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    ANTIVIRAL ACYLSULFONAMIDE DERIVATIVES
    5.
    发明申请
    ANTIVIRAL ACYLSULFONAMIDE DERIVATIVES 审中-公开
    抗病毒酰胺酰胺衍生物

    公开(公告)号：US20100135960A1

    公开(公告)日：2010-06-03

    申请号：US12619974

    申请日：2009-11-17

    申请人： Yat Sun Or ,  Lu Ying ,  Ce Wang ,  Xiaowen Peng ,  Yao-Ling Qiu

    发明人： Yat Sun Or ,  Lu Ying ,  Ce Wang ,  Xiaowen Peng ,  Yao-Ling Qiu

    IPC分类号： A61K38/21 ,  A61K39/00 ,  A61K38/19 ,  A61K31/4439 ,  A61K31/427 ,  A61K31/422 ,  C07D401/02 ,  C07D417/02 ,  C07D413/02 ,  A61P31/14

    CPC分类号： C07D417/14 ,  A61K38/21 ,  C07D231/12 ,  C07D401/12 ,  C07D413/12 ,  C07D417/12 ,  A61K2300/00

    摘要： The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit RNA-containing virus, particularly the hepatitis C virus (HCV). Consequently, the compounds of the present invention interfere with the life cycle of the hepatitis C virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The present invention relates to novel antiviral compounds represented herein above, pharmaceutical compositions comprising such compounds, and methods for the treatment or prophylaxis of viral (particularly HCV) infection in a subject in need of such therapy with said compounds.

    摘要翻译： 本发明公开了式（I）化合物或其药学上可接受的盐，酯或前药：其抑制含RNA病毒，特别是丙型肝炎病毒（HCV）。 因此，本发明的化合物干扰丙型肝炎病毒的生命周期，也可用作抗病毒剂。 本发明还涉及药物组合物，其包含用于给患有HCV感染的受试者施用的上述化合物。 本发明还涉及通过施用包含本发明化合物的药物组合物来治疗受试者的HCV感染的方法。 本发明涉及上文所示的新的抗病毒化合物，包含这些化合物的药物组合物，以及用于治疗或预防需要用所述化合物治疗的受试者中的病毒（特别是HCV）感染的方法。

    Linked dibenzimidazole derivatives
    6.
    发明授权
    Linked dibenzimidazole derivatives 有权
    连接的二苯并咪唑衍生物

    公开(公告)号：US08188132B2

    公开(公告)日：2012-05-29

    申请号：US12702692

    申请日：2010-02-09

    申请人： Yat Sun Or ,  Ce Wang ,  Xiaowen Peng ,  Lu Ying ,  Yao-Ling Qiu

    发明人： Yat Sun Or ,  Ce Wang ,  Xiaowen Peng ,  Lu Ying ,  Yao-Ling Qiu

    IPC分类号： A61K31/4184 ,  C07D403/04 ,  C07D235/14

    CPC分类号： A61K31/4184 ,  A61K31/427 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/496 ,  A61K31/5377 ,  C07D401/14 ,  C07D403/14 ,  C07D405/14 ,  C07D413/14 ,  C07D417/14

    摘要： The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit RNA-containing virus, particularly the hepatitis C virus (HCV). Consequently, the compounds of the present invention interfere with the life cycle of the hepatitis C virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.

    摘要翻译： 本发明公开了式（I）化合物或其药学上可接受的盐，酯或前药：其抑制含RNA病毒，特别是丙型肝炎病毒（HCV）。 因此，本发明的化合物干扰丙型肝炎病毒的生命周期，也可用作抗病毒剂。 本发明还涉及药物组合物，其包含用于给患有HCV感染的受试者施用的上述化合物。 本发明还涉及通过施用包含本发明化合物的药物组合物来治疗受试者的HCV感染的方法。

    NUCLEOSIDE PHOSPHONATE DERIVATIVES
    10.
    发明申请
    NUCLEOSIDE PHOSPHONATE DERIVATIVES 审中-公开
    核苷酸磷酸酯衍生物

    公开(公告)号：US20090274686A1

    公开(公告)日：2009-11-05

    申请号：US12434146

    申请日：2009-05-01

    申请人： Yat Sun Or ,  Lu Ying ,  Xiaowen Peng ,  Ce Wang ,  Yao-Ling Qiu

    发明人： Yat Sun Or ,  Lu Ying ,  Xiaowen Peng ,  Ce Wang ,  Yao-Ling Qiu

    IPC分类号： A61K31/7064 ,  C07H19/20 ,  C07H19/10 ,  A61K31/7076 ,  A61K39/395 ,  A61P35/00 ,  A61P31/12

    CPC分类号： C07H19/10 ,  C07H19/20

    摘要： The present invention discloses compounds of formula (I) or (II), or pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit, preventing or treating abnormal cellular proliferation and/or a viral infection, particularly by HIV, HCV or HBV. Consequently, the compounds of the present invention interfere with the replication cycle of a virus and are also useful as antiviral agents, or interfere with host cellular biochemical process and are also useful as antiproliferative agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from viral infection and/or cell proliferation. The invention also relates to methods of treating a viral infection and/or cell proliferation in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The present invention relates to novel antiviral/anti-proliferative compounds represented herein above, pharmaceutical compositions comprising such compounds, and methods for the treatment or prophylaxis of viral infection in a subject in need of such therapy with said compounds.

    摘要翻译： 本发明公开了式（I）或（II）的化合物或其药学上可接受的盐，酯或前药：其特别是通过HIV，HCV或HBV抑制，预防或治疗异常的细胞增殖和/或病毒感染。 因此，本发明的化合物干扰病毒的复制循环，也可用作抗病毒剂，或干扰宿主细胞生物化学过程，也可用作抗增殖剂。 本发明还涉及药物组合物，其包含用于给患有病毒感染和/或细胞增殖的受试者施用的上述化合物。 本发明还涉及通过施用包含本发明化合物的药物组合物来治疗受试者的病毒感染和/或细胞增殖的方法。 本发明涉及上文所述的新的抗病毒/抗增殖化合物，包含这些化合物的药物组合物，以及用于治疗或预防需要用所述化合物治疗的受试者的病毒感染的方法。