公开(公告)号：US20060035296A1

公开(公告)日：2006-02-16

申请号：US11051178

申请日：2005-02-03

申请人： Yoichi Taya ,  Katsuyuki Tamai ,  Toshiaki Miyazaki

发明人： Yoichi Taya ,  Katsuyuki Tamai ,  Toshiaki Miyazaki

IPC分类号： G01N33/537 ,  A61K31/665 ,  G01N33/53 ,  G01N33/543

CPC分类号： C12Q1/48 ,  C07K16/18 ,  G01N2500/02 ,  Y10S435/81 ,  Y10S435/814 ,  Y10S435/969 ,  Y10S435/975 ,  Y10S436/80 ,  Y10S436/805 ,  Y10S436/815 ,  Y10S436/823

摘要： A method for simply and conveniently detecting acetyltransferase and deacetylase activities of proteins by executing an acetylation reaction of a peptide substrate with an acetyltransferase, or a deacetylation reaction of an acetylated peptide substrate with a deacetylase, and after the completion of these reactions, detecting the acetyl group bound to the peptide substrate by using an anti-acetylated peptide antibody. This system for detecting acetyltransferase and deacetylase activities using the anti-acetylated peptide antibody enables screening inhibitors or enhancers of acetyltransferase and deacetylase. A system for screening deacetylase inhibitors or acetyltransferase enhancers using cultured cells is also provided.

摘要翻译： 通过执行肽底物与乙酰转移酶的乙酰化反应或乙酰化肽底物与脱乙酰酶的脱乙酰化反应来简单且方便地检测蛋白质的乙酰转移酶和脱乙酰酶活性的方法，并且在这些反应完成后，检测乙酰基 基团通过使用抗乙酰化肽抗体与肽底物结合。 使用抗乙酰化肽抗体检测乙酰转移酶和脱乙酰酶活性的该系统能够筛选乙酰转移酶和脱乙酰酶的抑制剂或增强子。 还提供了使用培养的细胞筛选脱乙酰酶抑制剂或乙酰转移酶增强子的系统。

公开(公告)号：US06884597B1

公开(公告)日：2005-04-26

申请号：US09618424

申请日：2000-07-18

申请人： Yoichi Taya ,  Katsuyuki Tamai ,  Toshiaki Miyazaki

发明人： Yoichi Taya ,  Katsuyuki Tamai ,  Toshiaki Miyazaki

IPC分类号： C07K16/18 ,  C12Q1/48 ,  G01N33/53 ,  G01N33/543

CPC分类号： C12Q1/48 ,  C07K16/18 ,  G01N2500/02 ,  Y10S435/81 ,  Y10S435/814 ,  Y10S435/969 ,  Y10S435/975 ,  Y10S436/80 ,  Y10S436/805 ,  Y10S436/815 ,  Y10S436/823

摘要： A method for simply and conveniently detecting acetyltransferase and deacetylase activities of proteins by executing an acetylation reaction of a peptide substrate with an acetyltransferase, or a deacetylation reaction of an acetylated peptide substrate with a deacetylase, and after the completion of these reactions, detecting the acetyl group bound to the peptide substrate by using an anti-acetylated peptide antibody. This system for detecting acetyltransferase and deacetylase activities using the anti-acetylated peptide antibody enables screening inhibitors or enhancers of acetyltransferase and deacetylase. A system for screening deacetylase inhibitors or acetyltransferase enhancers using cultured cells is also provided.

摘要翻译： 通过执行肽底物与乙酰转移酶的乙酰化反应或乙酰化肽底物与脱乙酰酶的脱乙酰化反应来简单且方便地检测蛋白质的乙酰转移酶和脱乙酰酶活性的方法，并且在这些反应完成后，检测乙酰基 基团通过使用抗乙酰化肽抗体与肽底物结合。 使用抗乙酰化肽抗体检测乙酰转移酶和脱乙酰酶活性的该系统能够筛选乙酰转移酶和脱乙酰酶的抑制剂或增强子。 还提供了使用培养的细胞筛选脱乙酰酶抑制剂或乙酰转移酶增强子的系统。

公开(公告)号：US5012283A

公开(公告)日：1991-04-30

申请号：US466674

申请日：1990-01-17

申请人： Mamoru Shimono ,  Tomoyuki Asada ,  Taiichi Kawaguchi ,  Yoichi Taya ,  Kouji Yukinaga ,  Susumu Nomura ,  Hajime Tagawa

发明人： Mamoru Shimono ,  Tomoyuki Asada ,  Taiichi Kawaguchi ,  Yoichi Taya ,  Kouji Yukinaga ,  Susumu Nomura ,  Hajime Tagawa

IPC分类号： G03G15/04 ,  G03G15/047 ,  G03G21/00 ,  G03G21/06 ,  G03G21/08

CPC分类号： G03G21/08 ,  G03G15/04036 ,  G03G15/0435

摘要： A copying apparatus includes a housing in which are arranged an image carrier and an exposure unit both for emitting light to an original placed on the original stand to form an electrostatic latent image on the image carrier and for emitting light to the image carrier to erase the electrostatic latent image. The exposure unit includes a lamp having light emitting portions and non-light emitting portions which are alternately connected together. A reflector is located around the lamp and directs the light emitted from the lamp toward the original. The reflector has a plurality of openings formed to face the lamp, so that part of the light emitted from the lamp passes through the openings and is directed to the image carrier. The reflector has a plurality of connecting portions facing the non-light-emitting portions and located between adjacent ones of the openings.

