公开(公告)号：US20070105135A1

公开(公告)日：2007-05-10

申请号：US11487164

申请日：2006-07-14

申请人： Yigong Ge ,  Matthew Taylor ,  Eldon Baird ,  Heinz Moser ,  Roland Burli

发明人： Yigong Ge ,  Matthew Taylor ,  Eldon Baird ,  Heinz Moser ,  Roland Burli

IPC分类号： C12Q1/68 ,  C07D417/14

CPC分类号： C07K14/47 ,  A61K31/7052 ,  A61K38/00 ,  C07D417/14 ,  Y02A50/475 ,  Y02A50/481

摘要： Charged compounds are provided that comprise one or more regions of localized positive charge, compositions comprising such compounds, methods of synthesizing such compounds, methods of screening such compounds to identify those having anti-infective activity, and methods of using such compounds to prevent or inhibit infections. These compounds, and compositions containing them, have multiple applications, including use in human and animal medicine and in agriculture.

公开(公告)号：US20060287247A1

公开(公告)日：2006-12-21

申请号：US11446598

申请日：2006-06-02

申请人： Yigong Ge ,  Matthew Taylor ,  Eldon Baird ,  Roland Burli ,  Jacob Kaizerman ,  Amanda Martin ,  Brie Cadman

发明人： Yigong Ge ,  Matthew Taylor ,  Eldon Baird ,  Roland Burli ,  Jacob Kaizerman ,  Amanda Martin ,  Brie Cadman

IPC分类号： A61K38/06 ,  A61K38/05 ,  A61K38/04 ,  C07K5/06 ,  C07K5/04 ,  C07D409/14

CPC分类号： C07D409/14

摘要： Halogen substituted thienyl compounds exhibit potential as nucleic acid (especially double stranded DNA) binders and as antibiotic compounds. A representative thienyl compound has the structure

公开(公告)号：US20060116326A1

公开(公告)日：2006-06-01

申请号：US11001237

申请日：2004-11-30

申请人： Roland Burli ,  Eldon Baird ,  Matthew Taylor ,  Jacob Kaizerman ,  Wenhao Hu

发明人： Roland Burli ,  Eldon Baird ,  Matthew Taylor ,  Jacob Kaizerman ,  Wenhao Hu

IPC分类号： A61K38/05 ,  A61K38/04 ,  A61K31/551 ,  A61K31/55 ,  A61K31/541 ,  A61K31/5377 ,  A61K31/497 ,  A61K31/496 ,  A61K31/506 ,  A61K31/501

CPC分类号： C07D409/14 ,  C07D207/42 ,  C07D217/26 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/14 ,  C07D409/04 ,  C07D413/14 ,  C07D417/04 ,  C07D417/14 ,  C07D495/04

摘要： Benzothiophene compounds such as are DNA binding compounds exhibiting antibacterial activity.

摘要翻译： 苯并噻吩化合物，例如具有抗菌活性的DNA结合化合物。

公开(公告)号：US20060128747A1

公开(公告)日：2006-06-15

申请号：US10523422

申请日：2003-08-01

申请人： Roland Burli ,  Eldon Baird ,  Jacob Kaizerman ,  Dustin McMinn

发明人： Roland Burli ,  Eldon Baird ,  Jacob Kaizerman ,  Dustin McMinn

IPC分类号： A61K31/4741 ,  A61K31/4439 ,  A61K31/4433 ,  A61K31/4436 ,  A61K31/425 ,  A61K31/381 ,  A61K31/343 ,  C07D417/02 ,  C07D491/02 ,  C07D409/02 ,  C07D405/02

CPC分类号： C07D401/12 ,  A61K31/44 ,  C07D307/81 ,  C07D405/12 ,  C07D405/14 ,  C07D409/12 ,  C07D409/14 ,  C07D417/12 ,  C07D417/14

摘要： Aromatic compounds exemplified by exhibit antimicrobial activity.

公开(公告)号：US06683189B1

公开(公告)日：2004-01-27

申请号：US09360344

申请日：1999-07-22

申请人： Peter B. Deryan ,  Eldon Baird

发明人： Peter B. Deryan ,  Eldon Baird

IPC分类号： C07D23102

CPC分类号： C07D403/14 ,  A61K38/00 ,  A61K47/645 ,  C07D207/34 ,  C07D233/90 ,  C07K5/06139 ,  C07K5/06182 ,  C07K7/02 ,  C07K7/04 ,  C08G69/00 ,  C12Q1/6839

摘要： The present invention describes a novel method for the solid phase synthesis of polyamides containing imidazole and pyrrole carboxamides. The polyamides are prepared on a solid support from aromatic carboxylic acids and aromatic amines with high stepwise coupling yields (>99%), providing milligram quantities of highly pure polyamides. The present invention also describes the synthesis of analogs of the natural products Netropsin and Distamycin A, two antiviral antibiotics. The present invention also describes a novel method for the solid phase synthesis of imidazole and pyrrole carboxamide polyamide-oligonucleotide conjugates. This methodology will greatly increase both the complexity and quantity of minor-groove binding polyamides and minor-groove binding polyamide-oligonucleotide conjugates which can be synthesized and tested.

摘要翻译： 本发明描述了一种固相合成含有咪唑和吡咯甲酰胺的聚酰胺的新方法。 聚酰胺在固体载体上由芳族羧酸和芳族胺制备，具有高逐步偶联收率（> 99％），提供毫克量的高纯度聚酰胺。 本发明还描述了天然产物Netropin和Distamycin A的类似物的合成，两种抗病毒抗生素。 本发明还描述了咪唑和吡咯甲酰胺聚酰胺 - 寡核苷酸共轭物的固相合成的新方法。 该方法将大大增加可合成和测试的次槽结合聚酰胺和次槽结合聚酰胺 - 寡核苷酸缀合物的复杂性和数量。

公开(公告)号：US6090947A

公开(公告)日：2000-07-18

申请号：US607078

申请日：1996-02-26

申请人： Peter B. Dervan ,  Eldon Baird

发明人： Peter B. Dervan ,  Eldon Baird

IPC分类号： C12N15/09 ,  A61K38/00 ,  A61K47/48 ,  C07D207/34 ,  C07D233/54 ,  C07D233/90 ,  C07D401/14 ,  C07D403/14 ,  C07D487/22 ,  C07H21/00 ,  C07K1/04 ,  C07K5/078 ,  C07K7/00 ,  C07K7/02 ,  C07K7/04 ,  C07K17/08 ,  C08G69/00 ,  C12Q1/68 ,  C07D231/02 ,  C07D233/04 ,  C07D403/02 ,  C07N19/00 ,  C07N21/02 ,  C07N21/04

CPC分类号： C07D403/14 ,  A61K47/48315 ,  C07D207/34 ,  C07D233/90 ,  C07K5/06139 ,  C07K5/06182 ,  C07K7/02 ,  C07K7/04 ,  C08G69/00 ,  C12Q1/6839 ,  A61K38/00

摘要： The present invention describes a novel method for the solid phase synthesis of polyamides containing imidazole and pyrrole carboxamides. The polyamides are prepared on a solid support from aromatic carboxylic acids and aromatic amines with high stepwise coupling yields (>99%), providing milligram quantities of highly pure polyamides. The present invention also describes the synthesis of analogs of the natural products Netropsin and Distamycin A, two antiviral antibiotics. The present invention also describes a novel method for the solid phase synthesis of imidazole and pyrrole carboxamide polyamide-oligonucleotide conjugates. This methodology will greatly increase both the complexity and quantity of minor-groove binding polyamides and minor-groove binding polyamide-oligonucleotide conjugates which can be synthesized and tested.