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    (2-chloro-3-oxo-1-alkenyl)bicyclo(3.3.0)octane derivative
    1.
    发明授权
    (2-chloro-3-oxo-1-alkenyl)bicyclo(3.3.0)octane derivative 失效
    （2-氯-3-氧代-1-烯基）双环（3.3.0）辛烷衍生物

    公开(公告)号：US4810805A

    公开(公告)日：1989-03-07

    申请号：US943484

    申请日：1986-12-19

    申请人： Masakatsu Shibasaki ,  Katsuhiko Iseki ,  Masaki Shinoda ,  Chiyoko Aoki ,  Yoshio Hayashi

    发明人： Masakatsu Shibasaki ,  Katsuhiko Iseki ,  Masaki Shinoda ,  Chiyoko Aoki ,  Yoshio Hayashi

    IPC分类号： C07F9/38 ,  C07C67/343 ,  C07C69/738 ,  C07C405/00 ,  C07F9/40 ,  C07D309/12

    CPC分类号： C07C405/0083

    摘要： There are disclosed a (2-chloro-3-oxo-1-alkenyl)-bicyclo[3.3.0 octene derivative represented by the formula: ##STR1## wherein R.sup.1 represents --CH.sub.2 CH.sub.2 CH.sub.2 COOR.sup.5, --CH.sub.2 CH.sub.2 --O--CH.sub.2 COOR.sup.5, --CH.dbd.CHCH.sub.2 COOR.sup.5 or --CH.sub.2 CH.sub.2 C.tbd.C--COOR.sup.5 group where R.sup.5 in the groups represents a hydrogen atom or an alkyl group having 1 to 6 carbon atoms; R.sup.2 represents a hydrogen atom, an acyl group having 1 to 7 carbon atoms, a tri(1 to 7 carbon atoms)-hydrocarbylsilyl group or a group forming an acetal bonding with an oxygen atom of a hydroxy group; R.sup.3 represents a straight or branched alkyl group having 3 to 10 carbon atoms, a cycloalkyl group having 4 to 7 carbon atoms, which may be substituted by at least one alkyl group having 1 to 4 carbon atoms, a straight or branched alkenyl group having 3 to 12 carbom atoms, a straight or branched alkynyl group having 3 to 8 carbon atoms, a phenyl group or a phenoxy group which may have substituents, an alkoxy group having 1 to 6 carbon atoms or an alkyl group substituted by a cycloalkyl group having 5 to 8 carbon atoms, and a process for preparing the same which comprises reacting an aldehyde represented by the formula: ##STR2## wherein R.sup.1 and R.sup.2 have the same meanings as defined above, with kotophosphonate represented by the formula: ##STR3## wherein R.sup.3 has the same meaning as defined above and R.sup.4 represents an alkyl group having 1 to 10 carbon atoms, in the presence of a base.

    摘要翻译： 公开了由下式表示的（2-氯-3-氧代-1-烯基） - 二环[3.3.0辛烯衍生物：其中R 1表示-CH 2 CH 2 CH 2 COOR 5，-CH 2 CH 2 -O-CH 2 COOR 5，-CH = CHCH 2 COOR 5 或-CH 2 CH 2 C 3 CON COROR 5基团，其中基团中的R 5表示氢原子或具有1至6个碳原子的烷基; R2表示氢原子，碳原子数1〜7的酰基，三（1〜7个碳原子） - 烃基甲硅烷基或与羟基形成缩醛键的基团。 R3表示可以被至少一个具有1至4个碳原子的烷基取代的具有3至10个碳原子的直链或支链烷基，具有4至7个碳原子的环烷基，具有3个碳原子的直链或支链烯基 至12个碳原子，具有3至8个碳原子的直链或支链炔基，可具有取代基的苯基或苯氧基，具有1至6个碳原子的烷氧基或被具有5个环烷基的环烷基取代的烷基 至8个碳原子，及其制备方法，其包括使由下式表示的醛：其中R 1和R 2具有与上述相同的含义，与下式表示的焦磷酸酯反应：其中R 3具有 在碱的存在下，与上述定义相同，R 4表示具有1至10个碳原子的烷基。

