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20 条记录 (耗时 0.079 秒)

    Novel human hydrolase family members and uses thereof
    3.
    发明申请
    Novel human hydrolase family members and uses thereof 审中-公开
    新型人类水解酶家族成员及其用途

    公开(公告)号：US20070048784A1

    公开(公告)日：2007-03-01

    申请号：US11591659

    申请日：2006-11-01

    申请人： Rachel Meyers ,  Maria Glucksmann ,  Rory Curtis ,  Laura Rudolph-Owen

    发明人： Rachel Meyers ,  Maria Glucksmann ,  Rory Curtis ,  Laura Rudolph-Owen

    IPC分类号： C12Q1/68 ,  C07H21/04 ,  C12P21/06 ,  C12N9/16 ,  C07K16/40

    CPC分类号： C12Q1/6883 ,  C12N9/82 ,  C12Q2600/156 ,  C12Q2600/158

    摘要： The invention provides isolated nucleic acids molecules, designated 26443 and 46873 nucleic acid molecules, which encode novel human hydrolase family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 26443 and 46873 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 26443 and 46873 gene has been introduced or disrupted. The invention still further provides isolated 26443 and 46873 proteins, fusion proteins, antigenic peptides and anti-26443 or 46873 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.

    摘要翻译： 本发明提供编码新的人水解酶家族成员的分离的核酸分子，命名为26443和46873核酸分子。 本发明还提供了反义核酸分子，含有26443和46873核酸分子的重组表达载体，已经引入表达载体的宿主细胞，以及引入或破坏了26443和46873基因的非人类转基因动物。 本发明还进一步提供分离的26443和46873蛋白，融合蛋白，抗原肽和抗26443或46873抗体。 还提供了利用本发明组合物的诊断方法。

    Novel human genes and methods of use thereof
    4.
    发明申请
    Novel human genes and methods of use thereof 审中-公开
    新型人类基因及其使用方法

    公开(公告)号：US20050214893A1

    公开(公告)日：2005-09-29

    申请号：US10968812

    申请日：2004-10-19

    申请人： Rachel Meyers ,  Rory Curtis ,  Maria Glucksmann ,  Rajasekhar Bandaru ,  Rosana Kapeller-Libermann

    发明人： Rachel Meyers ,  Rory Curtis ,  Maria Glucksmann ,  Rajasekhar Bandaru ,  Rosana Kapeller-Libermann

    IPC分类号： A61K38/00 ,  C07K14/47 ,  C07K14/705 ,  C12N9/02 ,  C12N9/10 ,  C12N9/48 ,  C12N9/90 ,  C12Q1/26 ,  G01N33/574

    CPC分类号： C12N9/0004 ,  A61K38/00 ,  C07K14/47 ,  C07K14/4702 ,  C07K14/705 ,  C12N9/1048 ,  C12N9/48 ,  C12N9/90 ,  G01N33/57411 ,  G01N2500/04

    摘要： The invention provides isolated nucleic acids molecules, designated 47476, 67210, 49875,46842,33201, 83378,84233,64708, 85041,84234,21617, 55562,23566,33489, and 57779 nucleic acid molecules, which encode novel human genes. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 47476, 67210, 49875, 46842, 33201, 83378, 84233, 64708, 85041, 84234, 21617, 55562, 23566, 33489, or 57779 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 47476, 67210, 49875, 46842, 33201, 83378, 84233, 64708, 85041, 84234, 21617, 55562, 23566, 33489, or 57779 gene has been introduced or disrupted. The invention still further provides isolated 47476, 67210, 49875, 46842, 33201, 83378, 84233, 64708, 85041, 84234, 21617, 55562, 23566, 33489, or 57779 proteins, fusion proteins, antigenic peptides and anti-47476, 67210, 49875, 46842, 33201, 83378, 84233, 64708, 85041, 84234, 21617, 55562, 23566, 33489, or 57779 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.

    摘要翻译： 本发明提供编码新的人基因的分离的核酸分子，命名为47476,67210,49875,46842,33201,83378,84233,64708,85041,84234,21617,55562,23566,33489和57779核酸分子。 本发明还提供反义核酸分子，包含47476,67210,49875,4642,33201,83378,84233,64708,85041,84234,161617,55562,23566,33489或57779核酸分子的重组表达载体，宿主细胞 已经引入了表达载体的非人类转基因动物，以及引入了47476,67210,49875,4642,43708,85041,84234,16617,55562,23566,33489或57779基因的非人类转基因动物，或 中断了 本发明还进一步提供分离的47476,67210,49875,4642,33201,83378,84233,64708,85041,84234,21617,55562,23566,33489或57779号蛋白，融合蛋白，抗原肽和抗-47476,67210， 49875,4462,33201,83378,84233,66708,85041,84234,21617,55562,253566,33489或57779抗体。 还提供了利用本发明组合物的诊断方法。

    43239, a novel GPCR-like molecule and uses thereof
    5.
    发明申请
    43239, a novel GPCR-like molecule and uses thereof 审中-公开
    43239，一种新型的GPCR样分子及其用途

