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    Pharmaceuticals containing prostaglandin I.sub.2
    4.
    发明授权
    Pharmaceuticals containing prostaglandin I.sub.2 失效
    含有前列腺素I2的药物

    公开(公告)号：US4699921A

    公开(公告)日：1987-10-13

    申请号：US763618

    申请日：1985-08-08

    申请人： Masakatsu Shibasaki ,  Mikiko Sodeoka ,  Yuji Ogawa ,  Toshiaki Mase ,  Akira Ishibashi ,  Daijiro Horii ,  Toshiji Kanayama ,  Katsuhiko Iseki ,  Masaki Shinoda ,  Chiyoko Ishiyama ,  Yoshio Hayashi

    发明人： Masakatsu Shibasaki ,  Mikiko Sodeoka ,  Yuji Ogawa ,  Toshiaki Mase ,  Akira Ishibashi ,  Daijiro Horii ,  Toshiji Kanayama ,  Katsuhiko Iseki ,  Masaki Shinoda ,  Chiyoko Ishiyama ,  Yoshio Hayashi

    IPC分类号： C07C59/46 ,  A61K31/557 ,  A61P1/04 ,  A61P7/02 ,  A61P9/00 ,  A61P9/08 ,  A61P9/12 ,  C07C51/00 ,  C07C67/00 ,  C07C69/732 ,  C07C405/00

    CPC分类号： C07C405/0083 ,  A61K31/557 ,  Y02P20/55

    摘要： Disclosed is a pharmaceutical composition having circulation ameliorating effect and antiulcer effect containing a prostaglandin I.sub.2 analogue represented by the formula shown below or a non-toxic salt or a cyclodextrin inclusion compound thereof as the effective ingredient: ##STR1## wherein R.sup.1 represents a hydrogen atom, an alkyl group having 1 to 12 carbon atoms, a cycloalkyl group having 4 to 7 carbon atoms or a phenyl group, A represents a pentyl group, a cyclopentyl group, a cyclohexyl group, a 1-methyl-3-hexynyl group, a 2-methyl-3-hexynyl group, a 1-methylhexyl group, a 2-phenethyl group, a 1,1-dimethylpentyl group, a 2-methylpentyl group, a 1-cyclohexylethyl group, a 2-methylhexyl group, a 1-methyl-3-pentynyl group or a 2,6-dimethyl-5-heptenyl group; the double bond between the carbon atoms at 4- and 5-positions is E or Z or a mixture thereof; the asymmetric center in the substituent represented by A is in the R-configuration or the S-configuration or a mixture thereof.Pharmaceutical compositions containing, as an active ingredient, prostaglandin I.sub.2 analogues of the present invention have potent platelet aggregation inhibiting effect, blood pressure depressing effect, vasodilative effect and antiulcer effect, and are also low in toxicity.

    摘要翻译： 本发明公开了一种具有循环改善作用和抗溃疡效果的药物组合物，其含有下述式表示的前列腺素I 2类似物或其无毒性盐或环糊精包合物作为有效成分：其中R 1表示氢原子， 碳原子数1〜12的烷基，碳原子数4〜7的环烷基或苯基，A表示戊基，环戊基，环己基，1-甲基-3-己炔基，2 1-甲基-3-己炔基，1-甲基己基，2-苯乙基，1,1-二甲基戊基，2-甲基戊基，1-环己基乙基，2-甲基己基，1-甲基 -3-戊炔基或2,6-二甲基-5-庚烯基; 4-和5-位的碳原子之间的双键是E或Z或它们的混合物; 由A表示的取代基中的不对称中心是R构型或S-构型或其混合物。 含有本发明的前列腺素I2类似物作为活性成分的药物组合物具有有效的血小板聚集抑制作用，降血压作用，血管扩张作用和抗溃疡作用，毒性也低。

    Pharmaceuticals containing prostaglandin I.sub.2
    5.
    发明授权
    Pharmaceuticals containing prostaglandin I.sub.2 失效
    含有前列腺素I2的药物

