公开(公告)号：US20100069824A1

公开(公告)日：2010-03-18

申请号：US12461758

申请日：2009-08-24

申请人： Yoshiharu Okamoto ,  Saburo Minami ,  Yoshimitsu Abiko ,  Satoshi Otsuka ,  Nobuhiko Ogawa ,  Masaru Matsui

发明人： Yoshiharu Okamoto ,  Saburo Minami ,  Yoshimitsu Abiko ,  Satoshi Otsuka ,  Nobuhiko Ogawa ,  Masaru Matsui

IPC分类号： A61M37/00

CPC分类号： A61N5/062 ,  A61K31/404 ,  A61K41/0052 ,  A61N2005/0644 ,  A61N2005/0659

摘要： A photodynamic hyperthermic chemotherapy of cancer comprising topically injecting a photosensitive dye agent, specifically indocyanine green, in the form of an acidic liquid formulation to a tumor or cancer tissue, or a surgically removed site thereof of a patient, and irradiating the tissue or site with light having such an output wavelength that the photosensitive dye agent absorbs the light and generates heat; and an apparatus and a system for photodynamic hyperthermic chemotherapy of cancer comprising a light source and a probe having a light introducing portion capable of topically irradiating a tumor or cancer tissue or a surgically removed site thereof of a patient with light derived from the light source by a continuous wave or a pulse wave at an output wavelength of 600 to 1600 nm and an output of 5000 mW or more.

摘要翻译： 癌症的光动力学高热化学疗法包括将酸性液体制剂形式的光敏染料，特别是吲哚菁绿局部注射到患者的肿瘤或癌组织或其外科手术移除的部位，并将组织或部位用 具有光敏染料剂吸收光并产生热量的输出波长的光; 以及用于癌症的光动力学高热化疗的装置和系统，包括光源和探针，所述探针具有能够通过光源衍生的光局部照射患者的肿瘤或癌组织或手术切除部位的光引入部分， 输出波长为600〜1600nm的连续波或脉波，输出为5000mW以上。

公开(公告)号：US20080096198A1

公开(公告)日：2008-04-24

申请号：US11665156

申请日：2005-10-14

申请人： Koichi Hiratsuka ,  Yoshimitsu Abiko ,  Michiko Kishikawa

发明人： Koichi Hiratsuka ,  Yoshimitsu Abiko ,  Michiko Kishikawa

IPC分类号： C12Q1/68 ,  C07H21/00 ,  C12P19/34

CPC分类号： C12Q1/6865 ,  C12N15/1096 ,  C12Q1/686 ,  C12Q2525/143

摘要： It is intended to provide a primer having a promoter region added thereto; and a method of using the primer having a promoter region added thereto in RNA amplification, gene expression analysis and/or identification analysis of an organism. A primer is constructed by adding a promoter region to a random primer capable of binding to a part highly complementary to an RNA or a primer containing a base sequence complementary to a specific gene. Then, the obtained primer is employed in RNA amplification, gene expression analysis and/or identification analysis of an organism.

摘要翻译： 目的在于提供一种其上添加有启动子区域的引物; 以及在生物体的RNA扩增，基因表达分析和/或鉴定分析中使用其中添加有启动子区的引物的方法。 通过向能够结合与RNA高度互补的部分的随机引物添加启动子区域，或者与特定基因互补的碱基序列的引物添加引物。 然后，将获得的引物用于生物体的RNA扩增，基因表达分析和/或鉴定分析。

公开(公告)号：US20070036734A1

公开(公告)日：2007-02-15

申请号：US10549289

申请日：2004-03-17

申请人： Tomoyuki Tahara ,  Yoshimitsu Abiko ,  Hiromasa Yoshie ,  Tetsuo Kobayashi ,  Toshio Umemoto ,  Nobushiro Hamada

发明人： Tomoyuki Tahara ,  Yoshimitsu Abiko ,  Hiromasa Yoshie ,  Tetsuo Kobayashi ,  Toshio Umemoto ,  Nobushiro Hamada

IPC分类号： A61K39/40 ,  C07K16/12 ,  A61K8/96 ,  G01N33/554 ,  C12N5/06

CPC分类号： C07K16/1257 ,  A61K2039/505 ,  C07K16/1203 ,  C07K2317/77

摘要： The present invention provides a human monoclonal antibody that has both activity of inhibiting the aggregation of pathogenic bacteria involved in periodontal diseases and activity of promoting sterilization by leukocytes, that is preferably a monoclonal antibody against 40-kDa OMP, which inhibits the binding of hemin, and that causes no concerns such as side effects. The present invention further provides an agent that acts against periodontal diseases containing the monoclonal antibody. The present invention relates to an antibody binding to 40-kDa OMP or a functional fragment thereof having at least one of (1) activity of inhibiting the coaggregation of P. gingivalis, (2) activity of promoting human neutrophilic phagocytosis, and (3) activity of inhibiting the binding of hemin to 40-kDa OMP.

摘要翻译： 本发明提供一种具有抑制牙周疾病病原菌聚集的活性和促进白细胞灭活的活性的人单克隆抗体，其优选为40kDa OMP的单克隆抗体，其抑制血红素的结合， 并且不会引起副作用等问题。 本发明还提供了一种对含有单克隆抗体的牙周病作用的药剂。 本发明涉及结合40-kDa OMP的抗体或其功能片段，其具有以下至少一种：（1）抑制牙龈卟啉单胞菌共聚的活性，（2）促进人嗜中性粒细胞吞噬作用的活性，和（3） 抑制血红素与40-kDa OMP结合的活性。