公开(公告)号：US09095613B2

公开(公告)日：2015-08-04

申请号：US12673122

申请日：2009-10-28

申请人： Yong-Doo Choi ,  Bo-Seung Jang ,  Jin-Young Park ,  Jung-Im Lee ,  In-Hoo Kim

发明人： Yong-Doo Choi ,  Bo-Seung Jang ,  Jin-Young Park ,  Jung-Im Lee ,  In-Hoo Kim

IPC分类号： A61B10/00 ,  A61B5/00 ,  A61B8/00 ,  A61K41/00 ,  A61K33/24 ,  A61K49/00

CPC分类号： A61K41/0071 ,  A61K33/24 ,  A61K49/0036 ,  A61K49/0065 ,  Y10T428/2991

摘要： Provided are a photosensitizer-metal nanoparticle charge complex and a composition for photodynamic therapy or diagnosis containing the same. The complex includes a metal nanoparticle, a photosensitizer charged with a first charge, and a linker bound to the metal nanoparticle and charged with a second charge having an opposite polarity to the first charge. During circulation in blood, the photosensitizer-metal nanoparticle charge complex is maintained in a complex type, and thus duration of a side effect of photosensitivity can be reduced. In a tumor tissue, the complex is specifically accumulated, but in a normal tissue, it is difficult for the complex to penetrate. Thus, the complex can selectively destroy the tumor tissue. Moreover, selective fluorescence in the tumor tissue can provide further improvement in accuracy of diagnosing a tumor using the complex.

摘要翻译： 提供了一种光敏剂 - 金属纳米颗粒电荷复合物和用于光动力学治疗或诊断的组合物。 络合物包括金属纳米颗粒，带有第一电荷的光敏剂和与金属纳米颗粒结合的连接体，并且与第一电荷具有相反极性的第二电荷充电。 在血液循环过程中，光敏剂 - 金属纳米粒子电荷复合物保持复合型，从而可以降低光敏感副作用的持续时间。 在肿瘤组织中，复合物被特异地累积，但在正常组织中，复合物难以渗透。 因此，复合物可以选择性地破坏肿瘤组织。 此外，肿瘤组织中的选择性荧光可以使用复合物进一步提高诊断肿瘤的准确性。

公开(公告)号：US20120014874A1

公开(公告)日：2012-01-19

申请号：US12673122

申请日：2009-10-28

申请人： Yong-Doo Choi ,  Bo-seung Jang ,  JIn-Young Park ,  Jung-Im Lee ,  In-Hoo Kim

发明人： Yong-Doo Choi ,  Bo-seung Jang ,  JIn-Young Park ,  Jung-Im Lee ,  In-Hoo Kim

IPC分类号： A61K49/00 ,  A61K38/00 ,  A61K31/7088 ,  A61K31/728 ,  A61K31/715 ,  A61K31/722 ,  A61K31/727 ,  A61K31/407 ,  C07K2/00 ,  C07K7/06 ,  C07K17/00 ,  C08B37/08 ,  C08B37/10 ,  C07H21/02 ,  C07H21/04 ,  C07H1/00 ,  C07D487/22 ,  C08F26/10 ,  C08F20/06 ,  C08G63/91 ,  A61K39/44

CPC分类号： A61K41/0071 ,  A61K33/24 ,  A61K49/0036 ,  A61K49/0065 ,  Y10T428/2991

摘要： Provided are a photosensitizer-metal nanoparticle charge complex and a composition for photodynamic therapy or diagnosis containing the same. The complex includes a metal nanoparticle, a photosensitizer charged with a first charge, and a linker bound to the metal nanoparticle and charged with a second charge having an opposite polarity to the first charge. During circulation in blood, the photosensitizer-metal nanoparticle charge complex is maintained in a complex type, and thus duration of a side effect of photosensitivity can be reduced. In a tumor tissue, the complex is specifically accumulated, but in a normal tissue, it is difficult for the complex to penetrate. Thus, the complex can selectively destroy the tumor tissue. Moreover, selective fluorescence in the tumor tissue can provide further improvement in accuracy of diagnosing a tumor using the complex.

