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1.发明授权Methods for identifying compounds that inhibit ubiquitin-mediated proteolysis of iκb 失效用于鉴定抑制泛素介导的ikappab蛋白水解的化合物的方法公开(公告)号：US06905836B2
公开(公告)日：2005-06-14
申请号：US10361394
申请日：2003-02-10
申请人： Yinon Ben-Neriah , Irit Alkalay-Snir , Ada Hatzubai , Etti Ben Shushan , Matti Davis , Avraham Yaron
发明人： Yinon Ben-Neriah , Irit Alkalay-Snir , Ada Hatzubai , Etti Ben Shushan , Matti Davis , Avraham Yaron
CPC分类号： C12N9/93 , C07K14/4738 , C12Q1/25
摘要： Compounds that inhibit ubiquitin-mediated proteolysis of phosphorylated IκB by interfering, directly or indirectly, with the ability of β-TrCP/E3RS to engage in protein-protein association involving hnRNP-U, are useful as drugs for treating conditions associated with NF-κB activation. Cellular and non-cellular screening methods for identifying such compounds are based on monitoring the association/dissociation of β-TrCP/E3RS.
摘要翻译： 通过直接或间接干扰β-TrCP / E3RS参与涉及hnRNP-U的蛋白质 - 蛋白质结合的能力来抑制泛素介导的磷酸化IkappaB蛋白水解的化合物可用作治疗与NF-κB相关的病症的药物 激活。 用于鉴定这些化合物的细胞和非细胞筛选方法是基于监测β-TrCP / E3RS的缔合/解离。
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公开(公告)号：US08263326B2
公开(公告)日：2012-09-11
申请号：US12189048
申请日：2008-08-08
申请人： Anthony M. Manning , Frank Mercurio , Sharon Amit , Yinon Ben-Neriah , Matti Davis , Ada Hatzubai , Avraham Yaron , Irit Alkalay , Aaron Ciechanover
发明人： Anthony M. Manning , Frank Mercurio , Sharon Amit , Yinon Ben-Neriah , Matti Davis , Ada Hatzubai , Avraham Yaron , Irit Alkalay , Aaron Ciechanover
CPC分类号： C12N9/93 , A61K38/00 , C12Y603/02019
摘要： Compositions and methods for modulating the activation of nuclear factor κB (NF-κB) are provided. The compositions comprise one or more agents that modulate ubiquitination of phosphorylated IκBα and/or IκBβ. Such compositions may be used for treating diseases associated with NF-κB activation. Modulating agents include human E3 ubiquitin ligases, antibodies thereto and variants thereof, as well as related proteins.
摘要翻译： 提供用于调节核因子激活的组合物和方法B（NF-κB）。 所述组合物包含一种或多种调节磷酸化Iα和Bα和/或I＆Kgr; B＆bgr的泛素化的试剂。 此类组合物可用于治疗与NF-κB活化相关的疾病。 调节剂包括人E3泛素连接酶，抗体及其变体，以及相关蛋白质。
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公开(公告)号：US07414120B2
公开(公告)日：2008-08-19
申请号：US11698848
申请日：2007-01-25
申请人： Anthony M. Manning , Frank Mercurio , Sharo Amit , Yinon Ben-Neriah , Matti Davis , Ada Hatzubai , Avraham Yaron , Irit Alkalay , Aaron Ciechanover
发明人： Anthony M. Manning , Frank Mercurio , Sharo Amit , Yinon Ben-Neriah , Matti Davis , Ada Hatzubai , Avraham Yaron , Irit Alkalay , Aaron Ciechanover
CPC分类号： C12N9/93 , A61K38/00 , C12Y603/02019
摘要： Compositions and methods for modulating the activation of nuclear factor κB (NF-κB) are provided. The compositions comprise one or more agents that modulate ubiquitination of phosphorylated IκBα and/or IκBβ. Such compositions may be used for treating diseases associated with NF-κB activation. Modulating agents include human E3 ubiquitin ligases, antibodies thereto and variants thereof, as well as related proteins.
摘要翻译： 提供了调节核因子κB（NF-κB）活化的组成和方法。 组合物包含一种或多种调节磷酸化IkappaBalpha和/或IkappaBβ的泛素化的试剂。 这样的组合物可用于治疗与NF-κB活化相关的疾病。 调节剂包括人E3泛素连接酶，抗体及其变体，以及相关蛋白质。
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公开(公告)号：US20090233855A1
公开(公告)日：2009-09-17
申请号：US12189048
申请日：2008-08-08
申请人： Anthony M. MANNING , Frank Mercurio , Sharon Amit , Yinon Ben-Neriah , Matti Davis , Ada Hatzubai , Avraham Yaron , Irit Alkalay , Aaron Ciechanover
发明人： Anthony M. MANNING , Frank Mercurio , Sharon Amit , Yinon Ben-Neriah , Matti Davis , Ada Hatzubai , Avraham Yaron , Irit Alkalay , Aaron Ciechanover
CPC分类号： C12N9/93 , A61K38/00 , C12Y603/02019
摘要： Compositions and methods for modulating the activation of nuclear factor κB (NF-κB) are provided. The compositions comprise one or more agents that modulate ubiquitination of phosphorylated IκBα and/or IκBβ Such compositions may be used for treating diseases associated with NF-κB activation. Modulating agents include human E3 ubiquitin ligases, antibodies thereto and variants thereof, as well as related proteins.
