公开(公告)号：US20150087673A1

公开(公告)日：2015-03-26

申请号：US14498921

申请日：2014-09-26

申请人： Yasumichi Hitoshi ,  Yonchu Jenkins ,  Vadim Markovtsov ,  Todd Kinsella ,  Tian-Qiang Sun

发明人： Yasumichi Hitoshi ,  Yonchu Jenkins ,  Vadim Markovtsov ,  Todd Kinsella ,  Tian-Qiang Sun

IPC分类号： A61K31/4545 ,  C07D401/14 ,  A61K45/06 ,  G01N33/573

CPC分类号： A61K31/4545 ,  A61K31/4427 ,  A61K31/501 ,  A61K31/5377 ,  A61K45/06 ,  C07D401/14 ,  G01N33/573 ,  G01N2500/04 ,  A61K2300/00

摘要： Disclosed are methods of using AMPK-activating compounds, for example, in the treatment of cancer and disorders of vascular flow. Also disclosed are biomarkers for AMPK and uses thereof, for example, in the diagnosis and treatment of AMPK-linked disorders. In certain embodiments, the AMPK-activating compounds have the structural formula wherein E, J, T, D1, D2, D3, the ring system denoted by “B”, T, R3, R4, w and x are as described herein.

摘要翻译： 公开了使用AMPK活化化合物的方法，例如用于治疗癌症和血管流动障碍。 还公开了AMPK的生物标志物及其用途，例如在AMPK相关疾病的诊断和治疗中。 在某些实施方案中，AMPK活化化合物具有其结构式，其中E，J，T，D1，D2，D3，由“B”，T，R3，R4，w和x表示的环系统如本文所述。

公开(公告)号：US07358040B2

公开(公告)日：2008-04-15

申请号：US10026331

申请日：2001-12-21

申请人： Yasumichi Hitoshi ,  Susan Demo ,  Yonchu Jenkins

发明人： Yasumichi Hitoshi ,  Susan Demo ,  Yonchu Jenkins

IPC分类号： C12Q1/00

CPC分类号： C12Q1/34 ,  G01N33/5011 ,  G01N33/573 ,  G01N2333/922 ,  G01N2500/02

摘要： The present invention relates to regulation of cellular proliferation. More particularly, the present invention is directed to nucleic acids encoding MRE11, which is a protein involved in modulation of cellular proliferation. The invention further relates to methods for identifying and using agents, including small molecule chemical compositions, antibodies, peptides, cyclic peptides, nucleic acids, antisense nucleic acids, and ribozymes, that modulate cellular proliferation via modulation of MRE11; as well as to the use of expression profiles and compositions in diagnosis and therapy related to modulation of cellular proliferation.

摘要翻译： 本发明涉及细胞增殖的调控。 更具体地，本发明涉及编码MRE11的核酸，其是涉及细胞增殖调节的蛋白质。 本发明还涉及用于鉴定和使用通过调节MRE11来调节细胞增殖的试剂，包括小分子化学组合物，抗体，肽，环肽，核酸，反义核酸和核酶的方法; 以及在与调节细胞增殖相关的诊断和治疗中使用表达谱和组合物。

公开(公告)号：US07482130B2

公开(公告)日：2009-01-27

申请号：US11460588

申请日：2006-07-27

申请人： Yasumichi Hitoshi ,  Yonchu Jenkins

发明人： Yasumichi Hitoshi ,  Yonchu Jenkins

IPC分类号： G01N33/574 ,  A61K38/00

CPC分类号： G01N33/5091 ,  C12Q1/6886 ,  C12Q2600/158 ,  G01N33/5008 ,  G01N33/5011 ,  G01N33/574 ,  G01N33/6872 ,  G01N2333/4703

摘要： The present invention relates to regulation of cellular proliferation. More particularly, the present invention is directed to nucleic acids encoding NP95, which is involved in modulation of cell cycle arrest. The invention further relates to methods for identifying and using agents, including small molecule chemical compositions, antibodies, peptides, cyclic peptides, nucleic acids, RNAi, antisense nucleic acids, and ribozymes, that modulate cell cycle arrest via modulation of NP95; as well as to the use of expression profiles and compositions in diagnosis and therapy related to cell cycle regulation and modulation of cellular proliferation, e.g., for treatment of cancer and other diseases of cellular proliferation.

