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公开(公告)号：US20070120070A1
公开(公告)日：2007-05-31
申请号：US11647031
申请日：2006-12-27
IPC分类号： G01J1/58
CPC分类号： G01N21/6486 , G01N21/6456
摘要： The invention provides a multiphoton-excitation-type examination apparatus that efficiently generates a multiphoton-excitation effect, that makes the measurement head compact, and that can be easily adjusted when the measurement head is replaced. The multiphoton-excitation-type examination apparatus comprises a laser light source that oscillates ultrashort pulsed laser light; an optical fiber that transmits the ultrashort pulsed laser light from the laser light source; a support member; a measurement head supported on the support member so as to be movable upwards and downwards and at an angle, and having an optical system that irradiates a specimen with the ultrashort pulsed laser light transmitted by the optical fiber that measures fluorescence or reflected light coming from the specimen; and a dispersion-compensating member, in the measurement head, that compensates for group velocity dispersion of the ultrashort pulsed laser light irradiated onto the specimen.
摘要翻译： 本发明提供了一种多光子激发型检查装置，其有效地产生使得测量头紧凑，并且在更换测量头时可以容易地调节的多光子激发效果。 多光子激发型检查装置包括：振荡超短脉冲激光的激光光源; 从激光光源发射超短脉冲激光的光纤; 支撑构件; 测量头支撑在支撑构件上，以便可上下移动一定角度，并且具有光学系统，该光学系统用由光纤透射的超短脉冲激光照射样本，该光纤测量荧光或来自 标本; 以及在测量头中补偿照射到样本上的超短脉冲激光的组速度色散的色散补偿部件。
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公开(公告)号：US20050279950A1
公开(公告)日：2005-12-22
申请号：US11070191
申请日：2005-03-03
CPC分类号： G01N21/6486 , G01N21/6456
摘要： The invention provides a multiphoton-excitation-type examination apparatus that efficiently generates a multiphoton-excitation effect, that makes the measurement head compact, and that can be easily adjusted when the measurement head is replaced. The multiphoton-excitation-type examination apparatus comprises a laser light source that oscillates ultrashort pulsed laser light; an optical fiber that transmits the ultrashort pulsed laser light from the laser light source; a support member; a measurement head supported on the support member so as to be movable upwards and downwards and at an angle, and having an optical system that irradiates a specimen with the ultrashort pulsed laser light transmitted by the optical fiber that measures fluorescence or reflected light coming from the specimen; and a dispersion-compensating member, in the measurement head, that compensates for group velocity dispersion of the ultrashort pulsed laser light irradiated onto the specimen.
摘要翻译： 本发明提供了一种多光子激发型检查装置，其有效地产生使得测量头紧凑，并且在更换测量头时可以容易地调节的多光子激发效果。 多光子激发型检查装置包括：振荡超短脉冲激光的激光光源; 从激光光源发射超短脉冲激光的光纤; 支撑构件; 测量头支撑在支撑构件上，以便可上下移动一定角度，并且具有光学系统，该光学系统用由光纤透射的超短脉冲激光照射样本，该光纤测量荧光或来自 标本; 以及在测量头中补偿照射到样本上的超短脉冲激光的组速度色散的色散补偿部件。
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公开(公告)号：US07176428B2
公开(公告)日：2007-02-13
申请号：US11070191
申请日：2005-03-03
CPC分类号： G01N21/6486 , G01N21/6456
摘要： The invention provides a multiphoton-excitation-type examination apparatus that efficiently generates a multiphoton-excitation effect, that makes the measurement head compact, and that can be easily adjusted when the measurement head is replaced. The multiphoton-excitation-type examination apparatus comprises a laser light source that oscillates ultrashort pulsed laser light; an optical fiber that transmits the ultrashort pulsed laser light from the laser light source; a support member; a measurement head supported on the support member so as to be movable upwards and downwards and at an angle, and having an optical system that irradiates a specimen with the ultrashort pulsed laser light transmitted by the optical fiber that measures fluorescence or reflected light coming from the specimen; and a dispersion-compensating member, in the measurement head, that compensates for group velocity dispersion of the ultrashort pulsed laser light irradiated onto the specimen.
摘要翻译： 本发明提供了一种多光子激发型检查装置，其有效地产生使得测量头紧凑，并且在更换测量头时可以容易地调节的多光子激发效果。 多光子激发型检查装置包括：振荡超短脉冲激光的激光光源; 从激光光源发射超短脉冲激光的光纤; 支撑构件; 测量头支撑在支撑构件上，以便可上下移动一定角度，并且具有光学系统，该光学系统用由光纤透射的超短脉冲激光照射样本，该光纤测量荧光或来自 标本; 以及在测量头中补偿照射到样本上的超短脉冲激光的组速度色散的色散补偿部件。
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公开(公告)号：US07015444B2
公开(公告)日：2006-03-21
申请号：US11085047
申请日：2005-03-22
CPC分类号： G02B21/0048 , G02B21/004 , G02B21/0076
摘要： The invention provides an optical-scanning examination apparatus with a simple configuration, in which the resolution of acquired images can be freely changed and in which the fluorescence image intensity and examination depth can be adjusted to suit the purpose of examination. The optical-scanning examination apparatus includes a light source unit; a focusing lens for forming a first intermediate image of excitation light; an imaging lens; a first objective lens; an optical fiber bundle; a second objective lens; and an imaging unit for imaging return light that returns via the second objective lens, the optical fiber bundle, the first objective lens, and the imaging lens. In addition, a scanning mirror device, which is disposed at the first intermediate image position, is formed of a plurality of mirrors that simultaneously receive the first intermediate image and that can be selectively turned on and off.