摘要翻译： 一种复印装置，包括：外壳，其中布置有图像载体和曝光单元，用于将光发射到放置在原稿台上的原稿，以在图像载体上形成静电潜像，并向图像载体发射光以擦除 静电潜像。 曝光单元包括具有交替连接在一起的发光部分和非发光部分的灯。 反射器位于灯周围，并将从灯发出的光引导到原稿。 反射器具有形成为面对灯的多个开口，使得从灯发射的光的一部分通过开口并被引导到图像载体。 反射器具有面对非发光部分并且位于相邻的开口之间的多个连接部分。

公开(公告)号：US20050232912A1

公开(公告)日：2005-10-20

申请号：US10490454

申请日：2002-09-25

申请人： Yoichi Taya ,  Tomoaki Tanaka ,  Yusuke Nakamura ,  Hirofumi Arakawa

发明人： Yoichi Taya ,  Tomoaki Tanaka ,  Yusuke Nakamura ,  Hirofumi Arakawa

IPC分类号： G01N33/50 ,  A61K38/00 ,  A61K38/45 ,  A61P35/00 ,  C07K14/47 ,  C12N9/12 ,  C12Q1/48 ,  G01N33/15 ,  G01N33/53 ,  G01N33/566 ,  A61K38/48

CPC分类号： C12N9/1205 ,  A61K38/00 ,  C07K14/4747

摘要： The inventors clarified the enzyme phosphorylating the serine residue at amino acid position 46 of tumor suppressor protein p53 and further elucidated the mechanism in regulation of inducibility of apoptosis by p53. As the results, the inventors provide a completely new enzyme comprising casein kinase 2 and p53DINP1

摘要翻译： 本发明人澄清了磷酸化肿瘤抑制蛋白p53的氨基酸位置46的丝氨酸残基的酶，并进一步阐明了p53诱导细胞凋亡调节的机制。 作为结果，本发明人提供了包含酪蛋白激酶2和p53DINP1的全新酶

公开(公告)号：US20060159692A1

公开(公告)日：2006-07-20

申请号：US10546829

申请日：2004-02-25

申请人： Yoichi Taya ,  Masato Enari

发明人： Yoichi Taya ,  Masato Enari

IPC分类号： C12N9/99 ,  A61K39/00

CPC分类号： C07K14/4702 ,  A61K38/1709 ,  C07K14/4746

摘要： A new method for treating cancer by inducing apoptosis exclusively in cancer cells and killing them is provided. The present invention relates to a transcriptional factor, comprising p53 or a mutated type p53, wherein one or more amino acids are deleted, substituted or added with respect to the amino sequence of p53, and clathrin heavy chains and having an activity to induce apoptosis of cancer cells. The transcriptional factor enhances the transcriptional activity of p53AIP1 promoter and induces apoptosis of cancer cells.

摘要翻译： 提供了一种通过仅在癌细胞中诱导凋亡并杀死癌症来治疗癌症的新方法。 本发明涉及包含p53或突变型p53的转录因子，其中相对于p53的氨基酸序列缺失，取代或添加一个或多个氨基酸，并且具有诱导细胞凋亡的活性的网格蛋白重链 癌细胞。 转录因子增强p53AIP1启动子的转录活性，诱导癌细胞凋亡。

公开(公告)号：US5666591A

公开(公告)日：1997-09-09

申请号：US497685

申请日：1995-06-30

申请人： Yoichi Taya

发明人： Yoichi Taya

IPC分类号： G03G15/02 ,  G03G15/06 ,  H01T19/00

CPC分类号： G03G15/065

摘要： An image forming apparatus having a voltage generating circuit for generating a bias voltage which is supplied to a developing unit upon reception of a discharge voltage from the charger, for charging a photosensitive drum, based on the discharge voltage. The voltage generating circuit is controlled by a timing signal supplied from the CPU, so that the bias voltage is applied to the developing unit when the photosensitive drum rotates by a predetermined angle and is set at a position where development is carried out.

摘要翻译： 一种图像形成装置，具有用于产生偏置电压的电压产生电路，该偏置电压根据放电电压从感光鼓接收到来自充电器的放电电压而被提供给显影单元。 电压产生电路由CPU提供的定时信号控制，使得当感光鼓旋转预定角度并将偏压施加到显影单元，并将其设置在进行显影的位置。