公开(公告)号：US20070292443A1

公开(公告)日：2007-12-20

申请号：US11810590

申请日：2007-06-06

申请人： Ying Wang ,  Yingmei Zhang ,  Wenling Han ,  Dalong Ma ,  Yanan Liu ,  Caihua Yin ,  Linjie Tian ,  Dan Li

发明人： Ying Wang ,  Yingmei Zhang ,  Wenling Han ,  Dalong Ma ,  Yanan Liu ,  Caihua Yin ,  Linjie Tian ,  Dan Li

IPC分类号： A61K39/395 ,  A61K38/17 ,  C07K16/46 ,  C07K14/16

CPC分类号： C07K14/521 ,  A61K38/00 ,  C07K16/18 ,  C07K2317/77

摘要： Polypeptides having an amino acid sequence of SEQ ID NO: 2, and having amino acid residues 9 to 27 of SEQ ID NO: 2 are disclosed, which are together named C-terminal polypeptides of CKLF1. Also disclosed is a pharmaceutical composition containing a therapeutically effective amount of the CKLF1 C-terminal polypeptide and pharmaceutically acceptable salts, carrier or excipient. Further disclosed are the polynucleotides encoding the C-terminal polypeptides of CKLF1, and vectors and host cells containing the polynucleotides; the in vitro assays for detecting the expression level of the polypeptide or polynucleotide in a test sample; and the monoclonal or polyclonal antibodies against the polypeptides or active fragments thereof. The polypeptides of the present invention can be pharmaceutically used for treating the HIV infection, allergic disease, allograft rejection, diseases in brain and autoimmune diseases.

摘要翻译： 公开了具有SEQ ID NO：2的氨基酸序列并且具有SEQ ID NO：2的氨基酸残基9至27的多肽，它们共同命名为CKLF1的C末端多肽。 还公开了含有治疗有效量的CKLF1 C末端多肽和药学上可接受的盐，载体或赋形剂的药物组合物。 还公开了编码CKLF1的C末端多肽的多核苷酸，以及含有多核苷酸的载体和宿主细胞; 用于检测测试样品中多肽或多核苷酸的表达水平的体外测定; 以及针对多肽或其活性片段的单克隆或多克隆抗体。 本发明的多肽可以用于治疗HIV感染，过敏性疾病，同种异体移植排斥，脑部疾病和自身免疫性疾病。

公开(公告)号：US07465453B2

公开(公告)日：2008-12-16

申请号：US11810590

申请日：2007-06-06

申请人： Ying Wang ,  Yingmei Zhang ,  Wenling Han ,  Dalong Ma ,  Yanan Liu ,  Caihua Yin ,  Linjie Tian ,  Dan Li

发明人： Ying Wang ,  Yingmei Zhang ,  Wenling Han ,  Dalong Ma ,  Yanan Liu ,  Caihua Yin ,  Linjie Tian ,  Dan Li

IPC分类号： A61K38/10 ,  A61K38/16 ,  C07K14/435 ,  C07K7/08 ,  C07H21/04

CPC分类号： C07K14/521 ,  A61K38/00 ,  C07K16/18 ,  C07K2317/77

摘要： Polypeptides having an amino acid sequence of SEQ ID NO: 2, and having amino acid residues 9 to 27 of SEQ ID NO: 2 are disclosed, which are together named C-terminal polypeptides of CKLF1. Also disclosed is a pharmaceutical composition containing a therapeutically effective amount of the CKLF1 C-terminal polypeptide and pharmaceutically acceptable salts, carrier or excipient. Further disclosed are the polynucleotides encoding the C-terminal polypeptides of CKLF1, and vectors and host cells containing the polynucleotides; the in vitro assays for detecting the expression level of the polypeptide or polynucleotide in a test sample; and the monoclonal or polyclonal antibodies against the polypeptides or active fragments thereof. The polypeptides of the present invention can be pharmaceutically used for treating the HIV infection, allergic disease, allograft rejection, diseases in brain and autoimmune diseases.

摘要翻译： 公开了具有SEQ ID NO：2的氨基酸序列并且具有SEQ ID NO：2的氨基酸残基9至27的多肽，它们共同命名为CKLF1的C末端多肽。 还公开了含有治疗有效量的CKLF1 C末端多肽和药学上可接受的盐，载体或赋形剂的药物组合物。 还公开了编码CKLF1的C末端多肽的多核苷酸，以及含有多核苷酸的载体和宿主细胞; 用于检测测试样品中多肽或多核苷酸的表达水平的体外测定; 以及针对多肽或其活性片段的单克隆或多克隆抗体。 本发明的多肽可以用于治疗HIV感染，过敏性疾病，同种异体移植排斥，脑部疾病和自身免疫性疾病。

公开(公告)号：US06800454B2

公开(公告)日：2004-10-05

申请号：US09801115

申请日：2001-03-07

申请人： Dalong Ma ,  Wenling Han ,  Yingmei Zhang ,  Quansheng Song ,  Chunhui Di ,  Jiaqiang Huang ,  Jian Tang ,  Guanghui Chen

发明人： Dalong Ma ,  Wenling Han ,  Yingmei Zhang ,  Quansheng Song ,  Chunhui Di ,  Jiaqiang Huang ,  Jian Tang ,  Guanghui Chen

