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公开(公告)号：US20100267116A1
公开(公告)日：2010-10-21
申请号：US11654863
申请日：2007-01-18
CPC分类号： C07K14/005 , A61K2039/525 , C12N15/86 , C12N2760/14122 , C12N2760/14123 , C12N2760/14143 , C12N2760/14145 , C12N2810/6072 , Y02A50/412
摘要： Cloned filovirus genomic cDNA and methods of using the cDNA are provided. Further provided are noninfectious lipid encapsulated filovirus-based particles.
摘要翻译： 提供克隆的叶病毒基因组cDNA和使用cDNA的方法。 还提供非感染性脂质包封的基于病毒的颗粒。
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公开(公告)号：US08900595B2
公开(公告)日：2014-12-02
申请号：US12245296
申请日：2008-10-03
IPC分类号： A61K39/12 , C12N15/86 , C07K14/005 , A61K39/00
CPC分类号： C07K14/005 , A61K2039/525 , C12N15/86 , C12N2760/14122 , C12N2760/14123 , C12N2760/14143 , C12N2760/14145 , C12N2810/6072 , Y02A50/412
摘要： Cloned filovirus genomic cDNA and methods of using the cDNA are provided. Further provided are noninfectious lipid encapsulated filovirus-based particles.
摘要翻译： 提供克隆的叶病毒基因组cDNA和使用cDNA的方法。 还提供非感染性脂质包封的基于病毒的颗粒。
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公开(公告)号：US07211378B2
公开(公告)日：2007-05-01
申请号：US10353856
申请日：2003-01-29
CPC分类号： C07K14/005 , A61K2039/525 , C12N15/86 , C12N2760/14122 , C12N2760/14123 , C12N2760/14143 , C12N2760/14145 , C12N2810/6072 , Y02A50/412
摘要： Cloned filovirus genomic cDNA and methods of using the cDNA are provided. Further provided are noninfectious lipid encapsulated filovirus-based particles.
摘要翻译： 提供克隆的叶病毒基因组cDNA和使用cDNA的方法。 还提供非感染性脂质包封的基于病毒的颗粒。
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4.发明申请FILOVIRUS VECTORS AND NONINFECTIOUS FILOVIRUS-BASED PARTICLES 有权FILOVIRUS VECTORS和非特异性FILOVIRUS-BASED颗粒公开(公告)号：US20100080825A1
公开(公告)日：2010-04-01
申请号：US12245296
申请日：2008-10-03
CPC分类号： C07K14/005 , A61K2039/525 , C12N15/86 , C12N2760/14122 , C12N2760/14123 , C12N2760/14143 , C12N2760/14145 , C12N2810/6072 , Y02A50/412
摘要： Cloned filovirus genomic cDNA and methods of using the cDNA are provided. Further provided are noninfectious lipid encapsulated filovirus-based particles.
摘要翻译： 提供克隆的叶病毒基因组cDNA和使用cDNA的方法。 还提供非感染性脂质包封的基于病毒的颗粒。
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公开(公告)号：US20170258888A1
公开(公告)日：2017-09-14
申请号：US15436245
申请日：2017-02-17
申请人： Yoshihiro Kawaoka , Gabriele Neumann , Jihui Ping
发明人： Yoshihiro Kawaoka , Gabriele Neumann , Jihui Ping
IPC分类号： A61K39/145 , C12N15/86 , C12N7/00
CPC分类号： A61K39/145 , A61K39/12 , A61K2039/5258 , C12N7/00 , C12N15/86 , C12N2760/16023 , C12N2760/16071 , C12N2760/16221 , C12N2760/16222 , C12N2760/16234 , C12N2760/16251
摘要： The invention provides a composition useful to prepare high titer influenza B viruses, e.g., in the absence of helper virus, which includes internal genes from an influenza B virus vaccine strain or isolate, e.g., one that is safe in humans, for instance, one that does not result in significant disease, that confer enhanced growth in cells in culture, such as MDCK cells, or in eggs.
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公开(公告)号：US08877448B2
公开(公告)日：2014-11-04
申请号：US13106080
申请日：2011-05-12
CPC分类号： C12N7/00 , A61K39/00 , A61K39/12 , A61K39/145 , A61K48/00 , A61K48/0091 , A61K2039/525 , A61K2039/5258 , C07K14/005 , C12N15/85 , C12N15/86 , C12N2760/16121 , C12N2760/16122 , C12N2760/16123 , C12N2760/16134 , C12N2760/16143 , C12N2760/16151 , C12N2760/16152 , C12N2800/30 , C12N2810/6081
摘要： The invention provides a composition useful to prepare influenza A viruses, e.g., in the absence of helper virus.
