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    Method for determining susceptibility to Escherichia coli urinary tract infections, method for diagnosing secretors and nonsecretors, and method and medicament for preventing Escherichia coli urinary tract infections
    4.
    发明授权
    Method for determining susceptibility to Escherichia coli urinary tract infections, method for diagnosing secretors and nonsecretors, and method and medicament for preventing Escherichia coli urinary tract infections 失效

    公开(公告)号：US6130205A

    公开(公告)日：2000-10-10

    申请号：US470045

    申请日：1995-06-06

    申请人： Ann Stapleton ,  Edward Nudelman ,  Sen-itiroh Hakomori ,  Walter E. Stamm ,  Mark Stroud

    发明人： Ann Stapleton ,  Edward Nudelman ,  Sen-itiroh Hakomori ,  Walter E. Stamm ,  Mark Stroud

    IPC分类号： A61K31/7028 ,  G01N33/50 ,  G01N33/66 ,  A61K31/70

    CPC分类号： A61K31/7028 ,  G01N33/5091 ,  G01N33/66 ,  Y10S435/96

    摘要： A method for determining susceptibility to E. coli urinary tract infection comprising assaying a sample of epithelial cells for the presence or absence of at least one of Le.sup.a, sialosyl galactosyl-globoside, disialosyl galactosyl-globoside and an extended globo structure carrying the same terminal epitopes as Le.sup.a, sialosyl galactosyl-globoside or disialosyl galactosyl-globoside or assaying a sample of vaginal secretions for the presence or absence of at least one of sialosyl galactosyl-globoside or disialosyl galactosyl-globoside, and detecting the presence or absence of the at least one of Le.sup.a, sialosyl galactosyl-globoside, disialosyl galactosyl-globoside and the extended globo structure, as well as a method for diagnosing secretors and nonsecretors of histo-blood group antigens comprising assaying a sample of vaginal epithelial cells, vaginal secretions or buccal epithelial cells for the presence or absence of at least one of sialosyl galactosyl-globoside and disialosyl galactosyl-globoside, and detecting the presence or absence of the at least one of sialosyl galactosyl-globoside and disialosyl galactosyl-globoside, and a method for diagnosing secretors of histo-blood group antigens comprising assaying a sample of vaginal epithelial cells or vaginal secretions for the presence or absence of at least one of globo H, globo ABO and lacto ABO, and detecting for the presence or absence of the at least one of globo H, globo ABO and lacto ABO and, further, a medicament comprising a biologically effective amount of at least one E. coli bacterial receptor analogue, and a pharmaceutically acceptable diluent, carrier or excipient as well as a method for preventing E. coli urinary tract infection comprising administering to a host a biologically effective amount of at least one E. coli bacterial receptor or bacterial receptor analogue.

    Blood treatment method
    6.
    发明授权
    Blood treatment method 失效
    血液处理方法

    公开(公告)号：US5418129A

    公开(公告)日：1995-05-23

    申请号：US803065

    申请日：1991-12-06

    申请人： Edward Nudelman ,  Anil Singhal ,  Henrik Clausen ,  Sen-itiroh Hakomori ,  Kazuo Muroi ,  Toshio Suda ,  Hisao Nojiri

    发明人： Edward Nudelman ,  Anil Singhal ,  Henrik Clausen ,  Sen-itiroh Hakomori ,  Kazuo Muroi ,  Toshio Suda ,  Hisao Nojiri

    IPC分类号： A61K38/00 ,  C07K16/30 ,  C12P21/08 ,  A01N1/02 ,  A61K39/395 ,  C07K15/28

    CPC分类号： C07K16/30 ,  A61K38/00

    摘要： A method of producing monoclonal antibodies that bind to tumor-associated gangliosides, the method comprising: (1) immunizing a host with tumor cells; (2) boosting the host with a suspension comprising a mixture of tumor cell membrane and at least one purified lactonized tumor-associated ganglioside; (3) boosting the host with an immunogen comprising a lactone of a tumor associated ganglioside adsorbed on or incorporated into a carrier; (4) fusing immunized cells from the host with myeloma cells to form hybridoma cells; (5) selecting hybridoma cells that produce antibody that binds to the ganglioside of step (3); (6) culturing the selected hybridoma cells; and (7) recovering the antibody.