摘要翻译： 本发明提供了一种具有简单结构的光学扫描检查装置，其中可以自由地改变所获取的图像的分辨率，并且可以调整荧光图像强度和检查深度以适应检查的目的。 光扫描检查装置包括：光源单元; 用于形成激发光的第一中间图像的聚焦透镜; 成像透镜; 第一个物镜; 光纤束; 第二个物镜; 以及用于对通过第二物镜，光纤束，第一物镜和成像透镜返回的返回光成像的成像单元。 此外，设置在第一中间图像位置的扫描镜装置由同时接收第一中间图像并且可以选择性地打开和关闭的多个反射镜形成。
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公开(公告)号：US20050211872A1
公开(公告)日：2005-09-29
申请号：US11085047
申请日：2005-03-22
CPC分类号： G02B21/0048 , G02B21/004 , G02B21/0076
摘要： The invention provides an optical-scanning examination apparatus with a simple configuration, in which the resolution of acquired images can be freely changed and in which the fluorescence image intensity and examination depth can be adjusted to suit the purpose of examination. The optical-scanning examination apparatus includes a light source unit; a focusing lens for forming a first intermediate image of excitation light; an imaging lens; a first objective lens; an optical fiber bundle; a second objective lens; and an imaging unit for imaging return light that returns via the second objective lens, the optical fiber bundle, the first objective lens, and the imaging lens. In addition, a scanning mirror device, which is disposed at the first intermediate image position, is formed of a plurality of mirrors that simultaneously receive the first intermediate image and that can be selectively turned on and off.
摘要翻译： 本发明提供了一种具有简单结构的光学扫描检查装置，其中可以自由地改变所获取的图像的分辨率，并且可以调整荧光图像强度和检查深度以适应检查的目的。 光扫描检查装置包括：光源单元; 用于形成激发光的第一中间图像的聚焦透镜; 成像透镜; 第一个物镜; 光纤束; 第二个物镜; 以及用于对通过第二物镜，光纤束，第一物镜和成像透镜返回的返回光成像的成像单元。 此外，设置在第一中间图像位置的扫描镜装置由同时接收第一中间图像并且可以选择性地打开和关闭的多个反射镜形成。
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公开(公告)号：US07301626B2
公开(公告)日：2007-11-27
申请号：US11182782
申请日：2005-07-18
IPC分类号： G01J3/30
CPC分类号： G01N21/6458 , G02B21/002 , G02B21/0064 , G02B21/0076 , G02B21/0084 , G02B21/16
摘要： The invention reduces the loss of fluorescence intensity obtained from a specimen to acquire clear fluorescence images when irradiating the specimen with ultrashort-pulse laser light produced by a laser light source. The invention provides a laser-scanning examination apparatus including a laser light source for producing ultrashort-pulse laser light; a laser light source for producing continuous-wave laser light; a measurement head including an optical scanning unit for scanning the laser light on a specimen and an objective optical system; an imaging unit for detecting return light from the specimen in response to the ultrashort-pulse laser light; and an imaging unit for detecting return light from the specimen in response to the continuous-wave laser light. The laser light sources and one imaging unit are connected to the measurement head by an optical fiber, and the other imaging unit is connected to the measurement head by another optical fiber with a larger core diameter.
摘要翻译： 本发明减少了从样品获得的荧光强度的损失，以便在用激光光源产生的超短脉冲激光照射样品时获得清晰的荧光图像。 本发明提供了一种激光扫描检查装置，其包括用于产生超短脉冲激光的激光光源; 用于产生连续波激光的激光源; 测量头，包括用于扫描样本上的激光的光学扫描单元和物镜光学系统; 用于响应于超短脉冲激光来检测来自样本的返回光的成像单元; 以及用于响应于连续波激光来检测来自样本的返回光的成像单元。 激光光源和一个成像单元通过光纤连接到测量头，另一个成像单元通过具有较大芯直径的另一光纤连接到测量头。
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公开(公告)号：US20050281476A1
公开(公告)日：2005-12-22
申请号：US11080561
申请日：2005-03-16
CPC分类号： A61B5/0059 , A61B5/0066 , A61B5/0068 , A61B5/0402 , A61B8/06 , H04N5/23212
摘要： An examination apparatus that can acquire detailed images from a specimen exhibiting dynamic behavior is provided. The examination apparatus comprises an imaging unit that images a specimen exhibiting dynamic behavior; a behavior detecting unit that detects the dynamic behavior of the specimen; an image storing unit that stores the dynamic behavior of the specimen detected by the behavior detecting unit and images of the specimen imaged by the imaging unit so as to be associated with each other; and a still-image extraction unit that extracts an image of the specimen when the specimen is substantially still based on the dynamic behavior of the specimen from the images of the specimen stored in the image storing unit.
