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公开(公告)号：US20130296796A1
公开(公告)日：2013-11-07
申请号：US13996145
申请日：2011-12-21
CPC分类号： A61M5/326 , A61M5/2033 , A61M5/24 , A61M5/46 , A61M2005/206 , A61M2005/208 , A61M2205/581 , A61M2205/582
摘要： The invention refers to an auto-injector for delivering a liquid medicament, comprising: an elongate housing arranged to contain a syringe with a hollow injection needle and a stopper, wherein the syringe is slidably arranged with respect to the housing, spring means capable of, upon activation: pushing the needle from a covered position inside the housing into an advanced position for insertion into the injection site, operating the syringe to inject the dose of medicament, and advancing a needle shroud over the needle for providing needle safety, activating means arranged to lock and release the spring means, wherein the spring means is a single drive spring in the shape of a compression spring grounded distally in the housing and proximally bearing against a thrust collar arranged to transmit load from the spring means via a plunger to the syringe and/or the stopper for needle insertion and injection, wherein the plunger is engageable to the thrust collar for joint axial translation, wherein the plunger is disengageable from the thrust collar on relative rotation so as to allow the thrust collar to be advanced further by the drive spring in order to engage the needle shroud for advancing it over the needle.
摘要翻译： 本发明涉及一种用于输送液体药物的自动注射器，包括：细长壳体，布置成容纳具有中空注射针头和塞子的注射器，其中所述注射器相对于所述壳体可滑动地布置， 激活时：将针从外壳内的覆盖位置推入到用于插入注射部位的前进位置，操作注射器以注射剂量的药物，并将针罩延伸到针上以提供针安全性，激活装置布置 以锁定和释放弹簧装置，其中弹簧装置是在壳体中向远侧接地的压缩弹簧的形状的单个驱动弹簧，并且向近侧支承着布置成将负载从弹簧装置经由柱塞传递到注射器的止推环 和/或用于针插入和注射的止动器，其中柱塞可接合到止推环用于关节轴向平移 其中所述柱塞在相对旋转时可与所述止推环脱开，从而允许所述推力环通过所述驱动弹簧进一步前进，以便与所述针罩接合以将其推进到所述针上。
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公开(公告)号：US09474866B2
公开(公告)日：2016-10-25
申请号：US13996145
申请日：2011-12-21
CPC分类号： A61M5/326 , A61M5/2033 , A61M5/24 , A61M5/46 , A61M2005/206 , A61M2005/208 , A61M2205/581 , A61M2205/582
摘要： The invention refers to an auto-injector for delivering a liquid medicament, comprising: an elongate housing arranged to contain a syringe with a hollow injection needle and a stopper, wherein the syringe is slidably arranged with respect to the housing, spring means capable of, upon activation: pushing the needle from a covered position inside the housing into an advanced position for insertion into the injection site, operating the syringe to inject the dose of medicament, and advancing a needle shroud over the needle for providing needle safety, activating means arranged to lock and release the spring means, wherein the spring means is a single drive spring in the shape of a compression spring grounded distally in the housing and proximally bearing against a thrust collar arranged to transmit load from the spring means via a plunger to the syringe and/or the stopper for needle insertion and injection, wherein the plunger is engageable to the thrust collar for joint axial translation, wherein the plunger is disengageable from the thrust collar on relative rotation so as to allow the thrust collar to be advanced further by the drive spring in order to engage the needle shroud for advancing it over the needle.
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公开(公告)号：US09474859B2
公开(公告)日：2016-10-25
申请号：US13807445
申请日：2011-06-22
CPC分类号： A61M5/2033 , A61M5/326 , A61M2005/2013 , A61M2005/206 , A61M2005/2086 , A61M2005/3247 , A61M2205/581 , A61M2205/582 , Y10T74/18984
摘要： The invention refers to a shuttering mechanism for controlling translation of a longitudinally moveable component within an elongate housing, the shuttering mechanism comprising at least one set of castellations on the housing and at least one resilient arm associated with the longitudinally moveable component, the resilient arm having a dog resiliently biased towards the castellations so as to engage between or behind the castellations and block the translation, wherein a respective shutter arm is arranged alongside the set of castellations, the shutter arm having a number of consecutive ramped protrusions spaced from each other, wherein the castellations and the ramped protrusions have the same pitch, wherein a profiled surface is formed by the castellations and the ramped protrusions, wherein the shutter arm is moveable in longitudinal direction with respect to the set of castellations, wherein the shutter arm has at least one locking position with its ramped protrusions essentially in phase with the castellations thus allowing the dog of the resilient arm to catch between or behind the castellations and wherein the shutter arm has at least one unlocking position with its ramped protrusions out of phase with the castellations in such a manner that the ramped protrusions prevent the dog from engaging with the castellations or disengage them thus allowing translation of the longitudinally moveable component.
