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公开(公告)号：US20050202572A1
公开(公告)日：2005-09-15
申请号：US11006757
申请日：2004-12-08
申请人： Yasuke Seki , Akira Tsukamoto , Daisuke Suzuki , Masahiro Yamaoka , Nami Sugita , Akihiko Kandori , Kazuo Saitoh
发明人： Yasuke Seki , Akira Tsukamoto , Daisuke Suzuki , Masahiro Yamaoka , Nami Sugita , Akihiko Kandori , Kazuo Saitoh
IPC分类号： G01N33/53 , G01N27/72 , G01N33/542 , G01N33/553
CPC分类号： G01N33/54373 , G01N27/745
摘要： The present invention provides an immunoassay technique which enables efficient detection of antigen-antibody reaction with high sensitivity by a magnetic method using magnetic particles and a SQUID magnetic sensor or sensors. A system based on the technique includes a disk-shaped sample holder which holds on a circle a plurality of sample containers for accommodating marked samples, resulting from marking of samples with magnetic particles by antigen-antibody reaction; rotating means for rotating the holder around its central shaft; magnetizing means for magnetizing the marked samples outside a magnetic shield; and a magnetic sensor for detecting, within the magnetic shield, magnetic fields generated from the marked samples which have been magnetized. By rotation of the holder, areas fixing and holding different ones of the sample containers are successively inserted into the magnetic shield, and the magnetization of the marked samples accommodated in first ones of the sample containers and the detection of magnetic fields generated from the marked samples accommodated in second ones of the sample containers are executed in parallel.
摘要翻译： 本发明提供了一种免疫测定技术，其能够通过使用磁性颗粒和SQUID磁性传感器的磁性方法高灵敏度地高效检测抗原 - 抗体反应。 基于该技术的系统包括：盘形样品保持器，其保持圆圈上的多个样品容器，用于容纳标记的样品，通过抗原 - 抗体反应用磁性颗粒标记样品; 用于使支架围绕其中心轴旋转的旋转装置; 用于将标记样品磁化在磁屏蔽外的磁化装置; 以及磁传感器，用于在磁屏蔽内检测从已经被磁化的标记样品产生的磁场。 通过保持器的旋转，将固定和保持不同样本容器的区域依次插入到磁屏蔽中，并且标记的样品的磁化容纳在第一个样品容器中，并且检测从标记的样品产生的磁场 容纳在第二个样品容器中并行执行。
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公开(公告)号：US07993581B2
公开(公告)日：2011-08-09
申请号：US11006757
申请日：2004-12-08
申请人： Yusuke Seki , Akira Tsukamoto , Daisuke Suzuki , Masahiro Yamaoka , Nami Sugita , Akihiko Kandori , Kazuo Saitoh
发明人： Yusuke Seki , Akira Tsukamoto , Daisuke Suzuki , Masahiro Yamaoka , Nami Sugita , Akihiko Kandori , Kazuo Saitoh
IPC分类号： G01N1/36 , G01N33/553
CPC分类号： G01N33/54373 , G01N27/745
摘要： The present invention provides an immunoassay technique which enables efficient detection of antigen-antibody reaction with high sensitivity by a magnetic method using magnetic particles and a SQUID magnetic sensor or sensors. A system based on the technique includes a disk-shaped sample holder which holds on a circle a plurality of sample containers for accommodating marked samples, resulting from marking of samples with magnetic particles by antigen-antibody reaction; rotating means for rotating the holder around its central shaft; magnetizing means for magnetizing the marked samples outside a magnetic shield; and a magnetic sensor for detecting, within the magnetic shield, magnetic fields generated from the marked samples which have been magnetized. By rotation of the holder, areas fixing and holding different ones of the sample containers are successively inserted into the magnetic shield, and the magnetization of the marked samples accommodated in first ones of the sample containers and the detection of magnetic fields generated from the marked samples accommodated in second ones of the sample containers are executed in parallel.
