利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

6 条记录 (耗时 0.018 秒)

    O-carbamoyl-phenylalaninol compounds, their pharmaceutically useful salts and process for preparing the same
    1.
    发明授权
    O-carbamoyl-phenylalaninol compounds, their pharmaceutically useful salts and process for preparing the same 失效
    O-氨基甲酰基 - 苯丙氨酸醇化合物，其药学上可用的盐及其制备方法

    公开(公告)号：US5756817A

    公开(公告)日：1998-05-26

    申请号：US726675

    申请日：1996-10-07

    申请人： Yong Moon Choi ,  Dong Il Han ,  Yong Kil Kim ,  Hun Woo Shin ,  Jeong-Han Park

    发明人： Yong Moon Choi ,  Dong Il Han ,  Yong Kil Kim ,  Hun Woo Shin ,  Jeong-Han Park

    IPC分类号： C07C271/12 ,  C07C261/00

    CPC分类号： C07C271/12

    摘要： The present invention relates to a racemic or enantiomerically enriched O-carbamoyl-phenylalaninol compound represented by the following structural formula V and pharmaceutically acceptable salts thereof to treat diseases of the central nervous system: ##STR1## wherein Ph is a phenyl group as described as follows: ##STR2## wherein R is a member selected from the group consisting of hydrogen, lower alkyl of 1 to 8 carbon atoms, halogen selected from F, Cl, Br and I, alkoxy containing 1 to 3 carbon atoms, nitro, hydroxy, trifluoromethyl, and thioalkoxy containing 1 to 3 carbon atoms, and x is an integer from 1 to 3, with the proviso that R is the same or different when x is 2 or 3, R.sup.1 and R.sup.2 may be the same or different from each other and are independently selected from the group consisting of hydrogen, lower alkyl of 1 to 8 carbon atoms, aryl, arylalkyl, cyclic propyl and 5 to 7-membered aliphatic cyclic compounds, and R.sup.1 and R.sup.2 may be joined to form a 5 to 7-membered cyclic compound which may comprise zero to one additional nitrogen atom substituted with a member selected from the group consisting of hydrogen, alkyl, and aryl groups, or zero to one oxygen atom directly unconnected, excluding the instance where R, R.sup.1, and R.sup.2 are all hydrogen, and the pharmaceutically acceptable salts thereof. The present invention also relates to O-carbamoyl-(D)-phenylalaninol compounds, represented by the following structural formula IX: ##STR3## wherein Ph, R.sup.1, and R.sup.2 are as described above, and the pharmaceutically acceptable salts thereof.

    摘要翻译： 本发明涉及由以下结构式V表示的外消旋或对映异构体富集的O-氨基甲酰基 - 苯丙氨酸酚化合物及其药学上可接受的盐，用于治疗中枢神经系统疾病：其中Ph是苯基作为 描述如下：其中R是选自氢，1至8个碳原子的低级烷基，选自F，Cl，Br和I的卤素，含1至3个碳原子的烷氧基，硝基， 羟基，三氟甲基和含有1至3个碳原子的硫代烷氧基，x是1至3的整数，条件是当x为2或3时，R相同或不同，R 1和R 2可以相同或不同 彼此独立地选自氢，1至8个碳原子的低级烷基，芳基，芳烷基，环丙基和5至7元脂族环状化合物，并且R 1和R 2可以连接形成5至 7元环状化合物 其可以包括被选自氢，烷基和芳基的成员或直接未连接的0至1个氧原子取代的0至1个另外的氮原子，不包括R 1，R 2和R 2全部为氢的情况， 及其药学上可接受的盐。 本发明还涉及由以下结构式IX表示的O-氨基甲酰基 - （D） - 苯丙氨醇化合物：其中Ph，R 1和R 2如上所述，其药学上可接受的盐。 \！

    O-carbamoyl-(d)-phenylalaninol compounds, their pharmaceutically useful salts and process for preparing the same
    2.
    发明授权
    O-carbamoyl-(d)-phenylalaninol compounds, their pharmaceutically useful salts and process for preparing the same 失效
    O-氨基甲酰基 - （d） - 苯丙氨酸醇化合物，其药学上可用的盐及其制备方法

