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公开(公告)号：US20050202572A1
公开(公告)日：2005-09-15
申请号：US11006757
申请日：2004-12-08
申请人： Yasuke Seki , Akira Tsukamoto , Daisuke Suzuki , Masahiro Yamaoka , Nami Sugita , Akihiko Kandori , Kazuo Saitoh
发明人： Yasuke Seki , Akira Tsukamoto , Daisuke Suzuki , Masahiro Yamaoka , Nami Sugita , Akihiko Kandori , Kazuo Saitoh
IPC分类号： G01N33/53 , G01N27/72 , G01N33/542 , G01N33/553
CPC分类号： G01N33/54373 , G01N27/745
摘要： The present invention provides an immunoassay technique which enables efficient detection of antigen-antibody reaction with high sensitivity by a magnetic method using magnetic particles and a SQUID magnetic sensor or sensors. A system based on the technique includes a disk-shaped sample holder which holds on a circle a plurality of sample containers for accommodating marked samples, resulting from marking of samples with magnetic particles by antigen-antibody reaction; rotating means for rotating the holder around its central shaft; magnetizing means for magnetizing the marked samples outside a magnetic shield; and a magnetic sensor for detecting, within the magnetic shield, magnetic fields generated from the marked samples which have been magnetized. By rotation of the holder, areas fixing and holding different ones of the sample containers are successively inserted into the magnetic shield, and the magnetization of the marked samples accommodated in first ones of the sample containers and the detection of magnetic fields generated from the marked samples accommodated in second ones of the sample containers are executed in parallel.
摘要翻译： 本发明提供了一种免疫测定技术，其能够通过使用磁性颗粒和SQUID磁性传感器的磁性方法高灵敏度地高效检测抗原 - 抗体反应。 基于该技术的系统包括：盘形样品保持器，其保持圆圈上的多个样品容器，用于容纳标记的样品，通过抗原 - 抗体反应用磁性颗粒标记样品; 用于使支架围绕其中心轴旋转的旋转装置; 用于将标记样品磁化在磁屏蔽外的磁化装置; 以及磁传感器，用于在磁屏蔽内检测从已经被磁化的标记样品产生的磁场。 通过保持器的旋转，将固定和保持不同样本容器的区域依次插入到磁屏蔽中，并且标记的样品的磁化容纳在第一个样品容器中，并且检测从标记的样品产生的磁场 容纳在第二个样品容器中并行执行。
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公开(公告)号：US07993581B2
公开(公告)日：2011-08-09
申请号：US11006757
申请日：2004-12-08
申请人： Yusuke Seki , Akira Tsukamoto , Daisuke Suzuki , Masahiro Yamaoka , Nami Sugita , Akihiko Kandori , Kazuo Saitoh
发明人： Yusuke Seki , Akira Tsukamoto , Daisuke Suzuki , Masahiro Yamaoka , Nami Sugita , Akihiko Kandori , Kazuo Saitoh
IPC分类号： G01N1/36 , G01N33/553
CPC分类号： G01N33/54373 , G01N27/745
摘要： The present invention provides an immunoassay technique which enables efficient detection of antigen-antibody reaction with high sensitivity by a magnetic method using magnetic particles and a SQUID magnetic sensor or sensors. A system based on the technique includes a disk-shaped sample holder which holds on a circle a plurality of sample containers for accommodating marked samples, resulting from marking of samples with magnetic particles by antigen-antibody reaction; rotating means for rotating the holder around its central shaft; magnetizing means for magnetizing the marked samples outside a magnetic shield; and a magnetic sensor for detecting, within the magnetic shield, magnetic fields generated from the marked samples which have been magnetized. By rotation of the holder, areas fixing and holding different ones of the sample containers are successively inserted into the magnetic shield, and the magnetization of the marked samples accommodated in first ones of the sample containers and the detection of magnetic fields generated from the marked samples accommodated in second ones of the sample containers are executed in parallel.
摘要翻译： 本发明提供了一种免疫测定技术，其能够通过使用磁性颗粒和SQUID磁性传感器的磁性方法高灵敏度地高效检测抗原 - 抗体反应。 基于该技术的系统包括：盘形样品保持器，其保持圆圈上的多个样品容器，用于容纳标记的样品，通过抗原 - 抗体反应用磁性颗粒标记样品; 用于使支架围绕其中心轴旋转的旋转装置; 用于将标记样品磁化在磁屏蔽外的磁化装置; 以及磁传感器，用于在磁屏蔽内检测从已经被磁化的标记样品产生的磁场。 通过保持器的旋转，将固定和保持不同样本容器的区域依次插入到磁屏蔽中，并且标记的样品的磁化容纳在第一个样品容器中，并且检测从标记的样品产生的磁场 容纳在第二个样品容器中并行执行。
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公开(公告)号：US08193003B2
公开(公告)日：2012-06-05
申请号：US12149990
申请日：2008-05-12
申请人： Akira Tsukamoto , Daisuke Suzuki , Akihiko Kandori
发明人： Akira Tsukamoto , Daisuke Suzuki , Akihiko Kandori
IPC分类号： G01N33/553 , G01N33/53
CPC分类号： G01N33/54333
摘要： Accurate measurement cannot be performed due to magnetic signals from magnetic impurities included in a specimen container. By finding a difference between two measurement signals obtained by applying an external magnetic field for orientation to respective normal and reverse directions, the magnetic signals from the magnetic impurities included in the specimen container which are not dependent on the external magnetic field for orientation can be cancelled. The influence of the magnetic impurities included in the specimen container is reduced, and the signal of the intended bound magnetic marker can be measured with high sensitivity.