    Pharmaceuticals containing prostaglandin I.sub.2
    2.
    发明授权
    Pharmaceuticals containing prostaglandin I.sub.2 失效
    含有前列腺素I2的药物

    公开(公告)号：US4699921A

    公开(公告)日：1987-10-13

    申请号：US763618

    申请日：1985-08-08

    申请人： Masakatsu Shibasaki ,  Mikiko Sodeoka ,  Yuji Ogawa ,  Toshiaki Mase ,  Akira Ishibashi ,  Daijiro Horii ,  Toshiji Kanayama ,  Katsuhiko Iseki ,  Masaki Shinoda ,  Chiyoko Ishiyama ,  Yoshio Hayashi

    发明人： Masakatsu Shibasaki ,  Mikiko Sodeoka ,  Yuji Ogawa ,  Toshiaki Mase ,  Akira Ishibashi ,  Daijiro Horii ,  Toshiji Kanayama ,  Katsuhiko Iseki ,  Masaki Shinoda ,  Chiyoko Ishiyama ,  Yoshio Hayashi

    IPC分类号： C07C59/46 ,  A61K31/557 ,  A61P1/04 ,  A61P7/02 ,  A61P9/00 ,  A61P9/08 ,  A61P9/12 ,  C07C51/00 ,  C07C67/00 ,  C07C69/732 ,  C07C405/00

    CPC分类号： C07C405/0083 ,  A61K31/557 ,  Y02P20/55

    摘要： Disclosed is a pharmaceutical composition having circulation ameliorating effect and antiulcer effect containing a prostaglandin I.sub.2 analogue represented by the formula shown below or a non-toxic salt or a cyclodextrin inclusion compound thereof as the effective ingredient: ##STR1## wherein R.sup.1 represents a hydrogen atom, an alkyl group having 1 to 12 carbon atoms, a cycloalkyl group having 4 to 7 carbon atoms or a phenyl group, A represents a pentyl group, a cyclopentyl group, a cyclohexyl group, a 1-methyl-3-hexynyl group, a 2-methyl-3-hexynyl group, a 1-methylhexyl group, a 2-phenethyl group, a 1,1-dimethylpentyl group, a 2-methylpentyl group, a 1-cyclohexylethyl group, a 2-methylhexyl group, a 1-methyl-3-pentynyl group or a 2,6-dimethyl-5-heptenyl group; the double bond between the carbon atoms at 4- and 5-positions is E or Z or a mixture thereof; the asymmetric center in the substituent represented by A is in the R-configuration or the S-configuration or a mixture thereof.Pharmaceutical compositions containing, as an active ingredient, prostaglandin I.sub.2 analogues of the present invention have potent platelet aggregation inhibiting effect, blood pressure depressing effect, vasodilative effect and antiulcer effect, and are also low in toxicity.

    摘要翻译： 本发明公开了一种具有循环改善作用和抗溃疡效果的药物组合物，其含有下述式表示的前列腺素I 2类似物或其无毒性盐或环糊精包合物作为有效成分：其中R 1表示氢原子， 碳原子数1〜12的烷基，碳原子数4〜7的环烷基或苯基，A表示戊基，环戊基，环己基，1-甲基-3-己炔基，2 1-甲基-3-己炔基，1-甲基己基，2-苯乙基，1,1-二甲基戊基，2-甲基戊基，1-环己基乙基，2-甲基己基，1-甲基 -3-戊炔基或2,6-二甲基-5-庚烯基; 4-和5-位的碳原子之间的双键是E或Z或它们的混合物; 由A表示的取代基中的不对称中心是R构型或S-构型或其混合物。 含有本发明的前列腺素I2类似物作为活性成分的药物组合物具有有效的血小板聚集抑制作用，降血压作用，血管扩张作用和抗溃疡作用，毒性也低。

    Pharmaceuticals containing prostaglandin I.sub.2
    3.
    发明授权
    Pharmaceuticals containing prostaglandin I.sub.2 失效
    含有前列腺素I2的药物

