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公开(公告)号：US10024819B2
公开(公告)日：2018-07-17
申请号：US13880973
申请日：2011-10-21
申请人： Yu-Hwa Lo , Wen Qiao , Gyoujin Cho , Hwiwon Kang
发明人： Yu-Hwa Lo , Wen Qiao , Gyoujin Cho , Hwiwon Kang
IPC分类号： G01N27/447 , B01L3/00 , B01J19/00 , G01N15/14
摘要： Techniques, devices and systems are described for incorporating a printed circuit with a microfluidic device and wirelessly powering the microfluidic device. In one aspect, a microfluidic device includes a substrate with a fluidic channel to provide a path for a fluid with particles. The fluidic channel includes fluid inlet and outlet. A pair of electrodes near the inlet and the outlet guides the particles toward a center of the fluidic channel using negative-dielectrophoresis (DEP) effect in response to an alternating current (AC) frequency voltage received at the pairs of electrodes. Additional pairs of electrodes are disposed along a border of the fluidic channel between the pairs of electrodes near the inlet and the outlet of the fluidic channel to isolate a subpopulation of the particles using positive and negative DEP effects in response to AC voltages of different frequencies received at different ones of the additional pairs of electrodes.
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公开(公告)号：US09484772B2
公开(公告)日：2016-11-01
申请号：US13884594
申请日：2011-11-09
CPC分类号： B81B7/02 , H01L25/167 , H01L2924/0002 , H02J17/00 , H02J50/10 , H02J50/20 , H04B5/0031 , H04B5/0037 , H01L2924/00
摘要： Methods, devices and systems are provided for wirelessly powering and controlling a lab-on-a-chip device. Direct current (DC) and alternating current (AC) signals can be produced at the lab-on-a-chip device in a wireless manner. In some configurations, integrated RF components and optoelectronic components of the lab-on-a-chip device are used to collaboratively produce the DC and AC signals. In other configurations only optoelectronic components on the lab-on-a-chip system can produce the DC and/or AC signals in response to incident light. By modulating the incident light, AC signals of various frequencies and waveforms can be generated. The DC and AC signals can be used by additional integrated electronic circuits and by a microfluidic chip lactated on the lab-on-a-chip device to control the behavior of the bioparticles in the microfluidic device.
摘要翻译： 提供了用于无线供电和控制芯片实验室设备的方法，设备和系统。 直流（DC）和交流（AC）信号可以在无线方式的芯片实验室设备上产生。 在一些配置中，使用片上实验室器件的集成RF组件和光电子组件来协同产生DC和AC信号。 在其他配置中，只有芯片实验室上的光电元件才能响应入射光而产生直流和/或交流信号。 通过调制入射光，可以产生各种频率和波形的交流信号。 DC和AC信号可以由额外的集成电子电路和由芯片实验室上的乳化的微流控芯片使用，以控制微流体装置中的生物颗粒的行为。
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公开(公告)号：US20140061049A1
公开(公告)日：2014-03-06
申请号：US13880973
申请日：2011-10-21
申请人： Yu-Hwa Lo , Wen Qiao , Gyoujin Cho , Hwiwon Kang
发明人： Yu-Hwa Lo , Wen Qiao , Gyoujin Cho , Hwiwon Kang
IPC分类号： G01N27/447
CPC分类号： G01N27/44704 , B01J19/0093 , B01J2219/00853 , B01J2219/00912 , B01L3/502715 , B01L3/502761 , B01L3/502776 , B01L2200/0652 , B01L2200/0668 , B01L2200/10 , B01L2200/12 , B01L2300/022 , B01L2300/023 , B01L2300/0645 , B01L2300/0822 , B01L2300/0887 , B01L2400/0421 , B01L2400/0424 , G01N2015/1422
摘要： Techniques, devices and systems are described for incorporating a printed circuit with a microfluidic device and wirelessly powering the microfluidic device. In one aspect, a microfluidic device includes a substrate with a fluidic channel to provide a path for a fluid with particles. The fluidic channel includes fluid inlet and outlet. A pair of electrodes near the inlet and the outlet guides the particles toward a center of the fluidic channel using negative-dielectrophoresis (DEP) effect in response to an alternating current (AC) frequency voltage received at the pairs of electrodes. Additional pairs of electrodes are disposed along a border of the fluidic channel between the pairs of electrodes near the inlet and the outlet of the fluidic channel to isolate a subpopulation of the particles using positive and negative DEP effects in response to AC voltages of different frequencies received at different ones of the additional pairs of electrodes.