    公开(公告)号：US5053526A

    公开(公告)日：1991-10-01

    申请号：US511945

    申请日：1990-04-16

    申请人： Masakatsu Shibasaki ,  Mikiko Sodeoka ,  Yuji Ogawa ,  Toshiaki Mase ,  Akira Ishibashi ,  Daijiro Horii ,  Toshiji Kanayama ,  Katsuhiko Iseki ,  Masaki Shinoda ,  Chiyoko Ishiyama ,  Yoshio Hayashi

    发明人： Masakatsu Shibasaki ,  Mikiko Sodeoka ,  Yuji Ogawa ,  Toshiaki Mase ,  Akira Ishibashi ,  Daijiro Horii ,  Toshiji Kanayama ,  Katsuhiko Iseki ,  Masaki Shinoda ,  Chiyoko Ishiyama ,  Yoshio Hayashi

    IPC分类号： A61K31/557 ,  C07C405/00

    CPC分类号： C07C405/0083 ,  A61K31/557

    摘要： Disclosed is a pharmaceutical having circulation ameliorating effect and antiulcer effect containing a prostaglandin I.sub.2 analogue represented by the formula shown below or a non-toxic salt of its salt or a cyclodextrin inclusion compound thereof as the effective ingredient: ##STR1## wherein R.sup.1 represents a hydrogen atom, an alkyl group having 1 to 12 carbon atoms, a cycloalkyl group having 4 to 7 carbon atoms or a phenyl group; A represents a pentyl group, a cyclopentyl group, a cyclohexyl group, a 1-methyl-3-hexynyl group, a 2-methyl-3-hexynyl group, a 1-methylhexyl group, a 2-phenethyl group, a 1,1-dimethylpentyl group, a 2-methylpentyl group, a 1-cyclohexylethyl group, a 2-methylhexyl group, a 1-methyl-3-pentynyl group or 1 2,6-dimethyl-5-heptenyl group; the double bond between the carbon atoms at 4- and 5-positions is E or Z or a mixture thereof, the asymmetric center in the substituent represented by A is R-configuration or S-configuration or a mixture thereof.The pharmaceuticals containing, as an active ingredient, prostaglandin I.sub.2 analogues of the present invention have potent platelet aggregation inhibiting effect, blood pressure depressing effect, vasodilative effect and antiulcer effect, and are also low in toxicity.

    摘要翻译： 本发明公开了一种具有循环改善作用和抗溃疡效果的药物，其含有下述式表示的前列腺素I2类似物或其盐的无毒性盐或其环糊精包合物作为有效成分：其中R1表示氢 原子，碳原子数1〜12的烷基，碳原子数4〜7的环烷基或苯基; A表示戊基，环戊基，环己基，1-甲基-3-己炔基，2-甲基-3-己炔基，1-甲基己基，2-苯乙基，1,1 2-甲基戊基，2-甲基戊基，1-环己基乙基，2-甲基己基，1-甲基-3-戊炔基或1,6-二甲基-5-庚烯基; 在4-和5-位碳原子之间的双键是E或Z或其混合物，由A表示的取代基中的不对称中心是R-构型或S-构型或其混合物。 含有本发明的前列腺素I2类似物作为活性成分的药物具有有效的血小板聚集抑制作用，降血压作用，血管扩张作用和抗溃疡作用，毒性也低。

    (2-chloro-3-oxo-1-alkenyl)bicyclo(3.3.0)octane derivative
    6.
    发明授权
    (2-chloro-3-oxo-1-alkenyl)bicyclo(3.3.0)octane derivative 失效
    （2-氯-3-氧代-1-烯基）双环（3.3.0）辛烷衍生物

    公开(公告)号：US4810805A

    公开(公告)日：1989-03-07

    申请号：US943484

    申请日：1986-12-19

    申请人： Masakatsu Shibasaki ,  Katsuhiko Iseki ,  Masaki Shinoda ,  Chiyoko Aoki ,  Yoshio Hayashi

    发明人： Masakatsu Shibasaki ,  Katsuhiko Iseki ,  Masaki Shinoda ,  Chiyoko Aoki ,  Yoshio Hayashi