摘要翻译： 由于样品容器中包含的磁性杂质的磁信号，无法进行准确的测量。 通过在相应的正反方向上施加用于取向的外部磁场获得的两个测量信号之间的差异，可以取消不依赖于用于取向的外部磁场的样本容器中包含的磁性杂质的磁信号 。 包含在标本容器中的磁性杂质的影响减小，可以高灵敏度地测量预期的结合磁性标记的信号。
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公开(公告)号：US20080284413A1
公开(公告)日：2008-11-20
申请号：US12149990
申请日：2008-05-12
申请人： Akira Tsukamoto , Daisuke Suzuki , Akihiko Kandori
发明人： Akira Tsukamoto , Daisuke Suzuki , Akihiko Kandori
IPC分类号： G01N27/74
CPC分类号： G01N33/54333
摘要： Accurate measurement cannot be performed due to magnetic signals from magnetic impurities included in a specimen container. By finding a difference between two measurement signals obtained by applying an external magnetic field for orientation to respective normal and reverse directions, the magnetic signals from the magnetic impurities included in the specimen container which are not dependent on the external magnetic field for orientation can be cancelled. The influence of the magnetic impurities included in the specimen container is reduced, and the signal of the intended bound magnetic marker can be measured with high sensitivity.
摘要翻译： 由于样品容器中包含的磁性杂质的磁信号，无法进行准确的测量。 通过在相应的正反方向上施加用于取向的外部磁场获得的两个测量信号之间的差异，可以取消不依赖于用于取向的外部磁场的样本容器中包含的磁性杂质的磁信号 。 包含在标本容器中的磁性杂质的影响减小，可以高灵敏度地测量预期的结合磁性标记的信号。
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公开(公告)号：US06853185B2
公开(公告)日：2005-02-08
申请号：US10844480
申请日：2004-05-13
IPC分类号： A61B5/05 , G01R33/025 , G01R33/035 , G01R33/02
CPC分类号： G01R33/0358 , G01R33/025
摘要： A magnetic field measurement system for canceling an external field is provided, in which plurality of sensing magnetometers (3) for measuring a magnetic field signal in a direction perpendicular to the center axis of a cylindrical magnetic shield (1) are arranged in two dimensions on a plane parallel to the center axis and a reference magnetometer (4) for measuring the external field parallel to the center axis as a reference signal is disposed on a plane perpendicular to the plane parallel to the center axis. The reference signal multiplied by a specified factor is subtracted from a difference between signals from the adjacent sensing magnetometers (3). The magnetic field measurement system allows measurement of an extremely weak magnetic field by efficiently canceling the external field.
摘要翻译： 提供了用于消除外部场的磁场测量系统，其中用于在与圆柱形磁屏蔽（1）的中心轴垂直的方向上测量磁场信号的多个感测磁力计（3）被二维地布置在 平行于中心轴的平面和用于测量与中心轴平行的外场作为参考信号的参考磁力计（4）设置在垂直于平行于中心轴的平面的平面上。 从相邻感测磁力计（3）的信号之间的差中减去乘以指定因子的参考信号。 磁场测量系统允许通过有效地消除外部场来测量极弱的磁场。
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公开(公告)号：US06815949B2
公开(公告)日：2004-11-09
申请号：US10162748
申请日：2002-06-06
申请人： Akihiko Kandori , Tsuyoshi Miyashita , Keiji Tsukada , Koichi Yokosawa , Daisuke Suzuki , Akira Tsukamoto
发明人： Akihiko Kandori , Tsuyoshi Miyashita , Keiji Tsukada , Koichi Yokosawa , Daisuke Suzuki , Akira Tsukamoto
IPC分类号： G01R33035
CPC分类号： G01R33/0356 , A61B5/04005 , A61B5/04007 , A61B5/04008 , A61B5/0522
摘要： An apparatus can detect a magnetic field with a high sensitivity using an ordinary-temperature pickup coil even when the pickup coil is arranged outside a cryostat. Specifically, the apparatus for measuring a magnetic field includes a pickup coil for detecting an external magnetic field, a SQUID electrically or magnetically connected to the pickup coil, a cryostat for holding the SQUID at low temperatures, and a driving device for driving the SQUID. The pickup coil is made of a normal-conducting material and is placed at an ordinary temperature outside the cryostat. By arranging outside the cryostat, the pickup coil can be brought close to a subject and can thereby detect a weak magnetic field in the subject with a high sensitivity.
