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13 条记录 (耗时 0.038 秒)

    Reciprocating slot cutting tool
    5.
    发明授权
    Reciprocating slot cutting tool 有权
    往复槽切割工具

    公开(公告)号：US6094826A

    公开(公告)日：2000-08-01

    申请号：US144777

    申请日：1998-09-01

    申请人： James J. Schmidt

    发明人： James J. Schmidt

    IPC分类号： B27B19/00 ,  B23D49/10

    CPC分类号： B27B19/006

    摘要： This invention is a tool for plunge cutting comprising a motor, a transmission connected to the motor and a blade assembly connected to the transmission, wherein the blades move in an oppositely reciprocating and sliding manner to provide plunge cuts of variable depth with closed ends and a continuous perimeter. The tool of the invention may be held and operated with one hand. The invention is designed to be held in juxtaposition to the area to be cut, and the invention further optionally includes a novel blade wherein the blades have opposite first and second sides, wherein the first side is completely flat, allowing it to slide unobstructed against the first side of the other blade; and wherein alternating teeth, including both end teeth, are straight and not bent or set; and wherein alternating even teeth are bent toward the second side of the blade; and wherein one-half of the teeth point forward and the other half of the teeth point aft; and wherein the blade teeth follow an arc; and wherein the front and aft edges of the blade are shaped to form a gullet.

    摘要翻译： 本发明是一种用于插入式切割的工具，包括电动机，连接到电动机的变速器和连接到变速器的叶片组件，其中叶片以相反的往复和滑动方式移动，以提供具有闭合端的可变深度的切入切口 连续的周长。 本发明的工具可以用一只手来保持和操作。 本发明被设计成与待切割的区域并置地保持，并且本发明还可选地包括一种新颖的刀片，其中刀片具有相对的第一和第二侧面，其中第一侧面是完全平坦的，从而使其能够不受阻碍地滑动 另一个叶片的第一面; 并且其中包括两个端齿的交替的齿是直的并且不弯曲或设置; 并且其中交替的均匀齿朝向所述叶片的第二侧弯曲; 并且其中一半的齿指向前方并且另一半的齿指向后方; 并且其中所述刀片齿跟随弧; 并且其中所述叶片的前边缘和后边缘成形为形成齿槽。

    Selectively configurable package for retaining separated items
    7.
    发明授权
    Selectively configurable package for retaining separated items 失效
    可选择配置的包，用于保留分隔的物品

    公开(公告)号：US5029705A

    公开(公告)日：1991-07-09

    申请号：US404745

    申请日：1989-09-08

    申请人： James J. Schmidt ,  Wilton M. Connor

    发明人： James J. Schmidt ,  Wilton M. Connor

    IPC分类号： B65D75/34 ,  B65D75/54

    CPC分类号： B65D75/54 ,  B65D75/323

    摘要： A package for retaining and displaying a plurality of cylindrical items in separated compartments as formed from a pair of compatibly configured plastic clam shells secured to one another. The plastic clam shells define a front package portion having a plurality of cylindrical item receptacles and a rear package portion having another plurality of cylindrical item receptacles. The front and rear package portions are interconnected to permit predetermined movement of the front and rear package portions relative to one another between a first display position in which the front and rear package portions are disposed in generally superimposed, adjacent relation to one another and a second access position in which the front and rear package portions are substantially displaced from one another to permit ready access to the cylindrical items retained in the item receptacles.

    摘要翻译： 一种用于保持和显示分离的隔室中的多个圆柱形物品的包装件，由一对彼此固定的相容配置的塑料蛤壳形成。 塑料蛤壳限定具有多个圆柱形物品容器的前包装部分和具有另外多个圆柱形物品容器的后包装部分。 前包装部分和后包装部分互连以允许前包装部分和后包装部分相对于彼此在第一显示位置和第二显示位置之间预定的移动，其中前包装部分和后包装部分之间以相互重叠的相邻关系设置在第一显示位置和第二显示位置之间， 进入位置，其中前包装部分和后包装部分基本上彼此移位，以允许准备进入保留在物品容器中的圆柱形物品。

