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公开(公告)号:US20110052562A1
公开(公告)日:2011-03-03
申请号:US12745357
申请日:2008-12-18
申请人: Yangbo Feng , Philip LoGrasso , Thomas Bannister , Thomas Schroeter , Hampton Sessions , Lei Yao , Bo Wang , Michael P. Smolinski , Yen Ting Chen , Yan Yin , Bozena Frackowiak-Wojtasek , Sarwat Chowdhury
发明人: Yangbo Feng , Philip LoGrasso , Thomas Bannister , Thomas Schroeter , Hampton Sessions , Lei Yao , Bo Wang , Michael P. Smolinski , Yen Ting Chen , Yan Yin , Bozena Frackowiak-Wojtasek , Sarwat Chowdhury
IPC分类号: A61K38/49 , C07D405/04 , A61K31/4184 , A61P9/10 , A61P9/12 , A61P25/28 , A61P25/16 , A61P11/06 , A61P19/02 , A61P19/10 , A61P17/06 , A61P27/06 , A61P3/10 , A61P13/00 , A61P31/12 , C07D405/14 , A61K31/4439 , C07D471/04 , A61K31/437 , C07D487/04 , A61K31/519 , A61K31/506 , A61K31/5377 , C07D413/14
CPC分类号: C07D405/12 , C07D405/14 , C07D409/14 , C07D471/04 , C07D487/04
摘要: Compounds useful as Rho kinase inhibitors according to formula IA or IB: wherein A, B, D, E, R1, R2 and Ar1 are as defined herein, and any tautomer, salt, stereoisomer, hydrate, solvent, or prodrug thereof, pharmaceutical compositions, methods of treatment, and synthetic methods are provided.
摘要翻译: 用作根据式IA或IB的Rho激酶抑制剂的化合物:其中A,B,D,E,R 1,R 2和Ar 1如本文所定义,以及其任何互变异构体,盐,立体异构体,水合物,溶剂或前药,药物组合物 ,治疗方法和合成方法。
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公开(公告)号:US20110150833A1
公开(公告)日:2011-06-23
申请号:US12746776
申请日:2008-12-18
申请人: Yangbo Feng , Philip LoGrasso , Thomas Bannister , Thomas Schroeter , Yen Ting Chen , Yan Yin , Hampton Sessions , Michael P. Smolinski , Lei Yao , Bo Wang , Bozena Frackowiak-Wojtasek
发明人: Yangbo Feng , Philip LoGrasso , Thomas Bannister , Thomas Schroeter , Yen Ting Chen , Yan Yin , Hampton Sessions , Michael P. Smolinski , Lei Yao , Bo Wang , Bozena Frackowiak-Wojtasek
IPC分类号: A61K31/4155 , C07D405/12 , A61K31/4433 , C07D405/14 , A61K31/496 , A61K31/506 , A61K31/519 , C07D471/02 , A61K31/4375 , A61K31/501 , A61K38/21 , A61K39/395 , A61K31/56 , A61P9/00 , A61P15/10 , A61P29/00 , A61P25/00 , A61P19/02 , A61P11/00 , A61P35/00 , A61P31/04
CPC分类号: C07D405/12 , C07D405/14 , C07D409/14 , C07D471/04 , C07D487/04
摘要: Compounds useful as Rho kinase inhibitors of formula (1) wherein the variables are as defined herein are provided. Methods of treatment of malconditions mediated by Rho kinase, and methods of preparation of the compounds, are also provided.