    公开(公告)号：US5053526A

    公开(公告)日：1991-10-01

    申请号：US511945

    申请日：1990-04-16

    申请人： Masakatsu Shibasaki ,  Mikiko Sodeoka ,  Yuji Ogawa ,  Toshiaki Mase ,  Akira Ishibashi ,  Daijiro Horii ,  Toshiji Kanayama ,  Katsuhiko Iseki ,  Masaki Shinoda ,  Chiyoko Ishiyama ,  Yoshio Hayashi

    发明人： Masakatsu Shibasaki ,  Mikiko Sodeoka ,  Yuji Ogawa ,  Toshiaki Mase ,  Akira Ishibashi ,  Daijiro Horii ,  Toshiji Kanayama ,  Katsuhiko Iseki ,  Masaki Shinoda ,  Chiyoko Ishiyama ,  Yoshio Hayashi

    IPC分类号： A61K31/557 ,  C07C405/00

    CPC分类号： C07C405/0083 ,  A61K31/557

    摘要： Disclosed is a pharmaceutical having circulation ameliorating effect and antiulcer effect containing a prostaglandin I.sub.2 analogue represented by the formula shown below or a non-toxic salt of its salt or a cyclodextrin inclusion compound thereof as the effective ingredient: ##STR1## wherein R.sup.1 represents a hydrogen atom, an alkyl group having 1 to 12 carbon atoms, a cycloalkyl group having 4 to 7 carbon atoms or a phenyl group; A represents a pentyl group, a cyclopentyl group, a cyclohexyl group, a 1-methyl-3-hexynyl group, a 2-methyl-3-hexynyl group, a 1-methylhexyl group, a 2-phenethyl group, a 1,1-dimethylpentyl group, a 2-methylpentyl group, a 1-cyclohexylethyl group, a 2-methylhexyl group, a 1-methyl-3-pentynyl group or 1 2,6-dimethyl-5-heptenyl group; the double bond between the carbon atoms at 4- and 5-positions is E or Z or a mixture thereof, the asymmetric center in the substituent represented by A is R-configuration or S-configuration or a mixture thereof.The pharmaceuticals containing, as an active ingredient, prostaglandin I.sub.2 analogues of the present invention have potent platelet aggregation inhibiting effect, blood pressure depressing effect, vasodilative effect and antiulcer effect, and are also low in toxicity.

    摘要翻译： 本发明公开了一种具有循环改善作用和抗溃疡效果的药物，其含有下述式表示的前列腺素I2类似物或其盐的无毒性盐或其环糊精包合物作为有效成分：其中R1表示氢 原子，碳原子数1〜12的烷基，碳原子数4〜7的环烷基或苯基; A表示戊基，环戊基，环己基，1-甲基-3-己炔基，2-甲基-3-己炔基，1-甲基己基，2-苯乙基，1,1 2-甲基戊基，2-甲基戊基，1-环己基乙基，2-甲基己基，1-甲基-3-戊炔基或1,6-二甲基-5-庚烯基; 在4-和5-位碳原子之间的双键是E或Z或其混合物，由A表示的取代基中的不对称中心是R-构型或S-构型或其混合物。 含有本发明的前列腺素I2类似物作为活性成分的药物具有有效的血小板聚集抑制作用，降血压作用，血管扩张作用和抗溃疡作用，毒性也低。

    Color cathode-ray tube and method of manufacturing the same
    8.
    发明授权
    Color cathode-ray tube and method of manufacturing the same 失效
    彩色阴极射线管及其制造方法

    公开(公告)号：US5801479A

    公开(公告)日：1998-09-01

    申请号：US681333

    申请日：1996-07-23

    申请人： Masaki Shinoda

    发明人： Masaki Shinoda

    IPC分类号： H01J29/07 ,  H01J29/06

    CPC分类号： H01J29/07 ,  H01J2229/0761

    摘要： A cathode-ray tube consuppress deterioration and reduce unevenness in color of a picture by preventing an electrode element thereof from being twisted. The color cathode-ray tube includes a frame and an aperture grill stretched across and fixed on the frame and having an electrode element. The aperture grill is stretched across and fixed on the frame in a state that the frame is applied with a compressive force and the aperture grill is applied with a tension. In a process of stretching and fixing the aperture grill across and on the frame, of the tension applied to the aperture grill, a maximum tension applied to the electrode element is set within the range from 30% to 85% of a tensile strength of the electrode element.