摘要翻译： 本发明提供了一种免疫测定技术，其能够通过使用磁性颗粒和SQUID磁性传感器的磁性方法高灵敏度地高效检测抗原 - 抗体反应。 基于该技术的系统包括：盘形样品保持器，其保持圆圈上的多个样品容器，用于容纳标记的样品，通过抗原 - 抗体反应用磁性颗粒标记样品; 用于使支架围绕其中心轴旋转的旋转装置; 用于将标记样品磁化在磁屏蔽外的磁化装置; 以及磁传感器，用于在磁屏蔽内检测从已经被磁化的标记样品产生的磁场。 通过保持器的旋转，将固定和保持不同样本容器的区域依次插入到磁屏蔽中，并且标记的样品的磁化容纳在第一个样品容器中，并且检测从标记的样品产生的磁场 容纳在第二个样品容器中并行执行。
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公开(公告)号：US20080284413A1
公开(公告)日：2008-11-20
申请号：US12149990
申请日：2008-05-12
申请人： Akira Tsukamoto , Daisuke Suzuki , Akihiko Kandori
发明人： Akira Tsukamoto , Daisuke Suzuki , Akihiko Kandori
IPC分类号： G01N27/74
CPC分类号： G01N33/54333
摘要： Accurate measurement cannot be performed due to magnetic signals from magnetic impurities included in a specimen container. By finding a difference between two measurement signals obtained by applying an external magnetic field for orientation to respective normal and reverse directions, the magnetic signals from the magnetic impurities included in the specimen container which are not dependent on the external magnetic field for orientation can be cancelled. The influence of the magnetic impurities included in the specimen container is reduced, and the signal of the intended bound magnetic marker can be measured with high sensitivity.
摘要翻译： 由于样品容器中包含的磁性杂质的磁信号，无法进行准确的测量。 通过在相应的正反方向上施加用于取向的外部磁场获得的两个测量信号之间的差异，可以取消不依赖于用于取向的外部磁场的样本容器中包含的磁性杂质的磁信号 。 包含在标本容器中的磁性杂质的影响减小，可以高灵敏度地测量预期的结合磁性标记的信号。
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公开(公告)号：US08193003B2
公开(公告)日：2012-06-05
申请号：US12149990
申请日：2008-05-12
申请人： Akira Tsukamoto , Daisuke Suzuki , Akihiko Kandori
发明人： Akira Tsukamoto , Daisuke Suzuki , Akihiko Kandori
IPC分类号： G01N33/553 , G01N33/53
CPC分类号： G01N33/54333
摘要： Accurate measurement cannot be performed due to magnetic signals from magnetic impurities included in a specimen container. By finding a difference between two measurement signals obtained by applying an external magnetic field for orientation to respective normal and reverse directions, the magnetic signals from the magnetic impurities included in the specimen container which are not dependent on the external magnetic field for orientation can be cancelled. The influence of the magnetic impurities included in the specimen container is reduced, and the signal of the intended bound magnetic marker can be measured with high sensitivity.
摘要翻译： 由于样品容器中包含的磁性杂质的磁信号，无法进行准确的测量。 通过在相应的正反方向上施加用于取向的外部磁场获得的两个测量信号之间的差异，可以取消不依赖于用于取向的外部磁场的样本容器中包含的磁性杂质的磁信号 。 包含在标本容器中的磁性杂质的影响减小，可以高灵敏度地测量预期的结合磁性标记的信号。
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公开(公告)号：US06853185B2
公开(公告)日：2005-02-08
申请号：US10844480
申请日：2004-05-13
IPC分类号： A61B5/05 , G01R33/025 , G01R33/035 , G01R33/02
CPC分类号： G01R33/0358 , G01R33/025
摘要： A magnetic field measurement system for canceling an external field is provided, in which plurality of sensing magnetometers (3) for measuring a magnetic field signal in a direction perpendicular to the center axis of a cylindrical magnetic shield (1) are arranged in two dimensions on a plane parallel to the center axis and a reference magnetometer (4) for measuring the external field parallel to the center axis as a reference signal is disposed on a plane perpendicular to the plane parallel to the center axis. The reference signal multiplied by a specified factor is subtracted from a difference between signals from the adjacent sensing magnetometers (3). The magnetic field measurement system allows measurement of an extremely weak magnetic field by efficiently canceling the external field.
