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公开(公告)号：US08529057B2
公开(公告)日：2013-09-10
申请号：US13193651
申请日：2011-07-29
申请人： Yongxing Qiu , Newton T. Samuel , John Dallas Pruitt , Chandana Kolluru , Arturo N. Medina , Lynn Cook Winterton , Daqing Wu , Xinming Qian , Jared Nelson
发明人： Yongxing Qiu , Newton T. Samuel , John Dallas Pruitt , Chandana Kolluru , Arturo N. Medina , Lynn Cook Winterton , Daqing Wu , Xinming Qian , Jared Nelson
IPC分类号： G02C7/00
CPC分类号： C09D177/06 , B29D11/00067 , C08G77/388 , C08J5/00 , C08J7/042 , C08J2383/04 , C08J2383/08 , C08J2433/02 , C08J2433/26 , C08J2487/00 , C08L83/04 , C09D5/1637 , C09D5/1681 , C09D133/02 , C09D133/14 , C09D133/26 , C09D171/02 , G02B1/043 , G02B1/10 , G02B1/18 , G02C7/049 , G02C2202/06 , G02C2202/16 , C08L101/14
摘要： The invention is related to a cost-effective method for making a silicone hydrogel contact lens having a crosslinked hydrophilic coating thereon. A method of the invention involves heating a silicone hydrogel contact lens in an aqueous solution in the presence of a water-soluble, highly branched, thermally-crosslinkable hydrophilic polymeric material having positively-charged azetidinium groups, to and at a temperature from about 40° C. to about 140° C. for a period of time sufficient to covalently attach the thermally-crosslinkable hydrophilic polymeric material onto the surface of the silicone hydrogel contact lens through covalent linkages each formed between one azetidinium group and one of the reactive functional groups on and/or near the surface of the silicone hydrogel contact lens, thereby forming a crosslinked hydrophilic coating on the silicone hydrogel contact lens. Such method can be advantageously implemented directly in a sealed lens package during autoclave.
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公开(公告)号：US20120026457A1
公开(公告)日：2012-02-02
申请号：US13193651
申请日：2011-07-29
申请人： Yongxing Qiu , Newton T. Samuel , John Dallas Pruitt , Chandana Kolluru , Arturo N. Medina , Lynn Cook Winterton , Daqing Wu , Xinming Qian , Jared Nelson
发明人： Yongxing Qiu , Newton T. Samuel , John Dallas Pruitt , Chandana Kolluru , Arturo N. Medina , Lynn Cook Winterton , Daqing Wu , Xinming Qian , Jared Nelson
CPC分类号： C09D177/06 , B29D11/00067 , C08G77/388 , C08J5/00 , C08J7/042 , C08J2383/04 , C08J2383/08 , C08J2433/02 , C08J2433/26 , C08J2487/00 , C08L83/04 , C09D5/1637 , C09D5/1681 , C09D133/02 , C09D133/14 , C09D133/26 , C09D171/02 , G02B1/043 , G02B1/10 , G02B1/18 , G02C7/049 , G02C2202/06 , G02C2202/16 , C08L101/14
摘要： The invention is related to a cost-effective method for making a silicone hydrogel contact lens having a crosslinked hydrophilic coating thereon. A method of the invention involves heating a silicone hydrogel contact lens in an aqueous solution in the presence of a water-soluble, highly branched, thermally-crosslinkable hydrophilic polymeric material having positively-charged azetidinium groups, to and at a temperature from about 40° C. to about 140° C. for a period of time sufficient to covalently attach the thermally-crosslinkable hydrophilic polymeric material onto the surface of the silicone hydrogel contact lens through covalent linkages each formed between one azetidinium group and one of the reactive functional groups on and/or near the surface of the silicone hydrogel contact lens, thereby forming a crosslinked hydrophilic coating on the silicone hydrogel contact lens. Such method can be advantageously implemented directly in a sealed lens package during autoclave.
摘要翻译： 本发明涉及制备其上具有交联亲水性涂层的硅氧水凝胶隐形眼镜的成本有效的方法。 本发明的方法涉及在具有带正电荷的氮杂环丁烷基团的水溶性，高度支化，热交联的亲水性聚合物材料存在下，在约40℃的温度下，在水溶液中加热硅酮水凝胶隐形眼镜 在约140℃下进行足够的时间以将可热交联的亲水聚合物材料共价连接到硅氧烷水凝胶隐形眼镜的表面上，通过共价连接，每个共价键在一个氮杂环丁烷基团和一个反应性官能团之间形成， 和/或靠近硅酮水凝胶隐形眼镜的表面，从而在硅氧水凝胶隐形眼镜上形成交联的亲水涂层。 这种方法可以有利地在高压釜中直接在密封的透镜包装中实现。
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公开(公告)号：US08409599B2
公开(公告)日：2013-04-02
申请号：US12917504
申请日：2010-11-02
申请人： Daqing Wu , Xinming Qian , John Dallas Pruitt
发明人： Daqing Wu , Xinming Qian , John Dallas Pruitt
IPC分类号： A61C8/00
CPC分类号： G02C7/04 , G02B1/043 , C08L101/14
摘要： The invention provides a cost-effective method for applying a hydrophilic coating onto a silicone hydrogel contact lens based on Fenton chemistry. The hydrophilic coating is covalently attached onto the contact lens at room temperature without UV irradiation. The invention also provides silicone hydrogel contact lenses having a hydrophilic coating obtained according to the method of the invention.
