公开(公告)号：US20070292443A1

公开(公告)日：2007-12-20

申请号：US11810590

申请日：2007-06-06

申请人： Ying Wang ,  Yingmei Zhang ,  Wenling Han ,  Dalong Ma ,  Yanan Liu ,  Caihua Yin ,  Linjie Tian ,  Dan Li

发明人： Ying Wang ,  Yingmei Zhang ,  Wenling Han ,  Dalong Ma ,  Yanan Liu ,  Caihua Yin ,  Linjie Tian ,  Dan Li

IPC分类号： A61K39/395 ,  A61K38/17 ,  C07K16/46 ,  C07K14/16

CPC分类号： C07K14/521 ,  A61K38/00 ,  C07K16/18 ,  C07K2317/77

摘要： Polypeptides having an amino acid sequence of SEQ ID NO: 2, and having amino acid residues 9 to 27 of SEQ ID NO: 2 are disclosed, which are together named C-terminal polypeptides of CKLF1. Also disclosed is a pharmaceutical composition containing a therapeutically effective amount of the CKLF1 C-terminal polypeptide and pharmaceutically acceptable salts, carrier or excipient. Further disclosed are the polynucleotides encoding the C-terminal polypeptides of CKLF1, and vectors and host cells containing the polynucleotides; the in vitro assays for detecting the expression level of the polypeptide or polynucleotide in a test sample; and the monoclonal or polyclonal antibodies against the polypeptides or active fragments thereof. The polypeptides of the present invention can be pharmaceutically used for treating the HIV infection, allergic disease, allograft rejection, diseases in brain and autoimmune diseases.

摘要翻译： 公开了具有SEQ ID NO：2的氨基酸序列并且具有SEQ ID NO：2的氨基酸残基9至27的多肽，它们共同命名为CKLF1的C末端多肽。 还公开了含有治疗有效量的CKLF1 C末端多肽和药学上可接受的盐，载体或赋形剂的药物组合物。 还公开了编码CKLF1的C末端多肽的多核苷酸，以及含有多核苷酸的载体和宿主细胞; 用于检测测试样品中多肽或多核苷酸的表达水平的体外测定; 以及针对多肽或其活性片段的单克隆或多克隆抗体。 本发明的多肽可以用于治疗HIV感染，过敏性疾病，同种异体移植排斥，脑部疾病和自身免疫性疾病。

公开(公告)号：US07465453B2

公开(公告)日：2008-12-16

申请号：US11810590

申请日：2007-06-06

申请人： Ying Wang ,  Yingmei Zhang ,  Wenling Han ,  Dalong Ma ,  Yanan Liu ,  Caihua Yin ,  Linjie Tian ,  Dan Li

发明人： Ying Wang ,  Yingmei Zhang ,  Wenling Han ,  Dalong Ma ,  Yanan Liu ,  Caihua Yin ,  Linjie Tian ,  Dan Li

IPC分类号： A61K38/10 ,  A61K38/16 ,  C07K14/435 ,  C07K7/08 ,  C07H21/04

CPC分类号： C07K14/521 ,  A61K38/00 ,  C07K16/18 ,  C07K2317/77

摘要： Polypeptides having an amino acid sequence of SEQ ID NO: 2, and having amino acid residues 9 to 27 of SEQ ID NO: 2 are disclosed, which are together named C-terminal polypeptides of CKLF1. Also disclosed is a pharmaceutical composition containing a therapeutically effective amount of the CKLF1 C-terminal polypeptide and pharmaceutically acceptable salts, carrier or excipient. Further disclosed are the polynucleotides encoding the C-terminal polypeptides of CKLF1, and vectors and host cells containing the polynucleotides; the in vitro assays for detecting the expression level of the polypeptide or polynucleotide in a test sample; and the monoclonal or polyclonal antibodies against the polypeptides or active fragments thereof. The polypeptides of the present invention can be pharmaceutically used for treating the HIV infection, allergic disease, allograft rejection, diseases in brain and autoimmune diseases.

