公开(公告)号：US20070292443A1

公开(公告)日：2007-12-20

申请号：US11810590

申请日：2007-06-06

申请人： Ying Wang ,  Yingmei Zhang ,  Wenling Han ,  Dalong Ma ,  Yanan Liu ,  Caihua Yin ,  Linjie Tian ,  Dan Li

发明人： Ying Wang ,  Yingmei Zhang ,  Wenling Han ,  Dalong Ma ,  Yanan Liu ,  Caihua Yin ,  Linjie Tian ,  Dan Li

IPC分类号： A61K39/395 ,  A61K38/17 ,  C07K16/46 ,  C07K14/16

CPC分类号： C07K14/521 ,  A61K38/00 ,  C07K16/18 ,  C07K2317/77

摘要： Polypeptides having an amino acid sequence of SEQ ID NO: 2, and having amino acid residues 9 to 27 of SEQ ID NO: 2 are disclosed, which are together named C-terminal polypeptides of CKLF1. Also disclosed is a pharmaceutical composition containing a therapeutically effective amount of the CKLF1 C-terminal polypeptide and pharmaceutically acceptable salts, carrier or excipient. Further disclosed are the polynucleotides encoding the C-terminal polypeptides of CKLF1, and vectors and host cells containing the polynucleotides; the in vitro assays for detecting the expression level of the polypeptide or polynucleotide in a test sample; and the monoclonal or polyclonal antibodies against the polypeptides or active fragments thereof. The polypeptides of the present invention can be pharmaceutically used for treating the HIV infection, allergic disease, allograft rejection, diseases in brain and autoimmune diseases.

摘要翻译： 公开了具有SEQ ID NO：2的氨基酸序列并且具有SEQ ID NO：2的氨基酸残基9至27的多肽，它们共同命名为CKLF1的C末端多肽。 还公开了含有治疗有效量的CKLF1 C末端多肽和药学上可接受的盐，载体或赋形剂的药物组合物。 还公开了编码CKLF1的C末端多肽的多核苷酸，以及含有多核苷酸的载体和宿主细胞; 用于检测测试样品中多肽或多核苷酸的表达水平的体外测定; 以及针对多肽或其活性片段的单克隆或多克隆抗体。 本发明的多肽可以用于治疗HIV感染，过敏性疾病，同种异体移植排斥，脑部疾病和自身免疫性疾病。

公开(公告)号：US07465453B2

公开(公告)日：2008-12-16

申请号：US11810590

申请日：2007-06-06

申请人： Ying Wang ,  Yingmei Zhang ,  Wenling Han ,  Dalong Ma ,  Yanan Liu ,  Caihua Yin ,  Linjie Tian ,  Dan Li

发明人： Ying Wang ,  Yingmei Zhang ,  Wenling Han ,  Dalong Ma ,  Yanan Liu ,  Caihua Yin ,  Linjie Tian ,  Dan Li

IPC分类号： A61K38/10 ,  A61K38/16 ,  C07K14/435 ,  C07K7/08 ,  C07H21/04

CPC分类号： C07K14/521 ,  A61K38/00 ,  C07K16/18 ,  C07K2317/77

摘要： Polypeptides having an amino acid sequence of SEQ ID NO: 2, and having amino acid residues 9 to 27 of SEQ ID NO: 2 are disclosed, which are together named C-terminal polypeptides of CKLF1. Also disclosed is a pharmaceutical composition containing a therapeutically effective amount of the CKLF1 C-terminal polypeptide and pharmaceutically acceptable salts, carrier or excipient. Further disclosed are the polynucleotides encoding the C-terminal polypeptides of CKLF1, and vectors and host cells containing the polynucleotides; the in vitro assays for detecting the expression level of the polypeptide or polynucleotide in a test sample; and the monoclonal or polyclonal antibodies against the polypeptides or active fragments thereof. The polypeptides of the present invention can be pharmaceutically used for treating the HIV infection, allergic disease, allograft rejection, diseases in brain and autoimmune diseases.

