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    Alkanoic acid derivatives process for their production and use thereof
    1.
    发明授权
    Alkanoic acid derivatives process for their production and use thereof 失效
    用于其生产和使用的烷酸衍生物方法

    公开(公告)号：US07238716B2

    公开(公告)日：2007-07-03

    申请号：US10465938

    申请日：2001-12-28

    申请人： Yu Momose ,  Tsuyoshi Maekawa ,  Nobuyuki Takakura ,  Hiroyuki Odaka ,  Hiroyuki Kimura ,  Tatsuya Ito

    发明人： Yu Momose ,  Tsuyoshi Maekawa ,  Nobuyuki Takakura ,  Hiroyuki Odaka ,  Hiroyuki Kimura ,  Tatsuya Ito

    IPC分类号： A61K31/4439 ,  C07D413/12

    CPC分类号： C07D403/04 ,  C07D263/32 ,  C07D277/24 ,  C07D277/42 ,  C07D413/04 ,  C07D413/06 ,  C07D413/12 ,  C07D413/14 ,  C07D417/06 ,  C07D417/12 ,  C07D417/14

    摘要： An alkanoic acid derivative useful as a prophylactic or therapeutic agent of diabetes mellitus, hyperlipidemia, impaired glucose tolerance and the like can be provided by a compound represented by the formula wherein R1 is an optionally substituted 5-membered aromatic heterocyclic group; X is a bond and the like; Q is a divalent hydrocarbon group having 1 to 20 carbon atoms; Y is a bond and the like; ring A is an aromatic ring optionally further having 1 to 3 substituents; Z is —(CH2)n-Z1-(n is an integer of 1 to 8 and Z1 is an oxygen atom and the like) and the like; ring B is a pyridine ring optionally further having 1 to 3 substituents, and the like; U is a bond and the like; W is a divalent hydrocarbon group having 1 to 20 carbon atoms; and R3 is —OH and the like, provided that, when ring B is a benzene ring optionally further having 1 to 3 substituents, U should be a bond, or a salt thereof.

    摘要翻译： 可用作糖尿病，高脂血症，葡萄糖耐量异常等的预防或治疗剂的链烷酸衍生物可由下式表示的化合物提供：其中R 1为任选取代的5元 芳香族杂环基; X是一个键等; Q为碳原子数为1〜20的二价烃基; Y是一个债券等; 环A是任选进一步具有1至3个取代基的芳环; Z是 - （CH 2）n - n 1 - （n是1至8的整数，Z <1） SUP>是氧原子等）等; 环B是任选还含有1至3个取代基的吡啶环等; U是一个债券等; W是碳原子数为1〜20的二价烃基; 且R 3为-OH等，条件是当环B为任选还含有1至3个取代基的苯环时，U应为键或其盐。

    Five-membered heterocyclic compounds
    2.
    发明申请
    Five-membered heterocyclic compounds 失效
    五元杂环化合物

    公开(公告)号：US20060135578A1

    公开(公告)日：2006-06-22

    申请号：US10527426

    申请日：2003-09-09

    申请人： Yu Momose ,  Nobuyuki Takakura ,  Tsuyoshi Maekawa ,  Hiroyuki Odaka ,  Hiroyuki Kimura

    发明人： Yu Momose ,  Nobuyuki Takakura ,  Tsuyoshi Maekawa ,  Hiroyuki Odaka ,  Hiroyuki Kimura

    IPC分类号： A61K31/422 ,  C07D413/14

    CPC分类号： C07D263/32 ,  C07F9/6558 ,  C07F9/65583

    摘要： The present invention provides a compound represented by the formula: wherein R1 is an optionally substituted 5-membered heterocyclic group; X, Y and V are the same or different and each is a bond, an oxygen atom, a sulfur atom and the like; Q is a divalent hydrocarbon group having 1 to 20 carbon atoms; ring A is an aromatic ring optionally further having 1 to 3 substituents; Z is —(CH2)n-Z1- or -Z1-(CH2)n— (n is an integer of 0 to 8, Z1 is a bond, an oxygen atom, a sulfur atom and the like); ring B is a nitrogen-containing heterocycle optionally further having 1 to 3 substituents; W is a bond or a divalent hydrocarbon group having 1 to 20 carbon atoms; R2 is a hydrogen atom, a cyano group, —PO(OR9)(OR10) (R9 and R10 are the same or different and each is a hydrogen atom or an optionally substituted hydrocarbon group, and R9 and R10 are optionally bonded to form an optionally substituted ring) and the like, or a salt thereof, which has a superior adipose tissue weight decreasing action, a hypoglycemic action and a hypolipidemic action, and which is useful as an agent for the prophylaxis or treatment of obesity, diabetes mellitus, hyperlipidemia, impaired glucose tolerance, hypertension and the like.