摘要翻译： 本发明涉及细胞增殖的调控。 更具体地，本发明涉及编码NP95的核酸，其涉及细胞周期停滞的调节。 本发明还涉及用于鉴定和使用通过调节NP95来调节细胞周期阻滞的试剂，包括小分子化学组成，抗体，肽，环肽，核酸，RNAi，反义核酸和核酶的方法; 以及在细胞周期调控和细胞增殖调节相关的诊断和治疗中使用表达谱和组合物，例如用于治疗癌症和其它细胞增殖疾病。

公开(公告)号：US20070128673A1

公开(公告)日：2007-06-07

申请号：US11460588

申请日：2006-07-27

申请人： Yasumichi Hitoshi ,  Yonchu Jenkins

发明人： Yasumichi Hitoshi ,  Yonchu Jenkins

IPC分类号： G01N33/574

CPC分类号： G01N33/5091 ,  C12Q1/6886 ,  C12Q2600/158 ,  G01N33/5008 ,  G01N33/5011 ,  G01N33/574 ,  G01N33/6872 ,  G01N2333/4703

摘要： The present invention relates to regulation of cellular proliferation. More particularly, the present invention is directed to nucleic acids encoding NP95, which is involved in modulation of cell cycle arrest. The invention further relates to methods for identifying and using agents, including small molecule chemical compositions, antibodies, peptides, cyclic peptides, nucleic acids, RNAi, antisense nucleic acids, and ribozymes, that modulate cell cycle arrest via modulation of NP95; as well as to the use of expression profiles and compositions in diagnosis and therapy related to cell cycle regulation and modulation of cellular proliferation, e.g., for treatment of cancer and other diseases of cellular proliferation.

摘要翻译： 本发明涉及细胞增殖的调控。 更具体地，本发明涉及编码NP95的核酸，其涉及细胞周期停滞的调节。 本发明还涉及用于鉴定和使用通过调节NP95来调节细胞周期阻滞的试剂，包括小分子化学组成，抗体，肽，环肽，核酸，RNAi，反义核酸和核酶的方法; 以及在细胞周期调控和细胞增殖调节相关的诊断和治疗中使用表达谱和组合物，例如用于治疗癌症和其它细胞增殖疾病。

公开(公告)号：US07413870B2

公开(公告)日：2008-08-19

申请号：US10026021

申请日：2001-12-21

申请人： Yasumichi Hitoshi ,  Susan Demo ,  Yonchu Jenkins

发明人： Yasumichi Hitoshi ,  Susan Demo ,  Yonchu Jenkins

IPC分类号： C12Q1/50

CPC分类号： G01N33/57484 ,  A61K38/00 ,  A61K2039/505 ,  G01N2333/912

摘要： The present invention relates to regulation of cellular proliferation. More particularly, the present invention is directed to nucleic acids encoding SAK, which is a protein kinase involved in modulation of cellular proliferation and cell cycle regulation. The invention further relates to methods for identifying and using agents, including small molecule chemical compositions, antibodies, peptides, cyclic peptides, nucleic acids, RNAi, antisense nucleic acids, and ribozymes, that modulate cell cycle regulation and cellular proliferation via modulation of SAK; as well as to the use of expression profiles and compositions in diagnosis and therapy related to cell cycle regulation and modulation of cellular proliferation, e.g., for treatment of cancer and other diseases of cellular proliferation.

摘要翻译： 本发明涉及细胞增殖的调控。 更具体地，本发明涉及编码SAK的核酸，其是参与调节细胞增殖和细胞周期调节的蛋白激酶。 本发明还涉及用于鉴别和使用通过调节SAK调节细胞周期调节和细胞增殖的试剂，包括小分子化学组合物，抗体，肽，环肽，核酸，RNAi，反义核酸和核酶的方法; 以及在细胞周期调控和细胞增殖调节相关的诊断和治疗中使用表达谱和组合物，例如用于治疗癌症和其它细胞增殖疾病。

公开(公告)号：US20060051755A1

公开(公告)日：2006-03-09

申请号：US10510903

申请日：2003-04-15

申请人： Yasumichi Hitoshi ,  Yonchu Jenkins

发明人： Yasumichi Hitoshi ,  Yonchu Jenkins

IPC分类号： C12Q1/68

CPC分类号： G01N33/5091 ,  C12Q1/6886 ,  C12Q2600/158 ,  G01N33/5008 ,  G01N33/5011 ,  G01N33/574 ,  G01N33/6872 ,  G01N2333/4703 ,  G01N2500/00