    公开(公告)号：US5705640A

    公开(公告)日：1998-01-06

    申请号：US596496

    申请日：1996-02-05

    申请人： Yong Moon Choi ,  Dong Il Han ,  Yong Kil Kim

    发明人： Yong Moon Choi ,  Dong Il Han ,  Yong Kil Kim

    IPC分类号： C07C269/04 ,  C07C271/12 ,  C07C271/20 ,  C07D295/205 ,  C07D265/30

    CPC分类号： C07D295/205 ,  C07C271/12 ,  C07B2200/07 ,  C07C2101/02 ,  C07C2101/14

    摘要： The present invention relates to O-carbamoyl-(D)-phenylalaninol compound represented by the following structural formula V and pharmaceutically acceptable salts thereof to treat diseases of the central nervous system: ##STR1## wherein R.sup.1 and R.sup.2 may be the same with or different from each other and are independently selected from the group consisting of hydrogen, lower alkyl containing 1 to 8 carbon atoms, and 5 to 7-membered aliphatic cyclic compounds which may comprise not more than two nitrogen or oxygen atoms directly unconnected, the total number of carbon atom of R.sup.1 and R.sup.2 ranging from 0 to 16.

    摘要翻译： 本发明涉及由以下结构式V表示的O-氨基甲酰基 - （D） - 苯丙氨醛化合物及其药学上可接受的盐以治疗中枢神经系统疾病：其中R1和R2可以相同 独立地选自氢，含有1至8个碳原子的低级烷基和5至7元脂肪族环状化合物，其可以包含不超过两个直接不连接的氮原子或氧原子， R1和R2的碳原子数为0〜16。

    O-thiocarbamoyl-aminoalkanol compounds, their pharmaceutically useful salts and process for preparing the same
    4.
    发明授权
    O-thiocarbamoyl-aminoalkanol compounds, their pharmaceutically useful salts and process for preparing the same 失效
    O-硫代氨基甲酰基 - 氨基烷醇化合物，其药学上可用的盐及其制备方法

    公开(公告)号：US5935997A

    公开(公告)日：1999-08-10

    申请号：US6528

    申请日：1998-01-13

    申请人： Yong Moon Choi ,  Yong Kil Kim

    发明人： Yong Moon Choi ,  Yong Kil Kim

    IPC分类号： C07C333/04 ,  C07C333/10 ,  C07D295/21 ,  A61K31/27

    CPC分类号： C07D295/21 ,  C07C333/04 ,  C07C333/10 ,  C07C2101/02

    摘要： The present invention relates to O-thiocarbamoyl-aminoalkanol compound represented by the following structural formula (VI), (VIII) and (IX) which are a racemic or enantiomerically enriched and pharmaceulically acceptable salts thereof to treat diseases of the central nervous system: ##STR1## wherein Ar is a phenyl group as described as follows: ##STR2## wherein R is a member selected from the group consisting of hydrogen, lower alkyl of 1 to 8 carbon atoms, halogen selected from F, Cl, Br, and I, alkoxy containing 1 to 3 carbon atoms, thioalkoxy containing 1 to 3 carbon atoms, nitro, hydroxy, or taifluorocarbon, and x is an integer from 1 to 3, with the proviso that R is the same or different when x is 2 or 3. R.sub.1 and R.sub.2 may be the same or different from each other and are independently selected from the group consisting of hydrogen, lower alkyl of 1 to 8 carbon atoms, aryl, 3 to 7-membered aliphatic cyclic compounds and R.sub.1 and R.sub.2, together with the adjoining N-atom, form a 5 to 7-membered cyclic compound which optionally comprises zero to one additional nitrogen atoms substituted with a member selected from the group consisting of hydrogen, alkyl and aryl groups, or zero to one oxygen atoms directly unconnected, R.sub.3 and R.sub.4 may be same or different from each other and are independently selected from the group consisting of hydrogen, lower alkyl of 1 to 8 carbon atoms, aryl, 3 to 7-membercd aliphatic cyclic compounds and R.sub.3 and R.sub.4, together with the adjoining N-atom, form a 5 to 7-membered cyclic compound which optidonally comprises zero to one additional nitrogen atoms substituted with a member selected from the group consisting of hydrogen, alkyl and aryl groups, or zero to one oxygen atoms directly unconnected, each of l, m and n is zero or 1, and the pharmaceutically acceptable salts thereof.