    Small molecules and a pharmacophore model for inhibition of botulinum toxin and methods of making and using thereof
    8.
    发明授权
    Small molecules and a pharmacophore model for inhibition of botulinum toxin and methods of making and using thereof 失效
    用于抑制肉毒杆菌毒素的小分子和药效团模型及其制备和使用方法

    公开(公告)号：US07574340B2

    公开(公告)日：2009-08-11

    申请号：US10935622

    申请日：2004-09-08

    申请人： Sina Bavari ,  James J. Schmidt ,  James Burnett ,  Rick Gussio

    发明人： Sina Bavari ,  James J. Schmidt ,  James Burnett ,  Rick Gussio

    IPC分类号： G06G7/48

    CPC分类号： A61K31/635 ,  A61K31/47 ,  A61K31/4706 ,  A61K45/06 ,  G06F19/705 ,  G06F19/706 ,  A61K2300/00

    摘要： Disclosed herein is a pharmacophore model for inhibiting Botulinum neurotoxin A metalloprotease activity which comprises a first plane A, a second plane B, a first hydrophobic moiety C, a second hydrophobic moiety D and a positive ionizable substituent E. The pharmacophore model may further comprise a heteroatom in the first plane A. In some embodiments, the distance between the center of the first plane A and the center of the second plane B is about 6.5 to about 9.5 Å. In some embodiments, the distance between the center of the first hydrophobic moiety C and the center of the second hydrophobic moiety D is about 8.0 to about 16.0 Å. In some embodiments, the distance between the center of the first plane to the center of the first hydrophobic moiety C is about 3.0 to about 5.0 Å. In some embodiments, the distance between the center of the second plane to the center of the second hydrophobic moiety C is about 3.0 to about 5.0 Å. In some embodiments, the distance between the center of the first plane to the center of the positive ionizable substituent is about 6.5 to about 9.5 Å.

    摘要翻译： 本文公开了用于抑制肉毒杆菌神经毒素A金属蛋白酶活性的药效团模型，其包含第一平面A，第二平面B，第一疏水部分C，第二疏水部分D和可阳离子化取代基E.药效基团模型还可包含 在一些实施例中，第一平面A的中心与第二平面B的中心之间的距离为约6.5至约9.5。 在一些实施方案中，第一疏水部分C的中心与第二疏水部分D的中心之间的距离为约8.0至约16.0。 在一些实施方案中，第一平面的中心与第一疏水部分C的中心之间的距离为约3.0至约5.0。 在一些实施方案中，第二平面的中心与第二疏水部分C的中心之间的距离为约3.0至约5.0。 在一些实施方案中，第一平面的中心与正电离取代基的中心之间的距离为约6.5至约9.5。

    High throughput assays for the proteolytic activities of clostridial neurotoxins
    9.
    发明授权
    High throughput assays for the proteolytic activities of clostridial neurotoxins 失效
    梭菌神经毒素蛋白水解活性的高通量测定

    公开(公告)号：US07034107B2

    公开(公告)日：2006-04-25

    申请号：US10802574

    申请日：2004-03-17

    申请人： James J. Schmidt ,  Robert G. Stafford

    发明人： James J. Schmidt ,  Robert G. Stafford

    IPC分类号： C07K14/00 ,  A61K39/08

    CPC分类号： C07K14/33 ,  C12Q1/37 ,  G01N33/542 ,  G01N33/56911 ,  G01N2333/33 ,  Y10S435/842

    摘要： In this application is described substrates for high-throughput assays of clostridial neurotoxin proteolytic activities. Two types of substrates are described for use in assays for the proteolytic activities of clostridial neurotoxins: (1) modified peptides or proteins that can serve as FRET substrates and (2) modified peptides or proteins that can serve as immobilized substrates. In both types a fluorescent molecules is present in the substrate, eliminating the requirement for the addition of a fluorigenic reagent. The assays described can be readily adapted for use in automated or robotic systems.

    摘要翻译： 在本申请中描述了用于梭菌神经毒素蛋白水解活性的高通量测定的底物。 描述了两种类型的底物用于梭菌神经毒素的蛋白水解活性的测定：（1）可用作FRET底物的修饰肽或蛋白质，和（2）可用作固定化底物的修饰肽或蛋白质。 在两种类型中，荧光分子存在于底物中，消除了添加荧光试剂的要求。 所描述的测定法可以容易地适用于自动化或机器人系统。