公开(公告)号：US20210060289A1

公开(公告)日：2021-03-04

申请号：US16553999

申请日：2019-08-28

Applicant: Yong D. Zhao ,  Jennifer Jinping Zhao

Inventor： Yong D. Zhao ,  Jennifer Jinping Zhao

IPC: A61M21/02 ,  A61N1/36

Abstract: A system and method of coupling acoustic and electrical stimulation of noninvasive neuromodulation is a therapeutic system and method preferably designed for the diagnosis and/or treatment of neurodegenerative diseases and neurological disorders including, but not limited to, tinnitus, hyperacusis, sleep disorder, depression, anxiety, dizziness, migraine, or ear suffocation. The system includes acoustic signal devices for deep brain electrical stimulation and electrical pulse devices for shallow brain electrical stimulation. Further, the system includes a signal-coupling module that includes an algorithm for coupling acoustic signals to electrical pulses. Parameters of each the acoustic signals and the electrical pulses are adjusted in order for the acoustic signals to be coupled to the electrical pulses. These parameters can also be adjusted based on patient feedback. Furthermore, the system can synchronously output the coupled acoustic signals and the coupled electrical pulses, asynchronously output the acoustic signals, or the electrical pulses based on patient feedback.

公开(公告)号：US08774434B2

公开(公告)日：2014-07-08

申请号：US13286642

申请日：2011-11-01

Applicant: Yong D. Zhao ,  Jennifer Jinping Zhao

Inventor： Yong D. Zhao ,  Jennifer Jinping Zhao

IPC: H04R25/00

CPC classification number: H04R25/656 ,  H04R25/658 ,  H04R2225/025

Abstract: An in-ear hearing aid device that provides users with a customizable ear piece to fit the ear canal of any user. More specifically, the present invention can comprises of a hard case to hold all the electronics of the device with a hearing device jacket that envelops the device. An ear mold is connected to the jacket and allows the user to insert the device into the ear canal to enhance the user's hearing.

Abstract translation: 入耳式助听器装置，为用户提供可定制的耳塞，以适应任何用户的耳道。 更具体地说，本发明可以包括一个硬壳，用来容纳该设备的所有电子设备，其中一个听觉装置夹套包围该设备。 耳模连接到护套，并允许使用者将装置插入耳道中以增强使用者的听力。

公开(公告)号：US11583656B2

公开(公告)日：2023-02-21

申请号：US16553999

申请日：2019-08-28

Applicant: Yong D. Zhao ,  Jennifer Jinping Zhao

Inventor： Yong D. Zhao ,  Jennifer Jinping Zhao

IPC: A61M21/00 ,  A61M21/02 ,  A61N1/36

Abstract: A system and method of coupling acoustic and electrical stimulation of noninvasive neuromodulation is a therapeutic system and method preferably designed for the diagnosis and/or treatment of neurodegenerative diseases and neurological disorders including, but not limited to, tinnitus, hyperacusis, sleep disorder, depression, anxiety, dizziness, migraine, or ear suffocation. The system includes acoustic signal devices for deep brain electrical stimulation and electrical pulse devices for shallow brain electrical stimulation. Further, the system includes a signal-coupling module that includes an algorithm for coupling acoustic signals to electrical pulses. Parameters of each the acoustic signals and the electrical pulses are adjusted in order for the acoustic signals to be coupled to the electrical pulses. These parameters can also be adjusted based on patient feedback. Furthermore, the system can synchronously output the coupled acoustic signals and the coupled electrical pulses, asynchronously output the acoustic signals, or the electrical pulses based on patient feedback.

公开(公告)号：US20170019739A1

公开(公告)日：2017-01-19

申请号：US14797210

申请日：2015-07-13

Applicant: Yong D. Zhao ,  Jennifer Jinping Zhao

Inventor： Yong D. Zhao ,  Jennifer Jinping Zhao

IPC: H04R25/00 ,  H04R1/10

CPC classification number: H04R25/60 ,  H04R2225/021 ,  H04R2225/0213

Abstract: A hearing aid with adjustable ear mount is an apparatus which assists users in hearing sounds that they are otherwise unable to hear. The hearing aid with adjustable ear mount includes a hearing aid control unit which detects sound, and sends a digital representation of the sound to a speaker through at least one electrical wire. At least one pliable wire is also connected between the hearing aid control unit and the speaker and can be shaped to properly fit around ears of various shapes and sizes. A flexible tube covers the at least one electrical wire and the at least one pliable wire for protection and added comfort. An earpiece is connected to the speaker and helps to secure the speaker in a position that directs sound into the user's ear canal. The earpiece is designed to fit ears of various shapes and sizes.

