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    Composition containing total triterpenoid sapogenins extracted from bamboo, and the preparation method and use thereof
    1.
    发明授权
    Composition containing total triterpenoid sapogenins extracted from bamboo, and the preparation method and use thereof 有权
    含有从竹提取的总三萜皂苷元的组合物及其制备方法和用途

    公开(公告)号：US07811997B2

    公开(公告)日：2010-10-12

    申请号：US10538463

    申请日：2003-04-28

    申请人： Ying Zhang ,  Xiaoqin Wu ,  Zhuoyu Yu ,  Yunlong Zhu ,  Lingen Chen ,  Shenggen Lou

    发明人： Ying Zhang ,  Xiaoqin Wu ,  Zhuoyu Yu ,  Yunlong Zhu ,  Lingen Chen ,  Shenggen Lou

    IPC分类号： A01N45/00 ,  A61K31/704 ,  A61K36/899 ,  C07H15/24

    CPC分类号： A61K36/899 ,  A61K31/704 ,  B01D11/0203 ,  B01D11/0288

    摘要： The invention relates to a composition containing total triterpenoid sapogenins extracted from bamboo, the preparation method and use thereof. These total triterpenoid sapogenins are extracted from many parts of bamboo such as bamboo shavings in Gramineae by CO2 Supercritical Fluid Extraction technique. In the extract, the content of total triterpenoid sapogenins is 10-90%, while the contents of friedelin and lupenone are 5-35% and 1-10%, respectively. The extract in the invention has good physiological and pharmacological activities such as anti-free radical, anti-oxidation, anti-tumor and anti-hypertension. It can be used in medicines or functional foods for the treatment or prevention of cardiovascular and cerebrovascular diseases and tumor. It is also useful in cosmetics field.

    摘要翻译： 本发明涉及一种含有从竹提取的总三萜皂苷元的组合物，其制备方法和用途。 这些总三萜皂甙元通过二氧化碳超临界流体萃取技术从禾本科的竹叶等多种部分中提取出来。 在提取物中，三萜皂甙元总含量为10-90％，而脂蛋白和鲁蛋白含量分别为5-35％和1-10％。 本发明提取物具有抗自由基，抗氧化，抗肿瘤，抗高血压等良好的生理，药理活性。 可用于药物或功能性食品，用于治疗或预防心血管和脑血管疾病和肿瘤。 在化妆品领域也很有用。

    Composition containing total triterpenoid saponins extracted from bamboo, and the preparation method and use thereof
    2.
    发明申请
    Composition containing total triterpenoid saponins extracted from bamboo, and the preparation method and use thereof 有权
    含有从竹提取的总三萜皂苷的组合物及其制备方法和用途

    公开(公告)号：US20060148733A1

    公开(公告)日：2006-07-06

    申请号：US10538463

    申请日：2003-04-28

    申请人： Ying Zhang ,  Xiaoqin Wu ,  Zhuoyu Yu ,  Yunlong Zhu ,  Lingen Chen ,  Shenggen Lou

    发明人： Ying Zhang ,  Xiaoqin Wu ,  Zhuoyu Yu ,  Yunlong Zhu ,  Lingen Chen ,  Shenggen Lou

    IPC分类号： A61K31/704 ,  A61K36/899 ,  C07H15/24

    CPC分类号： A61K36/899 ,  A61K31/704 ,  B01D11/0203 ,  B01D11/0288

    摘要： The invention relates to a composition containing total triterpenoid sapogenins extracted from bamboo, the preparation method and use thereof. These total triterpenoid sapogenins are extracted from many parts of bamboo such as bamboo shavings in Gramineae by CO2 Supercritical Fluid Extraction technique. In the extract, the content of total triterpenoid sapogenins is 10-90%, while the contents of friedelin and lupenone are 5-35% and 1-10%, respectively. The extract in the invention has good physiological and pharmacological activities such as anti-free radical, anti-oxidation, anti-tumor and anti-hypertension. It can be used in medicines or functional foods for the treatment or prevention of cardiovascular and cerebrovascular diseases and tumor. It is also useful in cosmetics field.

    摘要翻译： 本发明涉及一种含有从竹提取的总三萜皂苷元的组合物，其制备方法和用途。 这些总三萜皂甙元通过CO 2超临界流体提取技术从竹子的许多部分中提取，例如禾本科的竹刨。 在提取物中，三萜皂甙元总含量为10-90％，而脂蛋白和鲁蛋白含量分别为5-35％和1-10％。 本发明提取物具有抗自由基，抗氧化，抗肿瘤，抗高血压等良好的生理，药理活性。 可用于药物或功能性食品，用于治疗或预防心血管和脑血管疾病和肿瘤。 在化妆品领域也很有用。

    Antioxidant of Bamboo Leaves and Its Uses
    3.
    发明申请
    Antioxidant of Bamboo Leaves and Its Uses 审中-公开
    竹叶抗氧化及其用途

    公开(公告)号：US20080233242A1

    公开(公告)日：2008-09-25

    申请号：US10575007

    申请日：2004-10-08

    申请人： Ying Zhang ,  Xiaoqin Wu ,  Zhuoyu Yu ,  Dingding Luo ,  Boyi Lu ,  Yu Zhang

    发明人： Ying Zhang ,  Xiaoqin Wu ,  Zhuoyu Yu ,  Dingding Luo ,  Boyi Lu ,  Yu Zhang