    IPC分类号： C07F9/38 ,  C07C67/343 ,  C07C69/738 ,  C07C405/00 ,  C07F9/40 ,  C07D309/12

    CPC分类号： C07C405/0083

    摘要： There are disclosed a (2-chloro-3-oxo-1-alkenyl)-bicyclo[3.3.0 octene derivative represented by the formula: ##STR1## wherein R.sup.1 represents --CH.sub.2 CH.sub.2 CH.sub.2 COOR.sup.5, --CH.sub.2 CH.sub.2 --O--CH.sub.2 COOR.sup.5, --CH.dbd.CHCH.sub.2 COOR.sup.5 or --CH.sub.2 CH.sub.2 C.tbd.C--COOR.sup.5 group where R.sup.5 in the groups represents a hydrogen atom or an alkyl group having 1 to 6 carbon atoms; R.sup.2 represents a hydrogen atom, an acyl group having 1 to 7 carbon atoms, a tri(1 to 7 carbon atoms)-hydrocarbylsilyl group or a group forming an acetal bonding with an oxygen atom of a hydroxy group; R.sup.3 represents a straight or branched alkyl group having 3 to 10 carbon atoms, a cycloalkyl group having 4 to 7 carbon atoms, which may be substituted by at least one alkyl group having 1 to 4 carbon atoms, a straight or branched alkenyl group having 3 to 12 carbom atoms, a straight or branched alkynyl group having 3 to 8 carbon atoms, a phenyl group or a phenoxy group which may have substituents, an alkoxy group having 1 to 6 carbon atoms or an alkyl group substituted by a cycloalkyl group having 5 to 8 carbon atoms, and a process for preparing the same which comprises reacting an aldehyde represented by the formula: ##STR2## wherein R.sup.1 and R.sup.2 have the same meanings as defined above, with kotophosphonate represented by the formula: ##STR3## wherein R.sup.3 has the same meaning as defined above and R.sup.4 represents an alkyl group having 1 to 10 carbon atoms, in the presence of a base.

    摘要翻译： 公开了由下式表示的（2-氯-3-氧代-1-烯基） - 二环[3.3.0辛烯衍生物：其中R 1表示-CH 2 CH 2 CH 2 COOR 5，-CH 2 CH 2 -O-CH 2 COOR 5，-CH = CHCH 2 COOR 5 或-CH 2 CH 2 C 3 CON COROR 5基团，其中基团中的R 5表示氢原子或具有1至6个碳原子的烷基; R2表示氢原子，碳原子数1〜7的酰基，三（1〜7个碳原子） - 烃基甲硅烷基或与羟基形成缩醛键的基团。 R3表示可以被至少一个具有1至4个碳原子的烷基取代的具有3至10个碳原子的直链或支链烷基，具有4至7个碳原子的环烷基，具有3个碳原子的直链或支链烯基 至12个碳原子，具有3至8个碳原子的直链或支链炔基，可具有取代基的苯基或苯氧基，具有1至6个碳原子的烷氧基或被具有5个环烷基的环烷基取代的烷基 至8个碳原子，及其制备方法，其包括使由下式表示的醛：其中R 1和R 2具有与上述相同的含义，与下式表示的焦磷酸酯反应：其中R 3具有 在碱的存在下，与上述定义相同，R 4表示具有1至10个碳原子的烷基。