摘要翻译： 公开了具有SEQ ID NO：2的氨基酸序列并且具有SEQ ID NO：2的氨基酸残基9至27的多肽，它们共同命名为CKLF1的C末端多肽。 还公开了含有治疗有效量的CKLF1 C末端多肽和药学上可接受的盐，载体或赋形剂的药物组合物。 还公开了编码CKLF1的C末端多肽的多核苷酸，以及含有多核苷酸的载体和宿主细胞; 用于检测测试样品中多肽或多核苷酸的表达水平的体外测定; 以及针对多肽或其活性片段的单克隆或多克隆抗体。 本发明的多肽可以用于治疗HIV感染，过敏性疾病，同种异体移植排斥，脑部疾病和自身免疫性疾病。

公开(公告)号：US09751763B2

公开(公告)日：2017-09-05

申请号：US13810051

申请日：2011-04-06

申请人： Dan Li

发明人： Dan Li

IPC分类号： B01D67/00 ,  B01D69/10 ,  B01D71/02 ,  B01J21/18 ,  H01G11/36 ,  H01M4/86 ,  H01M8/02 ,  B32B9/00 ,  C01B31/00 ,  B01D69/14 ,  B01J13/00 ,  B82Y30/00 ,  H01M4/96 ,  H01M8/0234 ,  B01D61/02 ,  H01M4/02

CPC分类号： C01B32/00 ,  B01D61/027 ,  B01D67/0009 ,  B01D67/0079 ,  B01D69/10 ,  B01D69/148 ,  B01D71/021 ,  B01D2323/08 ,  B01D2325/02 ,  B01D2325/10 ,  B01D2325/24 ,  B01D2325/26 ,  B01J13/0052 ,  B01J21/185 ,  B32B9/007 ,  B82Y30/00 ,  H01G11/36 ,  H01M4/8626 ,  H01M4/96 ,  H01M8/0234 ,  H01M2004/023 ,  Y02E60/13 ,  Y10T428/249921

摘要： A gel film or an isolated gel film comprising sheets of graphene or chemically converted graphene at least partially separated by a dispersion medium, such as water, and arranged in a substantially planar manner to form an electrically conductive matrix.

公开(公告)号：US09510764B2

公开(公告)日：2016-12-06

申请号：US12754932

申请日：2010-04-06

申请人： Dan Li ,  David L. Perschbacher ,  Yanting Dong ,  Julie Stephenson

发明人： Dan Li ,  David L. Perschbacher ,  Yanting Dong ,  Julie Stephenson

IPC分类号： A61B5/0464 ,  A61B5/00 ,  A61B5/04 ,  A61N1/362 ,  A61N1/365

CPC分类号： A61B5/0464 ,  A61B5/0006 ,  A61B5/0031 ,  A61B5/04012 ,  A61B5/686 ,  A61N1/3624 ,  A61N1/36592

摘要： An apparatus comprises an implantable cardiac signal sensing circuit configured to provide a sensed depolarization signal from a ventricle and a processor. The processor includes a signal analyzer module and a tachyarrhythmia discrimination module. The signal analyzer module is configured to determine a measure of stability of ventricular (V-V) depolarization intervals using the depolarization signal, and determine a rate of change of the measure of stability. The tachyarrhythmia discrimination module is configured to detect an episode of tachyarrhythmia using the depolarization signal, determine whether the detected tachyarrhythmia is indicative of atrial tachyarrhythmia using the determined rate of change, and provide the determination to a user or process.

摘要翻译： 一种装置包括可植入心脏信号感测电路，其被配置为提供来自心室和处理器的感测去极化信号。 处理器包括信号分析器模块和快速心律失常辨别模块。 信号分析器模块被配置为使用去极化信号来确定心室（V-V）去极化间隔的稳定性的量度，并且确定稳定性测量的变化率。 快速心律失常辨别模块被配置为使用去极化信号来检测快速性心律失常发作，使用确定的变化率确定检测到的快速性心律失常是指示心房快速性心律失常，并且向用户或过程提供确定。

公开(公告)号：US09411503B2

公开(公告)日：2016-08-09

申请号：US12487995

申请日：2009-06-19

申请人： Takuo Ikeda ,  Satoshi Akagawa ,  Satoshi Asai ,  Takashi Kitao ,  Dan Li ,  Kazuto Mugura ,  Makoto Nishimura

发明人： Takuo Ikeda ,  Satoshi Akagawa ,  Satoshi Asai ,  Takashi Kitao ,  Dan Li ,  Kazuto Mugura ,  Makoto Nishimura

IPC分类号： G06F3/041 ,  G06F3/0488

CPC分类号： G06F3/04883

摘要： An information processing device includes: a main unit to be held; a display unit provided on the main unit such that an information display screen is positioned on a front face thereof, to display information on the information display screen; a touch position detection unit to detect a touch position on the information display screen, and generate touch position detection data represented in terms of coordinates based on two axes intersecting at the detected touch position; and a control unit to display predetermined information on the information display screen, in the event of detecting that the touch position on the information display screen is being continually displaced from within a predetermined region on the information display screen in a predetermined first diagonal direction as to two directions following the two axes, based on the touch position detection data generated by the touch position detection unit.

