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1.发明授权Isolated peptides consisting of amino acid sequences found in SSX or NY-ESO-1 molecules, which bind to HLA molecules 有权由SSX或NY-ESO-1分子中发现的与HLA分子结合的氨基酸序列组成的分离的肽公开(公告)号：US06548064B1
公开(公告)日：2003-04-15
申请号：US09344040
申请日：1999-06-25
IPC分类号： A61K3900
摘要： The invention relates to members of the SSX family of genes, as well as their uses. Also a part of the invention are peptides derived from SSX molecules and the NY-ESO-1 molecule, which form complexes with HLA molecules, leading to lysis of cells presenting these complexes, by cytolytic T cells.
摘要翻译： 本发明涉及SSX家族基因的成员及其用途。 本发明的一部分也是衍生自SSX分子和NY-ESO-1分子的肽，其与HLA分子形成复合物，导致细胞溶解性T细胞裂解呈现这些复合物的细胞。
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2.发明授权Isolated nucleic acid molecules encoding isolated peptides which correspond to contiguous amino acids of an SSX molecule or NY-ESO-1 and uses thereof 有权编码分离的肽的分离的核酸分子，其对应于SSX分子或NY-ESO-1的连续氨基酸并且其用途公开(公告)号：US07270819B2
公开(公告)日：2007-09-18
申请号：US10177277
申请日：2002-06-21
摘要： The invention relates to members of the SSX family of genes, as well as their uses. Also a part of the invention are peptides derived from SSX molecules and the NY-ESO-1 molecule, which form complexes with HLA molecules, leading to lysis of cells presenting these complexes, by cytolytic T cells.
摘要翻译： 本发明涉及SSX家族基因的成员及其用途。 本发明的一部分也是衍生自SSX分子和NY-ESO-1分子的肽，其与HLA分子形成复合物，导致细胞溶解性T细胞裂解呈现这些复合物的细胞。
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3.发明授权公开(公告)号：US06291658B1
公开(公告)日：2001-09-18
申请号：US08851138
申请日：1997-05-05
申请人： Ali O. Gure , Ozlem Tureci , Ugur Sahin , Solam Tsang , Matthew J. Scanlan , Alexander Knuth , Michael Pfreundschuh , Lloyd J. Old , Yao-Tseng Chen
发明人： Ali O. Gure , Ozlem Tureci , Ugur Sahin , Solam Tsang , Matthew J. Scanlan , Alexander Knuth , Michael Pfreundschuh , Lloyd J. Old , Yao-Tseng Chen
IPC分类号： C07H2102
CPC分类号： C07K14/47
摘要： The invention relates to members of the SSX family of genes, as well as their uses.
摘要翻译： 本发明涉及SSX家族基因的成员及其用途
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公开(公告)号：US6140050A
公开(公告)日：2000-10-31
申请号：US105907
申请日：1998-06-26
申请人： Ugur Sahin , Ozlem Tureci , Yao-Tseng Chen , Lloyd J. Old , Michael Pfreundschuh
发明人： Ugur Sahin , Ozlem Tureci , Yao-Tseng Chen , Lloyd J. Old , Michael Pfreundschuh
IPC分类号： C07K14/47 , C12Q1/68 , G01N33/574 , C07H21/04 , C12P19/34
CPC分类号： G01N33/57415 , C07K14/4748 , C12Q1/6886 , C12Q2600/106
摘要： The invention relates to assays for determining breast cancer or melanoma. It has been found that the accuracy of such assays can be improved by assaying samples for three or more known tumor rejection antigen precursors. For breast cancer, the tumor rejection antigen precursors known as SCP-1, NY-ESO-1, and SSX-2 are assayed. For melanoma, SSX-2, NY-ESO-1, and MAGE-3 are assayed. Additional known tumor rejection antigen precursors can also be determined to confirm the assays. It is preferred to carry these out via polymerase chain reactions.
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5.发明授权公开(公告)号：US07385044B2
公开(公告)日：2008-06-10
申请号：US10851884
申请日：2004-05-21
申请人： Ozlem Tureci , Ugur Sahin , Michael Pfreundschuh
发明人： Ozlem Tureci , Ugur Sahin , Michael Pfreundschuh
CPC分类号： C07K14/4748 , A61K38/00 , A61K39/00
摘要： Peptides which have an amino acid sequence identical to sequences found in tumor rejection antigen precursors, such as NY-ESO-1, and SSX-2, are disclosed. These peptides bind to MHC-Class II molecules, such as HLA-DR molecules, and provoke proliferation of CD4+ cells.
