利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

28 条记录 (耗时 0.035 秒)

    O-carbamoyl-phenylalaninol compounds, their pharmaceutically useful salts and process for preparing the same
    2.
    发明授权
    O-carbamoyl-phenylalaninol compounds, their pharmaceutically useful salts and process for preparing the same 失效
    O-氨基甲酰基 - 苯丙氨酸醇化合物，其药学上可用的盐及其制备方法

    公开(公告)号：US5756817A

    公开(公告)日：1998-05-26

    申请号：US726675

    申请日：1996-10-07

    申请人： Yong Moon Choi ,  Dong Il Han ,  Yong Kil Kim ,  Hun Woo Shin ,  Jeong-Han Park

    发明人： Yong Moon Choi ,  Dong Il Han ,  Yong Kil Kim ,  Hun Woo Shin ,  Jeong-Han Park

    IPC分类号： C07C271/12 ,  C07C261/00

    CPC分类号： C07C271/12

    摘要： The present invention relates to a racemic or enantiomerically enriched O-carbamoyl-phenylalaninol compound represented by the following structural formula V and pharmaceutically acceptable salts thereof to treat diseases of the central nervous system: ##STR1## wherein Ph is a phenyl group as described as follows: ##STR2## wherein R is a member selected from the group consisting of hydrogen, lower alkyl of 1 to 8 carbon atoms, halogen selected from F, Cl, Br and I, alkoxy containing 1 to 3 carbon atoms, nitro, hydroxy, trifluoromethyl, and thioalkoxy containing 1 to 3 carbon atoms, and x is an integer from 1 to 3, with the proviso that R is the same or different when x is 2 or 3, R.sup.1 and R.sup.2 may be the same or different from each other and are independently selected from the group consisting of hydrogen, lower alkyl of 1 to 8 carbon atoms, aryl, arylalkyl, cyclic propyl and 5 to 7-membered aliphatic cyclic compounds, and R.sup.1 and R.sup.2 may be joined to form a 5 to 7-membered cyclic compound which may comprise zero to one additional nitrogen atom substituted with a member selected from the group consisting of hydrogen, alkyl, and aryl groups, or zero to one oxygen atom directly unconnected, excluding the instance where R, R.sup.1, and R.sup.2 are all hydrogen, and the pharmaceutically acceptable salts thereof. The present invention also relates to O-carbamoyl-(D)-phenylalaninol compounds, represented by the following structural formula IX: ##STR3## wherein Ph, R.sup.1, and R.sup.2 are as described above, and the pharmaceutically acceptable salts thereof.

    摘要翻译： 本发明涉及由以下结构式V表示的外消旋或对映异构体富集的O-氨基甲酰基 - 苯丙氨酸酚化合物及其药学上可接受的盐，用于治疗中枢神经系统疾病：其中Ph是苯基作为 描述如下：其中R是选自氢，1至8个碳原子的低级烷基，选自F，Cl，Br和I的卤素，含1至3个碳原子的烷氧基，硝基， 羟基，三氟甲基和含有1至3个碳原子的硫代烷氧基，x是1至3的整数，条件是当x为2或3时，R相同或不同，R 1和R 2可以相同或不同 彼此独立地选自氢，1至8个碳原子的低级烷基，芳基，芳烷基，环丙基和5至7元脂族环状化合物，并且R 1和R 2可以连接形成5至 7元环状化合物 其可以包括被选自氢，烷基和芳基的成员或直接未连接的0至1个氧原子取代的0至1个另外的氮原子，不包括R 1，R 2和R 2全部为氢的情况， 及其药学上可接受的盐。 本发明还涉及由以下结构式IX表示的O-氨基甲酰基 - （D） - 苯丙氨醇化合物：其中Ph，R 1和R 2如上所述，其药学上可接受的盐。 \！

    O-carbamoyl-(d)-phenylalaninol compounds, their pharmaceutically useful salts and process for preparing the same
    3.
    发明授权
    O-carbamoyl-(d)-phenylalaninol compounds, their pharmaceutically useful salts and process for preparing the same 失效
    O-氨基甲酰基 - （d） - 苯丙氨酸醇化合物，其药学上可用的盐及其制备方法

    公开(公告)号：US5705640A

    公开(公告)日：1998-01-06

    申请号：US596496

    申请日：1996-02-05

    申请人： Yong Moon Choi ,  Dong Il Han ,  Yong Kil Kim

    发明人： Yong Moon Choi ,  Dong Il Han ,  Yong Kil Kim

    IPC分类号： C07C269/04 ,  C07C271/12 ,  C07C271/20 ,  C07D295/205 ,  C07D265/30

    CPC分类号： C07D295/205 ,  C07C271/12 ,  C07B2200/07 ,  C07C2101/02 ,  C07C2101/14

    摘要： The present invention relates to O-carbamoyl-(D)-phenylalaninol compound represented by the following structural formula V and pharmaceutically acceptable salts thereof to treat diseases of the central nervous system: ##STR1## wherein R.sup.1 and R.sup.2 may be the same with or different from each other and are independently selected from the group consisting of hydrogen, lower alkyl containing 1 to 8 carbon atoms, and 5 to 7-membered aliphatic cyclic compounds which may comprise not more than two nitrogen or oxygen atoms directly unconnected, the total number of carbon atom of R.sup.1 and R.sup.2 ranging from 0 to 16.

