公开(公告)号：US4737460A

公开(公告)日：1988-04-12

申请号：US762838

申请日：1985-08-06

申请人： Yoshifumi Shinmen ,  Sumio Asami ,  Norihide Amano ,  Teruo Amachi ,  Hajime Yoshizumi ,  Eiichi Kosugi

发明人： Yoshifumi Shinmen ,  Sumio Asami ,  Norihide Amano ,  Teruo Amachi ,  Hajime Yoshizumi ,  Eiichi Kosugi

IPC分类号： C12N9/08 ,  C12R1/645 ,  C12Q1/28

CPC分类号： C12N9/0065 ,  Y10S435/911

摘要： A novel peroxidase that is non specific and that does not contain isozymes and hence, is suitable as a diagnostic reagent or as a marker enzyme in enzyme immunoassay is provided as well as a process of its preparation. The novel peroxidase is produced by a microorganism of a new genus Arthromyces.

摘要翻译： 提供非特异性且不含同功酶的新型过氧化物酶，因此，其适用于酶免疫测定中的诊断试剂或标记酶，以及其制备方法。 新型过氧化物酶由新型Arthromyces的微生物产生。

公开(公告)号：US5116751A

公开(公告)日：1992-05-26

申请号：US643166

申请日：1991-01-22

申请人： Yoshifumi Shinmen ,  Sumio Asami ,  Norihide Amano ,  Teruo Amachi ,  Hajime Yoshizumi

发明人： Yoshifumi Shinmen ,  Sumio Asami ,  Norihide Amano ,  Teruo Amachi ,  Hajime Yoshizumi

IPC分类号： C12N9/08 ,  C12Q1/28 ,  C12R1/645

CPC分类号： C12N9/0065 ,  C12Q1/28 ,  Y10S435/911

摘要： A novel peroxidase was obtained from a fast growing microorganism of the genus Coprinus cinereus. The fungal peroxidase is comparable to the conventional peroxidase derived from horseradish or Japanese radish in that it can be used either as a clinical or diagnostic reagent or as a marker enzyme in enzyme immunoassay.

摘要翻译： 一种新型过氧化物酶是从快速生长的灰霉菌属微生物获得的。 真菌过氧化物酶与来自辣根或日本萝卜的常规过氧化物酶相当，因为它可以作为临床或诊断试剂或作为酶免疫测定中的标记酶使用。

公开(公告)号：US4774185A

公开(公告)日：1988-09-27

申请号：US915026

申请日：1986-10-03

申请人： Sumio Asami ,  Norihide Amano ,  Teruo Amachi ,  Hajime Yoshizumi

发明人： Sumio Asami ,  Norihide Amano ,  Teruo Amachi ,  Hajime Yoshizumi

IPC分类号： C12N9/02 ,  C12R1/01

CPC分类号： C12N9/0089 ,  Y10S435/822

摘要： A novel superoxide dismutase prepared from a superoxide dismutase-producing strain of the genus Nocardiopsis. The enzyme is a tetramer with a molecular weight of about 8.8.times.10.sup.4, composed of sub-units of about 2.2.times.10.sup.4. The superoxide dismutase contains 1.56 g-atoms of iron per mole but no copper or manganese. Potassium cyanide at a concentration of 1 mM does not inhibit activity, however exponential inactivation is caused by 5 mM hydrogen peroxide.

摘要翻译： 一种由Nocardiopsis属超氧化物歧化酶生产菌株制备的新型超氧化物歧化酶。 该酶是分子量约为8.8×10 4的四聚物，由约2.2×10 4的亚单位组成。 超氧化物歧化酶每摩尔含有1.56克原子铁，但不含铜或锰。 浓度为1mM的氰化钾不抑制活性，但是由5mM过氧化氢引起指数失活。

公开(公告)号：US5153128A

公开(公告)日：1992-10-06

申请号：US669574

申请日：1991-03-14

申请人： Toru Nakayama ,  Yukiko Kodama ,  Norihide Amano ,  Masahiro Nakao ,  Yuji Shibano ,  Teruo Amachi

发明人： Toru Nakayama ,  Yukiko Kodama ,  Norihide Amano ,  Masahiro Nakao ,  Yuji Shibano ,  Teruo Amachi

IPC分类号： A23C9/12 ,  C12N9/10 ,  C12P19/18

CPC分类号： C12Y302/01023 ,  A23C9/1206 ,  C12N9/1051 ,  C12P19/18 ,  Y10S435/822

摘要： Described herein are a novel heat-resistant .beta.-galactosyltransferase, a production process of the enzyme and a utilization method of the enzyme. The enzyme is produced preferably by produced by a microorganism belonging to the family of Actinomycetaceae, which may be selected from fungi belonging to the genus Saccharopolyspora, the genus Thermomonospora or the genus Thermoactinomyces.