摘要翻译： 提供了一种光敏剂 - 金属纳米颗粒电荷复合物和用于光动力学治疗或诊断的组合物。 络合物包括金属纳米颗粒，带有第一电荷的光敏剂和与金属纳米颗粒结合的连接体，并且与第一电荷具有相反极性的第二电荷充电。 在血液循环过程中，光敏剂 - 金属纳米粒子电荷复合物保持复合型，从而可以降低光敏感副作用的持续时间。 在肿瘤组织中，复合物被特异地累积，但在正常组织中，复合物难以渗透。 因此，复合物可以选择性地破坏肿瘤组织。 此外，肿瘤组织中的选择性荧光可以使用复合物进一步提高诊断肿瘤的准确性。

公开(公告)号：US09339557B2

公开(公告)日：2016-05-17

申请号：US12665013

申请日：2009-10-08

申请人： Yong-Doo Choi ,  Bo-Seung Jang ,  In-Hoo Kim ,  Jin-Young Park

发明人： Yong-Doo Choi ,  Bo-Seung Jang ,  In-Hoo Kim ,  Jin-Young Park

IPC分类号： A61K51/00 ,  A61K49/00 ,  A61B5/00 ,  A61K39/00 ,  C07D345/00 ,  C07B47/00 ,  C07D225/00 ,  C07D295/00 ,  A61K47/48 ,  A61K41/00 ,  C12N9/00

CPC分类号： A61K47/48861 ,  A61K41/0071 ,  A61K47/64 ,  A61K47/6923 ,  A61K49/0017 ,  A61K49/0065

摘要： Provided are a photosensitizer-metal nanoparticle complex and a composition for photodynamic therapy or diagnosis having the same. The complex includes a photosensitizer, a metal nanoparticle, and a backbone linking the photosensitizer with the metal nanoparticle. The backbone has a polypeptide substrate capable of being specifically degraded by a protease. When the complex is administered to a patient, fluorescence and production of reactive oxygen species from the conjugated photosensitizers are inhibited in normal tissues due to the resonance energy transfer between the photosensitizer and metal nanoparticles, but in tumor tissues, fluorescence and production of reactive oxygen species from the released photosensitizers are activated, thereby effectively destroying the tumor tissues. In addition, the selective fluorescence in the tumor tissues can further improve accuracy of tumor diagnosis using the protease-activatable photosensitizer-metal nanoparticle complex.

摘要翻译： 提供了一种光敏剂 - 金属纳米颗粒复合物和用于光动力学治疗或诊断的组合物。 复合物包括光敏剂，金属纳米颗粒和连接光敏剂与金属纳米颗粒的骨架。 骨架具有能够被蛋白酶特异性降解的多肽底物。 当将复合物施用于患者时，由于光敏剂和金属纳米颗粒之间的共振能量转移，共轭光敏剂的荧光和活性氧的产生被抑制在正常组织中，而在肿瘤组织中，荧光和活性氧的产生 从释放的光敏剂被激活，从而有效地破坏肿瘤组织。 此外，肿瘤组织中的选择性荧光可以使用蛋白酶激活的光敏剂 - 金属纳米颗粒复合物进一步提高肿瘤诊断的准确性。

公开(公告)号：US20110293728A1

公开(公告)日：2011-12-01

申请号：US12665013

申请日：2009-10-08

申请人： Yong-Doo Choi ,  Bo-Seung Jang ,  In-Hoo Kim ,  Jin-Young Park

发明人： Yong-Doo Choi ,  Bo-Seung Jang ,  In-Hoo Kim ,  Jin-Young Park

IPC分类号： A61K9/14 ,  A61P35/00 ,  A61K38/10 ,  A61K38/08 ,  C07K7/06 ,  C07K7/08

CPC分类号： A61K47/48861 ,  A61K41/0071 ,  A61K47/64 ,  A61K47/6923 ,  A61K49/0017 ,  A61K49/0065

摘要： Provided are a photosensitizer-metal nanoparticle complex and a composition for photodynamic therapy or diagnosis having the same. The complex includes a photosensitizer, a metal nanoparticle, and a backbone linking the photosensitizer with the metal nanoparticle. The backbone has a polypeptide substrate capable of being specifically degraded by a protease. When the complex is administered to a patient, fluorescence and production of reactive oxygen species from the conjugated photosensitizers are inhibited in normal tissues due to the resonance energy transfer between the photosensitizer and metal nanoparticles, but in tumor tissues, fluorescence and production of reactive oxygen species from the released photosensitizers are activated, thereby effectively destroying the tumor tissues. In addition, the selective fluorescence in the tumor tissues can further improve accuracy of tumor diagnosis using the protease-activatable photosensitizer-metal nanoparticle complex.

摘要翻译： 提供了一种光敏剂 - 金属纳米颗粒复合物和用于光动力学治疗或诊断的组合物。 复合物包括光敏剂，金属纳米颗粒和连接光敏剂与金属纳米颗粒的骨架。 骨架具有能够被蛋白酶特异性降解的多肽底物。 当将复合物施用于患者时，由于光敏剂和金属纳米颗粒之间的共振能量转移，共轭光敏剂的荧光和活性氧的产生被抑制在正常组织中，而在肿瘤组织中，荧光和活性氧的产生 从释放的光敏剂被激活，从而有效地破坏肿瘤组织。 此外，肿瘤组织中的选择性荧光可以使用蛋白酶激活的光敏剂 - 金属纳米颗粒复合物进一步提高肿瘤诊断的准确性。

