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1.发明授权Hyaluronic acid gel, a method of its production and medical material containing it 有权透明质酸凝胶，其生产方法和含有它的医用材料公开(公告)号：US06387413B1
公开(公告)日：2002-05-14
申请号：US09463993
申请日：2000-06-26
申请人： Yoshiaki Miyata , Akio Okamoto , Masatoshi Kawata , Kazuhiro Oshima , Masamichi Hashimoto , Kazuhiko Arai , Tomio Sawada
发明人： Yoshiaki Miyata , Akio Okamoto , Masatoshi Kawata , Kazuhiro Oshima , Masamichi Hashimoto , Kazuhiko Arai , Tomio Sawada
IPC分类号： A61K3534
CPC分类号： C08L5/08 , A61L15/28 , A61L27/20 , A61L31/042 , C08B37/0072 , Y10S514/944
摘要： A gel made of hyaluronic acid alone which is hardly soluble in a neutral aqueous solution and which keeps its shape for at least one day in a neutral aqueous solution at 25° C.
摘要翻译： 由透明质酸单独制成的凝胶，其几乎不溶于中性水溶液，并且在25℃的中性水溶液中保持至少一天的形状。
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2.发明授权Hyaluronic acid gel, method of its production and medical material containing it 有权透明质酸凝胶，其生产方法和含有它的医用材料公开(公告)号：US06790461B2
公开(公告)日：2004-09-14
申请号：US10047091
申请日：2002-01-17
申请人： Yoshiaki Miyata , Akio Okamoto , Masatoshi Kawata , Kazuhiro Oshima , Masamichi Hashimoto , Kazuhiko Arai
发明人： Yoshiaki Miyata , Akio Okamoto , Masatoshi Kawata , Kazuhiro Oshima , Masamichi Hashimoto , Kazuhiko Arai
IPC分类号： A61K3534
CPC分类号： C08L5/08 , A61L15/28 , A61L27/20 , A61L31/042 , C08B37/0072 , Y10S514/944
摘要： A gel made of hyaluronic acid alone which is hardly soluble in a neutral aqueous solution and which keeps its shape for at least one day in a neutral aqueous solution at 25° C.
摘要翻译： 由透明质酸单独制成的凝胶，其几乎不溶于中性水溶液，并且在25℃的中性水溶液中保持至少一天的形状。
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3.发明授权Hyaluronic acid gel, process for producing the same, and medical material containing the same 有权透明质酸凝胶，其制造方法以及含有该透明质酸凝胶的医用材料公开(公告)号：US07014860B1
公开(公告)日：2006-03-21
申请号：US10182467
申请日：2000-02-03
申请人： Masatoshi Kawata , Akio Okamoto , Yoshiaki Miyata , Kazuhiro Ohshima , Osamu Yamamoto , Teruzou Miyoshi , Kazuhiko Arai , Hironoshin Kitagawa , Toshihiko Umeda , Hiroshi Kaneko
发明人： Masatoshi Kawata , Akio Okamoto , Yoshiaki Miyata , Kazuhiro Ohshima , Osamu Yamamoto , Teruzou Miyoshi , Kazuhiko Arai , Hironoshin Kitagawa , Toshihiko Umeda , Hiroshi Kaneko
IPC分类号： A61F13/00
CPC分类号： A61L24/0031 , A61L24/08 , A61L27/20 , A61L27/52 , A61L31/042 , A61L31/145 , C08B37/0072 , C08L5/08
摘要： Production of a hyaluronic acid gel, which comprises keeping hyaluronic acid in water at a hyaluronic acid concentration of at least 5 wt % in the presence of an acid component in an amount at least equimolar with the carboxyl groups in the hyaluronic acid.