    摘要翻译： 本发明涉及由以下结构式V表示的O-氨基甲酰基 - （D） - 苯丙氨醛化合物及其药学上可接受的盐以治疗中枢神经系统疾病：其中R1和R2可以相同 独立地选自氢，含有1至8个碳原子的低级烷基和5至7元脂肪族环状化合物，其可以包含不超过两个直接不连接的氮原子或氧原子， R1和R2的碳原子数为0〜16。

    Sulfamate compound containing N-substituted carbamoyl group and method for preparing the same
    4.
    发明授权
    Sulfamate compound containing N-substituted carbamoyl group and method for preparing the same 失效
    含有N-取代氨基甲酰基的氨基磺酸酯化合物及其制备方法

    公开(公告)号：US5892088A

    公开(公告)日：1999-04-06

    申请号：US742929

    申请日：1996-11-01

    申请人： Yong Moon Choi ,  Dong Il Han ,  Hyung Cheol Kim

    发明人： Yong Moon Choi ,  Dong Il Han ,  Hyung Cheol Kim

    IPC分类号： C07C35/20 ,  C07C309/14 ,  C07C309/63 ,  C07C311/05

    CPC分类号： C07C35/20

    摘要： There are disclosed novel sulfamate compounds containing N-substituted carbomoyl group including their racemates and (R)- and (S)-optical isomers represented by Formulas I, II and III, pharmaceutically useful for the prophylaxis and treatment of the disorders of the central nervous system, especially for nervous myalgia, epilepsy and minimal brain dysfunction: ##STR1## (III).

    摘要翻译： 公开了含有N-取代的甲硅烷氧基的新型氨基磺酸酯化合物，包括它们的外消旋物和由式I，II和III表示的（R） - 和（S） - 光学异构体，可用于预防和治疗中枢神经疾病 系统，特别是对于紧张的肌肉酸痛，癫痫和极少的脑功能障碍：（I）（II）（III）（III）。

    O-thiocarbamoyl-aminoalkanol compounds, their pharmaceutically useful salts and process for preparing the same
    6.
    发明授权
    O-thiocarbamoyl-aminoalkanol compounds, their pharmaceutically useful salts and process for preparing the same 失效
    O-硫代氨基甲酰基 - 氨基烷醇化合物，其药学上可用的盐及其制备方法

    公开(公告)号：US5935997A

    公开(公告)日：1999-08-10

    申请号：US6528

    申请日：1998-01-13

    申请人： Yong Moon Choi ,  Yong Kil Kim

    发明人： Yong Moon Choi ,  Yong Kil Kim

    IPC分类号： C07C333/04 ,  C07C333/10 ,  C07D295/21 ,  A61K31/27

    CPC分类号： C07D295/21 ,  C07C333/04 ,  C07C333/10 ,  C07C2101/02

    摘要： The present invention relates to O-thiocarbamoyl-aminoalkanol compound represented by the following structural formula (VI), (VIII) and (IX) which are a racemic or enantiomerically enriched and pharmaceulically acceptable salts thereof to treat diseases of the central nervous system: ##STR1## wherein Ar is a phenyl group as described as follows: ##STR2## wherein R is a member selected from the group consisting of hydrogen, lower alkyl of 1 to 8 carbon atoms, halogen selected from F, Cl, Br, and I, alkoxy containing 1 to 3 carbon atoms, thioalkoxy containing 1 to 3 carbon atoms, nitro, hydroxy, or taifluorocarbon, and x is an integer from 1 to 3, with the proviso that R is the same or different when x is 2 or 3. R.sub.1 and R.sub.2 may be the same or different from each other and are independently selected from the group consisting of hydrogen, lower alkyl of 1 to 8 carbon atoms, aryl, 3 to 7-membered aliphatic cyclic compounds and R.sub.1 and R.sub.2, together with the adjoining N-atom, form a 5 to 7-membered cyclic compound which optionally comprises zero to one additional nitrogen atoms substituted with a member selected from the group consisting of hydrogen, alkyl and aryl groups, or zero to one oxygen atoms directly unconnected, R.sub.3 and R.sub.4 may be same or different from each other and are independently selected from the group consisting of hydrogen, lower alkyl of 1 to 8 carbon atoms, aryl, 3 to 7-membercd aliphatic cyclic compounds and R.sub.3 and R.sub.4, together with the adjoining N-atom, form a 5 to 7-membered cyclic compound which optidonally comprises zero to one additional nitrogen atoms substituted with a member selected from the group consisting of hydrogen, alkyl and aryl groups, or zero to one oxygen atoms directly unconnected, each of l, m and n is zero or 1, and the pharmaceutically acceptable salts thereof.