摘要翻译： 本发明涉及一种用于控制细长壳体内的纵向移动部件的平移的快门机构，所述遮蔽机构包括在所述壳体上的至少一组雉and和与所述纵向可移动部件相关联的至少一个弹性臂，所述弹性臂具有 一个朝向雉dog弹性地偏置的狗，以便在雉between之间或之后接合并阻挡平移，其中相应的襟翼臂被布置在cast the组旁边，快门臂具有彼此间隔开的多个连续的倾斜突起，其中 城堡和斜坡突起具有相同的间距，其中通过雉ations和倾斜的突起形成异形表面，其中，快门臂可相对于该组蓖体在纵向方向上移动，其中，快门臂具有至少一个 基本上具有斜坡突起的锁定位置 与雉房同相，从而允许弹性臂的狗抓住在蓖体之间或之后，并且其中快门臂具有至少一个解锁位置，其斜坡突起与雉房异相，使得倾斜的突起防止 狗与雉鸡接合或脱开，从而允许纵向可移动部件的平移。
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公开(公告)号：US20130296795A1
公开(公告)日：2013-11-07
申请号：US13807445
申请日：2011-06-22
CPC分类号： A61M5/2033 , A61M5/326 , A61M2005/2013 , A61M2005/206 , A61M2005/2086 , A61M2005/3247 , A61M2205/581 , A61M2205/582 , Y10T74/18984
摘要： The invention refers to a shuttering mechanism for controlling translation of a longitudinally moveable component within an elongate housing, the shuttering mechanism comprising at least one set of castellations on the housing and at least one resilient arm associated with the longitudinally moveable component, the resilient arm having a dog resiliently biased towards the castellations so as to engage between or behind the castellations and block the translation, wherein a respective shutter arm is arranged alongside the set of castellations, the shutter arm having a number of consecutive ramped protrusions spaced from each other, wherein the castellations and the ramped protrusions have the same pitch, wherein a profiled surface is formed by the castellations and the ramped protrusions, wherein the shutter arm is moveable in longitudinal direction with respect to the set of castellations, wherein the shutter arm has at least one locking position with its ramped protrusions essentially in phase with the castellations thus allowing the dog of the resilient arm to catch between or behind the castellations and wherein the shutter arm has at least one unlocking position with its ramped protrusions out of phase with the castellations in such a manner that the ramped protrusions prevent the dog from engaging with the castellations or disengage them thus allowing translation of the longitudinally moveable component.
摘要翻译： 本发明涉及一种用于控制细长壳体内的纵向移动部件的平移的快门机构，所述遮蔽机构包括在所述壳体上的至少一组雉and和与所述纵向可移动部件相关联的至少一个弹性臂，所述弹性臂具有 一个朝向雉dog弹性地偏置的狗，以便在雉between之间或之后接合并阻挡平移，其中相应的襟翼臂被布置在cast the组旁边，快门臂具有彼此间隔开的多个连续的倾斜突起，其中 城堡和斜坡突起具有相同的间距，其中通过雉ations和倾斜的突起形成异形表面，其中，快门臂可相对于该组蓖体在纵向方向上移动，其中，快门臂具有至少一个 基本上具有斜坡突起的锁定位置 与雉房同相，从而允许弹性臂的狗抓住在蓖体之间或之后，并且其中快门臂具有至少一个解锁位置，其斜坡突起与雉房异相，使得倾斜的突起防止 狗与雉鸡接合或脱开，从而允许纵向可移动部件的平移。
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公开(公告)号：US20120296261A1
公开(公告)日：2012-11-22
申请号：US13510117
申请日：2010-11-17
申请人： David Jonathan Townley Whitaker , Craig Harvey Nelson , David Morrison Russell , Thomas Mark Kemp , Simon Francis Brereton , Philip Andrew Dent , Paul Farenden
发明人： David Jonathan Townley Whitaker , Craig Harvey Nelson , David Morrison Russell , Thomas Mark Kemp , Simon Francis Brereton , Philip Andrew Dent , Paul Farenden
CPC分类号： A61F9/0008
摘要： Various delivery devices and methods are disclosed, including a delivery device (200) for delivering a dose substance (110) in powdered form to an eye. The device can include a pocket (100A, 100B, 100C) for holding dose substance and a propulsion system (202, 204, 908, 1004, 1006) for propelling a dose consisting of a predetermined volume of said dose substance from said pocket towards said eye, wherein one or both of said pocket and said propulsion system are configured to inhibit propulsion of particles having a size greater than a predetermined threshold to said eye.