摘要翻译： 提供了一种能够从表现动态行为的样本获得详细图像的检查装置。 该检查装置包括成像单元，其对表现出动态行为的样本进行成像; 行为检测单元，其检测所述检体的动态行为; 图像存储单元，其存储由所述行为检测单元检测到的样本的动态行为和由所述成像单元成像的所述样本的图像以使得彼此相关联; 以及静止图像提取单元，其基于来自存储在图像存储单元中的样本的图像的样本的动态行为，基本上静止时，提取样本的图像。
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公开(公告)号：US07304789B2
公开(公告)日：2007-12-04
申请号：US11057165
申请日：2005-02-15
IPC分类号： G02B21/00
CPC分类号： G02B21/0004 , G02B21/02
摘要： A microscope system includes a light source and an objective unit. The objective unit includes an objective optical system, including a small-diameter distal optical system arranged at an end brought near to or into contact with a specimen, for focusing light from the light source onto the specimen; a threaded mount at a coupling position; and an outer cylinder enclosing the small-diameter distal optical system. The microscope system further includes an imaging optical system for forming an image of light from the specimen through the objective optical system and a microscope main body for housing the imaging optical system. The objective unit is detachable from and attachable to the microscope main body with the threaded mount. Conditional expression Df/Da≦0.3 is satisfied, where Df represents the outer diameter of the outer cylinder and Da represents the outer diameter of the threaded mount.
摘要翻译： 显微镜系统包括光源和目标单元。 目标单元包括物镜光学系统，其包括设置在靠近或与样本接触的端部的小直径远端光学系统，用于将来自光源的光聚焦到样本上; 在联接位置的螺纹安装座; 以及包围小直径远端光学系统的外筒。 显微镜系统还包括用于通过物镜光学系统形成来自样本的光的图像的成像光学系统和用于容纳成像光学系统的显微镜主体。 目标单元可与螺纹安装座分离并附接到显微镜主体。 条件表达式Df / Da <= 0.3，其中Df表示外筒的外径，Da表示螺纹安装座的外径。
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公开(公告)号：US20070167842A1
公开(公告)日：2007-07-19
申请号：US11640921
申请日：2006-12-19
IPC分类号： A61B6/00
CPC分类号： A61B1/045 , A61B1/043 , A61B5/0068 , A61B5/0071 , A61B5/0084
摘要： An object is to easily and reliably reach an examination site. The present invention provides an examination method of carrying out in-vivo examination using an in-vivo examination apparatus capable of fluorescence examination and reflected-light examination and includes the steps of setting a reference position so as to set an examination site by carrying out reflected-light examination, switching from reflected-light examination to fluorescence examination, and moving from the reference position to the examination site.
摘要翻译： 目的是轻松可靠地到达考场。 本发明提供使用能够进行荧光检查和反射光检查的体内检查装置进行体内检查的检查方法，包括以下步骤：设定参考位置，以便通过进行反射 光线检查，从反射光检查切换到荧光检查，从参考位置移动到检查点。
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公开(公告)号：US20060017920A1
公开(公告)日：2006-01-26
申请号：US11182782
申请日：2005-07-18
IPC分类号： G01J3/30
CPC分类号： G01N21/6458 , G02B21/002 , G02B21/0064 , G02B21/0076 , G02B21/0084 , G02B21/16
摘要： The invention reduces the loss of fluorescence intensity obtained from a specimen to acquire clear fluorescence images when irradiating the specimen with ultrashort-pulse laser light produced by a laser light source. The invention provides a laser-scanning examination apparatus including a laser light source for producing ultrashort-pulse laser light; a laser light source for producing continuous-wave laser light; a measurement head including an optical scanning unit for scanning the laser light on a specimen and an objective optical system; an imaging unit for detecting return light from the specimen in response to the ultrashort-pulse laser light; and an imaging unit for detecting return light from the specimen in response to the continuous-wave laser light. The laser light sources and one imaging unit are connected to the measurement head by an optical fiber, and the other imaging unit is connected to the measurement head by another optical fiber with a larger core diameter.
摘要翻译： 本发明减少了从样品获得的荧光强度的损失，以便在用激光光源产生的超短脉冲激光照射样品时获得清晰的荧光图像。 本发明提供了一种激光扫描检查装置，其包括用于产生超短脉冲激光的激光光源; 用于产生连续波激光的激光源; 测量头，包括用于扫描样本上的激光的光学扫描单元和物镜光学系统; 用于响应于超短脉冲激光来检测来自样本的返回光的成像单元; 以及用于响应于连续波激光来检测来自样本的返回光的成像单元。 激光光源和一个成像单元通过光纤连接到测量头，另一个成像单元通过具有较大芯直径的另一光纤连接到测量头。
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