    OPTICAL PICKUP APPARATUS
    7.
    发明申请
    OPTICAL PICKUP APPARATUS 失效

    公开(公告)号：US20070127349A1

    公开(公告)日：2007-06-07

    申请号：US11560758

    申请日：2006-11-16

    申请人： Tohru Hotta ,  Yoshio Hayashi ,  Noriyoshi Ooyama ,  Kiyotaka Eizumi

    发明人： Tohru Hotta ,  Yoshio Hayashi ,  Noriyoshi Ooyama ,  Kiyotaka Eizumi

    IPC分类号： G11B7/00

    CPC分类号： G11B7/1381 ,  G11B7/0903 ,  G11B7/1275 ,  G11B7/1353 ,  G11B2007/0006

    摘要： An optical pickup apparatus comprising: a diffraction grating including a first grating for diffracting a first laser light beam, and a second grating for diffracting a second laser light beam which is shorter in wavelength than the first laser light beam, the diffraction grating being disposed in a common optical path for guiding the first laser light beam and the second laser light beam to an optical disc; and a photo detector including in a first light receiving area, a main light receiving unit, a front sub-light receiving unit, and a rear sub-light receiving unit that receive reflected light beams, which are reflected by the optical disc, of a main beam, of a front sub-beam, and of a rear sub-beam, respectively, the first laser light beam being diffracted by the diffraction grating into the main beam, the front sub-beam formed in front of the main beam, and the rear sub-beam formed at the back of the main beam, wherein the first grating is set such that the front sub-light receiving unit and the rear sub-light receiving unit in the first light receiving area are disposed at positions which substantially avoid unnecessary diffracted light beam spots which are generated by projecting to the first light receiving area unnecessary diffracted light beams, the unnecessary diffracted light beams generated by the second grating from the first laser light beam.

    摘要翻译： 一种光学拾取装置，包括：衍射光栅，包括用于衍射第一激光束的第一光栅和用于衍射比第一激光束波长短的第二激光束的第二光栅，所述衍射光栅设置在 用于将第一激光束和第二激光束引导到光盘的公共光路; 以及光接收单元，其包括在第一受光区域，主光接收单元，前副光接收单元和后副光接收单元中的光检测器，其接收由光盘反射的反射光束， 主子束，前子光束和后副光束，第一激光束被衍射光栅衍射成主光束，形成在主光束前面的前子光束，以及 形成在主光束后部的后副光束，其中第一光栅被设置为使得第一光接收区域中的前子光接收单元和后副光接收单元被设置在基本避免的位置 通过向第一光接收区域投射不需要的衍射光束而产生的不必要的衍射光束点，由第二光栅从第一激光束产生的不需要的衍射光束。

    Phenylahistin and the phenylahistin analogs, a new class of anti-tumor compounds
    8.
    发明授权
    Phenylahistin and the phenylahistin analogs, a new class of anti-tumor compounds 有权

    公开(公告)号：US07026322B2

    公开(公告)日：2006-04-11

    申请号：US10632688

    申请日：2003-08-01

    申请人： Yoshio Hayashi ,  Michael A. Palladino, Jr. ,  Jennifer Grodberg

    发明人： Yoshio Hayashi ,  Michael A. Palladino, Jr. ,  Jennifer Grodberg

    IPC分类号： C07D241/06 ,  C07D241/08 ,  A61K31/496 ,  A61K31/00

    CPC分类号： C07D403/06 ,  A61K31/496

    摘要： Methods of using a compound, its pharmaceutically acceptable salts, and/or its pro-drug esters, in isolated form, to treat cancer, and methods for isolating, for formulating, and for administering the compound, salt, and/or pro-drug ester as an antitumor agent, wherein the compound, salt, or pro-drug ester has the following structure: wherein: R1, R2, R5, R7, and R8 are each separately selected from the group consisting of a hydrogen atom, a halogen atom, and saturated C1-C24 alkyl, unsaturated C1-C24 alkenyl, cycloalkyl, cycloalkenyl, alkoxy, cycloalkoxy, aryl, substituted aryl, heteroaryl, substituted heteroaryl, amino, substituted amino, nitro, substituted nitro, phenyl, and substituted phenyl groups, R3, R4, and R6 are each separately selected from the group consisting of a hydrogen atom, a halogen atom, and saturated C1-C12 alkyl, unsaturated C1-C12 alkenyl, cycloalkyl, alkoxy, cycloalkoxy, aryl, substituted aryl, heteroaryl, substituted heteroaryl, amino, substituted amino, nitro, and substituted nitro groups, X1 and X2 are separately selected from the group consisting of an oxygen atom, and a sulfur atom, and the dashed bond represents a bond selected from the group consisting of a carbon-carbon single bond and a carbon-carbon double bond. Most preferably, R3 and R4 are hydrogen, and each are involved in hydrogen bonds, and/or the dashed bond is a double bond, such that the chemical backbone of the compound substantially retains a substantially planar conformation.

