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公开(公告)号：US20050232912A1
公开(公告)日：2005-10-20
申请号：US10490454
申请日：2002-09-25
申请人： Yoichi Taya , Tomoaki Tanaka , Yusuke Nakamura , Hirofumi Arakawa
发明人： Yoichi Taya , Tomoaki Tanaka , Yusuke Nakamura , Hirofumi Arakawa
IPC分类号： G01N33/50 , A61K38/00 , A61K38/45 , A61P35/00 , C07K14/47 , C12N9/12 , C12Q1/48 , G01N33/15 , G01N33/53 , G01N33/566 , A61K38/48
CPC分类号： C12N9/1205 , A61K38/00 , C07K14/4747
摘要： The inventors clarified the enzyme phosphorylating the serine residue at amino acid position 46 of tumor suppressor protein p53 and further elucidated the mechanism in regulation of inducibility of apoptosis by p53. As the results, the inventors provide a completely new enzyme comprising casein kinase 2 and p53DINP1
摘要翻译： 本发明人澄清了磷酸化肿瘤抑制蛋白p53的氨基酸位置46的丝氨酸残基的酶，并进一步阐明了p53诱导细胞凋亡调节的机制。 作为结果，本发明人提供了包含酪蛋白激酶2和p53DINP1的全新酶
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2.发明授权p53-dependent apoptosis-inducing protein and method of screening for apoptosis regulator 有权p53依赖性细胞凋亡诱导蛋白和筛选凋亡调节剂的方法公开(公告)号：US07371835B2
公开(公告)日：2008-05-13
申请号：US10484157
申请日：2002-07-18
申请人： Yusuke Nakamura , Hirofumi Arakawa
发明人： Yusuke Nakamura , Hirofumi Arakawa
CPC分类号： G01N33/5008 , C07K14/4747 , C07K16/18 , C12Q1/485 , G01N33/5011 , G01N33/68 , G01N33/6842 , G01N33/6875 , G01N2500/00 , G01N2510/00
摘要： p53-dependent Damage-Inducible Nuclear Protein 1 (p53DINP1 protein) is a p53-induced nuclear protein that induces p53-dependent apoptosis by regulating p53 function through Ser 46 phosphorylation. A DNA encoding p53DINP1 can be applied as anticancer agents for destroying neoplasms such as tumors, and as therapeutic or preventive agents for diseases associated with p53-mediated apoptosis abnormalities. It is also possible to apply the above protein and DNA in methods of screening for candidate compounds for regulating p53-mediated apoptosis.
摘要翻译： p53依赖性损伤诱导核蛋白1（p53DINP1蛋白）是p53诱导的核蛋白，其通过调节p53功能通过Ser 46磷酸化诱导p53依赖性凋亡。 编码p53DINP1的DNA可用作破坏肿瘤等肿瘤的抗癌剂，也可用作与p53介导的凋亡异常有关的疾病的治疗或预防剂。 还可以将上述蛋白质和DNA应用于筛选用于调节p53介导的凋亡的候选化合物的方法中。
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3.发明申请p53-DEPENDENT APOPTOSIS-INDUCING PROTEIN AND METHOD OF SCREENING FOR APOPTOSIS REGULATOR 审中-公开p53依赖性病毒诱导蛋白和筛选调节因子的方法公开(公告)号：US20080220455A1
公开(公告)日：2008-09-11
申请号：US12103867
申请日：2008-04-16
申请人： Yusuke Nakamura , Hirofumi Arakawa
发明人： Yusuke Nakamura , Hirofumi Arakawa
IPC分类号： G01N33/574 , C12N15/11 , C07K14/00 , C12N15/00 , C12N5/06 , C12P21/04 , C07K16/18 , C07H21/00 , G01N33/566
CPC分类号： G01N33/5008 , C07K14/4747 , C07K16/18 , C12Q1/485 , G01N33/5011 , G01N33/68 , G01N33/6842 , G01N33/6875 , G01N2500/00 , G01N2510/00
摘要： p53-dependent Damage-Inducible Nuclear Protein 1 (p53DINP1 protein) is a p53-induced nuclear protein that induces p53-dependent apoptosis by regulating p53 function through Ser 46 phosphorylation. A DNA encoding p53DINP1 can be applied as anticancer agents for destroying neoplasms such as tumors, and as therapeutic or preventive agents for diseases associated with p53-mediated apoptosis abnormalities. It is also possible to apply the above protein and DNA in methods of screening for candidate compounds for regulating p53-mediated apoptosis.