Abstract translation: 具有可调式耳罩的助听器是一种辅助用户聆听他们无法听到的声音的设备。 具有可调耳机的助听器包括一个检测声音的助听器控制单元，并通过至少一根电线将声音的数字表示发送到扬声器。 助听器控制单元和扬声器之间还连接有至少一根柔韧线，并且可以将其成形为适合于各种形状和尺寸的耳朵周围。 柔性管覆盖至少一根电线和至少一根柔韧线，用于保护并增加舒适性。 耳机连接到扬声器，并有助于将扬声器固定在将声音引导到用户的耳道中的位置。 听筒被设计成适合各种形状和尺寸的耳朵。

公开(公告)号：US07822484B1

公开(公告)日：2010-10-26

申请号：US11696020

申请日：2007-04-03

Applicant: Yong D. Zhao ,  Virote Indravudh ,  Xiaoyi Min ,  Geoff Daush

Inventor： Yong D. Zhao ,  Virote Indravudh ,  Xiaoyi Min ,  Geoff Daush

IPC: A61N1/05

CPC classification number: A61N1/056 ,  A61N1/086

Abstract: An implantable lead includes a lead body, having a distal end and a proximal end, configured to be implanted in a patient. An electrode assembly is provided at the distal end of the lead body, wherein the electrode assembly includes an electrode that is configured to deliver stimulating pulses. The electrode extends between a base and a tip at a distal end of the electrode. A shielding member is provided on the electrode assembly and is positioned to cover at least a portion of the electrode to electrically shield the electrode from RF fields. Optionally, the shielding member may include a shielding conductor that wraps about and extends longitudinally along a length of the electrode from the base to the tip. The shielding conductor may extend from the proximal end of the lead body at least to the distal end of the lead body.

Abstract translation: 可植入引线包括具有远端和近端的引线体，构造成植入患者体内。 电极组件设置在引线主体的远端处，其中电极组件包括被配置成输送刺激脉冲的电极。 电极在电极的远端处在基部和尖端之间延伸。 屏蔽构件设置在电极组件上并且被定位成覆盖电极的至少一部分以将电极与RF场电屏蔽。 可选地，屏蔽构件可以包括屏蔽导体，该屏蔽导体沿着电极的长度从基部向尖端卷绕并纵向延伸。 屏蔽导体可以从引线主体的近端至少延伸到引线主体的远端。

公开(公告)号：US20100114276A1

公开(公告)日：2010-05-06

申请号：US12262047

申请日：2008-10-30

Applicant: Xiaoyi Min ,  J. Christopher Moulder ,  Yong D. Zhao ,  Virote Indravudh ,  Ingmar Viohl

Inventor： Xiaoyi Min ,  J. Christopher Moulder ,  Yong D. Zhao ,  Virote Indravudh ,  Ingmar Viohl

IPC: A61N1/05

CPC classification number: A61N1/05 ,  A61N1/086 ,  H01F17/00

Abstract: An implantable medical lead is disclosed herein. In one embodiment, the lead includes a body and an electrical pathway. The body may include a distal portion with an electrode and a proximal portion with a lead connector end. The electrical pathway may extend between the electrode and lead connector end and include a coiled inductor including a first portion and a second portion at least partially magnetically decoupled from the first portion. The first portion may include a first configuration having a first SRF. The second portion may include a second configuration different from the first configuration. The second configuration may have a second SRF different from the first SRF. For example, the first SRF may be near 64 MHz and the second SRF may be near 128 MHz.

