请日：2007-03-05

    申请人： Rachel Meyers ,  Jose Lora

    发明人： Rachel Meyers ,  Jose Lora

    IPC分类号： C12Q1/68 ,  C07H21/04 ,  C12P21/06 ,  C12N9/12

    CPC分类号： C12N9/12 ,  C07K2319/00 ,  C12N9/1205

    摘要： The invention provides isolated nucleic acids molecules, designated 2150 nucleic acid molecules, which encode novel protein kinase family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 2150 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 2150 gene has been introduced or disrupted. The invention still further provides isolated 2150 proteins, fusion proteins, antigenic peptides and anti-2150 antibodies. Diagnostic and therapeutic methods utilizing compositions of the invention are also provided.