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    Azole compounds
    2.
    发明授权
    Azole compounds 失效
    唑类化合物

    公开(公告)号：US07183276B2

    公开(公告)日：2007-02-27

    申请号：US10505742

    申请日：2003-02-27

    申请人： Nozomu Sakai ,  Yu Momose ,  Katsuhito Murase ,  Masatoshi Hazama

    发明人： Nozomu Sakai ,  Yu Momose ,  Katsuhito Murase ,  Masatoshi Hazama

    IPC分类号： A61K31/5377 ,  A61K31/421 ,  A61K31/454 ,  A61K31/541 ,  C07D413/04 ,  C07D279/12 ,  C07F9/653 ,  C07D211/46

    CPC分类号： C07D413/04 ,  C07D263/32 ,  C07D263/38 ,  C07D263/46 ,  C07D263/48 ,  C07D277/30 ,  C07D277/40 ,  C07D277/46 ,  C07D413/06 ,  C07D413/12 ,  C07D413/14 ,  C07D417/04 ,  C07D417/14 ,  C07F9/653 ,  C07F9/6539

    摘要： The present invention provides a compound represented by the formula (I) wherein R1 is a hydrogen atom, a halogen atom, an optionally substituted hydrocarbon group, an optionally substituted heterocyclic group, an optionally substituted hydroxy group, an optionally substituted thiol group or an optionally substituted amino group, A is an optionally substituted cyclic amino group or —NR2—W—D wherein R2 is a hydrogen atom or an alkyl group, W is a bond or a divalent acyclic hydrocarbon group, and D is an optionally substituted cyclic group, an optionally substituted amino group or an optionally substituted acyl group, B is an optionally substituted hydrocarbon group or an optionally substituted heterocyclic group, X is an oxygen atom, a sulfur atom or an optionally substituted nitrogen atom, and Y is a bond or a divalent acyclic hydrocarbon group, or a salt thereof, which is useful for the prophylaxis or treatment of diabetic neuropathy and the like.

    摘要翻译： 本发明提供由式（I）表示的化合物，其中R 1为氢原子，卤素原子，任选取代的烃基，任选取代的杂环基，任选取代的羟基， 任选取代的硫醇基或任选取代的氨基，A是任选取代的环氨基或-NR 2 -WD，其中R 2是氢原子或烷基 基团，W是键或二价无环烃基，D是任选取代的环状基团，任选取代的氨基或任选取代的酰基，B是任选取代的烃基或任选取代的杂环基，X是 氧原子，硫原子或任选取代的氮原子，Y是可用于预防或治疗糖尿病性神经病变等的键或二价无环烃基或其盐。

    Neurotrophin production/secretion promoting agent
    3.
    发明申请
    Neurotrophin production/secretion promoting agent 失效
    神经营养素生产/分泌促进剂

    公开(公告)号：US20080269219A1

    公开(公告)日：2008-10-30

    申请号：US12080461

    申请日：2008-04-03

    申请人： Yu Momose ,  Katsuhito Murase

    发明人： Yu Momose ,  Katsuhito Murase

    IPC分类号： A61K31/5377 ,  A61K31/421 ,  A61K31/426 ,  A61K31/4525 ,  A61P25/00 ,  A61P1/00 ,  A61P29/00 ,  A61K31/496 ,  A61K31/443 ,  A61K31/506

    CPC分类号： C07D263/34 ,  C07D231/12 ,  C07D233/56 ,  C07D249/08 ,  C07D263/38 ,  C07D263/46 ,  C07D263/48 ,  C07D277/32 ,  C07D277/40 ,  C07D277/54 ,  C07D413/04 ,  C07D413/12 ,  C07D417/04 ,  C07D417/14

    摘要： A neurotrophin production/secretion promoting agent which comprises an azole derivative of the formula: wherein R1 represents a halogen atom, a heterocyclic group which may optionally be substituted, a hydroxy group which may optionally be substituted, a thiol group which may optionally be substituted, or an amino group which may optionally be substituted; A represents an acyl group which may optionally be substituted, a heterocyclic group which may optionally be substituted, a hydroxy group which may optionally be substituted, or a carboxyl group which may optionally be esterified or amidated; B represents an aromatic group which may optionally be substituted; X represents oxygen atom, sulfur atom, or nitrogen atom which may optionally be substituted; and Y represents a divalent hydrocarbon group or heterocyclic group, or a salt thereof; which is useful as an agent for preventing or treating neuropathy.

    摘要翻译： 神经营养蛋白产生/分泌促进剂，其包含下式的唑衍生物：其中R 1表示卤素原子，可任选被取代的杂环基，可任选被取代的羟基， 可以任选被取代的硫醇基，或可任意被取代的氨基; A表示可任选被取代的酰基，可任选被取代的杂环基，可任意取代的羟基或可任意被酯化或酰胺化的羧基; B表示可任选被取代的芳族基团; X表示可任选被取代的氧原子，硫原子或氮原子; Y表示二价烃基或杂环基，或其盐; 其可用作预防或治疗神经病的药剂。

    Neurotrophin production secretion promoting agent
    4.
    发明授权
    Neurotrophin production secretion promoting agent 有权
    神经营养蛋白生成分泌促进剂

    公开(公告)号：US06605629B1

    公开(公告)日：2003-08-12

    申请号：US09868304

    申请日：2001-06-29

    申请人： Yu Momose ,  Katsuhito Murase

    发明人： Yu Momose ,  Katsuhito Murase

    IPC分类号： C07D41312

    CPC分类号： C07D263/34 ,  C07D231/12 ,  C07D233/56 ,  C07D249/08 ,  C07D263/38 ,  C07D263/46 ,  C07D263/48 ,  C07D277/32 ,  C07D277/40 ,  C07D277/54 ,  C07D413/04 ,  C07D413/12 ,  C07D417/04 ,  C07D417/14

    摘要： A neurotrophin production/secretion promoting agent which comprises an azole derivative of the formula: wherein R1 represents a halogen atom, a heterocyclic group which may optionally be substituted, a hydroxy group which may optionally be substituted, a thiol group which may optionally be substituted, or an amino group which may optionally be substituted; A represents an acyl group which may optionally be substituted, a heterocyclic group which may optionally be substituted, a hydroxy group which may optionally be substituted, or a carboxyl group which may optionally be esterified or amidated; B represents an aromatic group which may optionally be substituted; X represents oxygen atom, sulfur atom, or nitrogen atom which may optionally be substituted; and Y represents a divalent hydrocarbon group or heterocyclic group, or a salt thereof; which is useful as an agent for preventing or treating neuropathy.

    摘要翻译： 一种神经营养因子产生/分泌促进剂，其包含下式的唑衍生物：其中R1表示卤素原子，可任意取代的杂环基，可任选被取代的羟基，可任选被取代的硫醇基， 或可任选被取代的氨基; A表示可任选被取代的酰基，可任选被取代的杂环基，可任意取代的羟基或可任意被酯化或酰胺化的羧基; B表示可任选被取代的芳族基团; X表示可任选被取代的氧原子，硫原子或氮原子; Y表示二价烃基或杂环基，或其盐; 其可用作预防或治疗神经病的药剂。