摘要翻译： 本发明提供了一种基于Fenton化学将亲水性涂层施加到硅酮水凝胶隐形眼镜上的成本有效的方法。 亲水涂层在室温下共价附着在隐形眼镜上，无紫外线照射。 本发明还提供了具有根据本发明方法获得的亲水涂层的硅酮水凝胶隐形眼镜。
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公开(公告)号：US08163206B2
公开(公告)日：2012-04-24
申请号：US12456364
申请日：2009-06-16
申请人： Frank Chang , Jürgen Vogt , John Dallas Pruitt , Xinming Qian , Dawn A. Smith , Angelika Maria Domschke , Troy Vernon Holland , Richard Charles Turek , Daqing Wu
发明人： Frank Chang , Jürgen Vogt , John Dallas Pruitt , Xinming Qian , Dawn A. Smith , Angelika Maria Domschke , Troy Vernon Holland , Richard Charles Turek , Daqing Wu
IPC分类号： B29D11/00
CPC分类号： G02B1/043 , C08F283/124 , C08L83/04 , C08L51/085
摘要： The invention provide a method for making silicone hydrogel based on the Lightstream Technology from a monomer mixture with a curing time of less than about 100 seconds. The present invention is also related to silicone hydrogel contact lenses made according to methods of the invention.
摘要翻译： 本发明提供了一种基于Lightstream Technology制造的硅氧烷水凝胶的方法，该方法来自具有小于约100秒的固化时间的单体混合物。 本发明还涉及根据本发明的方法制备的硅酮水凝胶隐形眼镜。
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公开(公告)号：US09097839B2
公开(公告)日：2015-08-04
申请号：US13419509
申请日：2012-03-14
申请人： Frank Chang , Jürgen Vogt , John Dallas Pruitt , Xinming Qian , Dawn A. Smith , Angelika Maria Domschke , Troy Vernon Holland , Richard Charles Turek , Daqing Wu
发明人： Frank Chang , Jürgen Vogt , John Dallas Pruitt , Xinming Qian , Dawn A. Smith , Angelika Maria Domschke , Troy Vernon Holland , Richard Charles Turek , Daqing Wu
IPC分类号： G02B1/04
CPC分类号： G02B1/043 , C08F283/124 , C08L83/04 , C08L51/085
摘要： The invention provide a method for making silicone hydrogel based on the Lightstream Technology from a monomer mixture with a curing time of less than about 100 seconds. The present invention is also related to silicone hydrogel contact lenses made according to methods of the invention.
摘要翻译： 本发明提供了一种基于Lightstream Technology制造的硅氧烷水凝胶的方法，该方法来自具有小于约100秒的固化时间的单体混合物。 本发明还涉及根据本发明的方法制备的硅酮水凝胶隐形眼镜。
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公开(公告)号：US20120172478A1
公开(公告)日：2012-07-05
申请号：US13419509
申请日：2012-03-14
申请人： Frank Chang , Jürgen Vogt , John Dallas Pruitt , Xinming Qian , Dawn A. Smith , Angelika Maria Domschke , Troy Vernon Holland , Richard Charles Turek , Daqing Wu
发明人： Frank Chang , Jürgen Vogt , John Dallas Pruitt , Xinming Qian , Dawn A. Smith , Angelika Maria Domschke , Troy Vernon Holland , Richard Charles Turek , Daqing Wu
IPC分类号： C08L83/07
CPC分类号： G02B1/043 , C08F283/124 , C08L83/04 , C08L51/085
摘要： The invention provide a method for making silicone hydrogel based on the Lightstream Technology from a monomer mixture with a curing time of less than about 100 seconds. The present invention is also related to silicone hydrogel contact lenses made according to methods of the invention.