摘要翻译： 公开了具有SEQ ID NO：2的氨基酸序列并且具有SEQ ID NO：2的氨基酸残基9至27的多肽，它们共同命名为CKLF1的C末端多肽。 还公开了含有治疗有效量的CKLF1 C末端多肽和药学上可接受的盐，载体或赋形剂的药物组合物。 还公开了编码CKLF1的C末端多肽的多核苷酸，以及含有多核苷酸的载体和宿主细胞; 用于检测测试样品中多肽或多核苷酸的表达水平的体外测定; 以及针对多肽或其活性片段的单克隆或多克隆抗体。 本发明的多肽可以用于治疗HIV感染，过敏性疾病，同种异体移植排斥，脑部疾病和自身免疫性疾病。

公开(公告)号：US10408200B2

公开(公告)日：2019-09-10

申请号：US14933419

申请日：2015-11-05

申请人： Yanan Liu ,  Dawei Wang

发明人： Yanan Liu ,  Dawei Wang

IPC分类号： F04B9/02 ,  F04B17/03 ,  F04B47/02 ,  E21B43/12

摘要： A vertical pumping unit for pumping oil from a well is disclosed including a vertically oriented frame, an electrically powered motor, a flexible beam connected on a first end to pumping machinery lowered into an oil well hole, a counterweight connected to a second end of the flexible beam and suspended by the frame, and a drum-type deceleration roller cone. The roller cone includes an input shaft receiving torque from the motor, internal reduction machinery, and an output drum translating the flexible beam back and forth to activate a pumping action.

公开(公告)号：USD908283S1

公开(公告)日：2021-01-19

申请号：US29686379

申请日：2019-04-04

申请人： Yanan Liu

设计人： Yanan Liu

公开(公告)号：US20160273323A1

公开(公告)日：2016-09-22

申请号：US14933419

申请日：2015-11-05

申请人： Yanan Liu ,  Dawei Wang

发明人： Yanan Liu ,  Dawei Wang

IPC分类号： E21B43/12 ,  F04B17/03 ,  F04B9/02 ,  F04B47/02

CPC分类号： F04B9/02 ,  E21B43/126 ,  F04B17/03 ,  F04B47/02 ,  F04B47/028

摘要： A vertical pumping unit for pumping oil from a well is disclosed including a vertically oriented frame, an electrically powered motor, a flexible beam connected on a first end to pumping machinery lowered into an oil well hole, a counterweight connected to a second end of the flexible beam and suspended by the frame, and a drum-type deceleration roller cone. The roller cone includes an input shaft receiving torque from the motor, internal reduction machinery, and an output drum translating the flexible beam back and forth to activate a pumping action.

摘要翻译： 公开了一种用于从井中泵送油的垂直泵送单元，包括垂直定向的框架，电动马达，连接在第一端上的泵送机械下降到油井孔中的柔性梁，连接到第二端的配重 柔性梁和由框架悬挂，以及鼓式减速辊锥。 滚子锥体包括从马达接收扭矩的输入轴，内部减速机构以及来回移动柔性梁的输出滚筒以激活泵送动作。

公开(公告)号：US10458214B2

公开(公告)日：2019-10-29

申请号：US16114017

申请日：2018-08-27

申请人： Yanan Liu ,  Dawei Wang

发明人： Yanan Liu ,  Dawei Wang

IPC分类号： E21B43/12 ,  G05B19/05 ,  F04B47/02

摘要： There is provided an oil pumping apparatus including: (1) a connector connected to a device; (2) a top platform; (3) a roller disposed on a top platform; (4) a motor disposed on the top platform; (5) a driven belt to enable synchronous drives to operate the roller; (6) a load belt moveable over the roller, one end of the load belt being connected to the connector, and the other end of the load belt being connected to a balance box to balance the weight of the device; and (7) a control system for the apparatus. When the motor rotates in a clockwise direction, the motor drives the roller rotate in the clockwise direction and the device moves down vertically; and when the motor rotates in an anticlockwise direction, the motor drives the roller rotate in the anticlockwise direction and the device moves up vertically.

公开(公告)号：US09982668B2

公开(公告)日：2018-05-29

申请号：US15239065

申请日：2016-08-17

申请人： Yanan Liu ,  Dawei Wang

发明人： Yanan Liu ,  Dawei Wang

IPC分类号： F04D15/00 ,  F04B47/02 ,  E21B43/12 ,  F04B49/06 ,  F16H19/06

CPC分类号： F04B47/026 ,  E21B43/121 ,  F04B49/065 ,  F16H19/06 ,  F16H35/18

摘要： There is provided an oil pumping apparatus including: a connector; a first roller mounted on a first frame and being rotatable about a first axle, a load belt moveable over the first roller, having one end connected to the connector and having another end connected with a hanging frame; a second roller being mounted with the hanging frame and being rotatable about a second axle; a third roller being mounted on the first frame and being rotatable about a third axle; a driven belt being moveable over the second roller, the driven belt being fixed at one end, and having another end being connected with the third roller; a control system for the apparatus; and a motor.