    摘要翻译： 阴极射线管通过防止其电极元件扭曲而抑制图像的劣化并减少图像的颜色不均匀。 彩色阴极射线管包括一个框架和一个横跨并固定在框架上并具有电极元件的孔格栅。 孔格栅在被施加压缩力并且孔格栅施加张力的状态下被拉伸并固定在框架上。 在将孔格栅拉伸并固定在框架上并在框架上施加到孔格栅上的张力的过程中，施加到电极元件的最大张力设定在拉伸强度的30％至85％的范围内 电极元件。

    Shadow-mask type color cathode-ray tube
    9.
    发明授权
    Shadow-mask type color cathode-ray tube 失效
    阴影掩模型彩色阴极射线管

    公开(公告)号：US5216321A

    公开(公告)日：1993-06-01

    申请号：US441965

    申请日：1989-11-28

    申请人： Takao Kawamura ,  Masaharu Kumada ,  Hideo Tanabe ,  Masaki Shinoda

    发明人： Takao Kawamura ,  Masaharu Kumada ,  Hideo Tanabe ,  Masaki Shinoda

    IPC分类号： G09F9/00 ,  H01J29/07 ,  H01J29/86 ,  H01J29/89 ,  H01J31/20

    CPC分类号： H01J29/073 ,  H01J29/861

    摘要： Disclosed is a shadow-mask type color cathode-ray tube comprising a faceplate having a curved inner surface which prevents degrouping and a substantially flat outer surface. In this color cathode-ray tube, the resolution is not deteriorated in the peripheral portion and an inespensive flat material is usable as a glass plate provided with a reflection reducing coating or a touch panel attached to the outer surface of the faceplate. Since a shadow mask supported with a tension applied thereto is usable, the positional deviation of the apertures due to the expansion of the shadow mask during operation is prevented.

    摘要翻译： 公开了一种荫罩型彩色阴极射线管，其包括具有弯曲内表面的面板，其防止分组和基本平坦的外表面。 在该彩色阴极射线管中，周边部分的分辨率不会变差，并且可以使用无阻碍的平面材料作为设置有安装在面板的外表面的反射减少涂层或触摸面板的玻璃板。 由于可以使用由其施加的张力支撑的荫罩，因此防止了由于操作期间荫罩的膨胀而引起的孔的位置偏差。

    Coil Device
    10.
    发明授权
    Coil Device 失效
    线圈装置

    公开(公告)号：US06809622B2

    公开(公告)日：2004-10-26

    申请号：US10124368

    申请日：2002-04-18

    申请人： Toru Hirohashi ,  Kiyoshi Hironaka ,  Yasuo Yamashita ,  Masaki Shinoda

    发明人： Toru Hirohashi ,  Kiyoshi Hironaka ,  Yasuo Yamashita ,  Masaki Shinoda

    IPC分类号： H01F2729

    CPC分类号： H01F27/292 ,  H01F27/027

    摘要： A coil device, which has a coil composed of a core and a winding on the core, and a terminal having a base seat for holding the coil and terminal elements. The coil device has a flange on one side of the core with no flange being provided on the other side of the core. This allows molding by using a mold and can reduce a thickness of the flange of the core and thereby realize a reduction in the thickness of the coil device.

    摘要翻译： 一种线圈装置，其具有由芯体和芯体上的绕组构成的线圈，以及具有用于保持线圈和端子元件的基座的端子。 线圈装置在芯的一侧具有凸缘，在芯的另一侧上没有设置凸缘。 这允许通过使用模具进行模制，并且可以减小芯的凸缘的厚度，从而实现线圈装置的厚度的减小。