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7 条记录 (耗时 0.022 秒)

    Inhibition of Ornithine Aminotransferase for the Treatment of Proliferative Disorders
    1.
    发明申请
    Inhibition of Ornithine Aminotransferase for the Treatment of Proliferative Disorders 有权
    抑制鸟氨酸氨基转移酶治疗增殖性疾病

    公开(公告)号：US20120245380A1

    公开(公告)日：2012-09-27

    申请号：US13484392

    申请日：2012-05-31

    申请人： Yaron ILAN ,  Ehud ZIGMOND ,  Richard B. SILVERMAN ,  Hejun LU

    发明人： Yaron ILAN ,  Ehud ZIGMOND ,  Richard B. SILVERMAN ,  Hejun LU

    IPC分类号： C07C229/48

    CPC分类号： A61K31/196 ,  A61K31/198

    摘要： The invention relates to inhibition of ornithine aminotransferase (OAT) for suppression of tumor cells proliferation. More particularly, the invention relates to methods of treatment of proliferative disorders by the selective inhibition of OAT, and further provides the use of OAT inhibitors, specifically, 5-amino-1,3-hexadienyl-carboxylic acid (Gabaculine), and Gabaculine analogue 8, for compositions and methods for the treatment of proliferative disorders such as hepatocellular carcinoma. The invention further provides methods and kits for the diagnosis of a pathologic proliferative disorder in a mammalian subject, based on determining the level of OAT expressed in a biological sample obtained from a subject.

    摘要翻译： 本发明涉及抑制鸟氨酸氨基转移酶（OAT）抑制肿瘤细胞增殖。 更具体地说，本发明涉及通过选择性抑制OAT来治疗增殖性疾病的方法，并进一步提供使用OAT抑制剂，特别是5-氨基-1,3-己二烯基羧酸（Gabaculine）和加珠菌素类似物 8，用于治疗增殖性疾病如肝细胞癌的组合物和方法。 本发明还基于确定从受试者获得的生物样品中表达的OAT水平，提供用于诊断哺乳动物受试者中病理性增殖性病症的方法和试剂盒。

    Immuno-Modulating Compositions for the Treatment of Immune-Mediated Disorders
    3.
    发明申请
    Immuno-Modulating Compositions for the Treatment of Immune-Mediated Disorders 审中-公开
    用于治疗免疫介导性疾病的免疫调节组合物

    公开(公告)号：US20110200610A1

    公开(公告)日：2011-08-18

    申请号：US12879129

    申请日：2010-09-10

    申请人： Yaron ILAN ,  Gadi LALAZAR ,  Ami Ben YA'ACOV ,  Tomer ADAR

    发明人： Yaron ILAN ,  Gadi LALAZAR ,  Ami Ben YA'ACOV ,  Tomer ADAR

    IPC分类号： A61K39/395 ,  A61P3/10 ,  A61P1/16 ,  C07K16/26

    CPC分类号： C07K16/26 ,  A61K39/395 ,  A61K2039/55588 ,  A61K2039/57 ,  A61K2300/00

    摘要： The present invention relates to immunomodulatory compositions comprising mammalian colostrum-derived immunoglobulin preparation and optionally further colostrums, milk or milk product component/s and any adjuvants for treating immune-related disorders. More specifically, the invention provides compositions comprising colostrum-derived anti-insulin immunoglobulin preparations for the treatment of Metabolic Syndrome. The invention further provides methods and uses of the immunomodulatory compositions for an active or passive immunization in a disease-antigen specific or non specific manner.

    摘要翻译： 本发明涉及免疫调节组合物，其包含哺乳动物初乳衍生的免疫球蛋白制备物和任选的另外的初乳，乳或乳制品成分和用于治疗免疫相关病症的任何佐剂。 更具体地，本发明提供了包含用于治疗代谢综合征的初乳衍生的抗胰岛素免疫球蛋白制剂的组合物。 本发明还提供免疫调节组合物在疾病 - 抗原特异性或非特异性方式中的主动或被动免疫的方法和用途。

    CLOSED LOOP ORGAN STIMULATION
    4.
    发明申请
    CLOSED LOOP ORGAN STIMULATION 审中-公开

    公开(公告)号：US20180221678A1

    公开(公告)日：2018-08-09

    申请号：US15889463

    申请日：2018-02-06

    申请人： Yaron ILAN

    发明人： Yaron ILAN

    IPC分类号： A61N2/00 ,  A61N2/02 ,  A61F7/12

    摘要： The present disclosure provides systems, devices and methods for providing abdominal or any other organ stimulation for affecting a physiological change, wherein the stimulation parameters are continuously, semi continuously, or conditionally being updated based on measurements and inputs provided to a computer circuitry configured to facilitate machine learning capabilities.

    DEVICES AND METHODS FOR DETECTION OF INTERNAL BLEEDING AND HEMATOMA
    5.
    发明申请
    DEVICES AND METHODS FOR DETECTION OF INTERNAL BLEEDING AND HEMATOMA 审中-公开

    公开(公告)号：US20190254536A1

    公开(公告)日：2019-08-22

    申请号：US16400729

    申请日：2019-05-01

    申请人： Dean NAHMAN ,  Yaron ILAN ,  Ilan BEN OREN ,  Yaron BAR-ILAN ,  Shmuel CHEN

    发明人： Dean NAHMAN ,  Yaron ILAN ,  Ilan BEN OREN ,  Yaron BAR-ILAN ,  Shmuel CHEN

    IPC分类号： A61B5/02 ,  A61B5/00

    摘要： A device for detection of internal bleeding in a patient's body is provided. An optical interface for transmitting IR light through an area of a skin of a patient and to collect IR light from the area of the skin, is provided. In some embodiments the optical interface includes one or more delivery components and one or more collection components. The delivery component includes a plurality of first optical channels configured to transmit the IR light through a plurality of respective first sub-areas on the area of the skin, into an internal layer of the body. The collection component includes a plurality of second optical channels, configured to collect IR light from a plurality of respective second sub-areas on the area of the skin.

    DEVICES AND METHODS FOR DETECTION OF INTERNAL BLEEDING AND HEMATOMA
    6.
    发明申请
    DEVICES AND METHODS FOR DETECTION OF INTERNAL BLEEDING AND HEMATOMA 审中-公开

    公开(公告)号：US20200281483A9

    公开(公告)日：2020-09-10

    申请号：US16400729

    申请日：2019-05-01

    申请人： Dean NAHMAN ,  Yaron ILAN ,  Ilan BEN OREN ,  Yaron BAR-ILAN ,  Shmuel CHEN

    发明人： Dean NAHMAN ,  Yaron ILAN ,  Ilan BEN OREN ,  Yaron BAR-ILAN ,  Shmuel CHEN

    IPC分类号： A61B5/02 ,  A61B5/00

    摘要： A device for detection of internal bleeding in a patient's body is provided. An optical interface for transmitting IR light through an area of a skin of a patient and to collect IR light from the area of the skin, is provided. In some embodiments the optical interface includes one or more delivery components and one or more collection components. The delivery component includes a plurality of first optical channels configured to transmit the IR light through a plurality of respective first sub-areas on the area of the skin, into an internal layer of the body. The collection component includes a plurality of second optical channels, configured to collect IR light from a plurality of respective second sub-areas on the area of the skin.