摘要:
Novel piperazinylquinazoline and homopiperazinylquinazoline compounds which have useful antihypertensive activity and their use including pharmaceutical compositions containing said derivatives as the active antihypertensive component thereof. Said compounds have the following formula. ##STR1## wherein m is 2 or 3 and R is as defined in the specification.
摘要:
Compounds of formula (I): ##STR1## in which: R.sup.1 is aryl or aromatic heterocyclic; R.sup.2 and R.sup.3 are hydrogen, alkyl, alkoxy, halogen, phenyl, phenoxy, C.sub.1 -C.sub.6 alkylthio, phenylthio, C.sub.1 -C.sub.6 haloalkyl, cyano or nitro, or together are alkylene optionally containing oxygen; R.sup.4 is hydrogen, aliphatic acyl, cycloalkylcarbonyl, cycloalkoxycarbonyl, aromatic acyl, alkoxycarbonyl or benzyloxycarbonyl; R.sup.5 and R.sup.6 are alkyl; and X is oxygen, sulfur or methylene, have calcium channel blocking activity and can serve for the treatment or prophylaxis of cardiovascular diseases and disorders. They may be prepared by reacting a corresponding compound where R.sup.4 is hydrogen and the aminoethyl group is replaced by hydrogen with a compound providing the aminoethyl group and the, if required, acylating the product.
摘要:
Thiazolidine derivatives of formula (I): ##STR1## (in which: R.sup.1, R.sup.2, R.sup.4, R.sup.5 are each hydrogen or alkyl; and R.sup.3 is hydrogen, aliphatic acyl, alkoxy-carbonyl, or arylcarbonyl and pharmaceutically acceptable salts thereof are anti-hypertensive agents and are useful in the treatment of obesity-related hypertension.
摘要翻译:式(I)的噻唑烷衍生物:其中:R 1,R 2,R 4,R 5各自为氢或烷基; R 3为氢,脂族酰基,烷氧羰基或芳基羰基及其药学上可接受的盐 是抗高血压剂,可用于治疗肥胖相关性高血压。
摘要:
1,4-Dihydro-6-methyl-4-(substituted phenyl)pyridine-3,5-dicarboxylic acid esters have an amino group at the 2-position and at least one nitrooxy group in at least one of the ester groups. These compounds have a variety of valuable activities, including antihypertensive and Ca.sup.++ -blocking activities, leading to their use for the treatment of circulatory and coronary disorders. They may be prepared by condensation of appropriate substituted acetic acid esters.
摘要:
2-(Amino or methyl)-6-(methyl or amino)-4-(substituted phenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid esters have a specific class of heterocyclic groups as thealcohol moiety. These compounds have a variety of valuable activities, including antihypertensive and Ca.sup.++ -blocking activities, leading to their use for the treatment of circulatory and coronary disorders. They may be prepared by condensation of appropriate substituted benzylideneacetoacetic acid esters with appropriate amidinoacetic acid esters.
摘要:
There is provided automotive lamp peripheral parts excellent in heat resistance, rigidity and fogging property. The lamp peripheral part according to the invention is obtained from a resin composition containing 70% by mass or more of a polyphenylene ether (A) and a styrene-based resin (B), and has a haze value of a glass plate of 1.0% or less after the glass plate is subjected to a fogging test using an apparatus according to ISO 6452.
摘要:
A conductive resin composition produced by melt-kneading a mixture comprising a polyamide (A), a polyphenylene ether (B) (non-terminal-modified polyphenylene ether and/or terminal-modified polyphenylene ether), a rubbery polymer (C), a conductive carbonaceous material (D) (carbon black and/or carbon fibril), and a low molecular weight modifier compound (E) (compatibility agent), wherein the mixture has the following characteristics: (1) the amount of (D) is 0.2 to 3% by weight, based on the total weight of (A) to (E), (2) the amount of (E) is more than 0.01% by weight and less than 0.20% by weight, based on the total weight of (A) to (E), and (3) the amount (a) of a volatile substance contained in (B) satisfies the following formula: 0≦a≦−7.3×E+1.83, wherein E is the % by weight of (E), based on the total weight of (A) to (E), the amount (a) being expressed in terms of a weight decrease (% by weight) of (B) as measured by subjecting (B) to vacuum drying in vacuo at 180 ° C. for 1 hour.
摘要:
A vibration gas density meter provided with a cylindrical resonator, a cylinder block that incorporates the above cylindrical resonator concentrically and has one end of the cylindrical resonator fixed to itself, and a case which concentrically incorporates the above cylinder block and supports both ends of the cylinder block, further comprising first and second elastic elements which are provided between both end faces of the cylinder block and the case respectively, and through which the cylinder block is supported by the case in the direction of cylindrical axis, sealing the gaps between the cylinder block and the case as well, and third and fourth elastic elements which are provided between both parts of the outer cylindrical surface on both end face sides of the above cylinder block and the case respectively and through which the cylinder block is supported by the case in the radial direction, sealing the gaps between the cylinder block and the case as well.
摘要:
A pulse combustion apparatus comprises (i) a single air supply section with a single air blower and (ii) a plurality of combustion sections each communicating with the air supply section. The air supply section includes passages communicating with both the blower and the respective combustion sections for admitting air from the blower into the respective combustion sections. The air admitting passages are physically separated from each other for separating air from the blower into streams which are not able to join together anywhere.
摘要:
A process for preparing a conductive coating composition comprising the steps of forming a graft copolymer onto the surfaces of graphite and carbon black, adding an azo compound to the reaction system to complete the reaction, and curing the resulting product to form a network structure inside the product.