摘要翻译： 公开了具有与在肿瘤排斥抗原前体中发现的序列相同的氨基酸序列的肽，例如NY-ESO-1和SSX-2。 这些肽结合MHC-II类分子，如HLA-DR分子，并引发CD4 +细胞的增殖。
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6.发明授权公开(公告)号：US06800730B1
公开(公告)日：2004-10-05
申请号：US09408036
申请日：1999-09-29
申请人： Ozlem Tureci , Ugur Sahin , Michael Pfreundschuh
发明人： Ozlem Tureci , Ugur Sahin , Michael Pfreundschuh
IPC分类号： C07K100
CPC分类号： C07K14/4748 , A61K38/00 , A61K39/00
摘要： Peptides which have an amino acid sequence identical to sequences found in tumor rejection antigen precursors, such as NY-ESO-1, and SSX-2, are disclosed. These peptides bind to MHC-Class II molecules, such as HLA-DR molecules, and provoke proliferation of CD4+ cells.
摘要翻译： 公开了具有与在肿瘤排斥抗原前体中发现的序列相同的氨基酸序列的肽，例如NY-ESO-1和SSX-2。 这些肽结合MHC-II类分子，如HLA-DR分子，并引发CD4 +细胞的增殖。
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公开(公告)号：US06339140B1
公开(公告)日：2002-01-15
申请号：US09796780
申请日：2001-03-01
申请人： Ali O. Gure , Ozlem Tureci , Ugur Sahin , Solam Tsang , Matthew J. Scanlan , Alexander Knuth , Michael Pfreundschuh , Lloyd J. Old , Yao-Tseng Chen
发明人： Ali O. Gure , Ozlem Tureci , Ugur Sahin , Solam Tsang , Matthew J. Scanlan , Alexander Knuth , Michael Pfreundschuh , Lloyd J. Old , Yao-Tseng Chen
IPC分类号： C07K100
CPC分类号： C07K14/47
摘要： The invention relates to members of the SSX family of genes, as well as their uses.
摘要翻译： 本发明涉及SSX家族基因的成员及其用途
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公开(公告)号：US06274145B1
公开(公告)日：2001-08-14
申请号：US08937263
申请日：1997-09-15
申请人： Yao-tseng Chen , Matthew Scanlan , Ali Guré , Lloyd J. Old , Elke Jäger , Knuth Alexander , Jan W. Drijfhout , Ozlem Tureci , Ugur Sahin , Michael Pfreundschuh
发明人： Yao-tseng Chen , Matthew Scanlan , Ali Guré , Lloyd J. Old , Elke Jäger , Knuth Alexander , Jan W. Drijfhout , Ozlem Tureci , Ugur Sahin , Michael Pfreundschuh
IPC分类号： A61K3900
摘要： The invention relates to the isolation of a nucleic acid molecule which encodes a cancer associated antigen. Also a part of the invention is the antigen itself, and the uses of the nucleic acid molecule and the antigen, and peptides derived from it.
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公开(公告)号：US06214983B1
公开(公告)日：2001-04-10
申请号：US09177325
申请日：1998-10-22
申请人： Ozlem Tureci , Ugur Sahin , Michael Pfreundschuh
发明人： Ozlem Tureci , Ugur Sahin , Michael Pfreundschuh
IPC分类号： C07H2102
CPC分类号： G01N33/6872 , A61K38/00 , C07K14/4748 , C07K16/18 , C12Q1/6886 , C12Q2600/158
摘要： The invention involves the recognition of a previously unidentified protein family which belongs to, the human SCP family. The members of the family, such as SCP-2 and rat SCP-3 homolog are markers for cell transformation. Diagnostic and therapeutic uses of these protein and related molecules are taught.
摘要翻译： 本发明涉及一种属于人类SCP家族的以前未知的蛋白质家族的识别。 家族成员，如SCP-2和大鼠SCP-3同系物是细胞转化的标志物。 教导了这些蛋白质和相关分子的诊断和治疗用途。
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公开(公告)号：US06306389B1
公开(公告)日：2001-10-23
申请号：US09590113
申请日：2000-06-08
申请人： Ozlem Tureci , Ugur Sahin , Michael Pfreundschuh
发明人： Ozlem Tureci , Ugur Sahin , Michael Pfreundschuh
IPC分类号： C12Q168
CPC分类号： G01N33/6872 , A61K38/00 , C07K14/4748 , C07K16/18 , C12Q1/6886 , C12Q2600/158
摘要： The invention involves the recognition of a previously unidentified protein family which belongs to, the human SCP family. The members of the family, such as SCP-2 and rat SCP-3 homolog are markers for cell transformation. Diagnostic and therapeutic uses of these protein and related molecules are taught.
摘要翻译： 本发明涉及一种属于人类SCP家族的以前未知的蛋白质家族的识别。 家庭成员，如SCP-2和大鼠SCP-3同源物是细胞转化的标志物。 教导了这些蛋白质和相关分子的诊断和治疗用途。
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