IPC分类号： C07H2104

CPC分类号： C07K14/521 ,  A61K38/00

摘要： The present invention provides chemokine-like factor (CKLF) polypeptides with chemotactic and hematopoietic stimulating activities and polynucleotides encoding such polypeptides. Additionally, a method for producing such CKLF polypeptides by recombinant techniques is provided. Also provided are the antibodies and antagonists against such polypeptides. The present invention further disclose a drug compound comprising a therapeutically effective amount of such CKLF polypeptides as well as pharmaceutically acceptable excipients and carriers. Also disclosed are the uses of such CKLF polypeptides and polynucleotides in diagnostics or therapeutics to treat immunodeficiency, hematopoietic diseases and primary tumors.

摘要翻译： 本发明提供具有趋化性和造血刺激活性的趋化因子样因子（CKLF）多肽和编码这些多肽的多核苷酸。 另外，提供了通过重组技术生产这种CKLF多肽的方法。 还提供了抗这种多肽的抗体和拮抗剂。 本发明还公开了包含治疗有效量的这种CKLF多肽以及药学上可接受的赋形剂和载体的药物化合物。 还公开了这样的CKLF多肽和多核苷酸在诊断或治疗中用于治疗免疫缺陷，造血疾病和原发性肿瘤的用途。

公开(公告)号：US20050124043A1

公开(公告)日：2005-06-09

申请号：US10859414

申请日：2004-06-02

申请人： Dalong Ma ,  Wenling Han ,  Yingmei Zhang ,  Quansheng Song ,  Chunhui Di ,  Jiaqiang Huang ,  Jian Tang ,  Guanghui Chen

发明人： Dalong Ma ,  Wenling Han ,  Yingmei Zhang ,  Quansheng Song ,  Chunhui Di ,  Jiaqiang Huang ,  Jian Tang ,  Guanghui Chen

IPC分类号： A61K38/00 ,  C07K14/52 ,  C12N15/19 ,  C07H21/04 ,  C12P21/02

CPC分类号： C07K14/521 ,  A61K38/00

摘要： The present invention provides chemokine-like factor (CKLF) polypeptides with chemotactic and hematopoietic stimulating activities and polynucleotides encoding such polypeptides. Additionally, a method for producing such CKLF polypeptides by recombinant techniques is provided. Also provided are the antibodies and antagonists against such polypeptides. The present invention further disclose a drug compound comprising a therapeutically effective amount of such CKLF polypeptides as well as pharmaceutically acceptable excipients and carriers. Also disclosed are the uses of such CKLF polypeptides and polynucleotides in diagnostics or therapeutics to treat immunodeficiency, hematopoietic diseases and primary tumors.

摘要翻译： 本发明提供具有趋化性和造血刺激活性的趋化因子样因子（CKLF）多肽和编码这些多肽的多核苷酸。 另外，提供了通过重组技术生产这种CKLF多肽的方法。 还提供了抗这种多肽的抗体和拮抗剂。 本发明还公开了包含治疗有效量的这种CKLF多肽以及药学上可接受的赋形剂和载体的药物化合物。 还公开了这样的CKLF多肽和多核苷酸在诊断或治疗中用于治疗免疫缺陷，造血疾病和原发性肿瘤的用途。

公开(公告)号：US07365171B2

公开(公告)日：2008-04-29

申请号：US10859414

申请日：2004-06-02

申请人： Dalong Ma ,  Wenling Han ,  Yingme Zhang ,  Quansheng Song ,  Chunhui Di ,  Jiaqiang Huang ,  Jian Tang ,  Guanghui Chen

发明人： Dalong Ma ,  Wenling Han ,  Yingme Zhang ,  Quansheng Song ,  Chunhui Di ,  Jiaqiang Huang ,  Jian Tang ,  Guanghui Chen

IPC分类号： C07K14/52 ,  C07H21/04 ,  C12P21/04

CPC分类号： C07K14/521 ,  A61K38/00

摘要： The present invention provides chemokine-like factor (CKLF) polypeptides with chemotactic and hematopoietic stimulating activities and polynucleotides encoding such polypeptides. Additionally, a method for producing such CKLF polypeptides by recombinant techniques is provided. Also provided are the antibodies and antagonists against such polypeptides. The present invention further disclose a drug compound comprising a therapeutically effective amount of such CKLF polypeptides as well as pharmaceutically acceptable excipients and carriers. Also disclosed are the uses of such CKLF polypeptides and polynucleotides in diagnostics or therapeutics to treat immunodeficiency, hematopoietic diseases and primary tumors.

摘要翻译： 本发明提供具有趋化性和造血刺激活性的趋化因子样因子（CKLF）多肽和编码这些多肽的多核苷酸。 另外，提供了通过重组技术生产这种CKLF多肽的方法。 还提供了抗这种多肽的抗体和拮抗剂。 本发明还公开了包含治疗有效量的这种CKLF多肽以及药学上可接受的赋形剂和载体的药物化合物。 还公开了这样的CKLF多肽和多核苷酸在诊断或治疗中用于治疗免疫缺陷，造血疾病和原发性肿瘤的用途。