摘要翻译： p53依赖性损伤诱导核蛋白1（p53DINP1蛋白）是p53诱导的核蛋白，其通过调节p53功能通过Ser 46磷酸化诱导p53依赖性凋亡。 编码p53DINP1的DNA可用作破坏肿瘤等肿瘤的抗癌剂，也可用作与p53介导的凋亡异常有关的疾病的治疗或预防剂。 还可以将上述蛋白质和DNA应用于筛选用于调节p53介导的凋亡的候选化合物的方法中。
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4.发明授权公开(公告)号：US06682917B1
公开(公告)日：2004-01-27
申请号：US10019733
申请日：2001-12-28
IPC分类号： C12N916
CPC分类号： C12N9/0093 , A01K2217/075 , A61K38/00 , A61K2039/505 , C07K16/30 , C07K16/40
摘要： Because the protein of the present invention has in its amino acid sequence a homology with, for example, ribonucleotide reductase, the protein of the present invention, its DNA, antibodies to these and the like are useful in the prevention, treatment and diagnosis, etc. of cancer.
摘要翻译： 因为本发明的蛋白质在其氨基酸序列中具有与例如核糖核苷酸还原酶的同源性，本发明的蛋白质，其DNA，对这些蛋白质的抗体等可用于预防，治疗和诊断等 癌症。
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公开(公告)号：US07569351B2
公开(公告)日：2009-08-04
申请号：US10343733
申请日：2001-08-02
申请人： Yusuke Nakamura , Hirofumi Arakawa
发明人： Yusuke Nakamura , Hirofumi Arakawa
IPC分类号： C07H21/04 , C12N15/63 , C12N15/85 , C12N15/86 , C12N1/21 , C12N1/15 , C12N1/19 , C12N5/14 , C12N15/00 , C07K5/00 , C07K14/00 , C12Q1/00 , G01N33/53
CPC分类号： C07K14/4747 , A61K48/00 , C07K14/4746 , G01N2500/02 , G01N2510/00
摘要： A novel apoptosis-associated gene p53AIPI is isolated by screening for a gene the expression of which is induced by p53. Since the protein encoded by this gene has an activity of inducing apoptosis, this gene is useful in developing effective therapeutic agents for cancer mediated by apoptosis. A method of screening for a compound controlling the induction of apoptosis which is expected as being useful in developing an apoptosis controlling agent.
摘要翻译： 通过筛选由p53诱导其表达的基因来分离新的凋亡相关基因p53AIPI。 由于该基因编码的蛋白质具有诱导细胞凋亡的活性，所以该基因可用于开发有效的由细胞凋亡介导的癌症治疗剂。 筛选控制细胞凋亡诱导的化合物的方法，其预期可用于开发凋亡控制剂。
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公开(公告)号：US07256279B2
公开(公告)日：2007-08-14
申请号：US10698228
申请日：2003-10-30
CPC分类号： C12N9/0093 , A01K2217/075 , A61K38/00 , A61K2039/505 , C07K16/30 , C07K16/40
摘要： A protein having ribonucleotide reductase activity, DNA encoding the protein, antibodies to these and the like are disclosed. The protein, DNA and antibodies are useful in the prevention, treatment and diagnosis, etc. of cancer.
摘要翻译： 公开了具有核糖核苷酸还原酶活性的蛋白质，编码蛋白质的DNA，针对这些蛋白质的抗体等。 蛋白质，DNA和抗体可用于癌症的预防，治疗和诊断等。
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