摘要翻译： 透明质酸凝胶的制备，其包括在透明质酸浓度为至少5重量％的水中，在酸组分存在下，与透明质酸中的羧基至少等摩尔的量保持水中的透明质酸。
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4.发明授权Hyaluronic acid gel composition, process for producing the same, and medical material containing the same 失效透明质酸凝胶组合物，其制造方法以及含有该透明质酸凝胶组合物的医用材料公开(公告)号：US06638538B1
公开(公告)日：2003-10-28
申请号：US09913718
申请日：2001-09-27
申请人： Masamichi Hashimoto , Toshihiko Umeda , Kazuhiko Arai , Yoshiaki Miyata , Osamu Yamamoto , Yasukazu Himeda
发明人： Masamichi Hashimoto , Toshihiko Umeda , Kazuhiko Arai , Yoshiaki Miyata , Osamu Yamamoto , Yasukazu Himeda
IPC分类号： A61K3534
CPC分类号： A61L31/042 , A61L26/0023 , A61L26/008 , A61L27/20 , A61L27/52 , C08B37/0072 , C08L1/286 , C08L5/08 , C08L29/04 , C08L1/26 , C08L2666/02
摘要： A hyaluronic acid gel composition comprising hyaluronic acid and a polymer, which is substantially unmodified with a chemical cross-linking agent or a chemical modifying agent and which has a percentage dissolution of hyaluronic acid of 50% or lower in 12 hours in a neutral aqueous solution of 37° C.
摘要翻译： 一种透明质酸凝胶组合物，其包含透明质酸和聚合物，其基本上用化学交联剂或化学改性剂未改性，并且在中性水溶液中在12小时内透明质酸溶解百分率为50％或更低 的37℃
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公开(公告)号：US20110039764A1
公开(公告)日：2011-02-17
申请号：US12912104
申请日：2010-10-26
IPC分类号： A61K38/12 , A61K31/7036 , A61K31/65 , A61P31/04
CPC分类号： A61K31/7036 , A61K31/65
摘要： A biodegradable composition containing an antibiotic or a physiologically active substance for use in surgical treatment of infection. A highly safe and biocompatible composition showing appropriately sustained release of an antibiotic or physiologically active substance which produces excellent antibiotic and bone regenerating effects. A composition having excellent effects in treatment of bone infection occurring after operations for total arthroplasty and/or bone fracture. (1) A medical composition for treatment of bone infection comprising an antibiotic and a polysaccharide.
摘要翻译： 一种可生物降解的组合物，其含有用于外科治疗感染的抗生素或生理活性物质。 显示适当缓释抗生素或生理活性物质的高度安全和生物相容的组合物，其产生优异的抗生素和骨再生效果。 一种在完全关节成形术和/或骨折手术后发生的骨感染治疗具有优异效果的组合物。 （1）一种用于治疗骨感染的医药组合物，其包含抗生素和多糖。
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公开(公告)号：US07807657B2
公开(公告)日：2010-10-05
申请号：US12027365
申请日：2008-02-07
IPC分类号： A01N43/04 , A61K31/715
CPC分类号： A61K31/728 , A61K9/0024 , A61K9/08 , A61K47/36 , A61L24/0031 , A61L24/08 , A61L27/20 , A61L27/52 , A61L31/042 , A61L31/145 , A61L2400/06 , C08B37/0072 , C08L5/08
摘要： A separate type medical material containing a hyaluronic acid ester derivative, which satisfies the storage stability of a hyaluronic acid ester derivative and avoidance of irritation and pain at the time of injecting a therapeutic agent for joints, is provided. A separate type medical material comprising liquid (A) which is an aqueous solution containing a hyaluronic acid ester derivative and buffered to a pH of from 4.5 to 6.5, and liquid (B) which is an aqueous solution having such a buffering power that when it is mixed with the liquid (A), the mixed liquid has a pH within a range of from 6.8 to 7.8, kept separately from each other.