摘要： The present invention relates to regulation of cellular proliferation. More particularly, the present invention is directed to nucleic acids encoding BRCA-1-Associated Protein-1 (BAP-1), Nuclear Protein 95 (NP95), Fanconi anemia group A protein (FANCA), DEAD/H box polypeptide 9 (DDX9), insulin-like growth factor 1 receptor (IGF1R), ubiquitin-conjugating enzyme E2 variant 1 (UBE2V1), aldehyde dehydrogenase, pyruvate kinase, glucose-6-phosphate dehydrogenase, HCDR-3, DEAD/H box polypeptide 21 (DDX21), serine threonine kinase 15 (ARK2), transmembrane 4 superfamily member 1, or ERCC1, which are involved in modulation of cell cycle arrest. The invention further relates to methods for identifying and using agents, including small molecule chemical compositions, antibodies, peptides, cyclic peptides, nucleic acids, RNAi, antisense nucleic acids, and ribozymes, that modulate cell cycle arrest via modulation of BRCA-1-Associated Protein-1 (BAP-1), Nuclear Protein 95 (NP95), Fanconi anemia group A protein (FANCA), DEAD/H box polypeptide 9 (DDX9), insulin-like growth factor 1 receptor (IGF1R), ubiquitin-conjugating enzyme E2 variant 1 (UBE2V1), aldehyde dehydrogenase, pyruvate kinase, glucose-6-phosphate dehydrogenase, HCDR-3, DEAD/H box polypeptide 21 (DDX21), serine threonine kinase 15 (ARK2), transmembrane 4 superfamily member 1, or ERCC1, as well as to the use of expression profiles and compositions in diagnosis and therapy related to cell cycle regulation and modulation of cellular proliferation, e.g., for treatment of cancer and other diseases of cellular proliferation.

摘要翻译： 本发明涉及细胞增殖的调控。 更具体地，本发明涉及编码BRCA-1相关蛋白-1（BAP-1），核蛋白95（NP95），Fanconi贫血A组蛋白（FANCA），DEAD / H盒多肽9（DDX9） ），胰岛素样生长因子1受体（IGF1R），泛素结合酶E2变体1（UBE2V1），醛脱氢酶，丙酮酸激酶，葡萄糖-6-磷酸脱氢酶，HCDR-3，DEAD / H盒多肽21（DDX21） ，丝氨酸苏氨酸激酶15（ARK2），跨膜4超家族成员1或ERCC1，其参与调节细胞周期停滞。 本发明还涉及用于鉴定和使用包括小分子化学组合物，抗体，肽，环肽，核酸，RNAi，反义核酸和核酶在内的试剂的方法，其通过调节BRCA-1相关的调节细胞周期阻滞 蛋白-1（BAP-1），核蛋白95（NP95），Fanconi贫血组A蛋白（FANCA），DEAD / H盒多肽9（DDX9），胰岛素样生长因子1受体（IGF1R），泛素缀合酶 E2变体1（UBE2V1），醛脱氢酶，丙酮酸激酶，葡萄糖-6-磷酸脱氢酶，HCDR-3，DEAD / H盒多肽21（DDX21），丝氨酸苏氨酸激酶15（ARK2），跨膜4超家族成员1或ERCC1 ，以及在与细胞周期调节和细胞增殖调节相关的诊断和治疗中使用表达谱和组合物，例如用于治疗癌症和其他细胞增殖疾病。

公开(公告)号：US07090990B2

公开(公告)日：2006-08-15

申请号：US10123568

申请日：2002-04-15

申请人： Yasumichi Hitoshi ,  Yonchu Jenkins

发明人： Yasumichi Hitoshi ,  Yonchu Jenkins

IPC分类号： G01N33/574

CPC分类号： G01N33/5091 ,  C12Q1/6886 ,  C12Q2600/158 ,  G01N33/5008 ,  G01N33/5011 ,  G01N33/574 ,  G01N33/6872 ,  G01N2333/4703

摘要： The present invention relates to regulation of cellular proliferation. More particularly, the present invention is directed to nucleic acids encoding NP95, which is involved in modulation of cell cycle arrest. The invention further relates to methods for identifying and using agents, including small molecule chemical compositions, antibodies, peptides, cyclic peptides, nucleic acids, RNAi, antisense nucleic acids, and ribozymes, that modulate cell cycle arrest via modulation of NP95; as well as to the use of expression profiles and compositions in diagnosis and therapy related to cell cycle regulation and modulation of cellular proliferation, e.g., for treatment of cancer and other diseases of cellular proliferation.

