公开(公告)号：US11542508B2

公开(公告)日：2023-01-03

申请号：US16346124

申请日：2017-11-28

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Rotem Sorek ,  Gil Amitai ,  Erez Zohar

IPC: C12N15/63 ,  C12N15/75 ,  C12N15/67 ,  C12N15/90 ,  C07K14/00 ,  C12N7/00 ,  C07K14/005

Abstract: Methods of expressing an expression product of interest are provided. Accordingly there is provided a method comprising introducing into a cell a polynucleotide comprising an AimR responsive element operatively linked to a nucleic acid sequence encoding the expression product of interest, and contacting said cell with an AimP peptide comprising an amino acid sequence of XXXXGG/A, wherein said AimP peptide is capable of binding said AimR polypeptide and dissociating said AimR polypeptide from said AimR responsive element. Also provided are articles of manufacture, isolated peptides, polynucleotides and nucleic acid constructs.

公开(公告)号：US20220031776A1

公开(公告)日：2022-02-03

申请号：US16644641

申请日：2018-09-07

Applicant: Keio University ,  BiomX Ltd. ,  Yeda Research and Development Co. Ltd. at the Weizmann Institute of Science

Inventor： Kenya Honda ,  Koji Atarashi ,  Seiko Narushima ,  Eran Elinav ,  Rotem Sorek ,  Efrat Khabra ,  Hava Ben David ,  Eyal Weinstock ,  Sarah Pollock ,  Yulia Matiuhin ,  Naomi Zak

IPC: A61K35/76 ,  C12N7/00

Abstract: Disclosed herein are bacteriophage compositions and therapeutic uses thereof. The disclosure also relates to bacteriophage that are capable of lysing Klebsiella bacterial strains, e.g., strains that are associated with inflammatory bowel disease, and thereby capable of modulating disease.

公开(公告)号：US10767156B2

公开(公告)日：2020-09-08

申请号：US15030876

申请日：2014-10-14

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Rotem Sorek ,  Hila Sberro ,  Tamara Goldfarb

IPC: C12N1/21 ,  C12N9/10 ,  C12N9/02 ,  C12N9/16 ,  C12N9/48 ,  C12N9/52 ,  C07K14/245 ,  C07K14/32 ,  C07K14/195 ,  C12N1/20 ,  A23C9/123 ,  C12N9/12 ,  C12N9/14 ,  C12N15/52

Abstract: Isolated polynucleotides encoding a BREX system are provided. Accordingly there is provided an isolated polynucleotide encoding a BREX system comprising a nucleic acid sequence encoding the BREX system comprising brxC/pglY, pglZ and at least one of pglX, pglXI, brxP, brxHI, brxHII, brxL, brxD, brxA, brxB, brxF, and brxE, with the proviso that said BREX system does not comprise pglW, and wherein said BREX system confers phage resistance to a bacteria recombinantly expressing same; Also provided is an isolated polynucleotide encoding a BREX system comprising a nucleic acid sequence encoding the BREX system comprising brxC/pglY, pglZ, pglX, pglW and at least one of brxD and brxHI, and wherein said BREX system confers phage resistance to a bacteria recombinantly expressing same. Also provided are compositions and methods for conferring phage resistance to bacteria or for conferring bacterial susceptibility to phages.

公开(公告)号：US20210177920A1

公开(公告)日：2021-06-17

申请号：US16770432

申请日：2018-12-04

Applicant: BIOMX LTD. ,  YEDA RESEARCH AND DEVELOPMENT CO. LTD.

Inventor： Eyal Weinstock ,  Hava Ben-David ,  Kobi Konstantin Sudakov ,  Ayelet Moses ,  Sarah Rachel Pollock ,  Rotem Sorek ,  Naomi Bluma Zak

IPC: A61K35/76 ,  A61K9/00 ,  A61P17/10 ,  A61P31/04 ,  A61K45/06

Abstract: Bacteriophage compositions and therapeutic uses thereof. In particular, compositions of lytic bacteriophages that are capable of lysing Propionibacterium acnes (P. acnes) bacterial strains associated with acne and biofilms, thereby treating or preventing acne and biofilms.

公开(公告)号：US09353359B2

公开(公告)日：2016-05-31

申请号：US14140793

申请日：2013-12-26

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Rotem Sorek ,  Hila Sberro ,  Azita Leavitt

IPC: C07K14/00 ,  C12N9/22 ,  C12N9/12 ,  C07K14/81 ,  A61K38/00

CPC classification number: A61K38/45 ,  A61K38/00 ,  C07K14/8107 ,  C12N9/1241 ,  C12N9/22 ,  C12Y207/07

Abstract: An isolated polypeptide is disclosed comprising an amino acid sequence selected from the group consisting of SEQ ID NOs: 2773-5544 and 11089-11094, wherein the polypeptide has antimicrobial activity. Uses thereof for treating microbial infections are also disclosed.

Abstract translation: 公开了分离的多肽，其包含选自SEQ ID NO：2773-5544和11089-11094的氨基酸序列，其中所述多肽具有抗微生物活性。 还公开了其用于治疗微生物感染的用途。

公开(公告)号：US20240100105A1

公开(公告)日：2024-03-28

申请号：US18481324

申请日：2023-10-05

Applicant: BIOMX LTD. ,  YEDA RESEARCH AND DEVELOPMENT CO. LTD.

Inventor： Eyal Weinstock ,  Hava Ben-David ,  Kobi Konstantin Sudakov ,  Ayelet Moses ,  Sarah Rachel Pollock ,  Rotem Sorek ,  Naomi Bluma Zak

IPC: A61K35/76 ,  A61K9/00 ,  A61K45/06 ,  A61P17/10 ,  A61P31/04

CPC classification number: A61K35/76 ,  A61K9/0014 ,  A61K45/06 ,  A61P17/10 ,  A61P31/04 ,  C12N2795/00032

Abstract: Bacteriophage compositions and therapeutic uses thereof. In particular, compositions of lytic bacteriophages that are capable of lysing Propionibacterium acnes (P. acnes) bacterial strains associated with acne and biofilms, thereby treating or preventing acne and biofilms.