摘要翻译： 提供了含有透明质酸酯衍生物的分离型药物，其满足透明质酸酯衍生物的保存稳定性，并且在注射用于关节的治疗剂时避免刺激和疼痛。 包含作为含有透明质酸酯衍生物并且缓冲至4.5至6.5的pH的水溶液的液体（A）的单独类型的医用材料和作为具有缓冲能力的水溶液的液体（B） 与液体（A）混合，混合液体的pH值在6.8〜7.8的范围内，彼此分开。
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7.发明申请公开(公告)号：US20130203697A1
公开(公告)日：2013-08-08
申请号：US13818848
申请日：2011-08-23
申请人： Masamichi Hashimoto , Tadashi Morikawa , Yoshiaki Miyata , Akio Ohno , Kei Takahashi , Daisuke Ogasawara , Kenji Fujii , Teruaki Kakema , Mariko Takeda
发明人： Masamichi Hashimoto , Tadashi Morikawa , Yoshiaki Miyata , Akio Ohno , Kei Takahashi , Daisuke Ogasawara , Kenji Fujii , Teruaki Kakema , Mariko Takeda
IPC分类号： A61K31/728
CPC分类号： A61K31/728 , A61K8/735 , A61K9/0019 , A61K9/0024 , A61K2800/87 , A61K2800/91 , A61Q19/08 , C08B37/0072 , C08L5/08 , Y10T428/2982
摘要： The present invention provides a crosslinked hyaluronic acid composition including self-crosslinking hyaluronic acid particles having an equilibrium swelling capacity of 3-fold to 10-fold, and an aqueous solvent, wherein a dry weight of the self-crosslinking hyaluronic acid particles based on the total volume of the crosslinked hyaluronic acid composition is 3 w/v % to 8 w/v %.The crosslinked hyaluronic acid composition of the invention uses self-crosslinking hyaluronic acid particles of which the equilibrium swelling capacity is within the above predetermined range. Accordingly, the viscosity does not sharply increase even if the concentration thereof is increased. Therefore, if the crosslinked hyaluronic acid composition is applied to an injection, it is possible to obtain a sufficient curative effect on knee osteoarthritis even with a small frequency of administration.
摘要翻译： 本发明提供一种交联透明质酸组合物，其包含平衡溶胀能力为3倍至10倍的自交联透明质酸颗粒和水性溶剂，其中基于所述自交联透明质酸颗粒的干重 交联透明质酸组合物的总体积为3w / v％至8w / v％。 本发明的交联透明质酸组合物使用自交联透明质酸颗粒，其平衡溶胀能力在上述预定范围内。 因此，即使其浓度增加，粘度也不会急剧增加。 因此，如果将交联透明质酸组合物应用于注射剂，则即使施用次数较少，也可以获得对膝关节骨性关节炎的充分治疗效果。
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公开(公告)号：US20080132585A1
公开(公告)日：2008-06-05
申请号：US12027365
申请日：2008-02-07
CPC分类号： A61K31/728 , A61K9/0024 , A61K9/08 , A61K47/36 , A61L24/0031 , A61L24/08 , A61L27/20 , A61L27/52 , A61L31/042 , A61L31/145 , A61L2400/06 , C08B37/0072 , C08L5/08
摘要： A separate type medical material containing a hyaluronic acid ester derivative, which satisfies the storage stability of a hyaluronic acid ester derivative and avoidance of irritation and pain at the time of injecting a therapeutic agent for joints, is provided.A separate type medical material comprising liquid (A) which is an aqueous solution containing a hyaluronic acid ester derivative and buffered to a pH of from 4.5 to 6.5, and liquid (B) which is an aqueous solution having such a buffering power that when it is mixed with the liquid (A), the mixed liquid has a pH within a range of from 6.8 to 7.8, kept separately from each other.