摘要翻译： 本发明提供了一种基于Lightstream Technology制造的硅氧烷水凝胶的方法，该方法来自具有小于约100秒的固化时间的单体混合物。 本发明还涉及根据本发明的方法制备的硅酮水凝胶隐形眼镜。
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公开(公告)号：US20110102736A1
公开(公告)日：2011-05-05
申请号：US12917504
申请日：2010-11-02
申请人： Daqing Wu , Xinming Qian , John Dallas Pruitt
发明人： Daqing Wu , Xinming Qian , John Dallas Pruitt
CPC分类号： G02C7/04 , G02B1/043 , C08L101/14
摘要： The invention provides a cost-effective method for applying a hydrophilic coating onto a silicone hydrogel contact lens based on Fenton chemistry. The hydrophilic coating is covalently attached onto the contact lens at room temperature without UV irradiation. The invention also provides silicone hydrogel contact lenses having a hydrophilic coating obtained according to the method of the invention.
摘要翻译： 本发明提供了一种基于Fenton化学将亲水性涂层施加到硅酮水凝胶隐形眼镜上的成本有效的方法。 亲水涂层在室温下共价附着在隐形眼镜上，无紫外线照射。 本发明还提供了具有根据本发明方法获得的亲水涂层的硅酮水凝胶隐形眼镜。
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公开(公告)号：US20100258961A1
公开(公告)日：2010-10-14
申请号：US12456364
申请日：2009-06-16
申请人： Frank Chang , Jürgen Vogt , John Dallas Pruitt , Xinming Qian , Dawn A. Smith , Angelika Maria Domschke , Troy Vernon Holland , Richard Charles Turek , Daqing Wu
发明人： Frank Chang , Jürgen Vogt , John Dallas Pruitt , Xinming Qian , Dawn A. Smith , Angelika Maria Domschke , Troy Vernon Holland , Richard Charles Turek , Daqing Wu
CPC分类号： G02B1/043 , C08F283/124 , C08L83/04 , C08L51/085
摘要： The invention provide a method for making silicone hydrogel based on the Lightstream Technology from a monomer mixture with a curing time of less than about 100 seconds. The present invention is also related to silicone hydrogel contact lenses made according to methods of the invention.
摘要翻译： 本发明提供了一种基于Lightstream Technology制造的硅氧烷水凝胶的方法，该方法来自具有小于约100秒的固化时间的单体混合物。 本发明还涉及根据本发明的方法制备的硅酮水凝胶隐形眼镜。
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公开(公告)号：US09052439B2
公开(公告)日：2015-06-09
申请号：US13186616
申请日：2011-07-20
申请人： Newton T. Samuel , John Dallas Pruitt , Daqing Wu , Selma Kuyu
发明人： Newton T. Samuel , John Dallas Pruitt , Daqing Wu , Selma Kuyu
CPC分类号： G02B1/043 , B29D11/00038 , B29D11/00048 , G02C7/04 , G02C7/049 , C08L101/14
摘要： Described herein is a cost-effective and time-efficient method for making UV-absorbing contact lenses. In contrast to the conventional method for making UV-absorbing contact lenses which involves copolymerizing a lens forming composition including a UV-absorbing vinylic monomer, a method of the invention involves covalent attachment of a UV-absorbing compound having a second reactive functional group to a preformed contact lens having a first reactive functional group therein and/or thereon.
摘要翻译： 本文描述了制造紫外线吸收隐形眼镜的成本效益和时间有效的方法。 与使紫外线吸收性隐形眼镜相关的常规方法与包含紫外线吸收性乙烯基单体的透镜形成组合物共聚，本发明的方法涉及将具有第二反应性官能团的紫外线吸收性化合物与 其中和/或其上具有第一反应性官能团的预成型隐形眼镜。
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公开(公告)号：US20120139138A1
公开(公告)日：2012-06-07
申请号：US13309654
申请日：2011-12-02
申请人： Newton T. Samuel , Horngyih Huang , Daqing Wu , Uwe Haken , John Dallas Pruitt , Angelika Maria Domschke , Yasuo Matsuzawa
发明人： Newton T. Samuel , Horngyih Huang , Daqing Wu , Uwe Haken , John Dallas Pruitt , Angelika Maria Domschke , Yasuo Matsuzawa
IPC分类号： B29D11/02
CPC分类号： B29D11/00153 , B08B9/00 , G02B1/043 , C08L83/04 , C08L101/14
摘要： The invention provides a method for washing, with a water-based system, reusable molds for making silicone hydrogel contact lenses. The water-based washing system comprises an ethoxylated silicone polyether surfactant. The water-based system of the invention can effectively wash away silicone-containing components and other components of a lens formulation left behind on the molding surfaces of a reusable mold, after removing a silicone hydrogel contact lens cast molded in the reusable mold.
摘要翻译： 本发明提供了一种用水洗系统清洗可重复使用的模具以制造硅酮水凝胶隐形眼镜的方法。 水基洗涤系统包括乙氧基化硅氧烷聚醚表面活性剂。 在去除在可重复使用的模具中铸造的硅酮水凝胶隐形眼镜之后，本发明的水基系统可以有效地洗掉留在可重复使用的模具的模制表面上的透镜制剂的含硅酮组分和其它组分。
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