Percutaneous controlled releasing material using nano-sized polymer particles and external application agent containing the same
    2.
    发明申请
    Percutaneous controlled releasing material using nano-sized polymer particles and external application agent containing the same 审中-公开
    使用纳米尺寸聚合物颗粒的经皮控制释放材料和含有其的外用施用剂

    公开(公告)号:US20090232855A1

    公开(公告)日:2009-09-17

    申请号:US09878712

    申请日:2001-06-11

    IPC分类号: A61K8/02 A61K9/14

    CPC分类号: A61K9/5138

    摘要: A percutaneous releasing material and agent having characteristics that include a high stability of an active agent in the formulation, a high topical absorption rate, decreased irritation on the skin, and an increased tactile comfort. The percutaneous releasing material incorporates an external application agent composition that is prepared by using nanometer-sized polymer particles, i.e., particles having a size or diameter between approximately 1 nm and approximately 500 nm, and more preferably having a size between about 30 nm and about 150 nm. Further, the percutaneous releasing material and agent according to the present invention incorporate polymer particles that preferably contain a physiologically active agent that more readily penetrates through the stratum corneum to the upper layer of the dermis, whereby the physiologically active agent is effused into the skin while staying in the upper layer of dermis.

    摘要翻译: 具有包含制剂中活性剂高稳定性,高局部吸收率,对皮肤刺激性降低以及增加的触觉舒适度的特征的经皮释放材料和试剂。 经皮释放材料包含通过使用纳米尺寸聚合物颗粒制备的外用施用剂组合物,即具有约1nm至约500nm之间的尺寸或直径的颗粒,更优选具有约30nm至约30nm的尺寸 150nm。 此外,根据本发明的经皮释放材料和试剂掺入优选含有更容易穿透角质层至生理活性剂的生物活性剂的聚合物颗粒,从而使生理活性剂流入皮肤,同时 留在真皮层的上层。

    Controlled drug delivery system using the conjugation of drug to biodegradable polyester
    3.
    发明授权
    Controlled drug delivery system using the conjugation of drug to biodegradable polyester 失效
    使用药物与生物可降解聚酯共轭的控制药物递送系统

    公开(公告)号:US06589548B1

    公开(公告)日:2003-07-08

    申请号:US09700380

    申请日:2000-11-14

    IPC分类号: A61F200

    摘要: The present invention relates to a molecular sustained controlled release system constructed by the conjugation of molecules to be released with biodegradable polyester polymer via covalent bond and method for preparation thereof. In accordance with the present invention, the system may be formulated into microspheres, nanoparticles, or films. The molecular release rate from the above system can be regulated to be proportional to the chemical degradation rate of the biodegradable polyester polymers, resulting in near zero order kinetics profile of release without showing a burst effect, Moreover, a high loading efficiency of hydrophilic drugs can be achieved.

    摘要翻译: 本发明涉及通过共价键将待释放的分子与可生物降解的聚酯聚合物共轭而构成的分子持续控制释放系统及其制备方法。 根据本发明,该系统可以配制成微球,纳米颗粒或薄膜。 可以调节上述体系的分子释放速率与生物可降解聚酯聚合物的化学降解速率成比例,导致释放的接近零级动力学特征,而不发生爆裂效应。此外,亲水性药物的高负载效率可以 实现。

    Controlled drug delivery system using the conjugation of drug to biodegradable polyester
    8.
    发明授权
    Controlled drug delivery system using the conjugation of drug to biodegradable polyester 失效
    使用药物与生物可降解聚酯共轭的控制药物递送系统

    公开(公告)号:US07163698B2

    公开(公告)日:2007-01-16

    申请号:US10423536

    申请日:2003-04-25

    IPC分类号: A61K9/14 A61K9/16 A61K9/50

    摘要: The present invention relates to the molecular sustained controlled release system constructed by the conjugation of molecules to be released with biodegradable polyester polymer via covalent bond and method for preparation thereof. In accordance with the present invention, the system may be formulated into microspheres, nanoparticles, or films. The molecular release rate from the above system can be regulated to be proportional to the chemical degradation rate of the biodegradable polyester polymers, resulting in near zero order kinetics profile of release without showing a burst effect. Moreover, the high loading efficiency of hydrophilic drugs can be achieved.

    摘要翻译: 本发明涉及通过共价键与待分解的分子与可生物降解的聚酯聚合物共轭构成的分子持续控制释放体系及其制备方法。 根据本发明,该系统可以配制成微球,纳米颗粒或薄膜。 可以调节上述体系的分子释放速率与可生物降解的聚酯聚合物的化学降解速率成比例,导致释放的接近零级动力学特征,而不发生爆裂效应。 此外,可以实现亲水药物的高负载效率。