Abstract translation: 本文公开了可植入医疗引线。 在一个实施例中，引线包括主体和电路径。 主体可以包括具有电极的远端部分和具有引线连接器端部的近端部分。 电路可以在电极和引线连接器端之间延伸，并且包括线圈电感器，其包括至少部分地与第一部分磁耦合的第一部分和第二部分。 第一部分可以包括具有第一SRF的第一配置。 第二部分可以包括不同于第一配置的第二配置。 第二配置可以具有与第一SRF不同的第二SRF。 例如，第一SRF可以接近64MHz，而第二SRF可以接近128MHz。

公开(公告)号：US08634931B2

公开(公告)日：2014-01-21

申请号：US12262047

申请日：2008-10-30

Applicant: Xiaoyi Min ,  J. Christopher Moulder ,  Yong D. Zhao ,  Virote Indravudh ,  Ingmar Viohl

Inventor： Xiaoyi Min ,  J. Christopher Moulder ,  Yong D. Zhao ,  Virote Indravudh ,  Ingmar Viohl

IPC: A61N1/00

CPC classification number: A61N1/05 ,  A61N1/086 ,  H01F17/00

Abstract: An implantable medical lead is disclosed herein. In one embodiment, the lead includes a body and an electrical pathway. The body may include a distal portion with an electrode and a proximal portion with a lead connector end. The electrical pathway may extend between the electrode and lead connector end and include a coiled inductor including a first portion and a second portion at least partially magnetically decoupled from the first portion. The first portion may include a first configuration having a first SRF. The second portion may include a second configuration different from the first configuration. The second configuration may have a second SRF different from the first SRF. For example, the first SRF may be near 64 MHz and the second SRF may be near 128 MHz.

Abstract translation: 本文公开了可植入医疗引线。 在一个实施例中，引线包括主体和电路径。 主体可以包括具有电极的远端部分和具有引线连接器端部的近端部分。 电路可以在电极和引线连接器端之间延伸，并且包括线圈电感器，其包括至少部分地与第一部分磁耦合的第一部分和第二部分。 第一部分可以包括具有第一SRF的第一配置。 第二部分可以包括不同于第一配置的第二配置。 第二配置可以具有与第一SRF不同的第二SRF。 例如，第一SRF可以接近64MHz，而第二SRF可以接近128MHz。

公开(公告)号：US08573062B2

公开(公告)日：2013-11-05

申请号：US13365005

申请日：2012-02-02

Applicant: Yong D. Zhao ,  Apratim Dixit

Inventor： Yong D. Zhao ,  Apratim Dixit

IPC: G01L7/00 ,  A61N1/365 ,  A61B5/0215 ,  A61B5/00 ,  G01L9/00

CPC classification number: A61B5/0215 ,  A61B5/686 ,  A61B5/6869 ,  A61B2562/0247 ,  A61B2562/0271 ,  A61B2562/028 ,  A61N1/056 ,  A61N1/3702 ,  G01L9/0073 ,  G01L27/002

Abstract: The disclosure relates in some aspects to an implantable pressure sensor and a method of measuring pressure. In some embodiments pressure may be measured through the use of an implantable lead incorporating one or more pressure sensors. In some aspects a pressure sensor is implemented in a micro-electromechanical system (“MEMS”) that employs direct mechanical sensing. A biocompatible material is attached to one or more portions of the MEMS sensor to facilitate implant in a body of a patient. The MEMS sensor may thus be incorporated into an implantable lead for measuring blood pressure in, for example, one or more chambers of the patient's heart.

Abstract translation: 本公开在一些方面涉及可植入压力传感器和测量压力的方法。 在一些实施例中，可以通过使用结合有一个或多个压力传感器的可植入引线来测量压力。 在一些方面，在采用直接机械感测的微机电系统（“MEMS”）中实现压力传感器。 生物相容性材料附接到MEMS传感器的一个或多个部分以便于植入患者体内。 因此，MEMS传感器可以被结合到可植入引线中，用于测量例如患者心脏的一个或多个腔室中的血压。