    摘要翻译： 本发明涉及由以下结构式（VI），（VIII）和（IX）表示的O-硫代氨基甲酰基 - 氨基链烷醇化合物，它们是用于治疗中枢神经系统疾病的外消旋或对映异构体富集和药物学上可接受的盐：其中 Ar是如下所述的苯基：其中R是选自氢，1至8个碳原子的低级烷基，选自F，Cl，Br和I的卤素，含1至3个碳原子的烷氧基 原子，含有1至3个碳原子的硫代烷氧基，硝基，羟基或taifluorocarbon，x是1至3的整数，条件是当x为2或3时，R相同或不同.R1和R2可以是 相同或不同，并且独立地选自氢，1至8个碳原子的低级烷基，芳基，3至7元脂族环状化合物和R 1和R 2以及相邻的N-原子形式 一个5到7元的循环 nd，其任选地包含被选自氢，烷基和芳基或0至1个直接未连接的氧原子的成员取代的0至1个另外的氮原子，R 3和R 4可以彼此相同或不同，并且独立地 选自氢，1至8个碳原子的低级烷基，芳基，3至7元脂肪族环状化合物和R3和R4以及相邻的N-原子形成5至7元环状化合物，其中 选择性地包含被选自氢，烷基和芳基的成员或直接不连接的0至1个氧原子取代的0至1个另外的氮原子，l，m和n各自为0或1，并且药学上可接受的 的盐。

    Apparatus for manufacturing steel tube and method for manufacturing the same
    6.
    发明授权
    Apparatus for manufacturing steel tube and method for manufacturing the same 失效
    钢管制造装置及其制造方法

    公开(公告)号：US07739980B2

    公开(公告)日：2010-06-22

    申请号：US11465813

    申请日：2006-08-21

    申请人： Gi Hyeoug Kim ,  Kyung Yun Kim ,  Yong Kil Kim ,  Sun Chang Kim ,  Jae Pyeong Sim ,  Jong Seo Kim

    发明人： Gi Hyeoug Kim ,  Kyung Yun Kim ,  Yong Kil Kim ,  Sun Chang Kim ,  Jae Pyeong Sim ,  Jong Seo Kim

    IPC分类号： B05C3/12

    CPC分类号： C23C2/006 ,  C23C2/00 ,  C23C2/02 ,  C23C2/12 ,  Y10T29/4998 ,  Y10T29/5185

    摘要： An apparatus and method for manufacturing a steel tube are provided. The apparatus includes: a tube-forming device for forming a steel plate into a steel tube; a heat treatment device connected in-line to the tube-forming device to heat the steel tube to a high temperature; a pre-treatment device for annealing the steel tube and providing a reduction atmosphere; and a plating device including a pot for storing a SeAHLume alloy composed of aluminum and zinc in a molten state, a level block selectively inserted into the molten alloy to adjust a level of the molten alloy, and a plating part into which the molten alloy flows in response to insertion of the level block and through which the steel tube passes substantially vertically. Therefore, it is possible to manufacture a steel tube having a plated surface to improve its corrosion-resistance.

    摘要翻译： 提供一种用于制造钢管的设备和方法。 该装置包括：用于将钢板形成钢管的管形成装置; 与管形成装置成直线连接的热处理装置，将钢管加热到高温; 用于退火钢管并提供还原气氛的预处理装置; 以及电镀装置，其包括用于储存熔融状态的由铝和锌组成的SeAHLume合金的罐，选择性地插入熔融合金中的级块，以调节熔融合金的水平，以及熔融合金流入的镀层 响应于水平块的插入，并且钢管通过其基本垂直地穿过。 因此，可以制造具有电镀表面的钢管，以提高其耐腐蚀性。