    摘要翻译： 本发明涉及由以下结构式（VI），（VIII）和（IX）表示的O-硫代氨基甲酰基 - 氨基链烷醇化合物，它们是用于治疗中枢神经系统疾病的外消旋或对映异构体富集和药物学上可接受的盐：其中 Ar是如下所述的苯基：其中R是选自氢，1至8个碳原子的低级烷基，选自F，Cl，Br和I的卤素，含1至3个碳原子的烷氧基 原子，含有1至3个碳原子的硫代烷氧基，硝基，羟基或taifluorocarbon，x是1至3的整数，条件是当x为2或3时，R相同或不同.R1和R2可以是 相同或不同，并且独立地选自氢，1至8个碳原子的低级烷基，芳基，3至7元脂族环状化合物和R 1和R 2以及相邻的N-原子形式 一个5到7元的循环 nd，其任选地包含被选自氢，烷基和芳基或0至1个直接未连接的氧原子的成员取代的0至1个另外的氮原子，R 3和R 4可以彼此相同或不同，并且独立地 选自氢，1至8个碳原子的低级烷基，芳基，3至7元脂肪族环状化合物和R3和R4以及相邻的N-原子形成5至7元环状化合物，其中 选择性地包含被选自氢，烷基和芳基的成员或直接不连接的0至1个氧原子取代的0至1个另外的氮原子，l，m和n各自为0或1，并且药学上可接受的 的盐。

    Sulfamate compound containing carbamoyl group
    7.
    发明授权
    Sulfamate compound containing carbamoyl group 失效
    氨基甲酸酯化合物

    公开(公告)号：US5654461A

    公开(公告)日：1997-08-05

    申请号：US616077

    申请日：1996-03-14

    申请人： Yong Moon Choi ,  Dong Il Han ,  Hyung Cheol Kim

    发明人： Yong Moon Choi ,  Dong Il Han ,  Hyung Cheol Kim

    IPC分类号： C07C307/02 ,  C07C309/63 ,  A61K31/255 ,  A61K31/27

    CPC分类号： C07C307/02 ,  C07C2101/02

    摘要： 3-O-Carbamoyl-2-phenyl-1,3-propanediol sulfamate racemate, represented by the following structural formula I: ##STR1## and its (R)- and (S)-optical isomers, which are very effective for prophylaxis and the treatment of central nervous system disorders including nervous muscular pain, epilepsy and minimal brain dysfunctions, are disclosed. They are prepared from 2-phenyl-1,3-propanediol monocarbamate and its optical isomers, respectively.

    摘要翻译： 由以下结构式I表示的3-O-氨基甲酰基-2-苯基-1,3-丙二醇氨基磺酸酯外消旋物：其非常有效的（I）及其（R） - 和（S） - 光学异构体 用于预防和治疗包括神经性肌肉疼痛，癫痫和最小脑功能障碍的中枢神经系统疾病。 它们分别由2-苯基-1,3-丙二醇单氨基甲酸酯及其旋光异构体制备。

    Phenylcarbamate compound and muscle relaxant containing the same
    8.
    发明授权
    Phenylcarbamate compound and muscle relaxant containing the same 有权
    苯基氨基甲酸酯化合物和含有相同的肌肉松弛剂

    公开(公告)号：US09018253B2

    公开(公告)日：2015-04-28

    申请号：US13175025

    申请日：2011-07-01

    申请人： Yong Moon Choi

    发明人： Yong Moon Choi

    IPC分类号： C07C261/00 ,  A61K31/27 ,  C07C271/12 ,  C07C271/24

    CPC分类号： C07C271/12 ,  A61K31/27 ,  C07C271/24 ,  C07C2601/02 ,  C07C2601/14

    摘要： A novel phenylcarbamate compound and a pharmaceutical composition containing the same are provided. More specifically, a novel phenylcarbamate compound, a composition for muscle relaxation containing the phenylcarbamate compound as an active ingredient, and a method of muscle relaxation comprising administering a therapeutically effective amount of the phenylcarbamate compound, are provided.