公开(公告)号：US20100331674A1

公开(公告)日：2010-12-30

申请号：US12612305

申请日：2009-11-04

申请人： Dae-Kyung Sohn ,  Kwang-Gi Kim ,  Yong-Doo Choi ,  Kyoung-Won Nam ,  Hyun-Ho Kim

发明人： Dae-Kyung Sohn ,  Kwang-Gi Kim ,  Yong-Doo Choi ,  Kyoung-Won Nam ,  Hyun-Ho Kim

IPC分类号： A61B6/00

CPC分类号： A61B17/1227 ,  A61B17/1285 ,  A61B2090/3908 ,  A61B2090/3941

摘要： Provided is a fluorescent indication clip for surgery that has an improved function as a position indicator due to a photo-reactive fluorescent material included in the bio-clip, and allows people to rapidly and easily detect the accurate position of an internal operation region, and thus can improve operation accuracy and reduce side effects caused by excessive incision. The fluorescent indication clip includes a self-spreadable clip body, a fluorescent indicator prepared at the rear end of the clip body and including a photo-reactive fluorescent material, and a clamper configured to slide from a position at which the clamper is mounted on the fluorescent indicator to the clip body by an external force, and fasten the clip body to narrow front ends of the clip body.

摘要翻译： 提供了一种用于手术的荧光指示夹，其由于生物夹中包含的光反应性荧光材料而具有作为位置指示器的功能的改善，并且允许人们快速且容易地检测内部操作区域的准确位置，以及 从而可以提高手术精度，减少由于切口引起的副作用。 荧光指示夹包括自扩展夹体，荧光指示器，其准备在夹主体的后端并包括光反应荧光材料，以及夹持器，构造成从夹持器安装在其上的位置滑动 通过外力将荧光指示器固定到夹体上，并将夹具本体固定在夹子主体的窄前端。

公开(公告)号：US06764698B1

公开(公告)日：2004-07-20

申请号：US09806287

申请日：2001-03-28

申请人： Young-Ro Byun ,  Sang-Yoon Kim ,  Sun-Hee Kim ,  Yong-Doo Choi ,  In-Suk Han ,  Kwang-Sun Lee ,  Chul-Hee Kim

发明人： Young-Ro Byun ,  Sang-Yoon Kim ,  Sun-Hee Kim ,  Yong-Doo Choi ,  In-Suk Han ,  Kwang-Sun Lee ,  Chul-Hee Kim

IPC分类号： A61K914

CPC分类号： A61K9/1647

摘要： The present invention relates to a controlled drug release system in which a certain ratio or retinoic acid is incorporated into a microsphere comprising biodegradable polymer and amphoteric block copolymer having both hydrophilic and hydrophobic groups.

摘要翻译： 本发明涉及一种受控药物释放系统，其中将一定比例或视黄酸引入包含具有亲水和疏水基团的可生物降解聚合物和两性嵌段共聚物的微球体中。

公开(公告)号：US08688195B2

公开(公告)日：2014-04-01

申请号：US12612305

申请日：2009-11-04

申请人： Dae-Kyung Sohn ,  Kwang-Gi Kim ,  Yong-Doo Choi ,  Kyoung-Won Nam ,  Hyun-Ho Kim

发明人： Dae-Kyung Sohn ,  Kwang-Gi Kim ,  Yong-Doo Choi ,  Kyoung-Won Nam ,  Hyun-Ho Kim

IPC分类号： A61B5/05

CPC分类号： A61B17/1227 ,  A61B17/1285 ,  A61B2090/3908 ,  A61B2090/3941

摘要： Provided is a fluorescent indication clip for surgery that has an improved function as a position indicator due to a photo-reactive fluorescent material included in the bio-clip, and allows people to rapidly and easily detect the accurate position of an internal operation region, and thus can improve operation accuracy and reduce side effects caused by excessive incision. The fluorescent indication clip includes a self-spreadable clip body, a fluorescent indicator prepared at the rear end of the clip body and including a photo-reactive fluorescent material, and a clamper configured to slide from a position at which the clamper is mounted on the fluorescent indicator to the clip body by an external force, and fasten the clip body to narrow front ends of the clip body.

摘要翻译： 提供了一种用于手术的荧光指示夹，其由于生物夹中包含的光反应性荧光材料而具有作为位置指示器的功能的改善，并且允许人们快速且容易地检测内部操作区域的准确位置，以及 从而可以提高手术精度，减少由于切口引起的副作用。 荧光指示夹包括自扩展夹体，荧光指示器，其准备在夹主体的后端并包括光反应荧光材料，以及夹持器，构造成从夹持器安装在其上的位置滑动 通过外力将荧光指示器固定到夹体上，并将夹具体紧固到夹子主体的窄前端。