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公开(公告)号：US07193413B2
公开(公告)日：2007-03-20
申请号：US10855374
申请日：2004-05-28
申请人： Akihiko Kandori , Keiji Tsukada , Daisuke Suzuki
发明人： Akihiko Kandori , Keiji Tsukada , Daisuke Suzuki
IPC分类号： G01R33/025 , G01R33/035
CPC分类号： G01R33/0354
摘要： A magnetic field measurement apparatus which reduces an interference magnetic field entering into a pick-up coil is provided. The magnetic field measurement apparatus includes a superconducting quantum interference device (SQUID) magnetometer having a pick-up coil for picking up a magnetic field generated from an examination object, a SQUID control unit for controlling the SQUID magnetometer, a magnetometer for picking up the interference magnetic field, a magnetometer control unit for controlling the magnetometer, a modulation circuit, a current converter, a current amount adjusting device, a coil which is positioned outside the pick-up coil and through which the current thus adjusted by the current amount adjusting device flows, a demodulation circuit, a low-pass filter (LPF) for extracting a low frequency element of the output voltage from the demodulation circuit, and a subtraction circuit for subtracting the output of the LPF from the output of the SQUID control unit.
摘要翻译： 提供了减少进入拾取线圈的干涉磁场的磁场测量装置。 磁场测量装置包括具有用于拾取从检查对象产生的磁场的拾取线圈的超导量子干涉装置（SQUID）磁力计，用于控制SQUID磁强计的SQUID控制单元，用于拾取干扰的磁力计 磁场，用于控制磁力计的磁力计控制单元，调制电路，电流转换器，电流量调节装置，位于拾取线圈外部的线圈，由电流量调节装置调节的电流 解调电路，用于从解调电路提取输出电压的低频元件的低通滤波器（LPF），以及从SQUID控制单元的输出中减去LPF的输出的减法电路。
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公开(公告)号：US06665552B2
公开(公告)日：2003-12-16
申请号：US09940507
申请日：2001-08-29
IPC分类号： A61B505
CPC分类号： G01R33/022 , G01R33/0358
摘要： A gradiometer integrating pickup coils comprises pickup coils 11Xp, 11Xn magnetically connected to a SQUID through associated input coils 2, and pickup coils 11Yp, 11Yn magnetically connected to a SQUID through associated input coils 2, respectively. Two superconducting loops are connected in series to each of the SQUIDs, when viewed from Josephson junctions 5. The input coils 2 form superconducting closed loops together with the pickup coils 11Xp, 11Xn, 11Yp, 11Yn associated therewith. The SQUIDs are respectively connected to form an 8-figured shape as a whole such that currents flow in two superconducting loops of each SQUID in opposite directions to each other, with respect to the application of a uniform field, in order to reduce environmental magnetic field noise.
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公开(公告)号：US06745063B2
公开(公告)日：2004-06-01
申请号：US09940542
申请日：2001-08-29
IPC分类号： A61B505
CPC分类号： A61B5/04005 , A61B5/4064
摘要： A biomagnetic field measuring apparatus includes a plurality of SQUID magneto-meters for measuring a biomagnetic field generated from a living body, living-body signal measuring devices and for measuring and collecting living-body signals generated periodically, an operation processing device for operation processing the biomagnetic field signal and the living-body signal measured simultaneously as pairs in a plurality of directions, and a display unit for displaying a result of the operation processing. Change in time of excitation can be grasped in detail by using a small number of maps without presumption of a magnetic field source and display of many iso-magnetic field maps.
摘要翻译： 生物磁场测量装置包括多个用于测量从生物体产生的生物磁场的SQUID磁电表，生物体信号测量装置，以及用于测量和收集周期性生成的生物体信号的操作处理装置， 生物磁场信号和在多个方向上成对测量的生物体信号以及用于显示操作结果的显示单元。 可以通过使用少量地图来详细了解激发时间的变化，而不考虑磁场源和显示许多等磁场图。
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公开(公告)号：US20080306373A1
公开(公告)日：2008-12-11
申请号：US12155191
申请日：2008-05-30
CPC分类号： A61B5/1126 , A61B5/4205 , A61B5/6822 , A61B7/008
摘要： Disclosed is a swallowing test apparatus including a laryngeal part displacement detection apparatus for detecting a distance of two positions located laterally at a laryngeal part of a subject, a swallowing sound detection apparatus for detecting a swallowing sound of the patient during swallowing, a display, a processing apparatus for displaying a waveform representing the distance of the two positions at the laryngeal part generated based on a signal obtained from the laryngeal part displacement detection apparatus, and a waveform representing the swallowing sound generated based on a signal obtained from the swallowing sound detection apparatus on the display.
摘要翻译： 本发明公开了一种吞咽试验装置，其包括：喉部位移检测装置，用于检测横向位于被检体的喉部的两个位置的距离;吞咽声检测装置，用于在吞咽期间检测患者的吞咽声，显示器， 处理装置，用于根据从喉部位移检测装置获得的信号显示表示在喉部产生的两个位置的距离的波形，以及表示基于从吞咽声音检测装置获得的信号产生的吞咽声音的波形 在显示器上。
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