公开(公告)号：US5861289A

公开(公告)日：1999-01-19

申请号：US55553

申请日：1993-05-03

申请人： Toru Nakayama ,  Yukiko Kodama ,  Norihide Amano ,  Masahiro Nakao ,  Yuji Shibano ,  Teruo Amachi

发明人： Toru Nakayama ,  Yukiko Kodama ,  Norihide Amano ,  Masahiro Nakao ,  Yuji Shibano ,  Teruo Amachi

IPC分类号： A23C9/12 ,  C12N9/10 ,  C12P19/18 ,  C12N9/38 ,  C12R1/01

CPC分类号： C12Y302/01023 ,  A23C9/1206 ,  C12N9/1051 ,  C12P19/18 ,  Y10S435/822

摘要： Described herein are a novel heat-resistant .beta.-galactosyltransferase, a production process of the enzyme and a utilization method of the enzyme. The enzyme is produced preferably by produced by a microorganism belonging to the family of Actinomycetaceae, which may be selected from fungi belonging to the genus Saccharopolyspora, the genus Thermomonospora or the genus Thermoactinomvces.

摘要翻译： 本文描述了新型耐热β-半乳糖基转移酶，酶的生产方法和酶的利用方法。 优选通过由属于放线菌科家族的微生物产生的酶，其可以选自属于Saccharopolyspora属，Thermomonospora属或Thermactinomvces属的真菌。

公开(公告)号：US5234828A

公开(公告)日：1993-08-10

申请号：US907639

申请日：1992-07-02

申请人： Toru Nakayama ,  Yukiko Kodama ,  Norihide Amano ,  Masahiro Nakao ,  Yuji Shibano ,  Teruo Amachi

发明人： Toru Nakayama ,  Yukiko Kodama ,  Norihide Amano ,  Masahiro Nakao ,  Yuji Shibano ,  Teruo Amachi

IPC分类号： A23C9/12 ,  C12N9/10 ,  C12P19/18

CPC分类号： C12Y302/01023 ,  A23C9/1206 ,  C12N9/1051 ,  C12P19/18 ,  Y10S435/822

摘要： Described herein are a novel heat-resistant .beta.-galactosyltransferase, a production process of the enzyme and a utilization method of the enzyme. The enzyme is produced preferably by produced by a microorganism belonging to the family of Actinomycetaceae, which may be selected from fungi belonging to the genus Saccharopolyspora, the genus Thermomonospora or the genus Thermoactinomyces.

摘要翻译： 本文描述了新型耐热β-半乳糖基转移酶，酶的生产方法和酶的利用方法。 该酶优选通过由属于放线菌科家族的微生物产生，该微生物可以选自属于Saccharopolyspora属，Thermomonospora属或Thermactinomyces属的真菌。

公开(公告)号：US5021406A

公开(公告)日：1991-06-04

申请号：US309673

申请日：1989-02-13

申请人： Mitsuru Maeda ,  Tohru Kodama ,  Sumio Asami ,  Norihide Amano ,  Takaaki Kusumi ,  Hidekazu Hosono

发明人： Mitsuru Maeda ,  Tohru Kodama ,  Sumio Asami ,  Norihide Amano ,  Takaaki Kusumi ,  Hidekazu Hosono

IPC分类号： A01N57/16 ,  A61K31/665 ,  C07D309/32 ,  C07F9/655 ,  C12P17/06 ,  C12R1/465

CPC分类号： C07F9/6552 ,  A01N57/16 ,  A61K31/665 ,  C12P17/06

摘要： A 2-pyranone derivative represented by the formula (I): ##STR1## wherein R represents a hydrogen atom, or a linear, branched alkylcarbonyloxy, or cyclo-alkylcarbonyloxy group having 3 to 10 carbon atoms, and salts thereof; a process for the production of the above-mentioned 2-pyranone derivative (I), comprising the steps of culturing a microorganism belonging to the genus Streptomyces and capable of producing the derivative, to produce the derivative, and recovering the produced derivative from the cultured product; a biocidal composition comprising the above-mentioned 2-pyranone derivative (I); and a microorganism belonging to the genus Stretromyces and capable of producing the above-mentioned 2-pyranone derivatives.

摘要翻译： 由式（I）表示的2-吡喃酮衍生物：其中R表示氢原子或具有3至10个碳原子的直链，支链烷基羰氧基或环烷基羰基氧基，以及盐 的; 一种制备上述2-吡喃酮衍生物（I）的方法，包括以下步骤：培养属于链霉菌属的微生物并能够制备该衍生物以产生该衍生物，并从培养的培养物中回收所产生的衍生物 产品; 包含上述2-吡喃酮衍生物（I）的杀生物组合物; 和属于Stretromyces属的微生物，能够生产上述2-吡喃酮衍生物。

公开(公告)号：US5087614A

公开(公告)日：1992-02-11

申请号：US271965

申请日：1988-11-16

申请人： Mitsuru Maeda ,  Tohru Kodama ,  Norio Iwasawa ,  Naoki Higuchi ,  Norihide Amano

发明人： Mitsuru Maeda ,  Tohru Kodama ,  Norio Iwasawa ,  Naoki Higuchi ,  Norihide Amano

IPC分类号： A61K38/55 ,  A61P1/04 ,  A61P9/12 ,  A61P13/02 ,  A61P15/00 ,  A61P43/00 ,  C07K5/02 ,  C07K5/06 ,  C07K14/195 ,  C07K14/41 ,  C07K14/81 ,  C12N9/99 ,  C12P21/02 ,  C12R1/01

CPC分类号： C07K5/0205 ,  Y10S435/826

摘要： Novel peptide analogues which exhibit inhibitory activity against aspartic proteinases, a novel species of actinomycetous microorganism which produces said novel peptide analogues, a process for producing said novel analogues by culturing said species and a pharmaceutical composition containing said analogues.