摘要翻译： 公开了各种输送装置和方法，包括用于将粉末形式的剂量物质（110）输送到眼睛的输送装置（200）。 该装置可以包括用于保持剂量物质的口袋（100A，100B，100C）和推进系统（202,204,908,1004,1006），用于将由预定体积的所述剂量物质组成的剂量从所述口袋推向所述 眼睛，其中所述口袋和所述推进系统中的一个或两个被配置为禁止具有大于预定阈值的尺寸的颗粒对所述眼睛的推进。
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公开(公告)号：US09789261B2
公开(公告)日：2017-10-17
申请号：US13996321
申请日：2011-12-21
CPC分类号： A61M5/3204 , A61M5/2033 , A61M5/31583 , A61M5/326 , A61M2005/206 , A61M2005/208
摘要： An auto-injector comprising an elongate housing containing a syringe. The housing having a an orifice intended to be applied against an injection site. The syringe is slidably arranged with respect to the housing. A spring pushing the needle from a covered position into an advanced position, operating the syringe and covering the needle. An activator arranged to lock the spring prior to manual operation and capable of, upon manual operation, releasing the spring means for injection. A first gear arrangement and a second gear arrangement arranged for converting torque from a first end and a second end of the torsion spring into a translative force. The first end groundable in the housing while the second end acts on a plunger through the second gear arrangement for advancing the needle and supplying the dose.
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公开(公告)号：US09457149B2
公开(公告)日：2016-10-04
申请号：US13996420
申请日：2011-12-21
CPC分类号： A61M5/2033 , A61M5/20 , A61M5/24 , A61M5/326 , A61M5/46 , A61M2005/206 , A61M2005/208 , A61M2005/2086
摘要： According to the invention, a back-end device of an auto-injector adapted to be attached to a packaged syringe comprises a plunger arranged to abut against a stopper of the packaged syringe to translate an injection needle of the packaged syringe in a proximal direction and to expel a dose of a medicament contained in the packaged syringe through the injection needle, a drive means capable of, upon release, driving the plunger in the proximal direction towards a proximal position, a rotary sleeve with a cam surface adapted to be engaged by a plunger follower formed to the plunger, a torsion spring arranged to exert a torque upon the rotary sleeve and a release element capable of, upon manual actuation, releasing the engagement of the plunger follower with the cam surface. The plunger follower is arranged to engage the cam surface to prevent the rotary sleeve from rotating with respect to the chassis in an initial state. Furthermore, in the initial state the plunger follower is arranged to engage the cam surface to prevent an axial translation of the plunger in the proximal direction. Upon release of the engagement of the plunger follower with the cam surface, the rotary sleeve is arranged to rotate within the chassis. The cam surface re-engages the plunger follower after a time delay determined by a rotation speed of the rotary sleeve. The time delay is set so as to allow the cam surface to re-engage the plunger follower after the plunger reaches the proximal position. The cam surface is arranged to withdraw the plunger from the proximal position in a distal direction by continued rotation of the rotary sleeve.
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公开(公告)号：US09233214B2
公开(公告)日：2016-01-12
申请号：US13581566
申请日：2011-03-03
CPC分类号： A61M5/322 , A61M5/2033 , A61M5/24 , A61M5/3202 , A61M5/3204 , A61M5/3234 , A61M5/326 , A61M2005/202 , A61M2005/206 , A61M2005/208 , A61M2005/2086 , A61M2005/2407 , A61M2005/2496 , A61M2005/3267
摘要： An injection device includes a syringe with a hollow needle and a stopper for sealing the syringe and displacing a medicament stored in the syringe. An arrangement for transferring a translation of a drive means to a plunger for pushing against the stopper includes a release latch pivoted at one end and connected to either the drive means or the plunger. The other end of the release latch engages the other one of the drive means or the plunger. The non-pivoted end of the release latch disengages by rotation upon contact between a ramp and another component when the stopper has displaced most of a predefined medicament dose. The release latch is long enough to provide a clearance between the plunger and the drive means when engaged to allow the plunger, stopper and needle to be retracted inside the syringe or a housing after disengaging the release latch.