摘要翻译： 提供了含有透明质酸酯衍生物的分离型药物，其满足透明质酸酯衍生物的保存稳定性，并且在注射用于关节的治疗剂时避免刺激和疼痛。 包含作为含有透明质酸酯衍生物并且缓冲至4.5至6.5的pH的水溶液的液体（A）的单独类型的医用材料和作为具有缓冲能力的水溶液的液体（B） 与液体（A）混合，混合液体的pH值在6.8〜7.8的范围内，彼此分开。
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公开(公告)号：US20060153893A1
公开(公告)日：2006-07-13
申请号：US10509323
申请日：2003-04-08
IPC分类号： A61K38/14 , A61K31/728 , A61K31/7034 , A61F2/00
CPC分类号： A61K31/7036 , A61K31/65
摘要： A biodegradable composition containing an antibiotic or a physiologically active substance for use in surgical treatment of infection. A highly safe and biocompatible composition showing appropriately sustained release of an antibiotic or physiologically active substance which produces excellent antibiotic and bone regenerating effects. A composition having excellent effects in treatment of bone infection occurring after operations for total arthroplasty and/or bone fracture. (1) A medical composition for treatment of bone infection comprising an antibiotic and a polysaccharide.
摘要翻译： 一种可生物降解的组合物，其含有用于外科治疗感染的抗生素或生理活性物质。 显示适当缓释抗生素或生理活性物质的高度安全和生物相容的组合物，其产生优异的抗生素和骨再生效果。 一种在完全关节成形术和/或骨折手术后发生的骨感染治疗具有优异效果的组合物。 （1）一种用于治疗骨感染的医药组合物，其包含抗生素和多糖。
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10.发明授权Crosslinked hyaluronic acid composition and self-crosslinking hyaluronic acid particles 有权交联透明质酸组合物和自交联透明质酸颗粒公开(公告)号：US09216193B2
公开(公告)日：2015-12-22
申请号：US13818848
申请日：2011-08-23
申请人： Masamichi Hashimoto , Tadashi Morikawa , Yoshiaki Miyata , Akio Ohno , Kei Takahashi , Daisuke Ogasawara , Kenji Fujii , Teruaki Kakema , Mariko Takeda
发明人： Masamichi Hashimoto , Tadashi Morikawa , Yoshiaki Miyata , Akio Ohno , Kei Takahashi , Daisuke Ogasawara , Kenji Fujii , Teruaki Kakema , Mariko Takeda
IPC分类号： A61K31/727 , A61K31/728 , C08B37/08 , C08L5/08 , A61K8/73 , A61K9/00
CPC分类号： A61K31/728 , A61K8/735 , A61K9/0019 , A61K9/0024 , A61K2800/87 , A61K2800/91 , A61Q19/08 , C08B37/0072 , C08L5/08 , Y10T428/2982
摘要： The present invention provides a crosslinked hyaluronic acid composition including self-crosslinking hyaluronic acid particles having an equilibrium swelling capacity of 3-fold to 10-fold, and an aqueous solvent, wherein a dry weight of the self-crosslinking hyaluronic acid particles based on the total volume of the crosslinked hyaluronic acid composition is 3 w/v % to 8 w/v %.The crosslinked hyaluronic acid composition of the invention uses self-crosslinking hyaluronic acid particles of which the equilibrium swelling capacity is within the above predetermined range. Accordingly, the viscosity does not sharply increase even if the concentration thereof is increased. Therefore, if the crosslinked hyaluronic acid composition is applied to an injection, it is possible to obtain a sufficient curative effect on knee osteoarthritis even with a small frequency of administration.
摘要翻译： 本发明提供一种交联透明质酸组合物，其包含平衡溶胀能力为3倍至10倍的自交联透明质酸颗粒和水性溶剂，其中基于所述自交联透明质酸颗粒的干重 交联透明质酸组合物的总体积为3w / v％至8w / v％。 本发明的交联透明质酸组合物使用自交联透明质酸颗粒，其平衡溶胀能力在上述预定范围内。 因此，即使其浓度增加，粘度也不会急剧增加。 因此，如果将交联透明质酸组合物应用于注射剂，则即使施用次数较少，也可以获得对膝关节骨性关节炎的充分治疗效果。
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