摘要翻译: 提供了可用作式(1)的Rho激酶抑制剂的化合物,其中变量如本文所定义。 还提供了由Rho激酶介导的病态治疗方法和化合物的制备方法。
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公开(公告)号:US20110038835A1
公开(公告)日:2011-02-17
申请号:US12808052
申请日:2008-12-18
申请人: Yangbo Feng , Philip LoGrasso , Thomas Bannister , Thomas Schroeter , Xingang Fang , Yen ting Chen , Yan Yin , Michael P. Smolinski , Lei Yao , Bo Wang , Hampton Sessions
发明人: Yangbo Feng , Philip LoGrasso , Thomas Bannister , Thomas Schroeter , Xingang Fang , Yen ting Chen , Yan Yin , Michael P. Smolinski , Lei Yao , Bo Wang , Hampton Sessions
IPC分类号: A61K31/5377 , C07D231/12 , A61K31/415 , C07D471/02 , A61K31/437 , C07D487/04 , A61K31/519 , C07D401/12 , A61K31/4439 , C07D217/00 , A61K31/47 , C07D413/10 , C07D413/14 , A61P9/00 , A61P9/12 , A61P9/10 , A61P25/00 , A61P25/16 , A61P11/06 , A61P19/02 , A61P3/00 , A61K39/395 , A61K33/24 , A61K31/675 , A61K38/21
CPC分类号: C07D405/12 , C07D405/14 , C07D409/14 , C07D471/04 , C07D487/04
摘要: Compounds useful as Rho kinase inhibitors of formula (I): wherein variable are as defined herein are provided. Methods of treatment of malconditions mediated by Rho kinase, and methods of preparation of the compounds, are also provided.
摘要翻译: 可用作式(I)的Rho激酶抑制剂的化合物:其中变量如本文所定义。 还提供了由Rho激酶介导的病症治疗方法和化合物的制备方法。
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公开(公告)号:US11484807B2
公开(公告)日:2022-11-01
申请号:US17026354
申请日:2020-09-21
申请人: Bo Wang
发明人: Bo Wang
IPC分类号: A63H27/10 , F21S9/02 , F21Y115/10
摘要: The present disclosure provides an apple-shaped light-emitting balloon. The apple-shaped light-emitting balloon includes a balloon body and a connecting rod. The connecting rod is positioned in the balloon body. The upper part and the lower part of the balloon body are fixed to the connecting rod respectively. An air inlet and an air outlet are formed in the connecting rod. A light-emitting part is further arranged in the balloon body. When the balloon is blown up, the connecting rod keeps a fixed distance between the upper part and the lower part of the balloon, so that the balloon is similarly apple-shaped, and the balloon is able to emit light.
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公开(公告)号:US10997170B2
公开(公告)日:2021-05-04
申请号:US15307935
申请日:2014-08-07
发明人: Jing-Hao Ju , Bo Wang , Bin Wu
IPC分类号: G06F16/00 , G06F16/2453 , G06F16/248 , G06F16/2455 , G06F12/0893
摘要: A stored procedure call may be transmitted to a database to execute a database query. As a result of the stored procedure call, results including a result record satisfying the database query and a set of records related to the result record may be received. The results may be stored in a local cache.
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公开(公告)号:US10385414B2
公开(公告)日:2019-08-20
申请号:US14371013
申请日:2012-03-29
申请人: Liang Zou , Bo Wang , Xiandong Liu , Aihua Ma , Shishu Xie , Hongxu Hei
发明人: Liang Zou , Bo Wang , Xiandong Liu , Aihua Ma , Shishu Xie , Hongxu Hei
IPC分类号: C21D8/12 , C22C38/04 , C22C38/06 , C22C38/00 , C22C38/02 , C21C7/00 , C21C7/064 , H01F1/16 , C22C38/12 , C22C38/14 , H01F1/147
摘要: An unoriented silicon steel having high magnetic conductivity and low iron loss at a working magnetic density of 1.0-1.5 T and method for manufacturing same. By proper deoxidation control in a RH refining and high-temperature treatment for a short time in a normalizing step, the method can reduce the amount of inclusions in the silicon steel and improve grain shape, so as to improve the magnetic conductivity and iron loss of the unoriented silicon steel at a magnetic density of 1.0-1.5 T.