摘要翻译： 注射装置包括具有中空针的注射器和用于密封注射器并使存储在注射器中的药物移位的止动件。 用于将驱动装置的平移传递到用于推动止动件的柱塞的装置包括在一端枢转并连接到驱动装置或柱塞的释放闩锁。 释放闩锁的另一端接合驱动装置或柱塞中的另一端。 当止动器已经取代大部分预定的药物剂量时，释放闩锁的非转动端部通过斜面和另一部件之间的接触时的旋转而脱离。 释放闩锁足够长以在接合时提供柱塞和驱动装置之间的间隙，以允许柱塞，止动器和针在分离释放闩锁之后在注射器或壳体内缩回。
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公开(公告)号：US09205199B2
公开(公告)日：2015-12-08
申请号：US13580271
申请日：2011-02-16
CPC分类号： A61M5/3202 , A61M5/2033 , A61M5/315 , A61M5/326 , A61M5/46 , A61M5/482 , A61M5/484 , A61M2005/206 , A61M2005/208 , A61M2005/2086 , A61M2005/2418 , A61M2005/3103 , A61M2005/3152 , A61M2005/3247 , A61M2205/581 , A61M2205/583 , F16H25/20 , F16H25/2056
摘要： An auto-injector may be used to administer a dose of a liquid medicament (M). In some embodiments, a shroud is arranged inside a housing, the shroud slidable in longitudinal direction between at least a retracted position, in which a hollow injection needle is exposable and an advanced position, in which the needle is covered by the shroud. A protective needle shield is attachable to the needle in a manner to partially protrude beyond the proximal end of the shroud through the orifice with the needle in its advanced position. A syringe carrier is arranged inside the shroud and comprises at least one snap for locking it to the shroud in order to prevent relative axial motion. The snap is configured to automatically disengage upon removal of the protective needle shield to allow the syringe and needle to be retracted into the covered position under load of the syringe spring.
摘要翻译： 可以使用自动注射器来施用剂量的液体药物（M）。 在一些实施例中，护罩布置在壳体内部，护罩可以在至少缩回位置（其中空心注射针可暴露于其中）和前进位置之间在纵向方向上滑动，在该位置中针被护罩覆盖。 保护针护罩可以以针部分地突出超过护罩的近端通过孔口的方式附接到针上，其中针处于其前进位置。 注射器托架布置在护罩内部并且包括至少一个卡扣以将其锁定到护罩上，以防止相对的轴向运动。 卡扣被配置为在移除保护针护罩时自动脱离，以允许注射器和针在注射器弹簧的负载下缩回到覆盖位置。
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公开(公告)号：US09180258B2
公开(公告)日：2015-11-10
申请号：US13581564
申请日：2011-03-03
CPC分类号： A61M5/3287 , A61M5/2033 , A61M5/24 , A61M5/3202 , A61M5/3204 , A61M5/3234 , A61M5/326 , A61M2005/202 , A61M2005/206 , A61M2005/208 , A61M2005/2086 , A61M2005/2407 , A61M2005/2496 , A61M2005/3267
摘要： An auto-injector for administering a dose of a liquid medicament (M) is presented having an elongate housing arranged to contain a syringe, a proximal end (P) with an orifice, wherein the syringe is slidably arranged with respect to the housing. A drive spring upon activation pushes the needle from a covered position inside the housing into an advanced position through the orifice and past the proximal end (P), and operates the syringe to supply the dose of medicament (M). An activating means locks the drive spring in a compressed state. The housing distal and a proximal portions are connected by a hinge, and are rotatable about the hinge between an aligned position and a maximum opening angle. A loading bay for holding the syringe is arranged in the proximal portion.
摘要翻译： 提供了一种用于施用剂量的液体药物（M）的自动注射器，其具有布置成容纳注射器的细长壳体，具有孔口的近端（P），其中所述注射器相对于所述壳体可滑动地布置。 激活时的驱动弹簧将针从壳体内的覆盖位置推入通过孔口并通过近端（P）的前进位置，并操作注射器以供应剂量的药物（M）。 激活装置将驱动弹簧锁定在压缩状态。 壳体远端和近端部分通过铰链连接，并且可以在对准位置和最大开启角度之间围绕铰链旋转。 用于保持注射器的装载隔间布置在近端部分中。
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