摘要翻译： 提供了用于消除外部场的磁场测量系统，其中用于在与圆柱形磁屏蔽（1）的中心轴垂直的方向上测量磁场信号的多个感测磁力计（3）被二维地布置在 平行于中心轴的平面和用于测量与中心轴平行的外场作为参考信号的参考磁力计（4）设置在垂直于平行于中心轴的平面的平面上。 从相邻感测磁力计（3）的信号之间的差中减去乘以指定因子的参考信号。 磁场测量系统允许通过有效地消除外部场来测量极弱的磁场。
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公开(公告)号：US06815949B2
公开(公告)日：2004-11-09
申请号：US10162748
申请日：2002-06-06
申请人： Akihiko Kandori , Tsuyoshi Miyashita , Keiji Tsukada , Koichi Yokosawa , Daisuke Suzuki , Akira Tsukamoto
发明人： Akihiko Kandori , Tsuyoshi Miyashita , Keiji Tsukada , Koichi Yokosawa , Daisuke Suzuki , Akira Tsukamoto
IPC分类号： G01R33035
CPC分类号： G01R33/0356 , A61B5/04005 , A61B5/04007 , A61B5/04008 , A61B5/0522
摘要： An apparatus can detect a magnetic field with a high sensitivity using an ordinary-temperature pickup coil even when the pickup coil is arranged outside a cryostat. Specifically, the apparatus for measuring a magnetic field includes a pickup coil for detecting an external magnetic field, a SQUID electrically or magnetically connected to the pickup coil, a cryostat for holding the SQUID at low temperatures, and a driving device for driving the SQUID. The pickup coil is made of a normal-conducting material and is placed at an ordinary temperature outside the cryostat. By arranging outside the cryostat, the pickup coil can be brought close to a subject and can thereby detect a weak magnetic field in the subject with a high sensitivity.
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公开(公告)号：US20130121879A1
公开(公告)日：2013-05-16
申请号：US13810832
申请日：2011-07-19
IPC分类号： G01N33/543
CPC分类号： G01N33/54333 , G01N27/745
摘要： The disclosed magnetic immunoassay device, which performs magnetic immunoassays using antigen-antibody reactions, can perform speedy immunoassays without bound/free separation in the test samples. The device is also practical, being capable of stable magnetism measurement without magnetic shielding. The disclosed magnetic immunoassay device is provided with: an excitation coil that uses an AC magnetic field to magnetize a test sample containing a magnetic marker; a magnetism sensor that measures magnetism in the test sample and outputs a magnetism signal; and a displacement sensor for detecting changes in the distance between the test sample and the magnetism sensor. By optimally setting the bandwidth of a lock-in amplifier, which detects changes in the phase of the magnetism signal outputted by the magnetism sensor, and the rotational speed produced by a drive system, which moves the test sample at low speeds, the impact of environment magnetic noise is reduced, and correcting the magnetism signal using distance information obtained from the displacement sensor allows stable magnetism measurement.
摘要翻译： 所公开的使用抗原 - 抗体反应进行磁性免疫测定的磁性免疫测定装置可以在测试样品中进行快速的免疫测定而无限制/自由分离。 该装置也是实用的，能够在没有磁屏蔽的情况下进行稳定的磁测量。 所公开的磁免疫测定装置具有：励磁线圈，其使用交流磁场来磁化含有磁性标记的测试样品; 磁传感器，其测量测试样品中的磁性并输出磁信号; 以及用于检测测试样本和磁传感器之间的距离变化的位移传感器。 通过最佳地设置检测由磁传感器输出的磁信号的相位变化的锁定放大器的带宽和由低速移动测试样本的驱动系统产生的转速， 环境磁噪声降低，并且使用从位移传感器获得的距离信息来校正磁信号，可以进行稳定的磁测量。
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公开(公告)号：US08945469B2
公开(公告)日：2015-02-03
申请号：US11715916
申请日：2007-03-09
申请人： Akira Tsukamoto , Kazuo Saitoh
发明人： Akira Tsukamoto , Kazuo Saitoh
IPC分类号： G01N33/543
CPC分类号： G01N33/54326
摘要： A magnetic immunoassay system with a mechanism for compensating the direct current residual magnetic field in the vicinity of the specimen measurement position, in a direction perpendicular to the magnetic marker direction of magnetization for the measurement target. This invention reduces the effects of the magnetic field emitted from the unbound magnetic marker due to the residual magnetic field in the specimen solution and detects with high sensitivity the signal of the bound target magnetic marker. The magnetic field at the measurement position is regulated so as to intersect the direction of magnetization of the magnetic marker for the measurement target, in order to make the magnetization direction of the magnetic marker that is unbound due to residual magnetism or remanence in the sample solution, intersect the magnetization direction of the magnetic marker for the measurement target. The signal of the bound target magnetic marker can be therefore measured with high sensitivity since it is isolated from the unbound magnetic marker signal.