    IPC分类号： A23L3/3463 ,  A23L1/302 ,  C07D311/30 ,  C07D311/08 ,  C07C69/732 ,  C07C59/52

    CPC分类号： C07C69/734 ,  A23L2/44 ,  A23L2/52 ,  A23L33/10 ,  A23L33/105 ,  A23V2002/00 ,  C07C59/52 ,  C07C59/64 ,  C07C2601/14 ,  C07D311/08 ,  C07D311/30 ,  A23V2200/02 ,  A23V2250/21 ,  A23V2250/2116 ,  A23V2250/2132 ,  A23V2250/028

    摘要： The present invention discloses the composition of antioxidant of bamboo leaves (AOB) and its use. The purpose of present invention is to provide a new food additive which is natural, nutritional, and muti-functional, and which is of rich resources, safety, good effect, and low cost. AOB is yellow or brown powders or particles obtained from bamboo leaves, wherein the main antioxidative components include flavones, lactones, phenolic acids. AOB can either inhibit lipid autoxidation chain reaction, or chelate transitional metal ions, and can be used as primary and second antioxidant. AOB can eliminate nitrite and inhibit the synthesis of N-nitrosamine, and has anti-bacteria, bacteriostatic, deodorizing, aroma enhancing etc. functions. AOB can be commonly used in oil-containing food, meat product, fishery product, expanded food etc. food systems.

    摘要翻译： 本发明公开了竹叶抗氧化剂（AOB）的组成及其用途。 本发明的目的是提供一种天然，营养，多功能的新型食品添加剂，其资源丰富，安全性好，效果好，成本低。 AOB是从竹叶获得的黄色或褐色粉末或颗粒，其中主要的抗氧化成分包括黄酮，内酯，酚酸。 AOB可以抑制脂质自氧化链反应或螯合过渡金属离子，并可用作一级和二级抗氧化剂。 AOB可以消除亚硝酸盐并抑制N-亚硝胺的合成，具有抗菌，抑菌，除臭，香气增强等功能。 AOB可以常用于含油食品，肉制品，渔业产品，膨化食品等食品系统。

    USE OF BAMBOO LEAF TOTAL FLAVONES IN THE PREPARATION OF MEDICINE AND HEALTH FOOD FOR PREVENTION AND TREATMENT OF PROSTATIC DISEASES
    5.
    发明申请
    USE OF BAMBOO LEAF TOTAL FLAVONES IN THE PREPARATION OF MEDICINE AND HEALTH FOOD FOR PREVENTION AND TREATMENT OF PROSTATIC DISEASES 审中-公开
    在制备药物和健康食品中用于预防和治疗前列腺疾病的BAMBOO叶叶总黄酮的应用

    公开(公告)号：US20100316677A1

    公开(公告)日：2010-12-16

    申请号：US10558130

    申请日：2004-05-24

    申请人： Ying Zhang ,  Xiaoqin Wu ,  Yonghua Zhang ,  Huafang Cai ,  Boyi Lu

    发明人： Ying Zhang ,  Xiaoqin Wu ,  Yonghua Zhang ,  Huafang Cai ,  Boyi Lu

    IPC分类号： A61K9/00 ,  A61K36/899

    CPC分类号： A61K36/899 ,  A61K31/352

    摘要： This invention discloses the new uses of Lophatherum Total Flavones in medical, pharmaceutical, and healthcare fields. Lophatherum Total Flavones have effects of anti-bacteria, inhibiting bacteria, anti-inflammation, anti-prostatic hyperplasia, anti-platelet aggregation, anti-tumor, and promotion of immunity, etc., with safety and without toxicity, suitable for chronic oral administration, and especially suitable for prevention and treatment of senile chronic degenerative diseases; Lophatherum Total Flavones may be used in fields of pharmaceutical and foods, as a natural drug for prevention and treatment of prostatitis, prostatic hyperplasia, and prostate cancer, or as a dietary supplement.

    摘要翻译： 本发明公开了Lophatherum总黄酮在医药，医药和保健领域的新用途。 枸杞总黄酮具有抗菌，抑菌，抗炎，抗前列腺增生，抗血小板聚集，抗肿瘤，促进免疫等功效，安全无毒，适合慢性口服 特别适用于老年慢性退行性疾病的预防和治疗; Lophatherum总黄酮可用于制药和食品领域，作为预防和治疗前列腺炎，前列腺增生和前列腺癌的天然药物，或作为膳食补充剂。

    RECOMBINANT ANTIBODIES TO PROGRAMMED DEATH 1 (PD-1) AND USES THEREFOR
    8.
    发明申请
    RECOMBINANT ANTIBODIES TO PROGRAMMED DEATH 1 (PD-1) AND USES THEREFOR 审中-公开

    公开(公告)号：US20200062847A1

    公开(公告)日：2020-02-27

    申请号：US16488667

    申请日：2017-03-04

    申请人： Ying ZHANG ,  Xiangtan Tenghua Bioscience

    发明人： Ying Zhang

    IPC分类号： C07K16/28

    摘要： Provided are monoclonal antibody, particularly rabbit recombinant antibody, which specifically binds to human PD-1 with biological functions and super high affinity, and methods of use. In various embodiments, the antibodies are fully humanized antibodies that bind to human PD-1. Nucleic acid molecules encoding the antibodies and methods for expressing the antibodies are also provided. In some embodiments, the antibodies are useful for inhibiting or neutralizing PD-1 activity, thus providing a means of treating, preventing and/or diagnosing a disease or disorder such as cancer or a viral infection.