    Optical head device
    9.
    发明申请
    Optical head device 有权
    光头设备

    公开(公告)号：US20050007899A1

    公开(公告)日：2005-01-13

    申请号：US10830748

    申请日：2004-04-23

    申请人： Yoshio Hayashi ,  Atsuhiro Hanaoka

    发明人： Yoshio Hayashi ,  Atsuhiro Hanaoka

    IPC分类号： G11B7/09 ,  G11B7/00 ,  G11B7/095 ,  G11B7/125

    CPC分类号： G11B7/0932 ,  G11B7/0956

    摘要： An optical head device including a lens holder which holds an objective lens, six wires for supporting the lens holder and a holder support member which movably supports the lens holder by the six wires in a tracking, focusing and tilt direction. The six wires comprise two pairs, each of the pairs comprising a composite wire composed of two wires and a single wire composed of one wire which are respectively disposed on an upper side and a lower side of the lens holder in the focusing direction. The spring constant of the composite wire is set to be approximately equal to a spring constant of the single wire. Alternatively, the six wires may be disposed on the same circumference with respect to a drive center in the tilt direction or the spring constant of one wire of the pair may be set to be smaller than spring constants of the other two wires of the pair.

    摘要翻译： 一种光学头装置，包括保持物镜的透镜保持器，用于支撑透镜保持器的六根电线和通过六根电线在跟踪，聚焦和倾斜方向上可移动地支撑透镜架的保持器支撑构件。 六条线包括两对，每对包括由两条线组成的复合线和由聚焦方向分别设置在透镜保持器的上侧和下侧的一根线组成的单根线。 复合线的弹簧常数设定为大致等于单线的弹簧常数。 或者，六根线可以相对于倾斜方向上的驱动中心设置在相同的圆周上，或者该对中的一根线的弹簧常数可以被设置为小于该对中的另外两根线的弹簧常数。

    Optical pickup device with split hologram element that diffracts light in direction parallel to track
    10.
    发明授权
    Optical pickup device with split hologram element that diffracts light in direction parallel to track 失效
    具有分裂全息元件的光学拾取装置，其在平行于轨道的方向衍射光

    公开(公告)号：US5761174A

    公开(公告)日：1998-06-02

    申请号：US523147

    申请日：1995-09-05

    申请人： Tadashi Takeda ,  Yoshio Hayashi ,  Ikuo Kasuga ,  Kazuo Higashiura ,  Noriyuki Satoh ,  Hisahiro Ishihara

    发明人： Tadashi Takeda ,  Yoshio Hayashi ,  Ikuo Kasuga ,  Kazuo Higashiura ,  Noriyuki Satoh ,  Hisahiro Ishihara

    IPC分类号： G11B7/09 ,  G11B7/135

    CPC分类号： G11B7/0916 ,  G11B7/0903 ,  G11B7/0908 ,  G11B7/1353 ,  G11B7/1381

    摘要： An optical pickup device includes a light source irradiating a record medium with plural light spots of light emitted therefrom, a plurality of light detecting elelments to which reflected light of the light spots are guided, respectively, to adequately synthesize and compare outputs of said light detecting elements, thereby reading information recorded in tracks of the record medium, and detecting an tracking error and a focusing error, and a hologram element which splits light emitted from the light source into plural beams is disposed in an optical path between the light source and the record medium, said hologram element is split by a split line, said split line elongating in a direction perpendicular to a track of the medium on an optical axis, and a hologram pattern having a diffraction function which is substantially directed in the track direction is disposed on at least one side of said split line, thereby differentiating diffraction conditions on both sides of said split line from each other.

    摘要翻译： 一种光学拾取装置包括：一个光源，用于照射具有从其发出的光的多个光点的记录介质，分别引导光点的反射光的多个光检测元件，以充分合成并比较所述光检测的输出 从而读取记录在记录介质的轨道中的信息，并且检测跟踪误差和聚焦误差，并且将从光源发射的光分解成多个光束的全息元件设置在光源和光源之间的光路中 记录介质，所述全息元件被分割线分开，所述分割线在垂直于光轴上的介质的轨道的方向上延伸，并且设置具有基本上指向轨道方向的衍射函数的全息图图案 在所述分割线的至少一侧上，从而使所述分割线的两侧的衍射条件有差异 从彼此。