    摘要翻译： 一种产生与肿瘤相关神经节苷脂结合的单克隆抗体的方法，所述方法包括：（1）用肿瘤细胞免疫宿主; （2）用包含肿瘤细胞膜和至少一种经内化的内源性肿瘤相关神经节苷脂的混合物的悬浮液加强宿主; （3）用包含吸附在载体上或结合到载体中的肿瘤相关神经节苷脂的内酯的免疫原来加强宿主; （4）将来自宿主的免疫细胞与骨髓瘤细胞融合以形成杂交瘤细胞; （5）选择产生与步骤（3）的神经节苷脂结合的抗体的杂交瘤细胞; （6）培养所选择的杂交瘤细胞; 和（7）回收抗体。

    Method for determining susceptibility to escherichia coli urinary tract infections and method for diagnosing secretors and nonsecretors
    7.
    发明授权
    Method for determining susceptibility to escherichia coli urinary tract infections and method for diagnosing secretors and nonsecretors 失效
    确定大肠杆菌尿路感染易感性的方法及诊断分泌物和非分泌物的方法

    公开(公告)号：US5374532A

    公开(公告)日：1994-12-20

    申请号：US936400

    申请日：1992-08-31

    申请人： Ann Stapleton ,  Edward Nudelman ,  Sen-itiroh Hakomori ,  Walter E. Stamm

    发明人： Ann Stapleton ,  Edward Nudelman ,  Sen-itiroh Hakomori ,  Walter E. Stamm

    IPC分类号： A61K31/7028 ,  G01N33/50 ,  G01N33/66 ,  G01N33/53 ,  G01N33/566 ,  G01N33/569

    CPC分类号： A61K31/7028 ,  G01N33/5091 ,  G01N33/66 ,  Y10S435/96

    摘要： A method for determining susceptibility to E. coli urinary tract infection comprising assaying a sample of epithelial cells for the presence or absence of at least one of sialosyl galactosyl-globoside, disialosyl galactosyl-globoside and an extended globo structure carrying the same terminal epitopes as sialosyl galactosyl-globoside or disialosyl galactosyl-globoside, or assaying a sample of vaginal secretions for the presence or absence of at least one of sialosyl galactosyl-globoside or disialosyl galactosyl-globoside, and detecting the presence or absence of the at least one of sialosyl galactosyl-globoside, disialosyl galactosyl-globoside and the extended globo structure, a medicament comprising a biologically effective amount of at least one E. coli bacterial receptor analogue and a pharmaceutically acceptable diluent, carrier or excipient as well as a method for preventing E. coli urinary tract infection comprising administering to a host a biologically effective amount of at least one E. coli bacterial receptor or bacterial receptor analogue are disclosed.

    摘要翻译： 用于测定对大肠杆菌尿道感染的敏感性的方法，包括测定上皮细胞样品中是否存在唾液糖基半乳糖基 - 球苷，唾液酸半乳糖基 - 球形蛋白和延伸的具有与唾液酸基相同的末端表位的延伸的球形结构 半乳糖基 - 球苷或二唾液酸半乳糖基 - 球苷，或测定阴道分泌物样品中是否存在至少一种唾液糖基半乳糖苷 - 甙基或二唾液酸半乳糖苷 - 球苷，并检测唾液糖基半乳糖基 - 甙基中至少一种的存在或不存在 珠糖苷，二唾液酸半乳糖苷 - 球蛋白和延长的球形结构，包含生物有效量的至少一种大肠杆菌细菌受体类似物和药学上可接受的稀释剂，载体或赋形剂的药物以及预防大肠杆菌尿 道感染包括向宿主施用生物有效量的lea 公开了第一大肠杆菌细菌受体或细菌受体类似物。