摘要翻译： 提供了调节核因子κB（NF-κB）活化的组成和方法。 组合物包含调节磷酸化IkappaBalpha和/或IkappaBβ的泛素化的一种或多种试剂。该组合物可用于治疗与NF-κB活化相关的疾病。 调节剂包括人E3泛素连接酶，抗体及其变体，以及相关蛋白质。
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公开(公告)号：US06656713B2
公开(公告)日：2003-12-02
申请号：US09832161
申请日：2001-04-09
申请人： Anthony M. Manning , Frank Mercurio , Sharon Amit , Yinon Ben-Neriah , Matti Davis , Ada Hatzubai , Avraham Yaron , Irit Alkalay , Aaron Ciechanover
发明人： Anthony M. Manning , Frank Mercurio , Sharon Amit , Yinon Ben-Neriah , Matti Davis , Ada Hatzubai , Avraham Yaron , Irit Alkalay , Aaron Ciechanover
IPC分类号： C12N900
CPC分类号： C12N9/93 , A61K38/00 , C12Y603/02019
摘要： Compositions and methods for modulating the activation of nuclear factor &kgr;B (NF-&kgr;B) are provided. The compositions comprise one or more agents that modulate ubiquitination of phosphorylated I&kgr;B&agr; and/or I&kgr;B&bgr;. Such compositions may be used for treating diseases associated with NF-&kgr;B activation. Modulating agents include human E3 ubiquitin ligases, antibodies thereto and variants thereof, as well as related proteins.
摘要翻译： 提供了调节核因子κB（NF-κB）活化的组成和方法。 组合物包含一种或多种调节磷酸化IkappaBalpha和/或IkappaBβ的泛素化的试剂。 这样的组合物可用于治疗与NF-κB活化相关的疾病。 调节剂包括人E3泛素连接酶，抗体及其变体，以及相关蛋白质。
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公开(公告)号：US20070208167A1
公开(公告)日：2007-09-06
申请号：US11698848
申请日：2007-01-25
申请人： Anthony Manning , Frank Mercurio , Sharon Amit , Yinon Ben-Neriah , Matti Davis , Ada Hatzubai , Avraham Yaron , Irit Alkalay , Aaron Ciechanover
发明人： Anthony Manning , Frank Mercurio , Sharon Amit , Yinon Ben-Neriah , Matti Davis , Ada Hatzubai , Avraham Yaron , Irit Alkalay , Aaron Ciechanover
IPC分类号： C07H21/04
CPC分类号： C12N9/93 , A61K38/00 , C12Y603/02019
摘要： Compositions and methods for modulating the activation of nuclear factor κB (NF-κB) are provided. The compositions comprise one or more agents that modulate ubiquitination of phosphorylated IκBα and/or IκBβ. Such compositions may be used for treating diseases associated with NF-κB activation. Modulating agents include human E3 ubiquitin ligases, antibodies thereto and variants thereof, as well as related proteins.
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公开(公告)号：US07186503B2
公开(公告)日：2007-03-06
申请号：US10665715
申请日：2003-09-19
申请人： Anthony M. Manning , Frank Mercurio , Sharo Amit , Yinon Ben-Neriah , Matti Davis , Ada Hatzubai , Avraham Yaron , Irit Alkalay , Aaron Ciechanover
发明人： Anthony M. Manning , Frank Mercurio , Sharo Amit , Yinon Ben-Neriah , Matti Davis , Ada Hatzubai , Avraham Yaron , Irit Alkalay , Aaron Ciechanover
CPC分类号： C12N9/93 , A61K38/00 , C12Y603/02019
摘要： Compositions and methods for modulating the activation of nuclear factor κB (NF-κB) are provided. The compositions comprise one or more agents that modulate ubiquitination of phosphorylated IκBα and/or IκBβ. Such compositions may be used for treating diseases associated with NF-κB activation. Modulating agents include human E3 ubiquitin ligases, antibodies thereto and variants thereof, as well as related proteins.
摘要翻译： 提供了调节核因子κB（NF-κB）活化的组成和方法。 组合物包含一种或多种调节磷酸化IkappaBalpha和/或IkappaBβ的泛素化的试剂。 这样的组合物可用于治疗与NF-κB活化相关的疾病。 调节剂包括人E3泛素连接酶，抗体及其变体，以及相关蛋白质。
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8.发明授权
公开(公告)号：US5932425A
公开(公告)日：1999-08-03
申请号：US802322
申请日：1997-02-18
申请人： Irit Alkalay , Yinon Ben-Neriah , Aaron Ciechanover , Anthony Manning , Frank Mercurio , Avraham Yaron
发明人： Irit Alkalay , Yinon Ben-Neriah , Aaron Ciechanover , Anthony Manning , Frank Mercurio , Avraham Yaron
IPC分类号： C12N15/09 , A61K38/00 , A61K45/00 , A61P29/00 , A61P31/12 , A61P35/00 , A61P37/06 , C07K14/47 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/12 , C12Q1/02 , G01N33/53 , A01N37/18 , C12Q1/00
CPC分类号： C07K14/4702 , A61K38/00
摘要： Compositions and methods for modulating the activation of nuclear factor .kappa.B (NF-.kappa.B) are provided. The compositions comprise one or more agents that modulate ubiquitination of phosphorylated I.kappa.B.alpha. and/or I.kappa.B.beta.. Such compositions may be used for treating diseases associated with NF-.kappa.B activation. Modulating agents include peptides that comprise a recognition domain for E3 ubiquitin ligase.
摘要翻译： 提供了调节核因子κB（NF-κB）活化的组合物和方法。 组合物包含一种或多种调节磷酸化IκBα和/或IκBβ的泛素化的试剂。 这样的组合物可用于治疗与NF-κB活化相关的疾病。 调节剂包括构成E3泛素连接酶识别结构域的肽。
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