    公开(公告)号：US20050089925A1

    公开(公告)日：2005-04-28

    申请号：US10435828

    申请日：2003-05-12

    申请人： Maria Glucksmann ,  Inmaculada Silos-Santiago

    发明人： Maria Glucksmann ,  Inmaculada Silos-Santiago

    IPC分类号： A61K38/00 ,  C07K14/705 ,  C12N15/12 ,  G01N33/53 ,  C07H21/04 ,  C12N5/06 ,  C12P21/02

    CPC分类号： C07K14/705 ,  A61K38/00

    摘要： Novel GPCR-like polypeptides, proteins, and nucleic acid molecules are disclosed. In addition to isolated, full-length GPCR-like proteins, the invention further provides isolated GPCR-like fusion proteins, antigenic peptides, and anti-GPCR-like antibodies. The invention also provides GPCR-like nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a GPCR-like gene has been introduced or disrupted. Diagnostic, screening, and therapeutic methods utilizing compositions of the invention are also provided.

    摘要翻译： 公开了新的GPCR样多肽，蛋白质和核酸分子。 除了分离的全长GPCR样蛋白之外，本发明还提供了分离的GPCR样融合蛋白，抗原肽和抗GPCR样抗体。 本发明还提供了GPCR样核酸分子，含有本发明的核酸分子的重组表达载体，已经引入了表达载体的宿主细胞和其中已经导入或破坏了GPCR样基因的非人转基因动物 。 还提供了利用本发明组合物的诊断，筛选和治疗方法。

    Novel nucleic acid sequences encoding G-protein coupled receptors
    8.
    发明申请
    Novel nucleic acid sequences encoding G-protein coupled receptors 审中-公开
    编码G蛋白偶联受体的新型核酸序列

    公开(公告)号：US20060275866A1

    公开(公告)日：2006-12-07

    申请号：US11268745

    申请日：2005-11-07

    申请人： Katherine Galvin ,  Maria Glucksmann ,  Martin Hodge ,  John Hunter ,  Laura Rudolph-Owen ,  Inmaculada Silos-Santiago ,  Nadine Weich

    发明人： Katherine Galvin ,  Maria Glucksmann ,  Martin Hodge ,  John Hunter ,  Laura Rudolph-Owen ,  Inmaculada Silos-Santiago ,  Nadine Weich

    IPC分类号： C07K14/705 ,  C07H21/04 ,  C12P21/06

    CPC分类号： C07K14/705

    摘要： The invention provides isolated nucleic acids molecules, designated 2871, 14926, 44576, 23992, 1983, 52881, 2398, and 52872 nucleic acid molecules, which encode novel G protein-coupled receptor family members that encode novel polypeptides. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 2871, 14926, 44576, 23992, 1983, 52881, 2398, or 52872 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 2871, 14926, 44576, 23992, 1983, 52881, 2398, or 52872 gene has been introduced or disrupted. The invention still further provides isolated 2871, 14926, 44576, 23992, 1983, 52881, 2398, or 52872 proteins, fusion proteins, antigenic peptides and anti-2871, 14926, 44576, 23992, 1983, 52881, 2398, or 52872 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.

    摘要翻译： 本发明提供分离的核酸分子，命名为2871,14926,4457,239992,1983,52881,2988和52872核酸分子，其编码编码新多肽的新型G蛋白偶联受体家族成员。 本发明还提供反义核酸分子，含有2871,14926,4576,23992,1983,52881,2398或52872核酸分子的重组表达载体，已经引入了表达载体的宿主细胞，以及非人转基因动物，其中 已经引入或破坏了2871,14926,44576,23992,1983,52881,2398或52872基因。 本发明还进一步提供了分离的2871,14926,4457,239992,1983,52881,2398或52872蛋白质，融合蛋白，抗原肽和抗-2871,14926,4457,23992,1983,52881,29898或52872抗体。 还提供了利用本发明组合物的诊断方法。

    14273 receptor, a novel G-protein coupled receptor
    9.
    发明申请
    14273 receptor, a novel G-protein coupled receptor 有权

    公开(公告)号：US20060177899A1

    公开(公告)日：2006-08-10

    申请号：US11283567

    申请日：2005-11-18

    申请人： Maria Glucksmann ,  Fong-Ying Tsai

    发明人： Maria Glucksmann ,  Fong-Ying Tsai

    IPC分类号： C07K14/705 ,  C07H21/04 ,  C12P21/06

    CPC分类号： C07K14/723

    摘要： The present invention relates to a newly identified receptor belonging to the superfamily of G-protein-coupled receptors. The invention also relates to polynucleotides encoding the receptor. The invention further relates to methods using the receptor polypeptides and polynucleotides as a target for diagnosis and treatment in receptor-mediated disorders, specifically, cardiovascular diseases, including congestive heart failure. The invention further relates to drug-screening methods using the receptor polypeptides and polynucleotides to identify agonists and antagonists for diagnosis and treatment. The invention further encompasses agonists and antagonists based on the receptor polypeptides and polynucleotides. The invention further relates to procedures for producing the receptor polypeptides and polynucleotides.