摘要翻译： 描述了技术，装置和系统，用于将具有微流体装置的印刷电路并入到微流体装置的无线供电中。 在一个方面，微流体装置包括具有流体通道以提供具有颗粒的流体的路径的基底。 流体通道包括流体入口和出口。 入口和出口附近的一对电极响应于在电极对接收的交流（AC）频率电压，使用负介电电泳（DEP）效应将颗粒引向流体通道的中心。 附加的电极对在沿着流体通道的入口和出口附近的电极对之间的流体通道的边界处设置，以响应于接收到的不同频率的AC电压，使用正和负DEP效应来隔离颗粒的亚群 在不同的附加电极对上。
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公开(公告)号：US20130285477A1
公开(公告)日：2013-10-31
申请号：US13884594
申请日：2011-11-09
IPC分类号： H02J17/00
CPC分类号： B81B7/02 , H01L25/167 , H01L2924/0002 , H02J17/00 , H02J50/10 , H02J50/20 , H04B5/0031 , H04B5/0037 , H01L2924/00
摘要： Methods, devices and systems are provided for wirelessly powering and controlling a lab-on-a-chip device. Direct current (DC) and alternating current (AC) signals can be produced at the lab-on-a-chip device in a wireless manner. In some configurations, integrated RF components and optoelectronic components of the lab-on-a-chip device are used to collaboratively produce the DC and AC signals. In other configurations only optoelectronic components on the lab-on-a-chip system can produce the DC and/or AC signals in response to incident light. By modulating the incident light, AC signals of various frequencies and waveforms can be generated. The DC and AC signals can be used by additional integrated electronic circuits and by a microfluidic chip lactated on the lab-on-a-chip device to control the behavior of the bioparticles in the microfluidic device.
摘要翻译： 提供了用于无线供电和控制芯片实验室设备的方法，设备和系统。 直流（DC）和交流（AC）信号可以在无线方式的芯片实验室设备上产生。 在一些配置中，使用片上实验室器件的集成RF组件和光电子组件来协同产生DC和AC信号。 在其他配置中，只有芯片实验室上的光电元件才能响应入射光而产生直流和/或交流信号。 通过调制入射光，可以产生各种频率和波形的交流信号。 DC和AC信号可以由额外的集成电子电路和由芯片实验室上的乳化的微流控芯片使用，以控制微流体装置中的生物颗粒的行为。
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公开(公告)号：US20110118834A1
公开(公告)日：2011-05-19
申请号：US12874150
申请日：2010-09-01
申请人： Yuhwa Lo , Wen Qiao , David Schanzlin , Gary L. Shields , Robert S. Vasko , Jeff Vasko
发明人： Yuhwa Lo , Wen Qiao , David Schanzlin , Gary L. Shields , Robert S. Vasko , Jeff Vasko
CPC分类号： G02B3/14 , A61F2/1635 , A61F2002/169 , A61F2240/001 , G02C7/08
摘要： The present invention relates to a fluidic intraocular lens inserted into a capsular bag of an eye to replace a crystalline lens. The fluidic intraocular lens may be shaped by elastic membranes bonded to a support ring. The space inside the device may be filled with optically transparent fluid or gel having an index of refraction greater than the index of vitreous humor. The device may be such designed so that the focusing power of the lens can be changed by the deformation of the capsular bag, which may be subsequently controlled by a ciliary muscle.
摘要翻译： 本发明涉及一种插入眼袋的液体眼内透镜，以取代晶状体。 流体眼内透镜可以通过粘结到支撑环的弹性膜成形。 装置内的空间可以填充光学透明的流体或凝胶，其折射率大于玻璃体液的指数。 该装置可以被设计成使得透镜的聚焦能量可以通过胶囊袋的变形来改变，该囊袋随后可由睫状肌控制。
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