    Synthesis of Le.sup.x ; dimeric Le.sup.x (difucosyl Y.sub.2 ; III.sup.3 FucV.sup.3 FucnLc.sub.6 Cer); sialylated forms thereof; and analogues thereof
    10.
    发明授权
    Synthesis of Le.sup.x ; dimeric Le.sup.x (difucosyl Y.sub.2 ; III.sup.3 FucV.sup.3 FucnLc.sub.6 Cer); sialylated forms thereof; and analogues thereof 失效
    合成Lex; 二聚Lex（二氟代基Y2; III3FucV3FucnLc6Cer）; 唾液酸化形式; 及其类似物

    公开(公告)号：US5421733A

    公开(公告)日：1995-06-06

    申请号：US705671

    申请日：1991-05-24

    申请人： Edward Nudelman ,  Khalid K. Sadozai ,  Henrik Clausen ,  Sen-itiroh Hakomori ,  Mark Stroud

    发明人： Edward Nudelman ,  Khalid K. Sadozai ,  Henrik Clausen ,  Sen-itiroh Hakomori ,  Mark Stroud

    IPC分类号： C12P19/26 ,  A61K39/00 ,  C12P19/04 ,  C12R1/91 ,  G01N33/574 ,  G01N33/577 ,  C12P19/02

    CPC分类号： C12P19/04

    摘要： A process for preparing difucosyl Y.sub.2 antigen (dimeric Le.sup.x) , said process comprising: (1) preparing a lactonorhexaosylceramide backbone or a lactonorhexaosylsaccharide backbone linked to a carrier molecule; and (2) enzymatically fucosylating said backbone at the III.sup.3 and V.sup.3 positions through an .alpha.1.fwdarw.3 linkage. A process for preparing Le.sup.y antigen analogues, said process comprising: (1) preparing a lactonorhexaosyl-ceramide backbone or a lactonorhexaosylsaccharide backbone linked to a carrier molecule; and (2) enzymatically fucosylating said backbone at the terminal .beta.-Gal through an .alpha.1.fwdarw.2 linkage; and (3) enzymatically fucosylating said backbone at one or more positions through an .alpha.1.fwdarw.3 linkage, provided that steps (2) and (3) can be conducted simultaneously or in any order. A process for preparing a fucosylated lactonorhexaosylceramide, lactonorhexaosylsaccharide linked to a carrier molecule or higher analogues thereof, said process comprising: (1) preparing a lactonorhexaosylceramide backbone, a lactonorhexaosylsaccharide backbone linked to a carrier molecule or backbones of higher analogues thereof; and (2) enzymatically fucosylating one or more residues of said backbone. A process for preparing sialyl Le.sup.x and sialyl dimeric Le.sup.x.

    摘要翻译： 一种制备二氟吗啉Y2抗原（二聚Lex）的方法，所述方法包括：（1）制备与载体分子连接的乳糖六烯酰基神经酰胺主链或乳糖六糖糖主链; 和（2）通过α1-> 3键在III3和V3位置酶解岩藻糖基化所述骨架。 一种制备Ley抗原类似物的方法，所述方法包括：（1）制备与载体分子连接的乳酰六烯酰基 - 神经酰胺主链或乳糖六糖糖主链; 和（2）通过α1-> 2键在末端β-Gal处对所述骨架进行酶促岩藻糖化; 和（3）通过α1-> 3键在一个或多个位置对所述主链进行酶促岩藻糖化，条件是步骤（2）和（3）可以同时或以任何顺序进行。 一种制备岩藻糖基化的乳酰六烯酰基神经酰胺，与载体分子或其更高类似物连接的内酯六糖基糖的方法，所述方法包括：（1）制备乳糖六烯酰基神经酰胺主链，连接于载体分子或其较高类似物的骨架的乳糖六糖糖主链; 和（2）酶促岩藻糖化所述骨架的一个或多个残基。 唾液酸Lex和唾液酸二聚体Lex的制备方法。