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82 条记录 (耗时 0.028 秒)

    2,3,4-Substituted cyclopentanones as therapeutic agents
    7.
    发明申请
    2,3,4-Substituted cyclopentanones as therapeutic agents 有权
    2,3,4-取代的环戊酮作为治疗剂

    公开(公告)号：US20060106088A1

    公开(公告)日：2006-05-18

    申请号：US10991284

    申请日：2004-11-16

    申请人： Yariv Donde ,  Robert Burk ,  Michael Garst ,  Jeremiah Nguyen

    发明人： Yariv Donde ,  Robert Burk ,  Michael Garst ,  Jeremiah Nguyen

    IPC分类号： A61K31/381 ,  C07D333/52

    CPC分类号： C07D333/62 ,  C07C405/0025 ,  C07D333/56

    摘要： Disclosed herein are compounds comprising or a pharmaceutically acceptable salt or a prodrug thereof, wherein a dashed line represents the presence or absence of a bond; Y is a carboxylic acid, sulfonic acid, or phosphonic acid functional group; or an amide or ester thereof comprising from 0 to 12 carbon atoms; or Y is hydroxymethyl or an ether thereof comprising from 0 to 12 carbon atoms; or Y is a tetrazolyl functional group; A is —(CH2)6—, cis —CH2—CH═CH—(CH2)3—, or —CH2—C≡C—(CH2)3— wherein 1 or 2 carbons may be substituted with S or O; B is hydrogen, C1-6 hydrocarbyl, CN, CO2H, or —(CH2)mX(CH2)pH, wherein m is at least 1 and the sum of m and p is from 1 to 5; X is S or O; J is H, CH3, or CF3; D is a covalent bond, CH2, O, or S; and E is an aromatic heterobicyclic ring system which may have substituents comprising up to 6 non-hydrogen atoms each. Methods, compositions, and medicaments related thereto are also disclosed.

    摘要翻译： 本文公开了包含其药学上可接受的盐或其前药的化合物，其中虚线表示存在或不存在键; Y是羧酸，磺酸或膦酸官能团; 或其包含0至12个碳原子的酰胺或酯; 或Y是含有0至12个碳原子的羟甲基或其醚; 或Y为四唑基官能团; A是 - （CH 2 CH 2）6 - ，顺式-CH 2 -CH-CH-（CH 2 CH 2） ）3 - 或 - CH 2-C≡C-（CH 2）3 - 其中1或 2个碳可以被S或O取代; B是氢，C 1-6烃基，CN，CO 2 H或 - （CH 2 CH 2）m H 其中m至少为1，m和p之和为1至5; X是S或O; J是H，CH 3或CF 3; D是共价键，CH 2，O或S; 并且E是芳族杂双环系统，其可以具有各自包含多达6个非氢原子的取代基。 还公开了与之相关的方法，组合物和药物。

    Cyclopentane heptan(ene)oic acid, 2-heteroarylalkenyl derivatives as therapeutic agents
    8.
    发明申请
    Cyclopentane heptan(ene)oic acid, 2-heteroarylalkenyl derivatives as therapeutic agents 有权
    环戊烷庚（烯）酸，2-杂芳基烯基衍生物作为治疗剂

    公开(公告)号：US20060035960A1

    公开(公告)日：2006-02-16

    申请号：US10915933

    申请日：2004-08-10

    申请人： Yariv Donde ,  Robert Burk ,  Michael Garst

    发明人： Yariv Donde ,  Robert Burk ,  Michael Garst

    IPC分类号： A61K31/558 ,  C07D333/24

    CPC分类号： C07D333/28

    摘要： A compound comprising or a pharmaceutically acceptable salt or a prodrug thereof, having the groups described in detail herein is disclosed. Also disclosed herein are compounds comprising or derivatives thereof, or pharmaceutically acceptable salts, tetrazoles, or prodrugs of compounds of the structure or derivatives thereof, said derivatives being described in detail herein. Also disclosed herein are methods of treating diseases or conditions, including glaucoma and elevated intraocular pressure. Compositions and methods of manufacturing medicaments related thereto are also disclosed.

    摘要翻译： 公开了具有本文详细描述的基团的化合物或其药学上可接受的盐或其前药。 本文还公开了包含其衍生物或其衍生物的化合物或其结构或衍生物的化合物的药学上可接受的盐，四唑或前药，所述衍生物在此详细描述。 本文还公开了治疗疾病或病症的方法，包括青光眼和眼内压升高。 还公开了与其相关的药物制备的组合物和方法。

    CYCLOPENTANE HEPTAN(ENE)OIC ACID, 2-HETEROARYLALKENYL DERIVATIVES AS THERAPEUTIC AGENTS
    9.
    发明申请
    CYCLOPENTANE HEPTAN(ENE)OIC ACID, 2-HETEROARYLALKENYL DERIVATIVES AS THERAPEUTIC AGENTS 有权
    环丙沙星（ENE）OIC酸，作为治疗剂的2-异亮氨酸衍生物

    公开(公告)号：US20070112051A1

    公开(公告)日：2007-05-17

    申请号：US11623417

    申请日：2007-01-16

    申请人： Yariv Donde ,  Robert Burk ,  Michael Garst

    发明人： Yariv Donde ,  Robert Burk ,  Michael Garst

    IPC分类号： A61K31/558

    CPC分类号： C07D333/28

    摘要： A compound comprising or a pharmaceutically acceptable salt or a prodrug thereof, having the groups described in detail herein is disclosed. Also disclosed herein are compounds comprising or derivatives thereof, or pharmaceutically acceptable salts, tetrazoles, or prodrugs of compounds of the structure or derivatives thereof, said derivatives being described in detail herein. Also disclosed herein are methods of treating diseases or conditions, including glaucoma and elevated intraocular pressure. Compositions and methods of manufacturing medicaments related thereto are also disclosed.

    摘要翻译： 公开了具有本文详细描述的基团的化合物或其药学上可接受的盐或其前药。 本文还公开了包含其衍生物或其衍生物的化合物或其结构或衍生物的化合物的药学上可接受的盐，四唑或前药，所述衍生物在此详细描述。 本文还公开了治疗疾病或病症的方法，包括青光眼和眼内压升高。 还公开了与其相关的药物制备的组合物和方法。