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公开(公告)号:US09944955B1
公开(公告)日:2018-04-17
申请号:US14479893
申请日:2014-09-08
申请人: Bo Wang , Weiwen Zhang , Deirdre Meldrum , David Nielsen
发明人: Bo Wang , Weiwen Zhang , Deirdre Meldrum , David Nielsen
CPC分类号: C12P7/52 , C07C59/01 , C12N9/0006 , C12N9/1029 , C12N9/16 , C12Y101/01036 , C12Y101/01157 , C12Y203/01009 , C12Y301/0202
摘要: Construction and expression of synthetic pathways to produce (5) or (R)-3-hydroxybutyrate (3HB) as enantiomerically-pure products by genetically engineering cyanobacterium Synechocystis sp. PCC 6803. Under optimized growth conditions, the pathway employing phaA and phaB from R. eutropha was the most effective, producing up to 533.4±5.5 mg/l (R)-3HB after 21 days photosynthetic cultivation. For the first time, the feasibility and high efficiency of producing 3HB using solar energy and CO2 as sole energy and carbon sources by engineered cyanobacteria is demonstrated.
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9.
公开(公告)号:US09816152B2
公开(公告)日:2017-11-14
申请号:US13637611
申请日:2011-04-27
申请人: Aihua Ma , Bo Wang , Shishu Xie , Zhanyuan Hu , Liang Zou , Zitao Wang , Yuhua Zhu , Jie Huang , Bingzhong Jin , Xiandong Liu
发明人: Aihua Ma , Bo Wang , Shishu Xie , Zhanyuan Hu , Liang Zou , Zitao Wang , Yuhua Zhu , Jie Huang , Bingzhong Jin , Xiandong Liu
IPC分类号: C21D8/00 , C22C38/60 , C22C38/00 , C22C38/02 , C22C38/04 , C22C38/06 , C22C38/14 , C21D8/12 , H01F1/16
CPC分类号: C21D8/005 , C21D8/1261 , C21D8/1272 , C22C38/001 , C22C38/002 , C22C38/004 , C22C38/02 , C22C38/04 , C22C38/06 , C22C38/14 , C22C38/60 , H01F1/16
摘要: A manufacture method of high-efficiency non-oriented silicon steel with excellent magnetic property includes the steps of smelting a chemical composition of non-oriented silicon steel, by weight percent, is: C≦0.0040%, Si:0.1˜0.8%, Al:0.002˜1.0%, Mn:0.10˜1.50%, P:≦0.2%, Sb:0.04˜0.08%, S≦0.0030%, N≦0.0020%, Ti≦0.0020%, and the rest is Fe and unavoidable inclusions. The molten steel is then cast into billets which are hot-rolled into a hot-rolled product. The heating temperature for the billet is 1100°˜1150° and the finish-rolling temperature is 860°˜920°. The hot-rolled product is then air cooled for a period of time within a range determined by air cooling time t: (2+30xSb %)s≦t≦7 s. The hot-rolled product is reeled at a temperature ≧720° and cold-rolled to form cold-rolled plate with a target thickness at a reduction ratio of 70˜78% followed by heating up the cold-rolled plate to 800˜1000° at heating rate of ≧15°/s, and holding time of 10 s˜25 s.
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公开(公告)号:US20170068703A1
公开(公告)日:2017-03-09
申请号:US15307935
申请日:2014-08-07
发明人: Jing-Hao Ju , Bo Wang , Bin Wu
IPC分类号: G06F17/30 , G06F12/0893
CPC分类号: G06F16/24542 , G06F12/0893 , G06F16/24539 , G06F16/24552 , G06F16/248 , G06F2212/1021 , G06F2212/1024 , G06F2212/465
摘要: A stored procedure call may be transmitted to a database to execute a database query. As a result of the stored procedure call, results including a result record satisfying the database query and a set of records related to the result record may be received. The results may be stored in a local cache.
摘要翻译: 可以将存储过程调用发送到数据库以执行数据库查询。 作为存储过程调用的结果,可以接收包括满足数据库查询的结果记录和与结果记录相关的一组记录的结果。 结果可能存储在本地缓存中。
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