公开(公告)号：US20090176202A1

公开(公告)日：2009-07-09

申请号：US12054272

申请日：2008-03-24

申请人： Yonchu Jenkins ,  Guoping Su

发明人： Yonchu Jenkins ,  Guoping Su

IPC分类号： C12Q1/70 ,  C12Q1/68 ,  C12Q1/66 ,  C12N5/00

CPC分类号： G01N33/56988 ,  C12Q1/6883 ,  C12Q2600/136 ,  C12Q2600/156 ,  G01N33/5008 ,  G01N2500/00

摘要： The invention comprises methods and cell lines for assaying APOBEC3G degradation and methods for identifying inhibitors of APOBEC3G degradation. The invention also provides methods of identifying inhibitors of HIV infection. The methods of the invention are useful for identifying inhibitors of viral infection, in particular, the methods of the invention are useful for treating retroviral infection.

摘要翻译： 本发明包括用于测定APOBEC3G降解的方法和细胞系以及鉴定APOBEC3G降解抑制剂的方法。 本发明还提供鉴定HIV感染抑制剂的方法。 本发明的方法可用于鉴定病毒感染的抑制剂，特别是本发明的方法可用于治疗逆转录病毒感染。

公开(公告)号：US20110104662A1

公开(公告)日：2011-05-05

申请号：US12948108

申请日：2010-11-17

申请人： Yonchu Jenkins ,  Guoping Su

发明人： Yonchu Jenkins ,  Guoping Su

IPC分类号： C12Q1/70

CPC分类号： G01N33/56988 ,  C12Q1/6883 ,  C12Q2600/136 ,  C12Q2600/156 ,  G01N33/5008 ,  G01N2500/00

摘要： The invention comprises methods and cell lines for assaying APOBEC3G degradation and methods for identifying inhibitors of APOBEC3G degradation. The invention also provides methods of identifying inhibitors of HIV infection. The methods of the invention are useful for identifying inhibitors of viral infection, in particular, the methods of the invention are useful for treating retroviral infection.

摘要翻译： 本发明包括用于测定APOBEC3G降解的方法和细胞系以及鉴定APOBEC3G降解抑制剂的方法。 本发明还提供鉴定HIV感染抑制剂的方法。 本发明的方法可用于鉴定病毒感染的抑制剂，特别是本发明的方法可用于治疗逆转录病毒感染。

公开(公告)号：US20050112562A1

公开(公告)日：2005-05-26

申请号：US10985804

申请日：2004-11-10

申请人： Donald Payan ,  Yonchu Jenkins

发明人： Donald Payan ,  Yonchu Jenkins

IPC分类号： A61K38/17 ,  A61K39/21 ,  C07K1/00 ,  C12N20060101 ,  C12Q1/70 ,  G01N33/569

CPC分类号： G01N33/56988 ,  G01N2333/163 ,  G01N2333/9015

摘要： The present invention relates to methods of inhibiting replication of a retrovirus, such as human immunodeficiency virus (HIV), by inhibiting modulation of ubiquitylation of a host cell substrate protein, such as CEM15 of CD4, where ubiquitylation modulation is mediated by a retroviral protein, such as HIV Vif or Vpu. The invention also relates to screening methods for identifying agents that inhibit viral replication by inhibiting retroviral protein-mediated modulation of host cell ubiquitylation.

摘要翻译： 本发明涉及通过抑制宿主细胞底物蛋白（例如CD4的CEM15）的泛素化调节来抑制逆转录病毒如人免疫缺陷病毒（HIV）的复制的方法，其中泛素化调节由逆转录病毒蛋白介导， 如HIV Vif或Vpu。 本发明还涉及通过抑制宿主细胞泛素化的逆转录病毒蛋白介导的调节来鉴定抑制病毒复制的试剂的筛选方法。