公开(公告)号：US08538553B2

公开(公告)日：2013-09-17

申请号：US12889189

申请日：2010-09-23

Applicant: Yong D. Zhao ,  Rolf Hill ,  Ingmar Viohl ,  Martin Cholette

Inventor： Yong D. Zhao ,  Rolf Hill ,  Ingmar Viohl ,  Martin Cholette

IPC: A61N1/00

CPC classification number: A61N1/056 ,  A61N1/086

Abstract: An implantable lead is provided that includes a lead body configured to be implanted in a patient. The lead body has a distal end and a proximal end, and a lumen extending between the distal and proximal ends and includes a connector assembly provided at the proximal end of the lead body. The connector assembly is configured to connect to an implantable medical device and includes an electrode provided proximate to the distal end of the lead body with the electrode configured to at least one of deliver stimulating pulses and sense electrical activity. A multi-layer coil is located within the lumen and extends at least partially along a length of the lead body. The coil includes a first winding formed with multiple winding turns, the winding turns being segmented in an alternating pattern of insulated segments and non-insulated segments along the length of the lead body. The multi-layer coil further includes a winding turn connective layer extending along and interconnecting the winding turns within at least one of the non-insulated segments. The multi-layer coil further includes a first winding formed with multiple winding turns, the winding turns being segmented into an alternating pattern of insulated segments and non-insulated segments along a length of the winding with a winding turn connective layer extending along and interconnecting the winding turns within at least one of the non-insulated segments.

Abstract translation: 提供了可植入引线，其包括构造成植入患者体内的引线主体。 引线体具有远端和近端，以及在远端和近端之间延伸的内腔，并且包括设置在引线本体的近端处的连接器组件。 所述连接器组件被配置成连接到可植入医疗装置，并且包括靠近所述引线本体的远端设置的电极，所述电极被配置为递送刺激脉冲和感测电活动中的至少一个。 多层线圈位于内腔内并且至少部分地沿着引线体的长度延伸。 线圈包括形成有多个绕组匝的第一绕组，绕组匝沿着引线主体的长度以绝缘段和非绝缘段的交替模式分段。 多层线圈还包括沿至少一个非绝缘段延伸并互连绕组匝的绕组匝连接层。 多层线圈还包括形成有多个绕组匝的第一绕组，绕组匝被分割成沿着绕组的长度的绝缘段和非绝缘段的交替图案，其中绕组匝连接层沿着并联连接 匝内至少一个非绝缘段。

公开(公告)号：US08108053B2

公开(公告)日：2012-01-31

申请号：US12370461

申请日：2009-02-12

Applicant: Yong D. Zhao

Inventor： Yong D. Zhao

IPC: A61N1/00

CPC classification number: A61N1/05 ,  A61N1/086

Abstract: Implantable medical leads have reduced diameter while providing for optimized mechanical and electrical properties, by reducing the diameters of the conducting cables used within the leads for sensing and delivery of therapeutic electrical stimulation. In an embodiment, conducting filaments within a cable have oval cross-sectional areas. Suitably orienting the oval filaments increases the contact surface between adjacent filaments, broadly distributing the pressure between filaments and reducing fretting fatigue, while the oval cross-sectional area also increases conductivity. In an embodiment, non-conducting coatings around filaments within a cable, or around groups of filaments organized into cable-layers, reduce fretting fatigue. In an embodiment, the cross-sectional area of filaments decreases as the filaments are positioned at increasing radial distances from the center of the cable. In an embodiment, the relative composition of various filament metals and/or alloys is varied in filaments at different radial distances from the center of the cable.

Abstract translation: 可植入的医疗引线通过减小引线内使用的导电电缆的直径来获得最佳的机械和电学性能，减小了直径，用于传感和传递治疗性电刺激。 在一个实施例中，电缆内的导电细丝具有椭圆形横截面。 适当地定向椭圆形长丝增加相邻细丝之间的接触表面，广泛地分布长丝之间的压力并减少微动疲劳，而椭圆形横截面积也增加导电性。 在一个实施例中，电缆周围的细丝周围的非导电涂层或组织成电缆层的细丝组周围的非导电涂层减少了微动疲劳。 在一个实施例中，长丝的横截面积随着电缆的距离中心距离增加的径向距离而减小。 在一个实施例中，各种细丝金属和/或合金的相对组成在长丝中在与电缆中心不同的径向距离处变化。