摘要翻译： 一种磁性免疫测定系统，其具有用于在垂直于测量对象的磁标记磁化方向的方向上补偿样本测量位置附近的直流残余磁场的机构。 本发明减少了由于样品溶液中的残留磁场而导致的未结合磁性标记物发射的磁场的影响，并以高灵敏度检测结合的目标磁性标记的信号。 调整测量位置处的磁场，以便与测量对象的磁性标记的磁化方向相交，以使磁性标记的磁化方向由于样品溶液中的剩余磁性或剩磁而未结合 与测量对象的磁性标记的磁化方向相交。 因此，可以高灵敏度地测量结合目标磁标记的信号，因为它与未结合的磁标记信号隔离。
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公开(公告)号：US20070254375A1
公开(公告)日：2007-11-01
申请号：US11715916
申请日：2007-03-09
申请人： Akira Tsukamoto , Kazuo Saitoh
发明人： Akira Tsukamoto , Kazuo Saitoh
IPC分类号： G01N27/00
CPC分类号： G01N33/54326
摘要： A magnetic immunoassay system with a mechanism for compensating the direct current residual magnetic field in the vicinity of the specimen measurement position, in a direction perpendicular to the magnetic marker direction of magnetization for the measurement target. This invention reduces the effects of the magnetic field emitted from the unbound magnetic marker due to the residual magnetic field in the specimen solution and detects with high sensitivity the signal of the bound target magnetic marker. The magnetic field at the measurement position is regulated so as to intersect the direction of magnetization of the magnetic marker for the measurement target, in order to make the magnetization direction of the magnetic marker that is unbound due to residual magnetism or remanence in the sample solution, intersect the magnetization direction of the magnetic marker for the measurement target. The signal of the bound target magnetic marker can be therefore measured with high sensitivity since it is isolated from the unbound magnetic marker signal.
摘要翻译： 一种磁性免疫测定系统，其具有用于在垂直于测量对象的磁标记磁化方向的方向上补偿样本测量位置附近的直流残余磁场的机构。 本发明减少了由于样品溶液中的残留磁场而导致的未结合磁性标记物发射的磁场的影响，并以高灵敏度检测结合的目标磁性标记的信号。 调整测量位置处的磁场，以便与测量对象的磁性标记的磁化方向相交，以使磁性标记的磁化方向由于样品溶液中的剩余磁性或剩磁而未结合 与测量对象的磁性标记的磁化方向相交。 因此，可以高灵敏度地测量结合目标磁标记的信号，因为它与未结合的磁标记信号隔离。
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10.发明申请公开(公告)号：US20080064605A1
公开(公告)日：2008-03-13
申请号：US11798021
申请日：2007-05-09
IPC分类号： H01L39/24
CPC分类号： H01L39/2487 , H01L39/141
摘要： A superconducting magnesium diboride (MgB2) thin film showing a high critical current density to an angle of an applied magnetic field for a wide range is provided. Columnar crystal grains of MgB2 grow with the same tilted to the normal line of the substrate by supplying a magnesium (Mg) flux and a boron (B) flux from direction tilted each to the normal axis of a substrate in high vacuum. The superconducting magnesium diboride (MgB2) thin film comprising a plurality of layers containing MgB2 columnar crystal grains with the angle of the grain boundaries being different from each other is formed by controlling the angle of supplying the magnesium (Mg) flux and the boron (B) flux to the substrate.
摘要翻译： 提供了一种超导二硼化镁（MgB 2 O 2）薄膜，其显示出对于宽范围施加的磁场的角度具有高的临界电流密度。 MgB 2的柱状晶粒通过从方向倾斜的方向以相对于基板的法线方向倾斜的方式以与基板的法线相同的方式生长，从而提供镁（Mg）助熔剂和硼（B） 底物在高真空中。 包含晶界的角度彼此不同的包含MgB 2柱状晶粒的多个层的超导二硼化镁（MgB 2 O 2）薄膜通过 控制向基板供应镁（Mg）助熔剂和硼（B）助焊剂的角度。
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