摘要翻译： 本发明提供了可用于制备甲型流感病毒的组合物，例如在没有辅助病毒的情况下。
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公开(公告)号：US09023603B2
公开(公告)日：2015-05-05
申请号：US13331314
申请日：2011-12-20
IPC分类号： G01N33/53 , A61K39/145 , A61K48/00 , C12N7/00 , A61K39/00
CPC分类号： C12N7/00 , A61K39/00 , A61K39/12 , A61K39/145 , A61K48/0091 , A61K2039/525 , A61K2039/5258 , C12N2760/16134 , C12N2760/16151
摘要： The invention provides compositions and methods useful to prepare segmented, negative strand RNA viruses, e.g., orthomyxoviruses such as influenza A viruses, entirely from cloned cDNAs and in the absence of helper virus.
摘要翻译： 本发明提供了用于制备分段的负链RNA病毒，例如完全来自克隆的cDNA并且不存在辅助病毒的正义粘病毒如甲型流感病毒的组合物和方法。
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公开(公告)号：US08859208B2
公开(公告)日：2014-10-14
申请号：US11110117
申请日：2005-04-20
IPC分类号： G01N33/53
CPC分类号： C12N7/00 , A61K39/00 , A61K39/12 , A61K39/145 , A61K48/00 , A61K48/0091 , A61K2039/525 , A61K2039/5258 , C07K14/005 , C12N15/85 , C12N15/86 , C12N2760/16121 , C12N2760/16122 , C12N2760/16123 , C12N2760/16134 , C12N2760/16143 , C12N2760/16151 , C12N2760/16152 , C12N2800/30 , C12N2810/6081
摘要： The invention provides compositions and methods useful to prepare segmented, negative strand RNA viruses, e.g., orthomyxoviruses such as influenza A viruses, entirely from cloned cDNAs and in the absence of helper virus.
摘要翻译： 本发明提供组合物和方法，其用于完全从克隆的cDNAs和不存在辅助病毒制备分段的负链RNA病毒，例如正义病毒如甲型流感病毒。
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公开(公告)号：US20110143424A1
公开(公告)日：2011-06-16
申请号：US12718573
申请日：2010-03-05
CPC分类号： C12N7/00 , A61K39/00 , A61K39/12 , A61K39/145 , A61K48/00 , A61K48/0091 , A61K2039/525 , A61K2039/5258 , C07K14/005 , C12N15/85 , C12N15/86 , C12N2760/16121 , C12N2760/16122 , C12N2760/16123 , C12N2760/16134 , C12N2760/16143 , C12N2760/16151 , C12N2760/16152 , C12N2800/30 , C12N2810/6081
摘要： The invention provides compositions and methods useful to prepare segmented, negative strand RNA viruses, e.g., orthomyxoviruses such as influenza A viruses, entirely from cloned cDNAs and in the absence of helper virus.
摘要翻译： 本发明提供了用于制备分段的负链RNA病毒，例如完全来自克隆的cDNA并且不存在辅助病毒的正义粘病毒如甲型流感病毒的组合物和方法。
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公开(公告)号：US20100021499A1
公开(公告)日：2010-01-28
申请号：US12481402
申请日：2009-06-09
IPC分类号： A61K39/145 , C12N7/04 , C12N5/07
CPC分类号： A61K39/145 , A61K39/12 , C12N7/00 , C12N2760/16034 , C12N2760/16051 , C12N2760/16134 , C12N2760/16151 , C12N2760/16234 , C12N2760/16251 , C12Y204/99007
摘要： The present invention relates to a cell-based method for producing influenza virus vaccines by enriching the population of surface-bound α2,6-sialic acid receptors on a cell surface, such as on a Chinese Hamster Ovary (CHO) cell surface. The host cell therefore presents numerous binding sites to which an influenza virus can bind via its hemagglutinin spike protein and infect the host cell. In contrast to wild-type CHO cells, the surface of the mutated CHO cells of the present invention contains an enriched population of α2,6-sialic acid receptors which makes the inventive CHO cells highly susceptible to viral infection, and therefore safe, effective, and highly efficient cells for rapidly producing influenza vaccines.
摘要翻译： 本发明涉及通过富集细胞表面如中国仓鼠卵巢（CHO）细胞表面上的表面结合的α2,6-唾液酸受体的群体来生产流感病毒疫苗的基于细胞的方法。 因此，宿主细胞呈现许多结合位点，流感病毒可以通过其血凝素尖峰蛋白结合并感染宿主细胞。 与野生型CHO细胞相比，本发明的突变的CHO细胞的表面含有富含α2,6-唾液酸受体的群体，这使得本发明的CHO细胞对病毒感染高度敏感，因此安全，有效， 以及用于快速生产流感疫苗的高效细胞。
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