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    Photosensitizer-metal nanoparticle charge complex and composition containing the complex for photodynamic therapy or diagnosis
    2.
    发明授权
    Photosensitizer-metal nanoparticle charge complex and composition containing the complex for photodynamic therapy or diagnosis 有权
    光敏剂 - 金属纳米粒子电荷复合物和含有光动力学治疗或诊断复合物的组合物

    公开(公告)号：US09095613B2

    公开(公告)日：2015-08-04

    申请号：US12673122

    申请日：2009-10-28

    申请人： Yong-Doo Choi ,  Bo-Seung Jang ,  Jin-Young Park ,  Jung-Im Lee ,  In-Hoo Kim

    发明人： Yong-Doo Choi ,  Bo-Seung Jang ,  Jin-Young Park ,  Jung-Im Lee ,  In-Hoo Kim

    IPC分类号： A61B10/00 ,  A61B5/00 ,  A61B8/00 ,  A61K41/00 ,  A61K33/24 ,  A61K49/00

    CPC分类号： A61K41/0071 ,  A61K33/24 ,  A61K49/0036 ,  A61K49/0065 ,  Y10T428/2991

    摘要： Provided are a photosensitizer-metal nanoparticle charge complex and a composition for photodynamic therapy or diagnosis containing the same. The complex includes a metal nanoparticle, a photosensitizer charged with a first charge, and a linker bound to the metal nanoparticle and charged with a second charge having an opposite polarity to the first charge. During circulation in blood, the photosensitizer-metal nanoparticle charge complex is maintained in a complex type, and thus duration of a side effect of photosensitivity can be reduced. In a tumor tissue, the complex is specifically accumulated, but in a normal tissue, it is difficult for the complex to penetrate. Thus, the complex can selectively destroy the tumor tissue. Moreover, selective fluorescence in the tumor tissue can provide further improvement in accuracy of diagnosing a tumor using the complex.

    摘要翻译： 提供了一种光敏剂 - 金属纳米颗粒电荷复合物和用于光动力学治疗或诊断的组合物。 络合物包括金属纳米颗粒，带有第一电荷的光敏剂和与金属纳米颗粒结合的连接体，并且与第一电荷具有相反极性的第二电荷充电。 在血液循环过程中，光敏剂 - 金属纳米粒子电荷复合物保持复合型，从而可以降低光敏感副作用的持续时间。 在肿瘤组织中，复合物被特异地累积，但在正常组织中，复合物难以渗透。 因此，复合物可以选择性地破坏肿瘤组织。 此外，肿瘤组织中的选择性荧光可以使用复合物进一步提高诊断肿瘤的准确性。