摘要翻译： 一种信息处理装置，包括：待保持的主单元; 显示单元，设置在主单元上，使得信息显示屏幕位于其正面上，以在信息显示屏幕上显示信息; 触摸位置检测单元，用于检测所述信息显示屏幕上的触摸位置，并且生成基于与所检测的触摸位置相交的两个轴线的坐标表示的触摸位置检测数据; 以及控制单元，用于在检测到信息显示屏幕上的触摸位置在预定的第一对角线方向上在信息显示屏幕上的预定区域内不断地移位的情况下，在信息显示屏幕上显示预定信息，以及 基于由触摸位置检测单元生成的触摸位置检测数据，沿着两个轴的两个方向。

公开(公告)号：US09314210B2

公开(公告)日：2016-04-19

申请号：US11151567

申请日：2005-06-13

申请人： Dan Li

发明人： Dan Li

IPC分类号： A61B5/04 ,  A61B5/00 ,  A61B5/0452 ,  A61B5/0464

CPC分类号： A61B5/7264 ,  A61B5/04525 ,  A61B5/0464

摘要： An implantable medical device includes a tachyarrhythmia detection and classification system that classifies tachyarrhythmias based on a morphological analysis of template and arrhythmic waveforms. The morphological analysis takes effect of heart rate on the morphological characteristics of the template and arrhythmic waveforms into consideration. Correlation between morphological features of the template waveform and corresponding morphological features of an arrhythmic waveform provides for the basis for classifying the tachyarrhythmia. In one embodiment, corresponding morphological features are extracted from the template and arrhythmic waveforms at locations determined by the heart rate associated with a detected arrhythmia episode. In another embodiment, weighting factors each being a function of the heart rate are applied to the template and arrhythmic morphological features before a correlation coefficient is calculated.

公开(公告)号：US08886312B2

公开(公告)日：2014-11-11

申请号：US13542261

申请日：2012-07-05

申请人： Yinghong Yu ,  Shibaji Shome ,  Dan Li ,  Michael Gold ,  Jagmeet Singh

发明人： Yinghong Yu ,  Shibaji Shome ,  Dan Li ,  Michael Gold ,  Jagmeet Singh

IPC分类号： A61B5/0456 ,  A61B5/0472 ,  A61N1/365 ,  A61B5/00 ,  A61B5/042 ,  A61N1/368

CPC分类号： A61N1/36592 ,  A61B5/0006 ,  A61B5/0422 ,  A61B5/0456 ,  A61B5/0472 ,  A61B5/686 ,  A61N1/3684

摘要： A system comprises a cardiac signal sensing circuit and a processor circuit. The cardiac signal sensing circuit is configured to sense a cardiac signal segment using a set of electrodes connectable to the cardiac signal sensing circuit. The processor circuit is communicatively coupled to the cardiac signal sensing circuit and includes a peak detector circuit. The peak detector circuit is configured to identify, in the cardiac signal segment, a fiducial indicative of ventricular activation that is local to at least one electrode of the first set of electrodes. The fiducial includes a first large positive or negative peak greater than a specified percentage of a maximum peak of the first cardiac signal segment. The processor circuit is configured to provide an indication of local ventricular activation to at least one of a user or process.

摘要翻译： 一种系统包括心脏信号感测电路和处理器电路。 心脏信号感测电路被配置为使用可连接到心脏信号感测电路的一组电极来感测心脏信号段。 处理器电路通信地耦合到心脏信号感测电路并且包括峰值检测器电路。 峰值检测器电路被配置为在心脏信号段中识别指示心室激活的基准，其对于第一组电极的至少一个电极是局部的。 基准包括大于第一心脏信号段的最大峰值的指定百分比的第一大的正或负峰值。 处理器电路被配置为向用户或过程中的至少一个提供局部心室激活的指示。