    摘要翻译： 提供了新的苯基氨基甲酸酯化合物和含有它们的药物组合物。 更具体地，提供新的苯基氨基甲酸酯化合物，包含苯基氨基甲酸酯化合物作为活性成分的肌肉松弛组合物和包括施用治疗有效量的苯基氨基甲酸酯化合物的肌肉松弛方法。

    PHENYLCARBAMATE COMPOUND AND MUSCLE RELAXANT CONTAINING THE SAME
    9.
    发明申请
    PHENYLCARBAMATE COMPOUND AND MUSCLE RELAXANT CONTAINING THE SAME 有权
    苯并噻唑类化合物和包含它的肌松弛剂

    公开(公告)号：US20140051753A9

    公开(公告)日：2014-02-20

    申请号：US13175025

    申请日：2011-07-01

    申请人： Yong Moon Choi

    发明人： Yong Moon Choi

    IPC分类号： A61K31/27 ,  A61P25/00 ,  A61P21/02 ,  A61P21/00 ,  C07C271/12 ,  C07C271/24

    CPC分类号： C07C271/12 ,  A61K31/27 ,  C07C271/24 ,  C07C2601/02 ,  C07C2601/14

    摘要： A novel phenylcarbamate compound and a pharmaceutical composition containing the same are provided. More specifically, a novel phenylcarbamate compound, a composition for muscle relaxation containing the phenylcarbamate compound as an active ingredient, and a method of muscle relaxation comprising administering a therapeutically effective amount of the phenylcarbamate compound, are provided.

    摘要翻译： 提供了新的苯基氨基甲酸酯化合物和含有它们的药物组合物。 更具体地，提供新的苯基氨基甲酸酯化合物，包含苯基氨基甲酸酯化合物作为活性成分的肌肉松弛组合物和包括施用治疗有效量的苯基氨基甲酸酯化合物的肌肉松弛方法。

    Methods for Treatment of Sexual Dysfunction
    10.
    发明申请
    Methods for Treatment of Sexual Dysfunction 有权
    治疗性功能障碍的方法

    公开(公告)号：US20090221553A1

    公开(公告)日：2009-09-03

    申请号：US11922128

    申请日：2006-06-13

    申请人： Joseph Palumbo ,  Jonathan Sporn ,  Thomas Steckler ,  Yong Moon Choi ,  James S. Lee

    发明人： Joseph Palumbo ,  Jonathan Sporn ,  Thomas Steckler ,  Yong Moon Choi ,  James S. Lee

    IPC分类号： A61K31/553 ,  A61K31/27 ,  A61K31/55 ,  A61P15/00

    CPC分类号： A61K31/165

    摘要： This invention is directed to a method of treating sexual dysfunction in a subject, comprising the step of administering a therapeutically effective amount of a compound of Formula (I): or a pharmaceutically acceptable salt or ester thereof wherein Rx is a member selected from the group consisting of hydrogen, lower alkyl of 1 to 8 carbon atoms, halogen selected from F, CI, Br and I, alkoxy containing 1 to 3 carbon atoms, nitro, hydroxy, trifluoromethyl, and thioalkoxy containing 1 to 3 carbon atoms; x is an integer of 1 to 3, with the proviso that R may be the same or different when x is 2 or 3; R1 and R2 can be the same or different from each other and are independently selected from the group consisting of hydrogen, lower alkyl of 1 to 8 carbon atoms, aryl, arylalkyl, cycloalkyl of 3 to 7 carbon atoms; R1 and R2 can be joined to form a 5 to 7-membered heterocycle substituted with a member selected from the group consisting of hydrogen, alkyl, and aryl groups, wherein the cyclic compound can comprise 1 to 2 nitrogen atoms and O to 1 oxygen atom, wherein the nitrogen atoms are not directly connected with each other or with the oxygen atom.

    摘要翻译： 本发明涉及治疗受试者的性功能障碍的方法，其包括施用治疗有效量的式（I）化合物或其药学上可接受的盐或酯的步骤，其中Rx是选自下组的成员 由氢，1至8个碳原子的低级烷基，选自F，Cl，Br和I的卤素，含有1至3个碳原子的烷氧基，硝基，羟基，三氟甲基和含有1至3个碳原子的硫代烷氧基组成; x为1〜3的整数，条件是当x为2或3时R可以相同或不同; R 1和R 2可以相同或不同，并且独立地选自氢，1至8个碳原子的低级烷基，芳基，芳基烷基，3至7个碳原子的环烷基; R1和R2可以连接形成被选自氢，烷基和芳基的成员所取代的5至7元杂环，其中环状化合物可包含1至2个氮原子和0至1个氧原子 其中氮原子彼此不直接连接或与氧原子直接连接。