    摘要翻译： 本发明提供由下式表示的化合物：其中R 1是任选取代的5元杂环基; X，Y和V相同或不同，各自为键，氧原子，硫原子等; Q为碳原子数为1〜20的二价烃基; 环A是任选进一步具有1至3个取代基的芳环; Z是 - （CH 2）n - - - - - - - - 1 - （CH 2） （n为0〜8的整数，Z 1为键，氧原子，硫原子等）; n为0〜8的整数。 环B是任选进一步具有1至3个取代基的含氮杂环; W是碳原子数为1〜20的键或二价烃基; R 2是氢原子，氰基，-PO（OR 9）（OR 10）（R 10） SUP＆gt;和R 10相同或不同，各自为氢原子或任选取代的烃基，R 9和R 10为 任选地键合以形成任选取代的环）等，或其盐，其具有优异的脂肪组织重量减少作用，降血糖作用和降血脂作用，并且其可用作预防或治疗 肥胖症，糖尿病，高脂血症，葡萄糖耐量降低，高血压等。

    Five-membered heterocyclic compounds
    3.
    发明授权
    Five-membered heterocyclic compounds 失效
    五元杂环化合物

    公开(公告)号：US07368578B2

    公开(公告)日：2008-05-06

    申请号：US10527426

    申请日：2003-09-09

    申请人： Yu Momose ,  Nobuyuki Takakura ,  Tsuyoshi Maekawa ,  Hiroyuki Odaka ,  Hiroyuki Kimura

    发明人： Yu Momose ,  Nobuyuki Takakura ,  Tsuyoshi Maekawa ,  Hiroyuki Odaka ,  Hiroyuki Kimura

    IPC分类号： C07D263/02 ,  C07D263/00 ,  C07D263/30 ,  C07D261/00 ,  C07D261/04 ,  C07D261/06 ,  A01N43/76 ,  A01N43/80

    CPC分类号： C07D263/32 ,  C07F9/6558 ,  C07F9/65583

    摘要： The present invention provides a compound represented by the formula: wherein R1 is an optionally substituted 5-membered heterocyclic group; X, Y and V are the same or different and each is a bond, an oxygen atom, a sulfur atom and the like; Q is a divalent hydrocarbon group having 1 to 20 carbon atoms; ring A is an aromatic ring optionally further having 1 to 3 substituents; Z is —(CH2)n-Z1- or -Z1-(CH2)n— (n is an integer of 0 to 8, Z1 is a bond, an oxygen atom, a sulfur atom and the like); ring B is a nitrogen-containing heterocycle optionally further having 1 to 3 substituents; W is a bond or a divalent hydrocarbon group having 1 to 20 carbon atoms; R2 is a hydrogen atom, a cyano group, —PO(OR9)(OR10) (R9 and R10 are the same or different and each is a hydrogen atom or an optionally substituted hydrocarbon group, and R9 and R10 are optionally bonded to form an optionally substituted ring) and the like, or a salt thereof, which has a superior adipose tissue weight decreasing action, a hypoglycemic action and a hypolipidemic action, and which is useful as an agent for the prophylaxis or treatment of obesity, diabetes mellitus, hyperlipidemia, impaired glucose tolerance, hypertension and the like.

    摘要翻译： 本发明提供由下式表示的化合物：其中R 1是任选取代的5元杂环基; X，Y和V相同或不同，各自为键，氧原子，硫原子等; Q为碳原子数为1〜20的二价烃基; 环A是任选进一步具有1至3个取代基的芳环; Z是 - （CH 2）n - - - - - - - - 1 - （CH 2） （n为0〜8的整数，Z 1为键，氧原子，硫原子等）; n为0〜8的整数。 环B是任选进一步具有1至3个取代基的含氮杂环; W是碳原子数为1〜20的键或二价烃基; R 2是氢原子，氰基，-PO（OR 9）（OR 10）（R 10） SUP＆gt;和R 10相同或不同，各自为氢原子或任选取代的烃基，R 9和R 10为 任选地键合以形成任选取代的环）等，或其盐，其具有优异的脂肪组织重量减少作用，降血糖作用和降血脂作用，并且其可用作预防或治疗 肥胖症，糖尿病，高脂血症，葡萄糖耐量降低，高血压等。

    Fused ring compounds and use thereof
    4.
    发明授权
    Fused ring compounds and use thereof 失效
    稠环化合物及其用途

    公开(公告)号：US08673942B2

    公开(公告)日：2014-03-18

    申请号：US12936785

    申请日：2009-04-09

    申请人： Tsuneo Yasuma ,  Nobuyuki Takakura

    发明人： Tsuneo Yasuma ,  Nobuyuki Takakura

    IPC分类号： A61K31/4436 ,  C07D417/14

    CPC分类号： C07D417/04 ,  C07D417/14

    摘要： The present invention aims to provide a glucokinase activator useful as a pharmaceutical agent such as an agent for the prophylaxis or treatment of diabetes, obesity and the like. The present invention provides a glucokinase activator containing a compound represented by the formula (I): wherein each symbol is defined in the specification, or a salt thereof or a prodrug thereof.

    摘要翻译： 本发明的目的在于提供一种用作预防或治疗糖尿病，肥胖症等药物的药剂的葡糖激酶活化剂。 本发明提供含有式（I）表示的化合物的葡糖激酶活化剂：其中每个符号在说明书中定义，或其盐或其前药。