公开(公告)号：US08837412B2

公开(公告)日：2014-09-16

申请号：US13536480

申请日：2012-06-28

申请人： Zheng Liang ,  Dan Li ,  Guohua Zhou ,  Lin Hua

发明人： Zheng Liang ,  Dan Li ,  Guohua Zhou ,  Lin Hua

IPC分类号： H04W4/00 ,  H04W72/04 ,  H04W28/04 ,  H04W88/08

CPC分类号： H04W72/0453 ,  H04W28/04 ,  H04W88/08

摘要： Embodiments of the present invention disclose a method and an apparatus for allocating an edge frequency band resource, and a base station. The method may include obtaining, through message interaction, usage information about an edge frequency band resource block of an adjacent mode; according to the usage information about the edge frequency band resource block of the adjacent mode and a characteristic resource block, determining an available edge frequency band resource block that is of the current mode and in a next adjustment period; and in the next adjustment period, allocating a determined available edge frequency band resource block of the current mode to each cell that is corresponding to the current mode.

摘要翻译： 本发明的实施例公开了一种用于分配边缘频带资源的方法和装置以及基站。 该方法可以包括通过消息交互来获得关于相邻模式的边缘频带资源块的使用信息; 根据关于相邻模式的边缘频带资源块的使用信息和特征资源块，确定当前模式的可用边缘频带资源块和下一个调整周期; 并且在下一个调整周期中，将当前模式的确定的可用边缘频带资源块分配给对应于当前模式的每个小区。

公开(公告)号：US08812102B2

公开(公告)日：2014-08-19

申请号：US13467695

申请日：2012-05-09

申请人： Dan Li ,  Amy Jean Brisben

发明人： Dan Li ,  Amy Jean Brisben

IPC分类号： A61N1/39 ,  A61N1/365

CPC分类号： A61N1/36507 ,  A61N1/36578 ,  A61N1/36585 ,  A61N1/3956

摘要： An apparatus comprises a cardiac signal sensing circuit, a physiologic sensor circuit configured to provide a physiologic sensor signal representative of mechanical cardiac activity, a therapy circuit, and a control circuit. The control circuit includes a cardiac depolarization detection circuit, a tachyarrhythmia detection circuit, and a timer circuit. A time interval between a mechanical cardiac event and a detected fiducial electrical cardiac event is monitored. The control circuit is configured to correct the monitored time interval for variation with heart rate to form a corrected electromechanical time interval, initiate anti-tachyarrhythmia therapy when the corrected electromechanical time interval satisfies a specified time interval threshold value during a detected episode of tachyarrhythmia, and withhold anti-tachyarrhythmia therapy otherwise.

摘要翻译： 一种装置包括心脏信号感测电路，生理传感器电路，其被配置为提供表示机械心脏活动的生理传感器信号，治疗电路和控制电路。 控制电路包括心脏去极化检测电路，快速心律失常检测电路和定时器电路。 监测机械心脏事件与检测到的基准电心脏事件之间的时间间隔。 控制电路被配置为校正所监视的心率变化的时间间隔，以形成校正的机电时间间隔，当校正的机电时间间隔在检测到的快速性心律失常发作期间满足规定的时间间隔阈值时启动抗慢性心律失常治疗，以及 否则禁止抗快速性心律失常治疗。

公开(公告)号：US08712507B2

公开(公告)日：2014-04-29

申请号：US11643220

申请日：2006-12-21

申请人： Shelley Cazares ,  Aaron McCabe ,  Alok Sathaye ,  Dan Li

发明人： Shelley Cazares ,  Aaron McCabe ,  Alok Sathaye ,  Dan Li

IPC分类号： A61B5/04

CPC分类号： A61B5/0464 ,  A61B5/726

摘要： Methods and systems for arranging and labeling cardiac episodes based on acquired cardiac episode data are described. Cardiac episodes are algorithmically arranged based on one or more discriminating features of the episode data. A user is presented with at least one episode selected from the arrangement of cardiac episodes. The user inputs a label that characterizes the selected episode. The label is algorithmically appended to the data of the selected episode and to other episodes of the arrangement of cardiac episodes based on the discriminating features.

摘要翻译： 描述了基于获得性心脏病发作数据来安排和标记心脏发作的方法和系统。 基于事件数据的一个或多个鉴别特征，算术地布置心脏事件。 向用户呈现从心脏发作的排列中选出的至少一个情节。 用户输入表征所选剧集的标签。 基于鉴别特征，标签被算法地附加到所选事件的数据和心脏发作的安排的其他发作。